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Open Journal of Nephrology 2023年第2期13卷 74-80页

作者： Suzanne J. Sanchez ruben A. Maguad Grecia P. Darunday Adult Nephrology Department Perpetual Succour Hospital Cebu City Philippine

Delayed onset low molecular weight heparin induced skin necrosis is a rare adverse event. It usually occurs at the site of injection, and typically develops within 2 weeks of starting therapy. However, in our case, we presented a 62-year-old woman who is on Hemodialysis twice a week. Her hemodialysis prescription included Enoxaparine 0.2 cc IV as anticoagulant. On her third month of regular hemodialysis, she developed skin necrosis on her right leg and left hand. The diagnosis was made clinically and by exclusion of other possible causes of skin necrosis in a chronic kidney disease patient, such as calciphylaxis. The most important aspect of management, in this case, is early recognition and withdrawal of its use, which were done in our patient.

关键词： Heparin Skin Necrosis Hemodialysis

A new approach for the treatment of CLL using chlorambucil/hydroxychloroquine-loaded anti-CD20 nanoparticles

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Nano Research 2016年第2期9卷 537-548页

作者： Sara Capolla Nelly Mezzaroba Sonia Zorzet Claudio Tripodo Ramiro Mendoza-Maldonado Marilena Granzotto Francesca Vita ruben Spretz Gustavo Larsen Sandra Noriega Eduardo Mansilla Michele Dal Bo Valter Gattei Gabriele Pozzato Luis Nunez Paolo Macor Department of Life Sciences University of Trieste 34127 Trieste Italy Department of Human Pathology University of Palermo 90133 Sicilia Italy Molecular Oncology Unit National Laboratory Consorzio Interuniversitatio per le Biotecnologie (CIB) 34012 Trieste Italy Dipartimento Universitario Clinico di Scienze mediche Chirurgiche e della Salute University of Trieste 34149 Trieste Italy LNK Chemsolutions LLC Lincoln NE 68521 USA Bio-Target Inc. Chicago IL 60637 USA Centro Unico Coordinador de Ablacion e Implante Provincia de Buenos Aires (C.U.CA.I.B.A.) Ministry of Health La Plata Buenos AiresArgentina Clinical and Experimental Onco-Hematology Unit Centro di Riferimento Oncologico Istituto di Ricerca e Cura a Carattere Scientifico(I.R.C.C.S.) 33081 Aviano Italy Callerio Foundation Onlus Institutes of Biological Researches 34127 Trieste Italy

Current approaches for the treatment of chronic lymphocytic leukemia （CLL） have greatly improved the prognosis for survival, but some patients remain refractive to these therapeutic regimens. Hence, in addition to reducing the long-term side- effects of therapeutics for all leukemia patients, there is an urgent need for novel therapeutic strategies for difficult-to-treat leukemia cases. Due to the cytotoxicity of drugs, the major challenge currently is to deliver the therapeutic agents to neoplastic cells while preserving the viability of non-malignant ceils. In this study, we propose a therapeutic approach in which high doses of hydroxychloroquine and chlorambucil were loaded into biodegradable polymeric nanopartides coated with an anti-CD20 *** first demonstrated the ability of the nanoparticles to target and internalize in tumor B-cells. Moreover, these nanoparticles could kill not only p53-mutated]deleted leukemia cells expressing a low amount of CD20, but also circulating primary ceils isolated from chronic lymphocytic leukemia patients. The safety of these nanoparticles was also demonstrated in healthy mice, and their therapeutic effects were shown in a new model of aggressive leukemia. These results showed that anti-CD20 nanoparticles containing hydroxychloroquine and chlorambucil can be effective in controlling aggressive leukemia and provided a rationale for adopting this approach for the treatment of other B-cell disorders.

关键词： chronic lymphocytic leukemia immune targeted nanoparticles treatment xenograft model

A New Approach to Electromagnetic Theories of Consciousness

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Journal of Chemistry and Chemical Engineering 2016年第5期10卷 235-237页

作者： Aibassov Erkin Zhakenovich Yemelyanova Valentina Savizky ruben Spataru Tudor Research Institute of New Chemical Technologies and Materials Kazakh National University Al-FarabL Almaty 005012 Kazakhstan Columbia University 3000 Broadway New York NY 10027 USA

The authors have proposed a new approach to the theory of consciousness, which takes into account the effect of the magnetic field on the process. The authors have shown that the process of information and thinking can be modeled on the basis of chemical thermodynamics. The authors offer general equations to calculate the thinking of the work of judgment the L and of entropy solutions G in the presence of a magnetic field. As a result, studies have shown that the magnetic effects strongly influence the thermodynamics of the process of thinking.

关键词： Magnetic effect thermodynamics process of thinking consciousness

A New Approach to the Magnetochemical Theory Near Death Experiences and of Formation Phosphine from Phosphates

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Journal of Chemistry and Chemical Engineering 2016年第5期10卷 245-247页

作者： Aibassov Erkin Zhakenovich Nakisbekov Narymzhan Yemelyanova Valentina Savizky ruben Research Institute of New Chemical Technologies and Materials Kazakh National University Al-Farabi Almaty 005012 Kazakhstan Columbia University 3000Broadway New York NE 10027 USA

The authors have proposed a new approach to the theory of formation of phosphine from phosphates and death. According to this hypothesis, the initial impetus for the beginning of the dying process is the formation of phosphates and phosphine decomposition of adenosine triphosphate molecule. This process makes people survived clinical death vision of ＂blue and white tunnel＂ and the separation of the soul from the body. The authors proposed chemical mechanism for the recovery of phosphate to phosphine.

关键词： Magnetic field phosphine adenosine triphosphate theory of death "blue and white tunnel"

Lignin engineering in forest trees: From gene discovery to field trials

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Plant Communications 2022年第6期3卷 1-25页

作者： Barbara De Meester ruben Vanholme Thatiane Mota Wout Boerjan Ghent University Department of Plant Biotechnology and BioinformaticsTechnologiepark 719052 GhentBelgium VIB Center for Plant Systems Biology Technologiepark 719052 GhentBelgium

Wood is an abundant and renewable feedstock for the production of pulp,fuels,and biobased ***,wood is recalcitrant toward deconstruction into cellulose and simple sugars,mainly because of the presence of lignin,an aromatic polymer that shields cell-wall ***,numerous research efforts have focused on engineering lignin amount and composition to improve wood ***,we focus on results that have been obtained by engineering the lignin biosynthesis and branching pathways in forest trees to reduce cell-wall recalcitrance,including the introduction of exotic lignin *** addition,we draw general conclusions from over 20 years of field trial research with trees engineered to produce less or altered *** discuss possible causes and solutions for the yield penalty that is often associated with lignin engineering in ***,we discuss how conventional and new breeding strategies can be combined to develop elite clones with desired lignin *** conclude this review with priorities for the development of commercially relevant lignin-engineered trees.

关键词： lignin genetic engineering breeding CRISPR field trial forest trees

Achieving exceptional wear resistance in a crack-free high-carbon tool steel fabricated by laser powder bed fusion without pre-heating

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Journal of Materials Science & Technology 2023年第25期156卷 1-19页

作者： Konrad Kosiba Daniel Wolf Matthias Bönisch Kai Neufeld ruben Hühne Tobias Gustmann Jozef Bednarčík Hongyu Chen Xiaoliang Han Volker Hoffmann Lukas Beyer Uta Kühn Sergio Scudino Lars Giebeler Julia K.Hufenbach Leibniz Institute for Solid State and Materials Research (IFW) Dresden E.V. Helmholtzstr. 20Dresden 01069Germany Department of Materials Engineering KU LeuvenKasteelpark Arenberg 44bus 2450Leuven 3001Belgium Department of Condensed Matter Physics Institute of PhysicsP.J. Safarik University in KosicePark Angelinum 9Kosice 04154Slovakia Institute of Experimental Physics Slovak Academy of ScienceWatsonova 47Kosice 040 01Slovakia Key Laboratory of Impact and Safety Engineering of Ministry of Education of China Ningbo UniversityNingbo 315211China TU Bergakademie Freiberg Institute of Materials ScienceGustav-Zeuner-Str. 5Freiberg 09599Germany

Laser powder bed fusion(LPBF)for the fabrication of dense components used for tooling applications,is highly *** stresses,which evolve in the additively manufactured part,are inherent to LPBF *** additional stress contribution in high-carbon steels arises from the austenite-to-martensite phase transformation,which may eventually lead to cracking or even *** an alternative to pre-heating the base plate,which is not striven by industry,lowering the martensite content which forms in the part,is essential for the fabrication of dense parts by LPBF of high-carbon tool steels which are then adapted to *** this study,a successful strategy demonstrates the processing of the Fe85Cr4Mo1V1W8C1(wt%)high-carbon steel by LPBF into dense parts(99.8%).The hierarchical microstructure consists of austenitic and martensitic grains separated by elemental segregations in which nanoscopic carbide particles form a network.A high density of microsegregation was observed at the molten pool boundary ultimately forming a *** LPBF-fabricated steel shows a yield strength,ultimate compressive stress,and total strain of 1210 MPa,3556 MPa,and 27.4%,*** mechanical and wear performance is rated against the industrially employed and highly wear-resistant 1.2379 tool steel taken as the *** its lower macro-hardness,the LPBF steel(58.6 HRC,0.0061 mm^(3) Nm^(-1))shows a higher wear resistance than the reference steel(62.6 HRC,0.0078 mm^(3) Nm^(-1)).This behavior results from the wear-induced formation of martensite in a microscale thick layer directly at the worn surface,as it was proven via high-energy X-ray diffraction mapping.

关键词： Additive manufacturing Laser powder bed fusion Steel Wear TRIP

Application of materials science to battery technologies

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Application of materials science to battery technologies

Control of disability glare by means of electrochromic filtering glasses:A pilot study

电动车及新型电池学术交流会

作者： CHEH Hukyuk Samuel ruben-Peter G.. Vice-president technology Duracell Global Business Management Group BethelCT 06801 USA Viele Professor Emeritus of Electrochemistry Department of Chemical Engineering Columbia UniversityNew YorkNY 10027 USA

The new content and power capability of a battery depend critically on the chemical nature as well as the structure of the active materials. In this paper, criteria for the choice of active materials in consumer batteries are presented. Two equally valid ,but conceptually very different approaches, to the development of new/improved battery active materials are discussed. One approach is to utilize the "Design of experiments" method to determine an optimal process for synthesizing materials of dersired properties;the second approach is to design/modify materials based on a thorough scientific understanding of the chemistry and structure aspects of materials. Practical examples will be given to illustrate these two methods.

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Journal of Innovative Optical Health Sciences 2017年第1期10卷 11-20页

作者： Rosa Maria Coco-Martín ruben Cuadrado-Asensio Ceesar Vega-Colado Ricardo Vergaz Jose M.Sanchez-Pena Ana Viñuales Sergi Peris Pau Artús M.Begona Coco-Martín IOBA Universidad de ValladolidValladolidSpain GDAF-UC3M Grupo de Displays y Aplicaciones Fotonicas Department de Tecnologia Electronica Universidad Carlos III de MadridSpain IK4-CIDETEC Parque Tecnologico de San Sebastian GuipuzcoaSpain Indo Optical Group Departamento I+D SantCugat del Valles BarcelonaSpain GIDFYS European University Miguel de Cervantes(UEMC)Department of HealthSciencesSpain

Purpose:To evaluate the potential clinical usability of a new prototype of ophthalmic blue light filters developed by using electrochromic technology in pseudophakic patients complaining of ***:A prototype of electrochromic device was developed,with a specific frame that enclosed an electronic driver that allowed personalizing its function for each patient.A pro-spective,observational case series study was performed to test *** patients who had un-dergone cataract surgery with clear intraocular lenses and complaining of glare were included in the *** outcome measures were the results obtained in the satisfaction questionnaire that was delivered to ***,visual acuity,contrast sensitivity,and reading ability data were evaluated with and without the prototype under diferent lighting conditions and different modes of the prototype after a complete month of *** transmittance was also ***:Visual acuity,contrast sensitivity and reading function did not change significantly with prototype *** main activity for which the prototype was used was *** one patient found that the dimming level was *** patients reported variable discomfort when passing tunnels,not sufficiently clear indoors,or put on and remove *** lenses slightly decreased their transmittance at the end of the ***:Glasses based on elect rochromic technology may be acceptable for outdoor/indoor use and for distance-near *** studies with larger samples must be conducted to confirm the clinical usability of these glasses.

关键词： Optical filters electro-optical devices technical visual aids electronic control.

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来自苏联的爱 SU-122

模型世界 2019年第4期 32-41页

作者： ruben GONZALEZ

这台田宫(TAHIYA)出品的SU-122年代已久,算是很有年头的老古董了。很多购入的玩家或许已将其忽视或遗忘,长期束之高阁。其实只需要一些胶条、网格、铜丝及Marquette的履带,再加上一点决心和耐心,这盒模型在一些基础技法的加持下完全可... 详细信息

这台田宫(TAHIYA)出品的SU-122年代已久,算是很有年头的老古董了。很多购入的玩家或许已将其忽视或遗忘,长期束之高阁。其实只需要一些胶条、网格、铜丝及Marquette的履带,再加上一点决心和耐心,这盒模型在一些基础技法的加持下完全可以呈现出焕然一新的面貌。事实上,虽然如今充斥市面的诸多包含高科技含量的模型使玩家的制作更为简易,但这盒中古套件反而是一种良性的返璞归真。因此,在用传统技法将模型制作完毕以后,我们来看看如何运用多种技法将这台模型做出风尘仆仆的老旧外观。

关键词：油画颜料 SU-122 抛光效果金属网