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jujuboside A ameliorates tubulointerstitial fibrosis in diabetic mice through down-regulating the YY1/TGF-β1 signaling pathway

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Chinese Journal of Natural Medicines 2022年第9期20卷 656-668页

作者： LIU Yang-Yang LI Lin JI Bei HAO Shi-Long KUANG Xiao-Feng CAO Xin-Yun YUAN Jia-Yu JIANG Zhen-Zhou QIAN Si-Tong WEI Chu-Jing XU Jing YIN Xiao-Xing LU Qian YANG ting-ting Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Xuzhou Medical UniversityXuzhou 221004China New Drug Screening Center Jiangsu Center for Pharmacodynamics Research and EvaluationChina Pharmaceutical UniversityNanjing 210009China

Diabetic nephropathy(DN)is one of the most common complications of diabetes mellitus,which is characterized in renal tubulointerstitial fibrosis(TIF).The current study was designed to investigate the protective effect of jujuboside A(ju A)on TIF in type 2 diabetes(T2DM)mice,and explore its underlying anti-fibrosis mechanism.A mouse T2DM model was established using high fat diet(HFD)feeding combined with intraperitoneal injection of streptozotocin(STZ).Then,diabetic mice were treated with ju A(10,20 and 40 mg·kg^(−1)·d^(−1),i.g.)for 12 *** showed that administration of ju A not only down-regulated fasting blood glucose(FBG)levels,but also improved hyperlipidemia and renal function in diabetic ***,the reduced ECM accumulation was observed in the renal cortex of ju A treated diabetic mice,while the TIF progression was also attenuated by ju A through blocking the epithelial-to-mesenchymal transition(EMT)of renal tubular epithelial cells(RTECs).Further mechanism studies showed that ju A treatment effectively down-regulated the protein expression and subsequent nuclear translocation of Yin Yang 1(YY1)in the renal cortex of diabetic mice,and reduced the levels of transforming growth factor-β1(TGF-β1)in the serum and renal cortex of ju A treated *** to in vitro studies,the up-regulated YY1/TGF-β1 signaling pathway was restored by ju A in high glucose(HG)cultured HK-2 *** together,these findings demonstrated that ju A can ameliorate the TIF of DN through down-regulating the YY1/TGF-β1 signaling pathway.

关键词： Diabetic nephropathy jujuboside A Tubulointerstitial fibrosis Extracellular matrix YY1/TGF-β1 signaling pathway

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DNA methyltransferase 3B promoter polymorphism and its susceptibility to primary hepatocellular carcinoma in the Chinese Han nationality population:A case-control study

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World Journal of Gastroenterology 2007年第45期13卷 6082-6086页

作者： Ying Wu ju-Sheng Lin Institute of Liver Diseases TongjiHospital Tongji Medical College Huazhong University ofScience and Technology Wuhan 430030 Hubei Province China

AIM： To investigate the correlation between C/T single nucleotide polymorphism （SNP） in the promoter of the DNA methyltransferase 3B （D/VMT3B） gene and risk for development and progression of primary hepatocellular carcinoma （HCC）. METHODS： One hundred case subjects were selected consecutively from Tongji Hospital （Wuhan, China）. from March to November 2006. They did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed HCC. One hundred and forty control subjects having no history of cancerous or genetic diseases were healthy volunteers to Wuhan Blood Center in the same period. Frequency was matched for sex, age, alcohol consumption and cigarette smoking status of the case subjects. C/T polymorphism of the DNMT3B promoter was analyzed using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） and sequencing analysis. The association between genotypes of DNMT3B and clinicopathological parameters among cases was also studied. RESULTS： The CC genotype HCC patients and controls. was not detected in both In control subjects, the frequency of TT and CT genotypes was 99.3% and 0.7% respectively, and that of T and C alleles was 99.6% and 0.4% respectively. The frequency of CT genotype was higher in HCC （3.0%）. The frequency of T and C alleles was 98.5% and 1.5% respectively. However, the genotype and allelotype distribution in HCC patients was not significantly different from that in controls. CONCLUSION： C/T polymorphism is not associated with the increased risk of HCC. DNMT3B genetic polymorphism is variable in different races, ethnic groups or geographic areas. Further study is needed to clarify the role of DNMT3B SNP in the development of HCCamong other populations.

关键词： DNA methyltransferase Single nucleotidepolymorphism Susceptibility Primary hepatocellularcarcinoma

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Secular decreasing trends in gastric cancer incidence in Taiwan:A population-based cancer registry study

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World Journal of Gastroenterology 2021年第34期27卷 5764-5774页

作者： Yen-Tzeng Lin Chun-ju Chiang Ya-Wen Yang Shih-Pei Huang San-Lin You School of Medicine College of MedicineFu Jen Catholic UniversityNew Taipei City 242008TaiwanChina Institute of Epidemiology and Preventive Medicine College of Public HealthNational Taiwan UniversityTaipei 10617TaiwanChina Department of Medical Education&Bioethics Graduate Institute of Medical Education&BioethicsNational Taiwan University College of MedicineTaipei 10051TaiwanChina School of Medicine&Big Data Research Center Fu Jen Catholic UniversityNew Taipei City 242008TaiwanChina

BACKGROUND Gastric cancer remains a leading cause of cancer death *** Taiwan,gastric cancer is the sixth leading cause of cancer mortality in both males and *** To evaluate secular trends in gastric cancer incidence according to age,sex,and Helicobacter pylori(***)treatment in *** In this population-based study,we used the national Taiwan Cancer Registry *** percent changes in incidence rates were used to describe secular trends in incidence rates and sex ratios of gastric cancer in ***’s product-moment correlation coefficients were used to analyze the correlation between annual age-adjusted incidence rates and the annual number of patients treated with antibiotic therapy for *** *** The annual percent changes showed continuously decreasing rates of gastric cancer among both males and ***,the decreasing trends differed by sex,with an annual percent change of-2.58%in males and-2.14%in *** age-specific incidence rates increased with *** the same age group,more recent time periods showed lower incidence rates than greater time ***,the sex ratio was lower in later birth cohorts than in earlier birth ***-adjusted incidence rates substantially decreased with increasing numbers of patients being treated with antibiotic therapy for *** infection during 2005 to 2016(r=0.72).CONCLUSION We observed steadily decreasing trends with differential sex ratios in the incidence of gastric cancer in *** results support *** eradication programs in Taiwan.

关键词： Gastric cancer Population-based study Taiwan Cancer Registry Sex difference Helicobacter pylori Helicobacter pylori eradication

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Effect of Simulated Acid Rain on Potential Carbon and Nitrogen Mineralization in Forest Soils

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Pedosphere 2008年第4期18卷 503-514页

作者： OUYANG Xue-jun ZHOU Guo-Yi HUANG Zhong-Liang LIU ju-Xiu ZHANG De-Qiang LI Jiong South China Botanic Garden Chinese Academy of Sciences Guangzhou 510650 （China） Graduate School of the Chinese Academy of Sciences Beijing 100049 （China）

Acid rain is a serious environmental problem worldwide. In this study, a pot experiment using forest soils planted with the seedlings of four woody species was performed with weekly treatments of pH 4.40, 4.00, 3.52, and 3.05 simulated acid rain (SAR) for 42 months compared to a control of pH 5.00 lake water. The cumulative amounts of C and N mineralization in the five treated soils were determined after incubation at 25 ℃ for 65 d to examine the effects of SAR treatments. For all five treatments, cumulative CO2-C production ranged from 20.24 to 27.81 mg kg-1 dry soil, net production of available N from 17.37 to 48.95 mg kg-1 dry soil, and net production of NO-3 -N from 9.09 to 46.23 mg kg-1 dry soil. SAR treatments generally enhanced the emission of CO2-C from the soils; however, SAR with pH 3.05 inhibited the emission. SAR treatments decreased the net production of available N and NO3-N. The cumulative CH4 and N2O productions from the soils increased with increasing amount of simulated acid rain. The cumulative CO2-C production and the net production of available N of the soil under Acmena acuminatissima were significantly higher (P ≤ 0.05) than those under Schima superba and Cryptocarya concinna. The mineralization of soil organic C was related to the contents of soil organic C and N, but was not related to soil pH. However, the overall effect of acid rain on the storage of soil organic matter and the cycling of important nutrients depended on the amount of acid deposition and the types of forests.

关键词： forest soils mineralization organic C organic N simulated acid rain

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11R24.5越野牵引型全钢载重子午线轮胎的设计

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轮胎工业 2024年第9期44卷 529-532页

作者：吕伟孙宗涛曲家玉鞠浩车明明浦林成山(山东)轮胎有限公司山东荣成264300

介绍11R24.5越野牵引型全钢载重子午线轮胎的设计。结构设计:外直径1 112.8 mm,断面宽280.7 mm,行驶面宽度240 mm,行驶面弧度高5.5 mm,胎圈着合直径621.8 mm,胎圈着合宽度223.6 mm,断面水平轴位置(H1/H2) 0.928,胎面采用大花纹块设计和... 详细信息

介绍11R24.5越野牵引型全钢载重子午线轮胎的设计。结构设计:外直径1 112.8 mm,断面宽280.7 mm,行驶面宽度240 mm,行驶面弧度高5.5 mm,胎圈着合直径621.8 mm,胎圈着合宽度223.6 mm,断面水平轴位置(H1/H2) 0.928,胎面采用大花纹块设计和花纹沟底保护筋设计,花纹深度26.5 mm,花纹饱和度65.5%,花纹周节数48。施工设计:胎面采用三复合挤出工艺,采用4层带束层结构,1#带束层采用4+3×0.33ST钢丝帘线,2#和3#带束层采用3+8×0.33HT钢丝帘线,4#带束层采用5×0.35HI钢丝帘线,胎体采用3+9+15×0.22+0.15钢丝帘线,采用三鼓一次法成型机成型、双模定型硫化机硫化。成品性能试验结果表明,轮胎的充气外缘尺寸、强度性能和耐久性能符合相应测试标准和设计要求。

关键词：越野牵引型轮胎全钢载重子午线轮胎结构设计施工设计成品轮胎性能

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Enhanced hydrogen storage of alanates: Recent progress and future perspectives

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Progress in Natural Science:Materials International 2021年第2期31卷 165-179页

作者： Li Zhao Fen Xu Chenchen Zhang Zhenyue Wang Hanyu ju Xu Gao Xiaoxu Zhang Lixian Sun Zongwen Liu Guangxi Key Laboratory of Information Materials Guangxi Collaborative Innovation Center of Structure and Property for New Energy and Materials School of Materials Science and Engineering Guilin University of Electronic Technology School of Chemical and Biomolecular Engineering The University of Sydney The University of Sydney Nano Institute The University of Sydney

The global energy crisis and environmental pollution have caused great concern. Hydrogen is a renewable and environmentally friendly source of energy and has potential to be a major alternative energy carrier in the *** to its high capacity and relatively low cost of raw materials, alanate has been considered as one of the most promising candidates for hydrogen storage. Among them, LiAlH4and NaAlH4, as two representative metal alanates, have attracted extensive attention. Unfortunately, the high desorption temperature and sluggish kinetics restrict its practical application. In this paper, the basic physical and chemical properties as well as the hydrogenation/dehydrogenation reaction mechanism of LiAlH4and NaAlH4are briefly reviewed. The recent progress on strategic optimizations toward tuning the thermodynamics and kinetics of the alanate including nanoscaling,doping catalysts and compositing modification are emphatically discussed. Finally, the coming challenges and the development prospects are also proposed in this review.

关键词： Hydrogen storage LiAlH4 NaAlH4 Nanoscaling Catalysts Mechanism

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OsSRK1,an Atypical S-Receptor-Like Kinase Positively Regulates Leaf Width and Salt Tolerance in Rice

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Rice science 2020年第2期27卷 133-142页

作者： ZHOU Jinjun ju Peina ZHANG Fang ZHENG Chongke BAI Bo LI Yaping WANG Haifeng CHEN Fan XIE Xianzhi Shandong Rice Research Institute Shandong Academy of Agricultural SciencesJinan 250100China Institute of Genetics and Development Biology the Chinese Academy of ScienceBeijing 100190China Shangdong Normal University Jinan 250014China

Receptor-like kinases(RLKs)are important for plant growth,development and defense *** S-receptor protein kinases(SRKs),which represent an RLK subfamily,control the selfincompatibility among Brassica ***,little information is available regarding SRK functions in *** identified a gene OsSRK1 encoding an atypical *** transcript of OsSRK1 was induced by abscisic acid(ABA),salt and polyethylene ***1 localized to the plasma membrane and *** width was increased in OsSRK1-overexpression(OsSRK1-OX)transgenic rice plants,likely because of an increase in cell number per ***,the expression levels of OsCYCA3-1 and OsCYCD2-1,which encode positive regulators of cell division,were up-regulated in leaf primordium of OsSRK1-OX rice plants relative to those in wild ***,the expression level of OsKRP1,which encodes cell cycle inhibitor,was down-regulated in the OsSRK1-OX ***,it is deduced that OsSRK1 regulates leaf width by promoting cell division in the leaf ***,OsSRK1-OX plants exhibited enhanced ABA sensitivity and salt tolerance compared with wild *** results suggest that OsSRK1 plays important roles in leaf development and salt responses in rice.

关键词： rice S-receptor-like protein kinase OsSRK1 salt tolerance leaf width cell division

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基于TOF相机的备煤仓清理识别定位方法

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机电产品开发与创新 2024年第5期37卷 21-24页

作者：任志墨张文昌李贞逸沈敏举北京机科国创轻量化科学研究院有限公司北京100083 先进成形技术与装备国家重点实验室北京100083

在传统制造业致力于自动化、智能化升级的时代背景下,针对钢铁行业备煤仓异物清理过程中生产环境复杂、工作周期长、危险性高等特点,提出一种基于TOF相机的备煤仓清理识别定位方法。首先使用TOF相机获取备煤仓下料口深度图像并将其投影... 详细信息

在传统制造业致力于自动化、智能化升级的时代背景下,针对钢铁行业备煤仓异物清理过程中生产环境复杂、工作周期长、危险性高等特点,提出一种基于TOF相机的备煤仓清理识别定位方法。首先使用TOF相机获取备煤仓下料口深度图像并将其投影为二维图像;其次使用预处理算法对图像进行增强处理得到清晰二值化图像;然后利用斑点检测计算落料口栏杆间隙中心坐标;进而计算异物中心点所在间隙坐标实现异物定位。最后通过实验证明该方法能够准确识别下料口处异物的位置,引导机器人完成对多种异物的抓取清理工作。

关键词：机器视觉 TOF相机 3D成像技术深度图像斑点检测

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烧结温度对钛铝靶材性能的影响

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有色金属加工 2024年第3期53卷 17-21页

作者：李心然居炎鹏赵泽良王永超河南东微电子材料有限公司河南郑州451100

文章采用热等静压工艺制备钛铝合金靶材(Ti∶Al=1∶1,at.%),研究烧结温度(1150~1350℃)对钛铝靶材性能的影响。结果表明,在保温时间均为2 h,保压压力均为130 MPa时,当烧结温度为1250℃时所制备的钛铝合金靶材综合性能最好,靶材的致密度... 详细信息

文章采用热等静压工艺制备钛铝合金靶材(Ti∶Al=1∶1,at.%),研究烧结温度(1150~1350℃)对钛铝靶材性能的影响。结果表明,在保温时间均为2 h,保压压力均为130 MPa时,当烧结温度为1250℃时所制备的钛铝合金靶材综合性能最好,靶材的致密度为99.72%,晶粒尺寸为78.70μm,维氏硬度为399.7HV,Ti元素和Al元素均匀分布。通过晶粒生长动力学方程计算出钛铝靶材的晶粒长大激活能为76.4 KJ/mol。

关键词：钛铝合金靶材热等静压工艺烧结温度靶材性能激活能

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QC小组活动在铸造企业开展情况总结及展望

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中国铸造装备与技术 2024年第2期59卷 72-76页

作者：时晓鞠欣宝张凯董志鹏綦宗超潍柴重机股份有限公司山东潍坊261001

立足大缸径材料成型中心质量管理小组活动实际,结合潍柴WOS管理模式的推进要求,介绍铸造企业质量管理小组的开展情况、活动推进的典型经验及常见的推进问题,阐述质量管理小组对质量管理和质量改进的重要贡献并对铸造业质量管理小组未来... 详细信息

立足大缸径材料成型中心质量管理小组活动实际,结合潍柴WOS管理模式的推进要求,介绍铸造企业质量管理小组的开展情况、活动推进的典型经验及常见的推进问题,阐述质量管理小组对质量管理和质量改进的重要贡献并对铸造业质量管理小组未来发展进行展望。

关键词： QC小组铸造质量管理

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