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International Journal of Digital Earth 2021年第3期14卷 271-287页

作者： Adrian Jesus Garcia Beatriz González-Rodrigo Sara martinez ruben martinez Miguel Marchamalo Topography and Geomatics Lab ETSI CaminosCanales y PuertosUniversidad Politécnica de MadridMadridSpain ETS de Ingeniería Civil Universidad Politécnica de MadridMadridSpain

The old city centers of many major cities represent a great challenge from a constructive point of view since the foundations of the buildings consist of an aggregation of previous *** endorses thorough monitoring activities during any underground *** capabilities of the persistent scatterer interferometry(PSI)can be exploited to cope with these monitoring ***,the old city centers represent a very challenging urban scenario since the rooftops are usually filled with air conditioning systems and due to the fact that the streets are usually *** work assesses the applicability of the PSI technique under this challenging ***,it proposes a set of novel classification indexes that allow an objective assessment of the building’s health and the impact derived from any *** can be applied in deformation monitoring and risk evaluation in urban *** applicability of the technique and the proposed indexes is validated in the monitoring of underground construction works in the old city center of Madrid comparing the results against on-ground measurements and identifying the potential and the limitation of the technique.

关键词： Satellite-based monitoring historical city center building health monitoring persistent scatterer interferometry urban planning

Tropical tree community composition and diversity variation along a volcanic elevation gradient

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Journal of Mountain Science 2022年第12期19卷 3475-3486页

作者： ruben martinez-CAMILO Manuel martinez-MELENDEZ Nayely martinez-MIELENDEZ Derio Antonio JIMENEZ-LOPEZ Mauricio JOSE-RIOS Unidad Villa Corzo Facultad de IngenieríaUniversidad de Ciencias y Artes de Chiapas30520 Villa CorzoChiapasMexico Instituto de Ciencias Biológicas Universidad de Ciencias y Artes de Chiapas29039 Tuxtla GutiérrezChiapasMexico Eizia A.C. 29045 Tuxtla GutiérrezChiapasMexico Departamento de Conservación de la Biodiversidad El Colegio de la Frontera Sur29290 San Cristóbal de las CasasChiapasMexico Orquidiario y Jardín Botánico de Comitán Secretaría de Medio Ambiente e Historia Natural30106 Comitán de DomínguezChiapasMexico Instituto de Investigación en Gestión de Riesgos y Cambio Climático Universidad de Ciencias y Artes de Chiapas29039 Tuxtla GutiérrezChiapasMexico

Unraveling the factors that determine variation of diversity in tropical mountain systems is a topic for debate in plant *** is especially true in areas where topography is complex due to volcano elevational gradients and where forests are vulnerable to human *** this study we used a set of climatic(temperature,rainfall,and radiation solar),topographic(elevation,slope aspect,and slope orientation)and human disturbance variables to determine their effect on diversity and composition patterns of a tree community,considering three slope aspects of a tropical volcano in southeastern *** sampled trees in seventy 0.1-ha plots distributed on three slope aspects of the Tacanávolcano along an elevational gradient of 1500 to 2500 *** determined diversity patterns(general tree richness,exponential of Shannon index,and pioneer species richness)with linear regression models,and for beta diversity,we used a dissimilarity index(within and between elevational bands 100 m wide).The effect of a set of environmental and human disturbance variables on tree diversity and community composition was analyzed with general linear models and multivariate analyses,*** registered 2,949 individual trees belonging to 176 species and *** average species richness and alpha diversity per plot were 13(standard deviation±6)and 9(±5),*** tree richness and alpha diversity increased in the middle part(unimodal patterns)of the elevational gradient,but pioneer species richness decreased linearly with *** variance explained by general linear models was greater in richness(32%)than in alpha diversity(25.3%).The most important predictor variables were temperature(elevational gradient),which explained the unimodal pattern(richness and alpha diversity increase at intermediate levels of temperature),and slope orientation,which explained the increase in richness and alpha diversity toward the geographic *** temperature had a signific

关键词： Composition Environmental gradient Tree diversity patterns Tropical humid cloud forest Tropical volcanoes

SCFD1 in amyotrophic lateral sclerosis:reconciling a genetic association with in vivo functional analysis

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Neural Regeneration Research 2024年第6期19卷 1201-1202页

作者： ruben J.Cauchi Centre for Molecular Medicine and Biobanking Biomedical Sciences BuildingDepartment of Physiology and BiochemistryFaculty of Medicine and SurgeryUniversity of MaltaMsidaMalta

Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons,resulting in muscle weakness and spasticity,eventually leading to death due to respiratory *** by our group of a casecontrol cohort from an isolated island population have found that genetics plays a significant role in disease etiology(Farrugia Wismayer et al.,2023).

关键词： sclerosis respiratory

Metabolic reprogramming of the inflammatory response in the nervous system:the crossover between inflammation and metabolism

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Neural Regeneration Research 2024年第10期19卷 2189-2201页

作者： Jesus Amo-Aparicio Charles A.Dinarello ruben Lopez-Vales Department of Medicine University of ColoradoAuroraCOUSA Institute of Neurosciences and Department Cell BiologyPhysiology and ImmunologyUniversitat Autònoma de BarcelonaBellaterraSpain Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud Carlos ⅢSpain

Metabolism is a fundamental process by which biochemicals are broken down to produce energy(catabolism) or used to build macromolecules(anabolism). Metabolism has received renewed attention as a mechanism that generates molecules that modulate multiple cellular responses. This was first identified in cancer cells as the Warburg effect, but it is also present in immunocompetent cells. Studies have revealed a bidirectional influence of cellular metabolism and immune cell function, highlighting the significance of metabolic reprogramming in immune cell activation and effector functions. Metabolic processes such as glycolysis, oxidative phosphorylation, and fatty acid oxidation have been shown to undergo dynamic changes during immune cell response, facilitating the energetic and biosynthetic demands. This review aims to provide a better understanding of the metabolic reprogramming that occurs in different immune cells upon activation, with a special focus on central nervous system disorders. Understanding the metabolic changes of the immune response not only provides insights into the fundamental mechanisms that regulate immune cell function but also opens new approaches for therapeutic strategies aimed at manipulating the immune system.

关键词： central nervous system fatty acid oxidation glycolysis inflammation macrophage metabolism microglia neurodegeneration oxidative phosphorylation

用于AVO分析的地震数据约束处理流程及实例

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石油物探译丛 1993年第3期 38-42页

作者： ruben martinez 杨勤勇

本文提出一种用于 AVO 分析的地震数据处理方法,并举例说明了该方法。在处理流程的主要阶段,用叠前合成地震记录对地震数据进行校正,该记录是在已知岩性条件和流体条件下钻透两层储层(浅层和深层)的一口钻井位置上求得的。我们还用岩石... 详细信息

本文提出一种用于 AVO 分析的地震数据处理方法,并举例说明了该方法。在处理流程的主要阶段,用叠前合成地震记录对地震数据进行校正,该记录是在已知岩性条件和流体条件下钻透两层储层(浅层和深层)的一口钻井位置上求得的。我们还用岩石物理模拟求出了横波速度,用于合成地震记录计算。AVO 分析结果表明,与地震数据非约束处理相比,P 波数据(截距)和合成数据间的吻合程度明显提高。AVO 梯度剖面直接显示了浅层油水界面。我们还进一步根据井中数据 P 波振幅和原始 AVO 梯度振幅等信息计算了视泊松比剖面。在本项研究过程中,我们还指出了 AVO 分析技术的某些局限性,尤其是在深层储层确定过程中,这些局限性主要是由 NMO 中的误差和浅层储层引起的局部传输效应造成的。综合应用某些井位的岩石物理模拟结果可以对处理步骤更好地进行控制。和简单的 P 波(零偏移距)分析相比,它能得到置信度更高的最终数据处理结果及更好的岩石物理解释结果。

关键词：地震数据约束处理 AVO分析

Exploring the modulatory role of bovine lactoferrin on the microbiome and the immune response in healthy and Shiga toxin‑producing *** challenged weaned piglets

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1278-1291页

作者： Matthias Dierick ruben Ongena Daisy Vanrompay Bert Devriendt Eric Cox Laboratory of Immunology Department of Translational PhysiologyInfectiology and Public HealthFaculty of Veterinary MedicineGhent UniversitySalisburylaan 1339820 MerelbekeBelgium Laboratory for Immunology and Animal Biotechnology Faculty of Bioscience EngineeringGhent UniversityCoupure links 6539000 GhentBelgium

Background Post-weaned piglets suffer from F18+Escherichia coli(***)infections resulting in post-weaning diar-rhoea or oedema *** used management strategies,including colistin and zinc oxide,have contrib-uted to the emergence and spread of antimicrobial *** antimicrobials capable of directly interacting with pathogens and modulating the host immune responses are being *** has shown promising results against porcine enterotoxigenic *** strains,both in vitro and in *** We investigated the influence of bovine lactoferrin(bLF)on the microbiome of healthy and infected weaned ***,we assessed whether bLF influenced the immune responses upon Shiga toxin-producing ***(STEC)***,2 in vivo trials were conducted:a microbiome trial and a challenge infection trial,using an F18+STEC *** did not affect theα-andβ-***,bLF groups showed a higher relative abundance(RA)for the Actinobacteria phylum and the Bifidobacterium genus in the ileal *** analysing the immune response upon infection,the STEC group exhibited a significant increase in F18-specific IgG serum levels,whereas this response was absent in the bLF *** Taken together,the oral administration of bLF did not have a notable impact on theα-andβ-diversity of the gut microbiome in weaned ***,it did increase the RA of the Actinobacteria phylum and Bifi-dobacterium genus,which have previously been shown to play an important role in maintaining gut ***,bLF administration during STEC infection resulted in the absence of F18-specific serum IgG responses.

关键词： E.coli Immune modulation Lactoferrin Microbiome

Effect of slake durability on time dependent swelling behavior of red-bed siltstone in Sichuan Basin

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Journal of Mountain Science 2024年第9期21卷 3123-3138页

作者： JIA Qinji ruben Angel GALINDO AIRES LIU Xiaoming XU Haifeng Department of Geotechnical Engineering College of Civil EngineeringHunan UniversityChangsha 410082China Escuela de Caminos Canales y PuertosUniversidad Politécnica de MadridMadrid 28040Spain

The swelling behavior of red-bed rocks is a significant factor in the abnormal uplift of subgrades for high-speed railways constructed on the red stratum in the Sichuan Basin,*** prime objective of this paper is to investigate the impact of mineralogical composition,moisture content,and overburden load on the time-dependent unconfined and oedometric swelling behavior of red-bed siltstone in the context of differences in the slake *** samples were prepared for the swelling test,with eleven used for the unconfined swelling and slake index tests and nine for the oedometric swelling *** temporal dependency of swelling is characterized by the viscosity coefficient of water absorption in a proposed swelling *** indicate that the swelling deformation of red-bed rocks is due to a combination of hydration swelling within the rock matrix and crack expansion caused by air *** the unconfined swelling test,the final axial swelling strain of red-bed rocks decreases linearly with increasing slake index,while the viscosity coefficient increases exponentially with the slake *** the oedometric swelling test,red-bed rocks with lower slake durability show greater sensitivity to lateral constraint and overburden load compared to those with higher slake durability.

关键词： Rock swelling Slake durability Time effect Unconfined swelling test Oedometric swelling test

A review on experimental techniques and their applications in the effects of mineral content on geomechanical properties of reservoir shale rock

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Rock Mechanics Bulletin

Rock Mechanics Bulletin 2024年第2期3卷 21-38页

作者： Romulus Mawa Tuzingila Lingyun Kong ruben Koy Kasongo Key Laboratory of Theory and Technology of Petroleum Exploration and Development in Hubei Province China University of GeosciencesWuhan 430074China Key Laboratory of Tectonics and Petroleum Resources(Ministry of Education) China University of GeosciencesWuhan 430074China Department of Petroleum Engineering College of Earth ResourcesChina University of GeosciencesWuhanChina Faculty of Oil Gas and Renewable EnergyDepartment of Exploration and ProductionUniversity of KinshasaDemocratic Republic of the Congo Faculty of Science Department of GeosciencesUniversity of KinshasaDemocratic Republic of the Congo

Understanding the effects of mineral composition on geomechanical characteristics is critical in order to design and optimize the hydraulic fracturing necessary for shale gas reservoir *** information is still missing in effects of mineral content and the experimental methodologies *** paper provided an in-depth assessment of the various experimental methodologies and their applications in the relationship between the mineralogical and geomechanical features of the shale *** results revealed that more brittle minerals increase their strength,but chemical reaction that creats pores decrease their *** content of carbonate or quartz increases a rock's brittleness,while a high content of clay increases a rock's plasticity and decreases its *** phyllosilicate content increases,the uniaxial compressive strength decreases,and this could be because phyllosilicate minerals have a weakening effect on the mineral ***'s modulus often climb as clay minerals decline and as silica with carbonate concentration rises,however Poisson's ratio increases in relation to an increase in clay minerals,which also increases the ductility of the reservoir shale ***,compared to minerals and matrix,does not significantly impact the strength of shale ***,the benefits and drawbacks of using uniaxial and triaxial compression,ultrasonic testing,and nano-indentation techniques in unconventional reservoirs were *** findings suggest that,because of the possibility for experimental testing repeatability for increased accuracy,ultrasonic testing is the most appropriate experimental approach in the scenes of assessing static and dynamic geomechanical properties of reservoir shale *** suggested that numerically-based simulation of experimental techniques used for shale geomechanical evaluations and numer-ical modeling of heterogeneous shale rock samples will be necessary in light of the limitations faced in the a

关键词： Reservoir shale rock Geomechanical properties Mineral content

Optimal Design of Hybrid Microgrid in Isolated Communities of Ecuador

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 488-499页

作者： Luis A.Pesantes ruben Hidalgo-León Johnny Rengifo Miguel Torres Jorge Aragundi JoséCordova-Garcia Luis F.Ugarte Facultad de Ingeniería en Electricidad y Computación of Escuela Superior Politécnica del Litoral(ESPOL)University GuayaquilEcuador Department of Electrical Engineering at Universidad Técnica Federico Santa María SantiagoChile IEEE

In rural territories, the communities use energy sources based on fossil fuels to supply themselves with electricity, which may address two main problems: greenhouse gas emissions and high fuel prices. Hence, there is an opportunity to include renewable resources in the energy mix. This paper develops an optimization model to determine the optimal sizing, the total annual investment cost in renewable generation, and other operating costs of the components of a hybrid microgrid. By running a k-means clustering algorithm on a meteorological dataset of the community under study, the hourly representative values become input parameters in the proposed optimization model. The method for the optimal design of hybrid microgrid is analyzed in six operating scenarios considering:(1) 24-hour continuous power supply;(2) load shedding percentage;(3) diesel power generator(genset) curtailment;(4) the worst meteorological conditions;(5) the use of renewable energy sources including battery energy storage systems(BESSs);and(6) the use of genset. A mathematical programming language(AMPL) tool is used to find solutions of the proposed optimization model. Results show that the total costs of microgrid in the scenarios that cover 100% of the load demand(without considering the scenario with 100% renewables) increase by over 16% compared with the scenario with genset operation limitation. For the designs with power supply restrictions, the total cost of microgrid in the scenario with load shedding is reduced by over 27% compared with that without load shedding.

关键词： Battery energy storage system(BESS) isolated community microgrid renewable energy optimization

Machine learning in liver surgery:Benefits and pitfalls

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World Journal of Clinical Cases 2024年第12期12卷 2134-2137页

作者： Rafael Calleja Manuel Durán María Dolores Ayllón ruben Ciria Javier Briceño Hepatobiliary Surgery and Liver Transplantation Unit Hospital Universitario Reina SofíaMaimonides Biomedical Research Institute of CordobaCórdoba 14004Spain

The application of machine learning(ML)algorithms in various fields of hepatology is an issue of ***,we must be cautious with the *** this letter,based on a published ML prediction model for acute kidney injury after liver surgery,we discuss some limitations of ML models and how they may be addressed in the *** the future faces significant challenges,it also holds a great potential.

关键词： Machine learning Liver surgery Artificial intelligence Random forest Prediction model