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Spe.troscopic and calorime.ric studie. of congo re. dye.amyloid pe.tide.comple.e.

Journal of Biophysical Che.istry 2010年第3期1卷 153-163页

作者： Kazushige.Yokoyama Andre. D. Fishe. Amanda R. Amori Danie. R. We.chons ruel e. mcknight 不详

The.modynamic prope.tie. of comple.e. of Con ?go Re. (CR) dye.with amyloid ? (A?) pe.tide. we.e.studie. by both absorption spe.troscopy and isothe.mal titration calorime.ry (ITC). Base. on the.absorption spe.trum for the.formation of CRAβ comple.e. in phosphate.buffe.e. saline.solution (pH 7.4), van’t Hoff plots ove. a te.pe.ature.range.of 10oC to 70oC we.e.cre.te. for CRAβ140, Aβ1228, and Aβ142. The.plot for CR Aβ1228 comple. showe. a re.ative.y line.r fe.ture.within the.give. te.pe.ature.range.with ?H = –10.1 ?0.6 kJ/mol and ?S = + 0.128 ? 0.002 kJ/(mol K). Howe.e., the.plot for CRAβ140 and CRAβ142 comple.e. e.hibite. two distinct line.r re.ions with opposite.slope. ce.te.e. at a spe.ific te.pe.ature. Ts, which was 54.7 ? 0.2℃ and 34.8 ? 0.2℃, re.pe.tive.y. The.ITC e.pe.ime.ts conducte. at 25℃in wate. e.hibite. quite.a diffe.e.t situation from the.above.me.tione. spe.troscopic approach. The.ITC studie. yie.de. a ?H of –85.3 ? 0.2 kJ/mol for the.CRAβ1228 comple. with ne.ative.e.tropy change.–0.152 kJ/mol K). For CRAβ140, the.ITC studie. indicate. the.pre.e.ce.of two binding site. with ?H1 = –81.8 ? 0.3 kJ/mol and ?H2 = –119.5 ? 0.2 kJ/mol with K1 = 5.5 ? 0.7 ? 106 M1 and K2 = 6.9 ? 2.4 ? 108 M1, re.pe.tive.y. The.e.binding constants are.consiste.t with the.mode. sugge.te. by se.e.al studie.. Both binding site. showe. ne.ative.e.tropy change. sugge.ting that the.formation of the.comple. is e.thalpically drive.. The.disagre.me.t in the.moche.ical value. be.we.n two diffe.e.t me.hods confirme. that the.e.thalpy and e.tropy are.he.vily de.e.de.t on te.pe.ature.and buffe./salt e.vironme.t, and may involve.inhe.e.tly diffe.e.t re.ction paths.

关键词： Amyloid Be.a Congo Re. Dye.Prote.n Inte.action Van’t Hoff Plot Isothe.mal Titration Calorime.ry Binding Site Te.pe.ature

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Ne. re.ord of the.fe.the. star Palae.comate.la hiwia(e.hinode.mata:Crinoide.:Comatulida)from Zhe.be. Se.mount in South China Se.:ne. insights into the.taxonomic position of Palae.comate.la

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Journal of Oce.nology and Limnology 2024年第1期42卷 244-251页

作者： Shao’e.SUN Zijie.Me. Zhongli SHA Jing WANG Nanshe.g CHe. De.artme.t of Marine.Organism Taxonomy and Phyloge.y Institute of OceanologyChinese Academy of SciencesQingdao 266071China CAS Ke. Laboratory of Marine.e.ology and e.vironme.tal Scie.ce. Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laoshan Laboratory Qingdao 266237China Shandong Province.Ke. Laboratory of e.pe.ime.tal Marine.Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China Ce.te. for Oce.n Me.a-Scie.ce Chinese Academy of SciencesQingdao 266071China Unive.sity of Chine.e.Acade.y of Scie.ce. Beijing 100049China

One.spe.ime. be.onging to the.family Comate.linae.was colle.te. from the.Zhe.be. Se.mount(332.5–478.2 m)in the.South China Se. in July *** on the.morphological characte.s,the.spe.ime. was ide.tifie. as Palae.comate.la hiwia mcknight,*** is first re.orde. from China Se. and re.e.cribe. in *** spe.ime. diffe.s from the.original de.cription from Ne. Ze.land for ne.e. showing syzygy at br4+5 or br5+6 on inte.ior and br1+2 on e.te.ior ***,it is much conform to the.re.e.cription to spe.ime.s from Indone.ia,with only diffe.e.ce. in position of the.se.ond syzygy and distalmost pinnule.*** is de.osite. in the.Institute.of Oce.nology,Chine.e.Acade.y of *** analyse. base. on the.mitochondrial c oxidase.subunit I(COI)and 16S rRNA ge.e. indicate. that *** was ne.te. within the.tribe.Phanoge.iini and cluste.e. with Aphanocomaste. ***,*** showe. same.morphological fe.ture. in te.ms of mouth place.e.t,comb location,and numbe. of comb te.th rows as othe. ge.e.a of ***,we.sugge.t that the.ge.us Palae.comate.la should be.put in the.tribe.Phanoge.iini.

关键词： ne. re.ord Palae.comate.la hiwia mcknight 1977 South China Se. phyloge.e.ic re.ationship taxonomy

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Impact of adalimumab on dise.se.burde. in mode.ate.to-se.e.e.ulce.ative.colitis patie.ts: The.one.ye.r, re.l-world UCanADA study

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World Journal of Gastroe.te.ology 2022年第34期28卷 5058-5075页

作者： Talat Be.sissow Ge.ffre. C Nguye. Osman Tarabain Laure.t Pe.rin-Biroule. Nathalie.Foucault Ke.in McHugh Joannie.ruel De.artme.t of Me.icine McGill University Health CenterMontreal H3G 1A4QuebecCanada Mount Sinai Hospital Inflammatory Bowe. Dise.se.Ce.tre Toronto M5T 3L9OntarioCanada Dr.O.Tarabain Clinic Windsor N8W 1E6OntarioCanada De.artme.t of Gastroe.te.ology University of LorraineCHRUNancyNancy F-54000France AbbVie.Corporation Saint-Laurent H4S 1Z1QuebecCanada De.artme.t of Me.icine Sherbrooke University Hospital CenterSherbrooke J1H 5N4QuebecCanada

BACKGROUND A gap re.ains in docume.ting the.impact of anti-tumor ne.rosis factor the.apy on dise.se.burde. in ulce.ative.colitis(UC)patie.ts tre.te. in a re.l-world *** use.of patie.t-re.orte. outcome.(PROs)has be.n discusse. as a primary e.dpoint in the.conte.t of the.FDA PRO Guidance.for labe.ling ***,the.e.ficacy and safe.y of adalimumab have.be.n de.onstrate. in pivotal trials;howe.e.,data are.ne.de. to unde.stand how clinical re.ults translate.into improve.e.ts in ke. aspe.ts of the.daily live. of UC patie.ts,such as symptoms,he.lth-re.ate. quality of life.HRQoL),and *** To asse.s re.l-world e.fe.tive.e.s of adalimumab on PRO me.sure. in patie.ts with mode.ate.to-se.e.e.*** UCanADA was a single.arm,prospe.tive.1-ye.r multice.te. Canadian post-marke.ing obse.vational study in which multiple.PRO que.tionnaire. we.e.comple.e.—with psychologic distre.s/de.re.sion symptoms as the.primary e.dpoint—by patie.ts with mode.ate.to-se.e.e.*** we.e.pe.forme. during patie.ts’routine.care.visit sche.ule.which was at the.initiation of adalimumab(base.ine.,afte. induction(approximate.y 8 wk),and 52 wk afte. *** optional asse.sme.ts be.we.n we.ks 8 and 52 we.e.colle.te. at le.st once.but no more.than two time. during this *** safe.y e.e.ts and pe.-protocol adve.se.e.e.ts we.e.*** From 23 Canadian ce.tre.,100 patie.ts we.e.e.rolle. and 48 comple.e. the.*** with the.Patie.t He.lth Que.tionnaire.9 ite.s at we.k 52,61.5%(40/65)[95%confide.ce.inte.val(CI):49.7%-73.4%]of the.patie.ts improve. in psychologic distre.s/de.re.sion symptoms,which was slightly highe. in comple.e.s[65.9%(29/44);95%CI:51.9%-79.9%].At we.k 52,clinical re.ponse.and clinical re.ission we.e.achie.e. re.pe.tive.y by 65.7%(44/73)and 47.8%(32/73)of the.*** odds of improving de.re.sive.symptoms for those.achie.ing a clinical re.ission at we.k 52 was 7.94 highe. compare. with those.not achie.ing a clinic

关键词： Dise.se.burde. Patie.t-re.orte. outcome De.re.sive.symptoms Ulce.ative.colitis Adalimumab Re.l-world data

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Drosophila se.zure.disorde.s： ge.e.ic suppre.sion of se.zure.susce.tibility

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Frontie.s in Biology 2016年第2期11卷 96-108页

作者： Arune.h Saras Laura e. Simon Harlan J. Brawe. Richard e. Price.Mark A. Tanouye Division of Organismal Biology Department of Environmental Science Policy and Management University of California Berkeley CA 94720 USA De.artme.t of Mole.ular and Ce.l Biology University of California Berkeley CA 94720 USA He.e. Wills Ne.roscie.ce.Institute University of California Berkeley CA 94720 USA

Various Drosophila mode.s of human dise.se.have.re.e.tly re.e.ve. incre.se. inte.e.t. The.main goal is to uncove. the.fundame.tal biological basis for human pathology taking advantage.of the.powe. of Drosophila ge.e.ics. This re.ie. e.amine. a se. of Drosophila se.zure.se.sitive.mutations that mode. human se.zure.disorde.s, e.pe.ially e.ile.sy. Also de.cribe. is a nove. se. of mutations that act as se.zure.suppre.sors that ame.iorate.e.ile.sy phe.otype. in double.mutant combinations.

关键词： Drosophila e.ile.sy se.zure.disorde.s sodium channe. se.zttre.suppre.sor ge.e.

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Alte.e. Lignin Biosynthe.is Improve. Ce.lulosic Bioe.hanol Production in Transge.ic Maize.Plants Down-Re.ulate. for Cinnamyl Alcohol De.ydroge.ase

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Mole.ular Plant 2012年第4期5卷 817-830页

作者： Silvia Fornale.Montse.rat Cape.lade. Antonio e.cina Kan Wang Sami Irara Cathe.ine.Lapie.re.Katia ruel Je.n-Paul Jose.e.ue.Jordi Be.e.gue. Pe.e.Puigdome.e.h Joan Rigau David Caparros-Ruiz Laboratori de.Ge.e.ica Mole.ular Ve.e.al Centre de Recerca en AgriGenomica (CRAG) Consorci CSIC-IRTA-UAB-UB Edifici CRAG Campus UAB Bellaterra (Cerdanyola del Valles) 08193 Barcelona Spain Are. de.Fisiologia Ve.e.al Universidad de Lean 24071 Spain Ce.te. for Plant Transformation Iowa State University G405 Agronomy Hall Ames IA 50011-1010 USA Institut Je.n-Pie.re.Bourgin INRA-AgroParisTech UMR 1318 78026 Versailles cedex France Ce.tre.de.Re.he.che. sur le. Macromole.ule. Ve.e.ale.-UPR-CNRS-5301 38041 Grenoble Cedex 09 France

Cinnamyl alcohol de.ydroge.ase.（CAD） is a ke. e.zyme.involve. in the.last ste. of monolignol biosynthe.is. The.e.fe.t of CAD down-re.ulation on lignin production was inve.tigate. through a transge.ic approach in maize. Trans- ge.ic CAD-RNAi plants show a diffe.e.t de.re. of e.zymatic re.uction de.e.ding on the.analyze. tissue.and show alte.- ations in ce.l wall composition. Ce.l walls of CAD-RNAi ste.s contain a lignin polyme. with a slight re.uction in the.S-to-G ratio without affe.ting the.total lignin conte.t. In addition, the.e.ce.l walls accumulate.highe. le.e.s of ce.lulose.and ara- binoxylans. In contrast, ce.l walls of CAD-RNAi midribs pre.e.t a re.uction in the.total lignin conte.t and of ce.l wall polysaccharide.. In vitro de.radability assays showe. that, although to a diffe.e.t e.te.t, the.change. induce. by the.re.re.sion of CAD activity produce. midribs and ste.s more.de.radable.than wild-type.plants. CAD-RNAi plants grown in the.fie.d pre.e.te. a wild-type.phe.otype.and produce. highe. amounts of dry biomass. Ce.lulosic bioe.hanol assays re.e.le. that CAD-RNAi biomass produce. highe. le.e.s of e.hanol compare. to wild-type. making CAD a good targe. to improve.both the.nutritional and e.e.ge.ic value. of maize.lignoce.lulosic biomass.

关键词： Maize lignification lignoce.lulosic biomass se.ondary ce.l wall.

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Physical ge.graphy a landscape.appre.iation Tom L. mcknight, Darre. He.s. Virtual field trip ed.; 6th ed.

Physical geography a landscape appreciation Tom L. McKnight,...

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2000年

作者： Tom L. mcknight Darre. He.s.

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Physical ge.graphy =自然地理: a landscape.appre.iation =景观鉴赏 Tom L. mcknight, Darre. He.s. 8th ed.

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2005年

作者： Tom L. mcknight Darre. He.s.

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生物质用于焦炭和烧结生产的实验室评价

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世界钢铁 2012年第6期12卷 8-17页

作者： S Thomas S J mcknight e.J Se.rano A Male.ová R Ze.insky J Tomá P Vlaic 王旭明美国钢铁公司研究与技术中心美国钢铁公司环境事务部美国钢铁公司USSe.究中心

生物质作为碳可供选择的环保替代燃料,用其进行炼焦和炼铁是一个非常好的选择,因此,应该积极调查、研究如何采取不同的方法利用生物质,以减少硫化物、氮氧化物、二氧化碳的排放和可能的成本投入。对生物质在炼焦生产与烧结生产中的实用... 详细信息

生物质作为碳可供选择的环保替代燃料,用其进行炼焦和炼铁是一个非常好的选择,因此,应该积极调查、研究如何采取不同的方法利用生物质,以减少硫化物、氮氧化物、二氧化碳的排放和可能的成本投入。对生物质在炼焦生产与烧结生产中的实用性在独立的试验中进行评估。生物质对炼焦生产的实用性研究如下:将1%～5%的木质生物质或是焙烤(轻度热解)的木质生物质作为部分高挥发性煤的替代物添加至配合煤中,在实验室焦炉中进行碳化试验。试验结果表明,当把粉碎的生物质加入到配合煤后,焦化压力显著降低,同时焦炭的硫含量下降,但是焦炭的高温强度和力学性能亦有轻微下降,但这种实测强度的降低需要进一步的研究。另外,在一系列独立试验中,通过利用生物质(分别是锯末、粉碎的玉米芯、树皮、木炭等)作为烧结用粉焦的替代燃料在实验室烧结锅进行评估。试验中,燃料用10%、20%、30%、40%的生物质代替。试验结果显示,烧结混合料的堆密度和烧结时间都有下降,添加了生物质的烧结矿质量没有显著恶化。这些初步的试验表明,在实际的炼焦与炼铁生产中生物质很有可能作为一种可再生能源替代部分传统的化石燃料。为了某种特定应用而进行产品优化则需要额外试验。

关键词：生物质干燥二氧化碳焦炭烧结矿试验炉烧结锅

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TDP-35,a truncate. fragme.t of TDP-43,induce. dose.de.e.de.t toxicity and apoptosis in flie.

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Ne.ral Re.e.e.ation Re.e.rch 2022年第11期17卷 2441-2442页

作者： De.pak Chhangani Die.o e.Rincon-Limas De.artme.t of Ne.rology McKnight Brain Instituteand Norman Fixel Institute for Neurological DiseasesUniversity of Florida De.artme.t of Ne.roscie.ce Center for Translational Research in Neurodegenerative DiseaseGenetics InstituteUniversity of Florida

TAR DNA-binding prote.n 43(TDP-43)is an e.se.tial 414 amino acid prote.n that re.ulate. multiple.aspe.ts of RNA bioge.e.is,proce.sing,and *** localize. primarily in the.nucle.s,but abnormal translocation and accumulation in the.cytosol occur unde. pathological conditions(Tziortzouda e. al.,2021).TDP-43 abnormalitie. are.typical pathological hallmarks of amyotrophic late.al scle.osis(ALS)and frontote.poral lobar *** in the.TDP-43-e.coding ge.e.TARDBP cause.familial ALS。

关键词： de.e.e.ation TDP

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Ne.roe.docrine.e.ige.e.ic,and inte.ge.e.ational e.fe.ts of ge.e.al ane.the.ics

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World Journal of Psychiatry 2020年第5期10卷 81-94页

作者： Anatoly e.Martynyuk Ling-Sha Ju Timothy e.More. Jia-Qiang Zhang De.artme.t of Ane.the.iology and the.mcknight Brain Institute University of Florida College of MedicineGainesvilleFL 32610United States De.artme.t of Ane.the.iology University of Florida College of MedicineGainesvilleFL 32610United States De.artme.t of Ane.the.iology and Pe.iope.ative.Me.icine Henan Provincial People’s HospitalPeople's Hospital of Zhengzhou UniversityZhengzhou 450003Henan ProvinceChina

The.progre.s of mode.n me.icine.would be.impossible.without the.use.of ge.e.al ane.the.ics(GAs).De.pite.advance.e.ts in re.ining ane.the.ia approache.,the.e.fe.ts of GAs are.not fully re.e.sible.upon GA *** de.icie.cie. attribute. to GA e.posure.may pe.sist in ne.nate. or e.dure.for we.ks to ye.rs in the.*** studie. on the.me.hanisms of the.long-te.m adve.se.e.fe.ts of GAs are.ne.de. to improve.the.safe.y of ge.e.al ane.the.ia but the. are.hampe.e. not only by e.hical limitations spe.ific to human re.e.rch,but also by a lack of spe.ific biological marke.s that can be.use. in human studie. to safe.y and obje.tive.y study such *** latte. can primarily be.attribute. to an insufficie.t unde.standing of the.full range.of the.biological e.fe.ts induce. by GAs and the.mole.ular me.hanisms me.iating such e.fe.ts e.e. in rode.ts,which are.far more.e.te.sive.y studie. than any othe. *** most re.e.t e.pe.ime.tal findings in rode.ts sugge.t that GAs may adve.se.y affe.t many more.pe.ple.than is curre.tly ***,we.have.shown that ane.the.ia with the.commonly use. GA se.oflurane.induce. in e.pose. animals not only ne.roe.docrine.abnormalitie.(somatic e.fe.ts),but also e.ige.e.ic re.rogramming of ge.m ce.ls(ge.m ce.l e.fe.ts).The.latte. may pass the.ne.robe.avioral e.fe.ts of pare.tal se.oflurane.e.posure.to the.offspring,who may be.affe.te. e.e. at le.e.s of ane.the.ia that are.not harmful to the.e.pose. *** large.numbe. of patie.ts who re.uire.ge.e.al ane.the.ia,the.e.e. large. numbe. of the.r future.une.pose. offspring whose.he.lth may be.affe.te.,and a growing numbe. of ne.rode.e.opme.tal disorde.s of unknown e.iology unde.score.the.translational importance.of inve.tigating the.inte.ge.e.ational e.fe.ts of *** this mini re.ie.,we.discuss e.e.ging e.pe.ime.tal findings on ne.roe.docrine.e.ige.e.ic,and inte.ge.e.ational e.fe.ts of GAs.

关键词： Brain Ge.e.al ane.the.ic Se.oflurane Corticoste.one Cortisol Histone.ace.ylation De.xyribonucle.c acid me.hylation Inte.ge.e.ational e.fe.ts Gamma aminobutyric acid

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