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Inhibitory effect of Phlai capsules on skin test responses among allergic rhinitis patients:a randomized,three-way crossover study

引用

Journal of Integrative Medicine 2017年第6期15卷 462-468页

作者： Pattara Tanticharoenwiwat Prapasri Kulalert Thaweephol Dechatiwongse Na Ayudhya Sittichai Koontongkaew Weena Jiratchariyakul ruedee soawakontha Prakongsiri Booncong Orapan Poachanukoon center of excellence for allergy asthma and pulmonary diseasethammasat university hospitalPathumthani 12120Thailand department of pediatrics faculty of medicinethammasat universityPathumthani 12120Thailand medicinal herb research unit for asthma faculty of medicinethammasat universityPathumthani 12120Thailand faculty of dentistry thammasat universityPathumthani 12120Thailand faculty of pharmacy mahidol universityBangkok 10400Thailand faculty of pharmaceutical sciences huachiew chalermprekiet universitySamut Prakan 10540Thailand department for development of thai traditional and alternative medicine ministry of public healthNonthaburi 11000Thailand

BACKGROUND： Zingiber cassumunar Roxb., commonly known as Phlai in Thai, has been used as a traditional medicine in Thailand for the treatment of various diseases, including inflammation and chronic airway disease. OBJECTIVE： The purpose of this study was to assess the antihistaminic effect of Phlai on skin testing DESIGN, SETTING, PARTICIPANTS AND INTERVENTION： This was a randomized, open-label, three- way crossover study. Twenty allergic rhinitis （AR） patients were enrolled. In randomized sequence, patients received a single dose of Ph/ai capsules （100 or 200 mg） or Ioratadine （10 mg） with a washout period of 1 week between each treatment. MAIN OUTCOME MEASURES： Skin prick testing for histamine and common aeroallergen （house dust mite） were performed before treatment and after 1,2, 3, 4, 6, 8, 12 and 24 hours of treatment. The main treatment outcomes were the mean wheal and flare responses to the skin prick test after treatment. RESULTS： Both 100 mg and 200 mg Phlai doses suppressed wheal and flare responses to house dust mite allergen, but only 200 mg of Phlai capsules significantly suppressed wheal and flare responses to histamine. Repeated measures analysis of variance showed that Ioratadine caused more wheal and flare suppression than Phial capsules in responses to the histamine skin prick test. However, there were no significant differences among the effects of 100 mg Phlai capsules, 200 mg Phlai capsules and Ioratadine in suppression of wheal and flare induced by the mite skin prick test. Both doses of Phlai were well-tolerated with no adverse ***： Both 100 mg （compound D 4 mg） when taken as a single therapeutic dose, inhibited AR patients. and 200 mg （compound D 8 mg） Phlai capsules, skin reactivity to histamine and mite skin prick tests in TRIAL REGISTRATION： Thai clinical trial registry （TCTR20160510001）

关键词： Zingiber cassumunac, Phlai antihistamine skin test rhinitis, allergic Ioratadine

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