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氮磷养分介导的植物–微生物互作研究进展

植物营养与肥料学报 2024年第7期30卷 1322-1328页

作者：阮文渊任剑豪郭美娜易可可中国农业科学院农业资源与农业区划研究所/北方干旱半干旱耕地高效利用全国重点实验室/农业农村部植物营养与肥料重点实验室北京100081 北京林业大学生物科学与技术学院/林木资源高效生产全国重点实验室/林木育种与生态修复国家工程研究中心北京100083

氮、磷是植物生长发育所必需的大量营养元素,植物对氮磷养分的高效吸收利用与外界环境密切相关,同时氮磷养分又会影响植物的环境适应性。为此,植物如何整合适应不同的外部环境,特别是生物环境,以实现氮磷养分的高效吸收利用,是植物营养... 详细信息

氮、磷是植物生长发育所必需的大量营养元素,植物对氮磷养分的高效吸收利用与外界环境密切相关,同时氮磷养分又会影响植物的环境适应性。为此,植物如何整合适应不同的外部环境,特别是生物环境,以实现氮磷养分的高效吸收利用,是植物营养研究领域的前沿新热点。本文对近年来氮磷养分介导的植物-微生物互作研究进展进行综述,主要涉及氮磷养分介导的有益和有害生物互作研究,阐释了氮磷核心转录调控因子NLPs和PHRs在调控植物-微生物互作过程中的重要作用,总结了植物体内磷素感受蛋白SPXs在调控植物-微生物互作过程中的功能多样性。此外,本文还对未来氮磷养分介导的植物-微生物互作研究的关键点进行了展望。

关键词：氮磷植物微生物互作有益生物有害生物

大麻二酚跨膜转运体内外吸收机制及抗炎活性研究

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中国中药杂志 2024年第17期49卷 4777-4785页

作者：李睿郝瑞陈珏路丽艳李敏阮文辉山西中医药大学中药与食品工程学院山西晋中030619 山西省药品审评中心(山西省医药与生命科学研究院) 山西太原030006

该研究利用Caco-2细胞和正常大鼠考察大麻二酚(cannabidiol,CBD)体外吸收特性和体内药代动力学特征,并进一步研究其抗炎机制。通过CCK-8法确定CBD安全浓度范围,研究时间、浓度、温度、内吞抑制剂和转运抑制剂对CBD跨膜吸收和转运的影响... 详细信息

该研究利用Caco-2细胞和正常大鼠考察大麻二酚(cannabidiol,CBD)体外吸收特性和体内药代动力学特征,并进一步研究其抗炎机制。通过CCK-8法确定CBD安全浓度范围,研究时间、浓度、温度、内吞抑制剂和转运抑制剂对CBD跨膜吸收和转运的影响;检测大鼠灌胃给药后不同时间的血药浓度,绘制药-时曲线,计算药代动力学参数;脂多糖(LPS)诱导Caco-2细胞建立炎症损伤模型,检测CBD干预处理后乳酸脱氢酶(LDH)活力、跨膜电阻(TEER)值以及细胞炎症因子水平探究CBD抗炎作用机制。结果表明在实验浓度范围内,Caco-2细胞对CBD的摄取在2 h达到饱和,CBD摄取量和浓度、温度呈正相关,可被内吞进入细胞。CBD可以通过多药耐药蛋白2(MRP2)和乳腺癌耐药蛋白(BCRP)参与的主动转运途径穿透Caco-2细胞,而加入P-gp抑制剂对CBD的转运没有影响。大鼠对CBD吸收迅速,达峰时间tmax为(1.00±0.11)h,在体内的消除较快,t1/2仅为(1.86±0.16)h。另外,CBD显著改善了炎症反应带来的LDH活力升高和TEER降低的现象,可通过降低促炎细胞因子白细胞介素-8(IL-8)、白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)的表达维持肠道屏障,起到抗炎作用。

关键词：大麻二酚 Caco-2细胞摄取转运药代动力学抗炎

Analytical potential energy function for the ground state(~1A_1) of hydrogen isotopic D_2O molecule

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Science China(Physics,Mechanics & Astronomy) 2009年第4期52卷 566-573页

作者： ruan wen LUO wenLang ZHANG Li ZHU ZhengHe Institute of Atomic and Molecular Physics Sichuan UniversityChengdu 610065China College of Mathematics and Physics Jinggangshan UniversityJi’an 343009China

The present work is to construct the potential energy function of isotopic molecules. The so-called molecular potential energy function is the electronic energy function under Born-Oppenheimer approximation,in which the nuclear motions(translational,rotational and vibration motions) are not included,therefore,its nuclear vibration motion and isotopic effect need to be considered. Based on group theory and atomic and molecular reactive statics(AMRS),the reasonable dissociation limits of D2O(1A1)are determined,its equilibrium geometry and dissociation energy are calculated by density-functional theory(DFT) B3lyp,and then,using the many-body expansion method the potential energy function of D2O(1A1) is obtained for the first time. The potential contours are drawn,in which it is found that the reactive channel D + OD→D2O has no threshold energy,so it is a free radical reaction. But the reactive channel O + DD→D2O has a saddle point. The study of collision for D2O(1A1) is under way.

关键词： D_2O(~1A_1) isotopic effect many-body expansion theory analytical potential energy function

我国儿童专用药品可及性真实世界数据的多中心调研

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中国新药杂志 2024年第9期33卷 849-855页

作者：阮文懿霍记平于飚蔡和平王晓玲赵志刚安徽省儿童医院临床药学部合肥230000 首都医科大学附属北京天坛医院药学部北京100050 首都医科大学附属北京儿童医院/国家儿童医学中心药学部北京100045

目的:调研目前整理出的儿童专用药品目录中药品在儿童医院、妇幼保健院和综合医院的可及性现状。方法:根据儿童专用药定义,北京儿童医院、北京天坛医院、河南省儿童医院和安徽省儿童医院联合整理出我国目前的儿童专用药品目录。采用现... 详细信息

目的:调研目前整理出的儿童专用药品目录中药品在儿童医院、妇幼保健院和综合医院的可及性现状。方法:根据儿童专用药定义,北京儿童医院、北京天坛医院、河南省儿童医院和安徽省儿童医院联合整理出我国目前的儿童专用药品目录。采用现况调查法,以问卷调查表的形式于2022年4月2—10日收集我国不同省市区域范围内67家医疗机构的儿童专用药品的可及性信息。调研内容包含可获得性、厂家、2021年使用量。结果:儿童专用药品目录共包含295个药品品规,其中有94个国家医保目录药品和16个国家基本药物目录药品。本次调研的67家医疗机构包括60家三甲医院、4家三乙医院和3家其他医院。经调研可知有140种(西药121种、疫苗19种)儿童专用药品可被获得,其西药品种在儿童医院、妇幼保健院和综合医院中的可获得性分别为42.85%,32.43%,27.41%,疫苗品种为50%,38.89%,47.22%。将儿童专用药品按照ATC解剖学分类分为12类,其可获得性基本呈现出儿童医院>妇幼保健院>综合医院。16个基本药品的可获得率≥30%的品种数分别为儿童医院10个、妇幼保健院7个、综合医院5个。46个儿童专用药品能够查询到限定日剂量值(DDD)并列出使用频度(DDDs)排名前10位的药品。本次调研经统计共有152家药品生产厂家,国内厂家为127家(83.6%)、国外厂家25家(16.4%)。结论:儿童专用药品中的西药和疫苗的可及性现状分别为:儿童医院西药可获得性低、疫苗可获得性比较高;妇幼保健院的西药和疫苗均可获得性低;综合医院的西药可获得性非常低、疫苗可获得性低。需要加强儿童专用药品的研发力度及可及性。

关键词：儿童专用药品可及性多中心调研

衰弱对社区获得性肺炎患者的临床疗效及生活质量的影响研究

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四川生理科学杂志 2024年第4期46卷 800-802,809页

作者：余义丰阮雯静廖玲上饶市人民医院全科医学科江西上饶334000 上饶市人民医院药学部临床药学室江西上饶334000

目的:探究衰弱对社区获得性肺炎患者的临床疗效及生活质量的影响。方法:选取2022年1月至2023年8月期间我院收治的60例获得性肺炎患者作为研究对象。按照患者的衰弱表型评估方法(Fried衰弱评估)评分是否小于3分将患者分为非衰弱组(n=23)... 详细信息

目的:探究衰弱对社区获得性肺炎患者的临床疗效及生活质量的影响。方法:选取2022年1月至2023年8月期间我院收治的60例获得性肺炎患者作为研究对象。按照患者的衰弱表型评估方法(Fried衰弱评估)评分是否小于3分将患者分为非衰弱组(n=23)和衰弱组(n=37)。根据《中国成人社区获得性肺炎诊断和治疗指南》的建议,对患者采取相应的治疗措施。比较两组患者临床疗效、临床症状消退时间、肺功能[第1秒用力呼气量(First second forced expiratory volume,FEV1)、用力肺活量(Forced vital capacity,FVC)及FEV1与FVC的比值(Ratio of FEV1 to FVC,FEV1/FVC)]、生活质量[生活质量量表(SF-36)]的差异。结果:治疗后4 w,衰弱组的总有效率明显低于非衰弱组(P<0.05);衰弱组患者的临床症状消失时间明显长于非衰弱组(P<0.05);两组患者FEV1、FVC、FEV1/FVC肺功能明显高于治疗前,但衰弱组明显低于非衰弱组(P<0.05);衰弱组患者的生活质量指标评分明显低于非衰弱组(P<0.05)。结论:针对社区获得性肺炎患者,衰弱对临床疗效有负面影响,会延长患者的临床症状消退时间,影响患者肺功能恢复,降低患者的生活质量。

关键词：衰弱社区获得性肺炎临床疗效生活质量

Internal phosphate starvation signaling and external phosphate availability have no obvious effect on the accumulation of cadmium in rice

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Journal of Integrative Agriculture 2019年第9期18卷 2153-2161页

作者： WANG Xue-qing ruan wen-yuan YI Ke-ke Key Laboratory of Plant Nutrition and Fertilizer Ministry of Agriculture and Rural Affairs/Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural Sciences

Phosphorus(P)is a limiting nutrient element for *** obtain maximum crop yield,P fertilizer is often over-applied,which leads to accelerating exhaustion of phosphate resources and serious environmental *** the application of P fertilizer and enhancing the P utilization efficiency of crops are significant for the sustainable development of ***(Cd)contamination in rice is another serious agricultural ***,whether reducing the application of P fertilizer and enhancing the P utilization efficiency of crops will increase the risk of Cd accumulation in crops remains *** this study,we are aiming to elucidate the relationship between Cd and P in rice from physiological and genetic *** this purpose,the wild type(WT)rice plants and phosphate(Pi)-starvation signaling repressed mutant phr2 were used to analyze the relationship between Cd and ***,we found that Cd stress could promote P accumulation and induce Pi-starvation signaling in WT and phr2 shoots under Pi-sufficient condition in a PHOSPHATE STARVATION RESPONSE 2(PHR2)independent ***,the expression level of Cd transporter of OsNramp5 and the uptake speed of Cd2+were not obviously changed under Pi-sufficient and Pi-deficient ***,our Cd determination results showed that the Cd concentrations in WT and phr2 were not obviously changed under Pi-sufficient and Pi-deficient *** results indicate that the external P availability and internal Pi-starvation signaling cannot obviously affect the accumulation of Cd in rice seedling.

关键词： cadmium phosphorus Cd-accumulation Pi-starvation signaling Pi-availability

Thermodynamic properties of bioleaching liquid mixtures with and without mesophilic bacteria at different temperatures

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Rare Metals 2007年第6期26卷 528-535页

作者： LIU Meilin ruan Renman wen Jiankang WANG Dianzuo National Engineering Laboratory of Biohydrometallurgy General Research Institute for Non-Ferrous Metals Beijing 100088 China

In this work, low-grade copper sulfide mine has been treated by the bioleaching process using native cultures of Acidithiobacillus ferrooxidans. The bioleaching experiments were carded out in shake flasks at pH 2.0, 180 ***^-1 and 30℃ for mesophilic bacteria The conductivity of copper bioleaching liquid was determined by the electric conductivity method at temperatures ranging from 298 K to 313 K. The ionic activity coefficients were estimated using Debye-Hucker and Osager-Falkenlagen equations. Meanwhile, the effects of temperature and concentrtion on the mean ionic activity coefficients were discussed. The relative partial molar free energies, enthalpies and entropies of copper teaching solution at above experimental temperatures were calculated. The behaviors of change of relative partial molar quantities were discussed on the basis of electrolytic solution theory. Simultaneously, the thermodynamic characters of bioleaching solution with and without mesophilic bacteria were compared. The existence of mesophilic bacteria changed the Fe^3＋/Fe^2＋ ratio, which resulted in the difference of ionic interaction. The experimental data show that the determination of the thermodynamic properties during the bioleaching processes should be important.

关键词： activity coefficient thermodynamic properties bioleaching solution mesophilic bacteria

Influences of solid particles on the formation of the third phase crud during solvent extraction

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Rare Metals 2007年第1期26卷 89-96页

作者： ZHENG Qi ruan Renman wen Jiankang SONG Yongsheng DONG Qinghai WU Minglin YAO Guocheng General Research Institute for Nonferrous Metals Beijing 100088 China

The influences of solid particles in leach solution on the formation of the third phase crud during solvent extraction of copper were studied. Analyzed from the point of view of pH value and surface tension, the study results showed that the solid particle is one of the most important contributors for the formation of the third phase crud. During solvent extraction, if the pH value was greater than 2.30, the number of solid particles in the mother solution increased, in which case the possibility of forming the third phase crud could also increase, and the interface tension value might grow in pace with the quantity of the third phase crud.

关键词： solvent extraction solid particle the third phase crud surface tension

Inter-Professional-Compassionate pain management during endotracheal suctioning: a valuable lesson from a Chinese surgical intensive care unit

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Frontiers of Nursing 2022年第1期9卷 19-27页

作者： Qian-wen ruan Maneewat Khomapak Hathairat Sangchan Faculty of Nursing Prince of Songkla UniversityKho HongHat YaiSongkhla 90110Thailand The Second Affiliated Hospital of Kunming Medical University KunmingYunnan 650000China

Objective:To compare the effects of a pain management program and routine suctioning methods on the level of pain presence and agitation in Chinese adults admitted to the intensive care *** disseminate the results from the implementation of the evidence-informed pain management interventions for reducing pain presence and agitation during endotracheal tube suctioning(ETS)and translate the key finding to clinical nursing ***:A quasi-experimental study of a two-group post-test design was conducted in adults admitted after surgery to a surgical intensive care unit(SICU)of the Second Affiliated Hospital of Kunming Medical University,Yunnan,China in ***-two adults who met the study eligibility were included after consent,26 in each *** in the control group received usual care while patients in the intervention group received interventions to reduce agitation and pain-related *** impacts of the intervention on the level of pain presence and agitation were measured at 5 measuring time points using the Chinese versions of Critical-Care Pain Observation Tool(CPOT)and Richmond Agitation Sedation Scale(RASS).Results:The level of pain presence in the intervention group statistically significantly decreased during,immediately after,and 5 min after *** level of agitation in the intervention group significantly decreased during and immediately after ***:The findings provide support for the positive pain-relieving effects of the evidence-informed pain-related ETS management interventions when compared with the usual ETS *** study interventions were sufficiently effective and safe to maintain patent airway clean and patent as standardized suctioning and helps pain ***,evidence-based pain-related ETS management intervention is worthy of recommending to utilize in SICU patients as well as other patients who required *** is worth noting that integrating pre-emptive analgesia prescription and a

关键词： agitation China endotracheal tube suctioning intensive care unit pain management pain presence