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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi Xu Junqiu Jia rui mao Xiang Cao Yun Xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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A parallel computing framework for big data

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Frontiers of Computer Science 2017年第4期11卷 608-621页

作者： Guoliang CHEN rui mao Kezhong LU Guangdong Province Key Laboratory of Popular High Performance Computers Shenzhen 518060 China College of Computer Science and Software Engineering Shenzhen University Shenzhen 518060 China

Abstract Big data has received great attention in research and application. However, most of the current efforts focus on system and application to handle the challenges of ＂volume＂ and ＂velocity＂, and not much has been done on the theoreti- cal foundation and to handle the challenge of ＂variety＂. Based on metric-space indexing and computationalcomplexity the- ory, we propose a parallel computing framework for big data. This framework consists of three components, i.e., universal representation of big data by abstracting various data types into metric space, partitioning of big data based on pair-wise distances in metric space, and parallel computing of big data with the NC-class computing theory.

关键词： NC-computing metric space data partitioning,parallel computing

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A Precise RFID Indoor Localization System with Sensor Network Assistance

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China Communications 2015年第4期12卷 13-22页

作者： ZHANG Dian LU Kezhong mao rui Guangdong Province Key Laboratory of Popular High Performance Computers College of Computer Science and Software EngineeringShenzhen University

Indoor localization is very critical for medical care applications, e.g., the patient localization or tracking inside the building of the hospital. Traditional Radio Frequency Identification(RFID) technologies are very popular in this area since their cost is very low. In such technologies, each tag acts as the transmitter and the Radio Signal Strength Indicator(RSSI) information is measured from the readers. However, RSSI information suffers severely from the multi- path phenomenon. As a result, if in a very large area, the localization accuracy will be affected seriously. In order to solve this problem, we introduce Wireless Sensor Networks(WSNs) with only a few nodes, each of which acts as both transmitter and receiver. In such networks, the change of signal strength(referred as dynamic of RSSI) is leveraged to select a cluster of reference tags as candidates. Then the fi nal target location is estimated by using the RSSI relationships between the target tag and candidate reference tags. Thus, the localization accuracy and scalability are able to be improved. We proposed two algorithms, SA-LANDMARC, and COCKTAIL. Experiments show that the localization accuracy of the two algorithms can reach 0.7m and 0.45 m, respectively. Compared to most traditional Radio Frequency(RF)-based approaches, the localization accuracy is improved at least 50%.

关键词： radio frequency RFID wirelesssensor networks hybrid support vectorregression

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Precise Transceiver-Free Localization in Complex Indoor Environment

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China Communications 2016年第5期13卷 28-37页

作者： rui mao Peng Xiang Dian Zhang College of Computer Science and Software Shenzhen University

Transceiver-free object localization can localize target through using Radio Frequency(RF) technologies without carrying any device, which attracts many researchers' attentions. Most traditional technologies usually first deploy a number of reference nodes which are able to communicate with each other, then select only some wireless links, whose signals are affected the most by the transceiver-free target, to estimate the target position. However, such traditional technologies adopt an ideal model for the target, the other link information and environment interference behavior are not considered comprehensively. In order to overcome this drawback, we propose a method which is able to precisely estimate the transceiver-free target position. It not only can leverage more link information, but also take environmental interference into account. Two algorithms are proposed in our system, one is Best K-Nearest Neighbor(KNN) algorithm, the other is Support Vector Regression(SVR) algorithm. Our experiments are based on Telos B sensor nodes and performed in different complex lab areas which have many different furniture and equipment. The experiment results show that the average localization error is round 1.1m. Compared with traditional methods, the localization accuracy is increased nearly two times.

关键词： indoor localization transceiver-free radio map support vector regression

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A Novel Synergy Selection Mechanism among Multi- Devices for Ubiquitous Services

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China Communications 2014年第A01期11卷 128-134页

作者： rui Lanlan mao Xiyue QIU Xuesong StateKeyLaboratoryofNetworkingandSwitchingTechnology BeijingUniversityofPostsandTelecommunicationsBeijingChina

It is a challenge to select an optimal set of devices to accomplish a graph-based ubiquitous service and execute it continuously under the circumstances of dynamic environments and limited device capability. We elaborate a Synergy- aware Selection Mechanism （SSM） considering synergetic among devices. In the SSM, we design a distributed algorithm to integrate the devices and a dynamic updating weight method. The simulation results show that SSM can make devices composed together to ensure the continuity and smoothness of service

关键词： ubiquitous service synergy-aware quality of service sustainability

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Knowledge-based bridge detection from SAR images

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Journal of Systems Engineering and Electronics 2009年第5期20卷 929-936页

作者： Wang Wenguang Sun Jinping Hu rui mao Shiyi School of Electronic and Information Engineering Beihang Univ. Beijing 100191 P. R. China

Automatic bridge detection is an important application of SAR images. Differed from the classical CFAR method, a new knowledge-based bridge detection approach is proposed. The method not only uses the backscattering intensity difference between targets and background but also applies the contextual information and spatial relationship between objects. According to bridges＇ special characteristics and scattering properties in SAR images, the new knowledge-based method includes three processes： river segmentation, potential bridge areas detection and bridge discrimination. The application to AIRSAR data shows that the new method is not sensitive to rivers＇ shape. Moreover, this method can detect bridges successfully when river segmentation is not very exact and is more robust than the radius projection method.

关键词： knowledge-based bridge detection SAR contextual information mathematical morphology.

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Stealth-ACK: stealth transmissions of No C acknowledgements

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Science China(Information Sciences) 2017年第9期60卷 21-35页

作者： Jinhua TAO Shi QIU Shaoli LIU Tianshi CHEN rui mao Institute of Computing Technology Chinese Academy of Sciences College of Computer Science and Software Engineering Shenzhen University

Network-on-Chip(No C) is a promising replacement of bus architecture due to its better *** state-of-the-art No Cs, each packet contains several fixed-length flits, which facilitates allocations of network resources but brings in many unused bits. In this paper, we propose a novel technique called Stealth-ACK to effectively address the above problem. Stealth-ACK leverages unused bits in head flits of non-ACK packets to carry and stealthily transmit ACK information. Such stealth transmissions of ACK information effectively reduce not only the amount of dedicated ACK packets on No C, but also the number of unused bits in head flits of non-ACK packets, which significantly reduces wastes on No C bandwidth. Experimental results show that Stealth-ACK averagely increases the throughput of 16 × 16 2-D mesh No C by 11.9%, and averagely reduces the No C latency by 34.8% on application traces of SPLASH-2. Moreover, Stealth-ACK only requires trivial hardware modification to basic router architectures, which incurs negligible power consumption and area cost.

关键词： networks-on-chip acknowledgement packet router architecture optimisation routing algorithm

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Synthesis of Dimethyl Carbonate from CO_2, Methanol, and Epoxides Using Re(CO)_5Cl/K_2CO_3 as Catalyst System

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Chemical Research in Chinese Universities 2007年第3期23卷 374-376页

作者： JIANG Jia-li HUA rui-mao Department of Chemistry Innovative Catalysis Program Key Laboratory of Organic Optoelectronics ＆ Molecular Engineering of Ministry of Education Tsinghua University Beifing 100084 P. R. China

Over the past few years, dimethyl carbonate （DMC） has been proven to be an efficient methylating, methoxylating, and methoxycarbonylating agent in organic syntheses, in which DMC is used to replace the toxic methyl halides, dimethyl sulfate or carbon monoxide, and so forth. Furthermore, DMC has been used in the syntheses of polycarbonates and polyurethane to develop the nonphosgene routes Therefore, DMC has become one of the most important compounds in the development of green synthetic chemistry.

关键词： Carbon dioxide Dimethyl carbonate Epoxide Methanol Potassium Carbonate Rhenium

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Labor Market Dynamics and Structural Change： Evidence from China

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China & World Economy 2015年第4期23卷 60-83页

作者： rui mao Jianwei Xu School of Management Zhejiang University Hangzhou China School of Finance Beijing Normal University Beijing China

Structural change theories usually assume agents are homogeneous. However, because of demand-side or supply-side heterogeneities, the probability of switching among sectors differs across people. This paper reveals these differences through restoring a long-period, individual-level panel dataset from China＇s Urban Household Survey for 1986-2009. We find that both for people who started working for the first time and those who switched jobs, the sector choice depends on personal characteristics. In particular, women and people with higher educational attainment or a previous white- collar job are more likely to join the tertiary sector and less likely to join the primary sector. These effects are substantial even if the macroeconomic variables used in conventional structural change theories are controlled. They are also robust in various periods and at more detailed industry levels. Our research suggests that it is important to pay greater attention to the labor composition when mal^ng policy related to economic structural change.

关键词： labor market dynamics personal characteristics sectoral switch structural change

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Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke

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Neuroscience Bulletin 2022年第10期38卷 1229-1247页

作者： rui mao Ningning Zong Yujie Hu Ying Chen Yun Xu Department of Neurology Affiliated Drum Tower HospitalMedical School of Nanjing UniversityNanjing210008China The State Key Laboratory of Pharmaceutical Biotechnology Institute of Brain ScienceNanjing UniversityNanjing210008China Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjing210008China Jiangsu Province Stroke Center for Diagnosis and Therapy Nanjing210008China Nanjing Neurology Clinic Medical Center Nanjing210008China

Ischemic stroke caused by intracranial vascular occlusion has become increasingly prevalent with considerable mortality and disability,which gravely burdens the global *** relatively effective clinical treatments are limited to intravenous alteplase and *** so,patients still benefit little due to the short therapeutic window and the risk of ischemia/reperfusion *** is therefore urgent to figure out the neuronal death mechanisms following ischemic stroke in order to develop new neuroprotective *** the pathogenesis,multiple pathological events trigger the activation of cell death *** attention should be devoted to excitotoxicity,oxidative stress,and inflammatory ***,in this article,we first review the principal mechanisms underlying neuronal death mediated by these significant events,such as intrinsic and extrinsic apoptosis,ferroptosis,parthanatos,pyroptosis,necroptosis,and autophagic cell ***,we further discuss the possibility of interventions targeting these pathological events and summarize the present pharmacological achievements.

关键词： Ischemic stroke Neuronal death Mechanisms Therapeutic strategy

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