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Potential therapeutic role of spermine via Rac1 in osteoporosis:Insights from zebrafish and mice

Zoological Research 2024年第2期45卷 367-380页

作者： rui-xue Jiang Nan Hu Yu-Wei Deng Long-Wei Hu Hao Gu Nan Luo Jin Wen Xin-Quan Jiang Department of Prosthodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China College of Stomatology Shanghai Jiao Tong UniversityNational Center for StomatologyNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of StomatologyShanghai Research Institute of StomatologyShanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai 200125China Department of Endodontics Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Oral and Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China Department of Preventive Dentistry Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai 200011China

Osteoporosis(OP)is a prevalent metabolic bone *** drug therapy is essential to prevent bone loss in osteoporotic patients,current treatments are limited by side effects and high costs,necessitating the development of more effective and safer targeted *** a zebrafish(Danio rerio)larval model of osteoporosis,we explored the influence of the metabolite spermine on bone *** showed that spermine exhibited dual activity in osteoporotic zebrafish larvae by increasing bone formation and decreasing bone *** not only demonstrated excellent biosafety but also mitigated prednisolone-induced embryonic neurotoxicity and ***,spermine showcased protective attributes in the nervous systems of both zebrafish embryos and *** the molecular level,Rac1 was identified as playing a pivotal role in mediating the antiosteoporotic effects of spermine,with P53 potentially acting downstream of *** findings were confirmed using mouse(Mus musculus)models,in which spermine not only ameliorated osteoporosis but also promoted bone formation and mineralization under healthy conditions,suggesting strong potential as a bonestrengthening *** study underscores the beneficial role of spermine in osteoporotic bone homeostasis and skeletal system development,highlighting pivotal molecular *** their efficacy and safety,human endogenous metabolites like spermine are promising candidates for new anti-osteoporotic drug development and daily bone-fortifying agents.

关键词： Osteoporosis Spermine Rac1 Zebrafish Mice

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Dicer Deletion in Astrocytes Inhibits Oligodendroglial Differentiation and Myelination

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Neuroscience Bulletin 2021年第8期37卷 1135-1146页

作者： Kun Liu Bin Yu Jing-Fei Chen rui-xue Li Lin Chen Shu-Yu Ren Fei Wang Feng Mei Lan Xiao Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Laboratory of Chongqing Education CommissionThird Military Medical University(Army Medical University)Chongqing400038China Department of Neurosurgery 2nd affiliated HospitalThird Military Medical University(Army Medical University)Chongqing400038China

Increasing evidence has shown that astrocytes are implicated in regulating oligodendrocyte myelination,but the underlying mechanisms remain largely *** understand whether microRNAs in astrocytes function in regulating oligodendroglial differentiation and myelination in the developing and adult CNS,we generated inducible astrocyte-specific Dicer conditional knockout mice(hGFAP-CreERT;Dicer fl/fl).By using a reporter mouse line(mT/mG),we confirmed that hGFAP-CreERT drives an efficient and astrocyte-specific recombination in the developing CNS,upon tamoxifen treatment from postnatal day 3(P3)to *** Dicer deletion in astrocytes resulted in inhibited oligodendroglial differentiation and myelination in the developing CNS of Dicer cKO mice at P10 and P14,and did not alter the densities of neurons or axons,indicating that Dicer in astrocytes is required for oligodendrocyte ***,the Dicer deletion in astrocytes at P3 resulted in impaired spatial memory and motor coordination at the age of 9 *** understand whether Dicer in astrocytes is also required for remyelination,we induced Dicer deletion in 3-month-old mice and then injected lysolecithin into the corpus callosum to induce *** Dicer deletion in astrocytes blocked remyelination in the corpus callosum 14 days after induced ***,our results indicate that Dicer in astrocytes is required for oligodendroglia myelination in both the developing and adult CNS.

关键词： White matter Myelination MicroRNA GFAP MT/mG Microglia Oligodendrocyte Demyelination Remyelination

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LDPC-CPM Scheme and Its Iterative Receiving for MIMO System

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International Journal of Communications, Network and System Sciences 2017年第5期10卷 154-162页

作者： rui xue xue Lv Yang Cao College of Information and Communication Engineering Harbin Engineering University Harbin China Tianjin Key Laboratory of Intelligent Information Processing in Remote Sensing Tianjin China

One of the advantages of Multiple-Input Multiple-Output (MIMO) techniques is that they can provide link throughput, but the reliability of them remains to be improved. In order to improve the performance of bit error, based on the decomposed model of continuous phase modulation (CPM), combined with LDPC code and random interweaver, a scheme of joint coded modulation is introduced. In this paper, the model of LDPC-CPM iterative MIMO system is established firstly, then scheme of receiver by iterative detection realized and the decoding is proposed, finally the effect of main parameters on the performance of the system is studied, which can provide the reference basis for practical application. The research results show that the proposed scheme can improve channel capacity and BER performance in the background of extremely low SNR effectively, and give attention to both high-speed transmission and reliable transmission.

关键词： Communication Technology Continuous Phase Modulation Multiple-Input Multiple-Output (MIMO) Iterative Detection and Decoding

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Long-term observation on safety and visual quality of implantable collamer lens V4c implantation for myopia correction:a 5-year follow-up

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1123-1129页

作者： Xiao Chen Li Li Jing Rao Yue-Xi Chen Yang Gao rui-xue Huang Qi-Zhi Zhou Aier Eye Hospital Jinan UniversityGuangzhou 510071Guangdong ProvinceChina Chongqing Aier and Vision Care Hospital Chongqing 400000China Aier Eye Hospital Group Company Limited Changsha 410000Hunan ProvinceChina Jinan University Guangzhou 510000Guangdong ProvinceChina

AIM:To elucidate the safety and visual quality of implantable collamer lens with central hole(ICL V4c)implantation for correcting moderate and high myopia for at least ***:This retrospective study was conducted on 58 patients(114 eyes)who were followed up for at least 5y after ICL V4c *** observation was done before and on 1d,1mo,1 and 5y or more after the surgical *** visual acuity,subjective refraction,intraocular pressure,vault,axial length,central hole position,pupil diameter,visual quality,and adverse events were *** visual quality includes aberration,the modulation transfer function cutoff frequency(MTF cutoff),objective scattering index(OSI),Stroller's ratio(SR),and visual quality ***:The average follow-up period was 69.25±3.80mo(range 60–82mo)and the preoperative spherical equivalent(SE)was-8.66±1.97 *** 5y after operation,the safety index was 1.01±0.02 and the efficacy index was 0.99±0.42 and SE was-0.65±0.63 *** 59.6%of the eyes achieved an uncorrected distance visual acuity of 20/20,76.3%of the eyes had SE within±1.0 D at the last *** axial length increased by 0.29±0.71 mm 5y after the surgery(t=-3.843,P<0.001).The mean vault at the last follow-up was 510.59±245.61μ*** central hole was on the temporal side in 80 eyes(84.2%).The visual quality questionnaire showed that 98.2%patients were satisfied with the surgical *** events occurred in 4 eyes(3.5%),including the posttraumatic toric ICL rotation(2 eyes),iris incarceration(1 eye),and posttraumatic ICL displacement(1 eye)at the last ***:Long-term ICL V4c implantation is safe,effective,and stable for correcting moderate and to high myopia,and the visual quality with patients is excellent and satisfactory,but the progression of axial length still needs attention after surgery.

关键词： implantable collamer lens with central hole myopia correction refractive surgery visual quality

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New technology to examine and improve the purity of hybrid rice with herbicide resistant gene

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Chinese Science Bulletin 1998年第9期43卷 784-787页

作者： Danian Huang Jingyang Li Shanqing Zhang rui xue Wei Yang Zhihua Hua Xiaobo Xie Xiaoling Wang China Natl Rice Res Inst Hangzhou 310006 Peoples R China

The herbicide resistant bar gene has been widely used as selectable marker genes in the study on plant genetic transformation. Owing to the integration of the gene into rice genome, transgenic rice was resistant to the herbicide Basta. Therefore, selection of transgenic plant and genetic analysis became easier. In the studies, bar gene was introduced as a genetic marker gene into rice restore line variety of two-line or three-line. Combined with conventional breeding method, the good herbicide resistant individual plant was derived as the new restore line for hybrid combination. After sprayed with Basta at seedling phase, the real hybrid rice that had herbicide resistance could grow normally, while the fake hybrid rice and weeds, having no bar gene, were killed by herbicide. The method described above helped rapidly to examine and improve the purity of hybrid rice.

关键词： herbicide resistant bar gene transgenic hybrid rice purity of hybrid rice.

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PERSISTENCE AND EXTINCTION OF A STOCHASTIC SIS EPIDEMIC MODEL WITH DOUBLE EPIDEMIC HYPOTHESIS

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Annals of Applied Mathematics 2017年第1期33卷 77-89页

作者： rui xue Fengying Wei College of Math. and Computer Science Fuzhou University Fuzhou 350116 Fujian PR China

In this paper, we aim at dynamical behaviors of a stochastic SIS epidemic model with double epidemic hypothesis. Sufficient conditions for the extinction and persistence in mean are derived via constructing suitable functions. We obtain a threshold of stochastic SIS epidemic model, which determines how the diseases spread when the white noises are small. Numerical simulations are used to illustrate the efficiency of the main results of this article.

关键词： double epidemic hypothesis Brownian motion extinction persistence

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人造系统动力学多元系统传递矩阵法初探

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科学通报 2023年第25期68卷 3250-3258页

作者：芮筱亭王勋芮雪南京理工大学发射动力学研究所南京210094 复杂多体系统动力学全国重点实验室南京210094

人造系统也称人工系统,是人类为了达到某种目的而构造的系统,例如各种加工系统、运输系统、电力系统、机械系统、武器系统等.现代科学、技术和工程已发展到从全系统动力学角度分析、提高人造系统设计、加工、试验、评估和运用全生命周... 详细信息

人造系统也称人工系统,是人类为了达到某种目的而构造的系统,例如各种加工系统、运输系统、电力系统、机械系统、武器系统等.现代科学、技术和工程已发展到从全系统动力学角度分析、提高人造系统设计、加工、试验、评估和运用全生命周期能力,以获得期望性能的工程产品的高级阶段,其目标是建立精确的人造系统动力学数学模型并对其快速数值求解,从而准确、快速地预测和提高系统性能[1].坦克、舰艇、飞机、运载火箭、卫星、汽车、高铁、发电机、电动机、精密机床等各种现代人造系统发展,推动了科技和人类文明进步,是一个国家重大战略布局和综合实力的象征,是国计民生和国家安全的关键标志.由于缺乏先进的人造系统动力学快速计算等理论与软件,现代人造系统发展至今仍面临提高设计性能、提高加工质量、降低试验评估成本、保障运用安全的严峻挑战.

关键词：人工系统人造系统系统动力学多元系统现代科学精密机床动力学数学模型机械系统

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De novel heterozygous copy number deletion on 7q31.31-7q31.32 involving TSPAN12 gene with familial exudative vitreoretinopathy in a Chinese family

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 1952-1961页

作者： Shuang Zhang Hai-Ming Yong Gang Zou Mei-Jiao Ma xue rui Shang-Ying Yang Xun-Lun Sheng People’s Hospital of Ningxia Hui Autonomous Region Ningxia Medical UniversityNingxia Eye HospitalNingxia Clinical Research Center on Diseases of Blindness in EyeYinchuan 750001Ningxia Hui Autonomous RegionChina

AIM:To investigate the genetic and clinical characteristics of patients with a large heterozygous copy number deletion on ***:A family with familial exudative vitreoretinopathy(FEVR)phenotype was included in the ***-exome sequencing(WES)was initially used to locate copy number variations(CNVs)on 7q31.31-31.32,but failed to detect the precise *** long-read sequencing,Oxford Nanopore sequencing Technology(ONT)was used to get the accurate breakpoint which is verified by quantitative real-time polymerase chain reaction(QPCR)and Sanger ***:The proband,along with her father and younger brother,were found to have a heterozygous 4.5 Mb CNV deletion located on 7q31.31-31.32,which included the FEVRrelated gene *** specific deletion was confirmed as del(7)(q31.31q31.32)chr7:g.119451239_*** proband exhibited a phase 2A FEVR phenotype,characterized by a falciform retinal fold,macular dragging,and peripheral neovascularization with leaking of *** symptoms led to a significant decrease in visual acuity in both *** the other hand,the affected father and younger brother showed a milder ***:The heterozygous CNV deletion located on 7q31.31-7q31.32 is associated with the FEVR *** use of long-read sequencing techniques is essential for accurate molecular diagnosis of genetic disorders.

关键词： familial exudative vitreoretinopathy copy number variation copy number deletion TSPAN12 longread sequencing

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Experimental study on the movement law of overlying rock non-pillar coal overhead mining

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Journal of Mountain Science 2023年第6期20卷 1759-1773页

作者： LI Yong ZHENG Jing WANG Feng-nian MA Xin-gen ZHANG rui-xue SUN Ying-ying YIN Jian-bin TAO Zhi-gang College of Geoscience and Surveying Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Coal Resources and Safe Mining China University of Mining and Technology-BeijingBeijing 100083China Shanxi Provincial Transportation Technology Research and Development Co.Ltd. Key Laboratory of Highway Construction and Maintenance Technology in Loess AreaTransportation IndustryTaiyuan 030000China Huaneng Coal Technology Research Co.Ltd. Beijing 10o83China State Key Laboratory for Geo Mechanics and Deep Underground Engineering China University of Mining and Technology-BeijingBeijing 10083China School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China

Pillarless coal mining technology is a new practical *** on the compensating mechanical behavior of the Negative Poisson’s Ratio(NPR)anchor cable on the roof,the roadway was successfully retained by the top cutting and pressure relief *** study utilizes the Digital Speckle Monitoring(DIC monitoring),stress-strain monitoring,and infrared thermal imaging systems to conduct physical model experiment of similar materials from the displacement,stress-strain,and temperature fields to investigate in depth the fracture change law of the overlying *** addition,it uses FLAC3D numerical simulation to invert the surface displacement *** results show that the non-pillar overhead mining under the 110 mining method has little influence on the rock crack in the middle of the coal seam,and the crack development area is mainly concentrated in the overlying rock mass of the upward coal *** compensatory mechanical behavior of NPR anchor cable and the dilatation characteristics of rock mass have a good effect of retaining roadway along goaf,and can also reduce surface *** 110 mining method provides a scientific basis for ecological environment protection and the development of other kilometer deep soft rock high ground stress underground projects.

关键词： No pillar mining Overhead mining NPR anchor cable Physical model of similar materials FLAC3D Numerical simulation Motion of overburden

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Ionic liquid-induced ultrathin and uniform N-doped carbon-wrapped T-Nb_(2)O_(5) microsphere anode for high-performance lithium-ion battery

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Rare Metals 2021年第11期40卷 3205-3214页

作者： rui-xue Sun Yang Yue Xin-Feng Cheng Ke Zhang Su-Ying Jin Guang-Yin Liu Yu-Xin Fan Yan Bao Xiao-Di Liu College of Chemistry and Pharmaceutical Engineering Engineering Technology Research Center of Henan Province for Solar CatalysisNanyang Normal UniversityNanyang 473061China College of Science Henan Agricultural UniversityZhengzhou 450001China

Orthorhombic-phase Nb_(2)O_(5)(T-Nb_(2)O_(5)) has been widely investigated as an intercalation anode material for Li-ion batteries due to the larger interplanar lattice spacing and high ***,its applications are limited by the intrinsic low electric ***,an ultrathin N-doped carbon-coating layer was constructed on porous T-Nb_(2)O_(5) microspheres uniformly via a convenient thermal treatment method with ionic liquid as a carbon *** synthesized T-Nb_(2)O_(5)@N-C exhibits significantly enhanced rate capability(155.5 mAh·g^(-1) at 20 C) than initial T-Nb_(2)O_(5)(110.2 mAh·g^(-1) at 20C).Besides,T-Nb_(2)O_(5)@N-C shows ultralong cycle life,with only a 0.02% decrease in the capacity per cycle at a high current density of 10 *** corresponding electrochemical tests show that the preferable rate capability of T-Nb_(2)O_(5)@N-C electrode is attributed to the increased electronic conductivity and pseudocapacitance contribution induced by ultrathin surface N-doped carbon *** the other hand,the mesoporous structure of T-Nb_(2)O_(5)@N-C ensures fast Li+ diffusion dynamics and electrolyte ***,T-Nb_(2)O_(5)@N-C also performs well in a LiNi_(0.5)Mn_(0.3)Co_(0.2)O_(4) llT-Nb_(2)O_(5)@N-C full *** work provides a facile method to construct integrated anode materials for potential applications in lithium-ion batteries.

关键词： Ionic liquid Ultrathin N-doped carbon T-Nb_(2)O_(5) Lithium-ion battery Full cell

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