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藜麦即食粥粉配方研究及营养评价

食品工业 2024年第9期45卷 67-73页

作者：陈静沙芮丁洁牛犇甘肃省商业科技研究所有限公司兰州730010

研制以藜麦为基料的即食粥粉。将藜麦膨化、粉碎并标准化后作为基料,将青稞、莜麦、荞麦等小杂粮膨化、粉碎、标准化后作为辅料,混合调配,以模糊综合感官评分为指标,研制出藜麦即食粥粉的配方。通过单因素试验及响应面曲线法对藜麦即食... 详细信息

研制以藜麦为基料的即食粥粉。将藜麦膨化、粉碎并标准化后作为基料,将青稞、莜麦、荞麦等小杂粮膨化、粉碎、标准化后作为辅料,混合调配,以模糊综合感官评分为指标,研制出藜麦即食粥粉的配方。通过单因素试验及响应面曲线法对藜麦即食粥粉配方进行优选,得到最佳配方。藜麦即食粥粉最优配方为W藜麦粉∶W_(青稞粉)∶W_(莜麦粉)∶W_(荞麦粉)=10∶4.1∶3.7∶3.7。工艺条件优选后调配出的藜麦即食粥粉感官评分为80.1分。通过营养质量指数对藜麦即食粥粉进行营养评价,结果表明,藜麦即食粥粉中除硒元素外,6种矿物质元素的营养质量指数(INQ)均大于1,且富含烟酸、维生素B_(1)和维生素B_(2)。通过冲调性试验,藜麦即食粥粉最佳冲调水温为70℃,添加8倍水进行冲调时效果最佳。

关键词：藜麦模糊数学感官评价响应面营养质量指数

Research progress of composite cathode materials for Solid oxide fuel cells

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Progress in Natural Science:Materials International 2023年第3期33卷 267-278页

作者： Qunyang Long rui sha Ruohang Wang Bo Xu Haichao Men Qi Wang Jie Hou Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral Materials School of Materials Science and Technology China University of Geosciences School of Resource Environment and Safety Engineering University of South China

Solid oxide fuel cell(SOFC) is a device that converts the chemical energy of hydrogen or hydrocarbons and oxygen into electric energy through electrochemical reaction, with high efficiency and low emissions. Cathode materials with high electrochemical catalytic activity, stability and medium-low temperature durability continue to play a crucial role in SOFC. However, single-phase cathode materials suffer from low conductivity, low activity and poor thermal matching. Therefore, various composite technologies have been employed to enhance the performance of SOFC cathodes. In this review, various composite methods have been illustrated including mechanical-physical composite, infiltration composite and in-situ composite. Besides, this article provides an overview of the fundamentals, recent advances, advantages, disadvantages, challenges, and prospects of these composite methods. Furthermore, this article provides valuable guidance and potential directions for the development of composite cathode materials.

关键词： SOFC Composite cathode materials Composite methods Mechanical-physical composite Infiltration composite In-situ composite

Novel Metal-organic Framework Compound Pb(C_5H_4NCOO)_2 Showing One-dimensional Channel Defined as Four Leads and Four Nicotinic Acids

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Chemical Research in Chinese Universities 2009年第3期25卷 279-281页

作者： XU Xiao-yu ZHOU rui-sha SONG Jiang-feng XU Ji-qing College of Chemistry and State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun 130012 P. R. China

A novel metal-organic framework（MOF） compound of Pb（C5H4NCOO）2 was hydrothermally synthesized and structurally determined by X-ray single-crystal diffraction. The data of unit cell： orthorhombic space group Pccn, a=1.0325（2） nm, b=1.3597（3） nm, c=0.8499（2） nm, V=1.1931（4） nm^3, Z=4, Dc=2.513 g/cm^3, R1=0.047 were obtained on the basis of 1365 reflections with Fo〉2σ（Fo）. PbN2O6 polyhedron adopts the distorted cubic configuration which is assigned to the holodirected geometry. These PbN2O6 polyhedra can form the zigzag chain by edge-sharing mode along（001） direction. Pb atom is connected by six nicotinic acid molecules, leading neutral 3D metal-organic framework with a channel defined by four Pb atoms and four nicotinic acid molecules.

关键词： Metal-organic framework(MOF) Lead Holodirected structure

2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor

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Journal of Environmental Sciences 2019年第2期31卷 368-376页

作者： Yangsheng Chen rui sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li Heidi Qunhui Xie Naijun Tang Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of Sciences Department of Occupational and Environmental Health sTianjin Medical University

Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels.

关键词： 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Astrocyte Migration Gene expression Aryl hydrocarbon receptor (AhR) pathway

Dioxin induces expression of hsa-mi R-146b-5p in human neuroblastoma cells

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Journal of Environmental Sciences 2018年第1期30卷 260-267页

作者： Tuan Xu Heidi Q.Xie Yunping Li Yingjie Xia rui sha Lingyun Wang Yangsheng Chen Li Xu Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Dioxin can cause a series of neural toxicological effects. Micro RNAs（mi Rs） play important roles in regulating nervous system function and mediating cellular responses to environmental pollutants, such as dioxin. Hsa-mi R-146 b-5 p appears to be involved in neurodegenerative diseases and brain tumors. However, little is known about effects of dioxin on the expression of hsa-mi R-146 b-5 p. We found that the hsa-mi R-146 b-5 p expression and its promoter activity were significantly increased in dioxin treated SK-N-SH cells, a human-derived neuroblastoma cell line. Potential roles of hsa-mi R-146 b-5 p in mediating neural toxicological effects of dioxin may be due to the regulation of certain target genes. We further confirmed that hsa-mi R-146 b-5 p significantly suppressed acetylcholinesterase（ACh E） activity and targeted the3′-untranslated region of the ACh E T subunit, which has been down-regulated in dioxin treated SK-N-SH cells. Functional bioinformatic analysis showed that the known and predicted target genes of hsa-mi R-146 b-5 p were involved in some brain functions or cyto-toxicities related to known dioxin effects, including synapse transmission, in which ACh E may serve as a responsive gene for mediating the effect.

关键词： 2 3 7 8-Tetrachlorodibenzo-p-dioxin(TCDD) MicroRNA Acetylcholinesterase(AChE) Neuron Transcription regulation Post-transcriptional regulation

创新生态竞争视角下新型研发机构发展策略研究

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科技管理研究 2024年第5期44卷 65-71页

作者：陈力于磊杭磊王赫然沙锐田满霞科学技术部火炬高技术产业开发中心北京100045 阜新市产业技术创新推广中心辽宁阜新123000 国家自然科学基金委员会高技术研究发展中心北京100044 河北省社会科学院河北石家庄050051 西南财经大学四川成都611130

为进一步综合研究分析新型研发机构发展策略,以1321家全国新型研发机构为研究对象,在系统总结新型研发机构发展现状的基础上,基于有关文献及有关理论研究,构建新型研发机构核心竞争力六维评价指标体系,通过人工蜂群(ABC)算法优化后的BP... 详细信息

为进一步综合研究分析新型研发机构发展策略,以1321家全国新型研发机构为研究对象,在系统总结新型研发机构发展现状的基础上,基于有关文献及有关理论研究,构建新型研发机构核心竞争力六维评价指标体系,通过人工蜂群(ABC)算法优化后的BP神经网络模型对新型研发机构核心竞争力进行评估。结果表明,35.30%的新型研发机构核心竞争力处于较强水平,总体上新型研发机构核心竞争力具有良好的发展基础和前景;新型研发机构主要通过延长创新服务链条、创新科技成果对接机制等策略占据有利的生态位。新型研发机构未来要进一步强化科技人才培养能力,创新企业孵化机制,激发科技金融竞争力来进一步推动新型研发机构高质量发展。

关键词：创新生态体系新型研发机构 ABC-BP网络模型核心竞争力发展策略

Identification of differentially expressed genes response to TCDD in rat brain after long-term low-dose exposure

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Journal of Environmental Sciences 2017年第12期29卷 92-99页

作者： Yangsheng Chen Li Xu Heidi Q.H.Xie Tuan Xu Hualing Fu Songyan Zhang rui sha Yingjie Xia Bin Zhao State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China

Several cohort studies have reported that dioxin and dioxin-like polychlorinated biphenyls might impair the nervous system and lead to neurological or neurodegenerative diseases in the elder people, but there is limited research on the involved mechanism. By using microarray analysis, we figured out the differentially expressed genes between brain samples from SD rats after low-dose（0.1 μg/（kg？bw）） dioxin exposure for six months and controls. To investigate the function changes in the course of dioxin exposure, Gene Ontology（GO） annotation and Kyoto Encyclopedia of Genes and Genomes（KEGG） pathway analysis were performed on the differentially expressed genes. And the changes of several picked genes have been verified by real-time PCR. A total of 145 up-regulated and 64 down-regulated genes were identified. The metabolic processes, interleukin-1 secretion and production were significantly associated with the differentially expressed genes. And the genes regulated by dioxin also clustered to cholinergic synapse and long-term potentiation. Candidate biomarker genes such as egr1, gad2, gabrb3, abca1, ccr5 and pycard may be toxicological targets for dioxin. Furthermore, synaptic plasticity and neuro-immune system may be two principal affected areas by dioxin.

关键词： TCDD Long-term exposure Neurotoxicity Microarray Neuroinflammation

PbGIF1 promoting cell-proliferation in pear fruit is transcriptionally activated by Pb RR1

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Horticultural Plant Journal 2024年第3期10卷 689-697页

作者： Huibin Wang Guangya sha rui Gao Jianwen Pang rui Zhai Chengquan Yang Zhigang Wang Lingfei Xu College of Horticulture Northwest A&F UniversityYanglingShaanxi 712100China College of Life Science Hebei Agricultural UniversityBaodingHebei 071000China

As a cell proliferation regulator involved in wide biological processes in plants,GRF-INTERACTING FACTOR(GIF)controls different tissues ***,whether GIF participates in fruit development remains *** to transcriptome data,we identified PbGIF1was highly expressed during fruit development in cytokinins induced parthenocarpy *** the present study,the biofunction of PbGIF1 was initially *** of PbGIF1 promoted fruit size of transgenic *** size of flesh fruit was not affected by cell expansion but the cell proliferation was promoted by overexpressing Pb *** accelerated cell proliferation process was also observed in PbGIF1-overexpressed transgenic pear fruit *** transcriptional regulation of cytokinins on PbGIF1 was further confirmed by exogenous CPPU treatments in pear *** investigate the underlying mechanism,the cytokinins-responded factor,PbRR1,was further focused *** results of Yeast-one-hybrid assay suggested that PbRR1 can bind to the promoter sequence of *** transcriptional activation of PbRR1 on PbGIF1 was also confirmed by Dual-Luciferase *** together,the results showed that cytokinins control pear fruit development via the transcriptional activation of PbGIF1 by PbRR1.

关键词： PbGIF1 Cell proliferation Pear Fruit development Cytokinins PbRR1

Armoring lithium metal anode with soft±rigid gradient interphase toward high-capacity and long-life all-solid-state battery

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Green Energy & Environment 2024年第8期9卷 1279-1289页

作者： rui Zhang Biao Chen Yuhan Ma Yue Li Junwei sha Liying Ma Chunsheng Shi Naiqin Zhao School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Department of Chemical and Biomolecular Engineering National University of Singapore Collaborative Innovation Centre of Chemical Science and Engineering

Solid polymer electrolytes （SPEs） are highly promising for realizing high-capacity,low-cost,and safe Li metal ***,the Li dendritic growth and side reactions between Li and SPEs also plague these ***,a fluorinated lithium salt coating （FC） with organicinorganic gradient and soft-rigid feature is introduced on Li surface as an artificial protective layer by the in-situ reaction between Li metal and fluorinated carboxylic *** FC layer can improve the interface stability and wettability between Li and SPEs,assist the transport of Li ions,and guide Li nucleation,contributing to a dendrite-free Li deposition and long-lifespan Li metal *** symmetric cell with FC-Li anodes exhibits a high areal capacity of 1 mAh cm-2at 0.5 mA cm-2,and an ultra-long lifespan of 2000 h at a current density of 0.1 m A ***,the full cell paired with the LiFePO4cathode exhibits improved cycling stability,remaining 83.7%capacity after 500 cycles at 1 *** matching with the S cathode,the FC layer can prevent the shuttle effect,contributing to stable and high-capacity Li-S *** work provided a promising way for the construction of stable all-solid-state lithium metal batteries with prolonged lifespan.

关键词： All-solid-state battery Solid polymer electrolyte Li metal anode Li nucleation Interface stability