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Novel Polyamides Containing Biphenyl-phthalazinone Moieties

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Chinese Chemical Letters 2001年第6期12卷 517-518页

作者： Xiu ling ZHU Xi Gao JIAN rui ling WANG Department of Polymer Science&Materials Dalian University of TechnologyDalian 116012

A novel diamine monomer 2H-(4-aminophenyl)-4-[4-(4-aminophenoxy) biphenyl]phthalazinone 1 containing aza hetero cycle was synthesized and utilized for preparation of new high molecular weight aromatic polyamides with various aromatic dicarboxylic acids with the inherent viscosity of 0.50 similar to 1.62 g/dL. These polyamides had rather high glass transition temperatures of 327 similar to 356 degreesC and their structure was confirmed by IR, H-1 NMR and MS. They are readily soluble in polar solvents such as NMP, DMF etc, and easily cast into tough, flexible films.

关键词： Polyarylamide biphenyl-phthalazinone solubility thermostability

Steering control strategy guide by two preview vision cues

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Science China(Technological Sciences) 2012年第9期55卷 2662-2670页

作者： SHEN Huan ling rui MAO JianGuo LI ShunMing College of Energy&Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Vision cues play an important role in states feedback in motion ***,the existing driver steering models consider little about vision cues utilized by human drivers during their steering *** paper presents a novel steering control strategy based on two preview points(far point and near point).The far point is used to compensate the steering wheel by predicting the upcoming curvature change with respect to the lane,while the near point as vision feedback,which is used to tune the steering wheel by estimating the errors of vehicle states and lane *** obtain much smoother lateral acceleration during steering,a forward internal model is established using a second-order yaw dynamics system that captures the influence of yaw angular acceleration caused by steering wheel *** input parameter of the second-order system is the vision cues of both the near and far points,and the output parameters are the ideal yaw angle and yaw *** calculate suitable the steering wheel angle,an adaptive controller is designed using fuzzy sliding technology,which is used as the input of the vehicle system *** simulation results show that the proposed method performs better than the existing driver steering models in case of imitating human drivers' behavior,and exhibits excellent adaption to the lane curvature change.

关键词： autonomous driving lateral control driver model fuzzy logic cognitive vehicle

Embedding aligned nanofibrous architectures within 3D-printed polycaprolactone scaffolds for directed cellular infiltration and tissue regeneration

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International Journal of Extreme Manufacturing 2023年第2期5卷 190-206页

作者： Zijie Meng Xingdou Mu Jiankang He Juliang Zhang rui ling Dichen Li State Key Laboratory for Manufacturing Systems Engineering Xi an Jiaotong UniversityXi an 710049People's Republic of China NMPA Key Laboratory for Research and Evaluation of Additive Manufacturing Medical Devices Xi'an Jiaotong UniversityXi'an 710049People's Republic of China Department of Vascular and Endocrine Surgery Xijing HospitalThe Air Force Medical UniversityXi'an 710049People's Republic of China

Three-dimensional(3D) printing provides a promising way to fabricate biodegradable scaffolds with designer architectures for the regeneration of various ***,the existing3D-printed scaffolds commonly suffer from weak cell-scaffold interactions and insufficient cell organizations due to the limited resolution of the 3D-printed ***,composite scaffolds with mechanically-robust frameworks and aligned nanofibrous architectures are presented and hybrid manufactured by combining techniques of 3D printing,electrospinning,and unidirectional *** was found that the composite scaffolds provided volume-stable environments and enabled directed cellular infiltration for tissue *** particular,the nanofibrous architectures with aligned micropores served as artificial extracellular matrix materials and improved the attachment,proliferation,and infiltration of *** proposed scaffolds can also support the adipogenic maturation of adipose-derived stem cells(ADSCs)in ***,the composite scaffolds were found to guide directed tissue infiltration and promote nearby neovascularization when implanted into a subcutaneous model of rats,and the addition of ADSCs further enhanced their adipogenic *** presented hybrid manufacturing strategy might provide a promising way to produce additional topological cues within 3D-printed scaffolds for better tissue regeneration.

关键词： hybrid manufacturing 3D printing unidirectional freeze-casting nanofibrous architectures tissue regeneration

Negative pressure for diabetic foot:Evaluation based on calcitonin gene-related peptide in the limb skin of dogs

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Neural Regeneration Research 2006年第7期1卷 601-604页

作者： rui ling Jun Yi ling Wang Mofan Ning Third Department of General Surgery Xijing HospitalFourth Military Medical University of Chinese PLAXi''an 710032Shaanxi ProvinceChina

BACKGROUND:Very good therapeutic effect has been obtained for limb negative pressure in treating limb ischemic *** its mechanism in treating diabetic foot needs further ***:To observe the changes of calcitonin gene related peptide(CGRP)in sensory nerve fiber of skin of dogs with diabetic foot before and after limb negative pressure treatment,and make a comparison with normal dogs,then analyze the mechanism of limb negative pressure in treating diabetic ***:A randomized controlled animal ***:Third Department of General Surgery,Xijing Hospital,Fourth Military Medical University of Chinese ***:Fifteen healthy hybrid dogs,of either gender,weighing 12-18 kg,were provided by Animal Room,Xijing Hospital of the Fourth Military Medical University of Chinese *** being numbered,the involved dogs were randomly assigned into 3 groups:treatment group,model group and normal control group,5 dogs *** negative pressure therapeutic machine(self-made);Anti-CGRP serum(primary antibody,Watpa Company,England);rabbit anti-BigG(second antibody),ABC compound solution,DAB reagent,glucose oxidase reagent,Trixon-X100 solution(Sigma company,USA),ammonium nickelous sulfate reagent(Xi'an Chemical Reagent Factory),neutral gum-solution(import,Shanghai Reagent Co.,Ltd.);Leitz1400 sliding freezing microtome(Leitz Company,Germany);Leica1800 cryostat microtome(Leica Company,Germany);Quantimet570 image analyzer(Leica Company,Germany).METHODS:This experiment was carried out in the Animal Room,Xijing Hospital,Fourth Military Medical University of Chinese PLA from October 2005 to June 2006.①After the dogs in the treatment and model groups were anesthetized,their pancreatic tissues were removed completely and animal models of typeⅠdiabetes mellitus were *** the femoral artery branches including deep femoral artery were ligated and cut off.A helical wire was inserted into the distal femoral artery cavity for narrowing femoral

关键词： MF Negative pressure for diabetic foot gene

Oxygen-assisted preparation of mechanoluminescent ZnS：Mn for dynamic pressure mapping

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Nano Research 2018年第4期11卷 1967-1976页

作者： Xiandi Wang rui ling Yufei Zhang Miaoling Que Yiyao Peng Caofeng Pan Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 100083 China CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology (NCNST) Beijing 100190 China School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Key Laboratory of Aerospace Materials and Performance (Ministry of Education) School of Materials Science and Engineering Beihang University Beijing 100191 China

Mechanoluminescent materials that convert mechanical stimuli to light emission have attracted extensive attention for potential applications in human-machine interactions. Here, we report a simple and available novel approach for the oxygen-assisted preparation of ZnS：Mn particles by solid-state reaction at atmospheric pressure without the formation of the corresponding oxides. The existence of O2 has a positive impact on the formation of S vacancies in wurtzite-phase ZnS, leading to the introduction of Mn2＋ ion luminescent centers and shallow donor levels, which can improve the electron-hole recombination rate. The O2 ratio and Mn2＋ ion doping concentration have significant effects on the luminous efficienc）5 which is optimal at 1%-20% and 1 at.%-2 at.% respectively. In addition, a device based on the piezo-photonic effect with excellent pressure sensitivity of 0.032 MPa-1 was fabricated, which can map the two-dimensional pressure distribution ranging from 2.2 to 40.6 MPa in situ. This device can be applied to real-time pressure mapping, smart sensor networks, high-level security systems, human-machine interfaces, and artificial skins.

关键词： oxygen assistance piezo-photonic effect pressure mapping ZnS:Mn

VP22 fusion protein-based dominant negative mutant can inhibit hepatitis B virus replication

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World Journal of Gastroenterology 2005年第41期11卷 6429-6432页

作者： Jun Yi Wei-Dong Gong ling Wang rui ling Jiang-Hao Chen Jun Yun Department of General Surgery Xijing-Hospital Fourth Military Medical University Xi'an 710033 Shaanxi Province China Oncology Center Zhujiang Hospital Southern Medical University Guangzhou 510282 Guangdong Province China

AIM： To investigate the inhibitory effect of VP22 fusion protein-based dominant negative （DN） mutant on Hepatitis Bvrus （HBV） replication. METHODS： Full-length or truncated fragment of VP22 was fused to C terminal of HBV core protein （HBc）, and subcloned into pcDNA3.1 （-） vector, yielding eukaryotic expression plasmids of DN mutant. After transfection into HepG2.2.15 cells, the expression of DN mutant was identified by immunofluorescence staining. The inhibitory effect of DN mutant on HBV replication was indexed as the supernatant HBsAg concentration determined by RIA and HBV-DNA content by fluorescent quantification-PCR （FQ-PCR）. Meanwhile, metabolism of HepG2.2.25 cells was evaluated by MTI- colorimetry. RESULTS： VP22-based DN mutants and its truncated fragment were expressed in HepG2.2.15 cells, and had no toxic effect on host cells. DN mutants could inhibit HBV replication and the transduction ability of mutantbearing protein had a stronger inhibitory effect on HBV replication. DN mutants with full length of VP22 had the strongest inhibitory effect on HBV replication, reducing the HBsAg concentration by 81.94%, and the HBV-DNA content by 72.30%. MTT assay suggested that there were no significant differences in cell metabolic activity between the groups. CONCLUSION： VP22-based DN mutant can inhibit HBV replication effectively.

关键词： Hepatitis B virus Dominant negative mutant VP22

Review:A survey for image resizing

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Journal of Zhejiang University-Science C(Computers and Electronics) 2014年第9期15卷 697-716页

作者： Xiao LIN Ying-lan MA Li-zhuang MA rui-ling ZHANG Department of Computer Science and Engineering Shanghai Jiao Tong University Academy of Information Technology Luoyang Normal University Department of Computer Science College of Engineering University of Illinois at Urbana-Champaign

Image resizing is a key technique for displaying images on different devices, and has attracted much attention in the past few years. This paper reviews the image resizing methods proposed in recent years, gives a detailed comparison on their performance, and reveals the main challenges raised in several important issues such as preserving an important region, minimizing distortions, and improving efficiency. Furthermore, this paper discusses the research trends and points out the possible hotspots in this field. We believe this survey can give some guidance for researchers from relevant research areas, offering them an overall and novel view.

关键词： Image resizing Saliency measures Cropping Seam carving Warping

Identification of hub genes for glaucoma:a study based on bioinformatics analysis and experimental verification

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International Journal of Ophthalmology(English edition) 2023年第7期16卷 1015-1025页

作者： rui-ling Xie Hai-Yan Nie Yu-Xin Xu Department of Ophthalmology Anhui Public Health Clinical Centerthe First Affiliated Hospital of Anhui University North DistrictHefei 230000Anhui ProvinceChina Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina

AIM:To explore hub genes for glaucoma based on bioinformatics analysis and an experimental model ***:In the Gene Expression Omnibus(GEO)database,the GSE25812 and GSE26299 datasets were selected to analyze differentially expressed genes(DEGs)by the GEO2R *** bioinformatics analysis,9 hub genes were *** operating characteristic(ROC)curves and principal component analysis(PCA)were performed to verify whether the hub gene can distinguish glaucoma from normal *** mouse model of glaucoma was constructed,and the real-time reverse transcriptasepolymerase chain reaction(RT-q PCR)assay was performed to detect the expression levels of hub genes in ***:There were 128 overlapping DEGs in the GSE25812 and GSE26299 datasets,mainly involved in intracellular signalling,cell adhesion molecules and the Ras signalling pathway.A total of 9 hub genes were screened out,including GNAL,BGN,ETS2,FCGP4,MAPK10,MMP15,STAT1,TSPAN8,and *** area under the curve(AUC)values of 9 hub genes were greater than *** PC1 axle could provide a 70.5%interpretation rate to distinguish glaucoma from normal *** the ocular tissues of glaucoma in the mice model,the expression of BGN,ETS2,FCGR4,STAT1,TSPAN8,and VCAM1 was increased,while the expression of GNAL,MAPK10,and MMP15 was ***:Nine hub genes in glaucoma are identified,which may provide new biomarkers and therapeutic targets for glaucoma.

关键词： glaucoma biomarkers hub genes

Degradation of MTBE and TBA by a new isolate from MTBE-contaminated soil

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Journal of Environmental Sciences 2007年第9期19卷 1120-1124页

作者： ZHANG rui-ling HUANG Guo-qiang LIAN Jing-yan LI Xin-gang School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China National Engineering Research Center for Distillation Technology Tianjin 300072 China School of Chemistry and Chemical Engineering Tianjin University of Technology Tianjin 300191 China

Methyl ten-butyl ether （MTBE）, a gasoline additive, possesses serious problems to the environmental health. In the present study, a bacterial culture named A-3 which could effectively degrade MTBE was isolated from the MTBE contaminated soil. The isolate was identified as Chryseobacterium sp., a new species capable of degrading MTBE. In order to enhance its degradation ability, selected environment factors were investigated. The results showed that the optimal temperature was in the range of 25-30℃, the pH was 7.0, the inoculum size was 2 × 10^8 CFU/ml and the optimal concentration of MTBE was from 50 to 100 mg/L. The maximum MTBE utilization rate （Vmax） was 102 nmol MTBE/（mg cell protein.h）. Furthermore, it was found that the isolate could also degrade tert-butyl alcohol （TBA）. The degradation rates of TBA were much faster than those of MTBE. The additional TBA would lead to the decrease of the initial MTBE degradation rate and the inhibitory effect of TBA increased with the increase of TBA concentration. Similar protein profiles at least seven peptides were demonstrated after SDS-PAGE analysis of crude extracts obtained from the cells growing in MTBE and TBA culture.

关键词： methyl ten-butyl ether (MTBE) biodegradation ten-butyl alcohol (TBA)