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Paeoniflorin,the Main Monomer Component of Paeonia lactiflora,Exhibits Anti-inflammatory Properties in Osteoarthritis Synovial Inflammation

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Chinese Journal of Integrative Medicine 2024年第5期30卷 433-442页

作者： CHEN Pu ZHOU jun ruan An-min MA Yu-feng WANG Qing-fu Department of Orthopaedic Surgery Beijing University of Chinese Medicine Third Affiliated HospitalBeijing 100029China Department of Orthopaedic Surgery Guangdong Provincial Hospital of Chinese MedicineGuangzhou 510120China Department of Orthopaedic Surgery Beijing Longfu HospitalBeijing 100010China

Objective:To explore the mechanism of paeoniflorin(PF)on osteoarthritis(OA)synovial inflammation from network pharmacology to experimental ***:Targets of OA were constructed by detecting the database of network database platforms(Therapeutic Target database,Drug Bank and Gene Cards),and the targets of PF were constructed by Pub Chem and Herbal Ingredients'Targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of these co-targeted genes were conducted via Database for Annotation,Visualization,and Integrated Discovery(DAVID)database,and protein-protein interaction(PPI)networks were conducted via the search tool for the retrieval of interacting genes(STRING)*** counting kit-8(CCK-8)assay was performed to assess the potential toxicity of PF on human OA fibroblast-like synoviocytes(FLS),quantitative real-time polymerase chain reaction(q PCR),enzyme-linked immunosorbent assay(ELISA)and Western blot were used to verify the potential mechanism of PF in synovial ***:Twenty-six co-targeted genes were *** enrichment results showed that these co-targeted genes were most likely localized in the cytoplasm,and the biological processes mainly involved'cellular response to hypoxia''lipopolysaccharide(LPS)-mediated signaling pathway'and'positive regulation of gene expression'.KEGG pathway analysis indicated that these co-targeted genes may function through pathways associated with'hypoxia-inducible factor-1(HIF-1)signaling pathway'and'tumornecrosis factor(TNF)signaling pathway'.The PPI network showed that the top 3 hub genes were TP53,TNF,and *** docking results showed that PF was well docking with ***-8 showed no potential toxicity of 10,20 and 50μmol/L PF on human OA *** PF significantly decreased the expression levels of interleukin-1β,interleukin-6,TNF-αmatrix metalloproteinase 13(MMP13),and a disintegrin and metalloproteinase with thrombospondin motifs 5(ADAMTS5)and TNF

关键词： paeoniflorin osteoarthritis synovial inflammation tumor necrosis factor-α network pharmacology Paeonia lactiflora

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Programmable complex pumping field induced color-on-demand random lasing in fiber-integrated microbelts for speckle free imaging

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Science China(Information Sciences) 2023年第12期66卷 251-260页

作者： Xiaoyu SHI Kaiyue SHEN Yaoxing BIAN Wanting SONG jun ruan Zhaona WANG Tianrui ZHAI College of Physics and Optoelectronics Faculty of ScienceBeijing University of Technology Applied Optics Beijing Area Major Laboratory Department of PhysicsBeijing Normal University

Miniaturized lasers with on-demand color emission have immense potential in the development of integrated imaging sources. Random lasers(RLs) with cavity-free structures and low spatial coherence are promising candidates for multicolor imaging sources. However, the wide tuning range and high tuning accuracy of continuous and reversible random lasing color with a defined emissive direction remain challenging. Here, random lasing with on-demand color emission and defined emissive direction is realized in fiber-integrated microbelts through programmable pumping. Individual RL microbelts as RL units doped with blue(B)-, green(G)-, and red(R)-emissive dyes and titanium dioxide nanoparticles are assembled on an optical fiber, resulting in high-performance B/G/R lasing. The optical fiber functions as a waveguide that guides the multicolor RL to ensure a defined directional emission. By manipulating the combination of the B/G/R RL units on the waveguide, distinctive lasing colors covering the entire visible spectrum are obtained, including white-colored random lasing. To realize dynamically controllable lasing for on-demand color emission, a pumping strategy with programmable excitation is proposed by shaping the pump beams into different beam arrays for precisely pumping the RL unit combination. We envision that fiber-integrated RL sources can be implemented in various imaging applications, such as biomedical diagnosis, multiplexed communication, and optical sensing.

关键词： random laser multi-color pump control fiber-integrated directional emission

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Regulating charge heterogeneity of lithium-ion battery via tab design toward maximizing extreme fast-charging performance

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Progress in Natural Science:Materials International 2023年第5期33卷 660-667页

作者： jun Yang Yuzuo Wang Yanqing Hu Dengfeng Liu Bin Yang Dianbo ruan Zhijun Qiao Faculty of Mechanical Engineering and Mechanics Ningbo University Institute of Advanced Energy Storage Technology and Equipment Ningbo University Hesheng Alternative Energy Technology Co. Ltd.

Construction of high-throughput electrical transmission structure via tab design is an effective way of developing high-power lithium-ion batteries(LIBs). In this paper, five types of 18650-cylindrical LIBs with different tab structures were prepared to analyze the mechanism of the effects of tab structure on battery performance,including internal resistance, C-rate performance, thermal and cycle. Research showed that the number of tabs and position were important factors, which strongly decided the internal resistance of battery. By adjusting tab structure, an extremely fast charging performance surpassing 10C can be achieved. Besides, the battery showed excellent cycle stability of more than 3000 cycles at 6C, which was proved to be due to optimizing the Li-ion concentration distribution of electrodes. The work also emphasized that excessive tabs contributed to no significant improvement in electrochemical performances at normal charging/discharging rates(<1C) for 18650 *** relationship between the operation conditions and tab design is established to further guide the manufacturing.

关键词： High-power lithium-ion batteries Tab structure Tabless electrolyte potential

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Lipschitz equivalence of generalized {1,3,5}-{1,4,5} self-similar sets

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Science China Mathematics 2007年第11期50卷 1537-1551页

作者： Li-feng XI~(1+) huo-jun ruan~2 1 Institute of Mathematics,Zhejiang Wanli University,Ningbo 315100,China 2 Department of Mathematics,Zhejiang University,Hangzhou 310027,China Institute of Mathematics Zhejiang Wanli University Ningbo China Department of Mathematics Zhejiang University Hangzhou China

This paper investigates the Lipschitz equivalence of generalized {1,3,5}-{1,4,5} self-similar sets D=(r_1D)∪(r_2D+(1+r_1-r_2-r_3)/2)∪(r_3D+1+r_3) and E=(r_1E)∪(r_2E+1-r_2- r_3)∪(r_3E+1-r_3),and proves that D and E... 详细信息

关键词： self-similar set overlap Lipschitz equivalence graph-directed construction ergodicity martingale

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Real-time continuous-wave imaging with a 1.63THz OPTL and a pyroelectric camera

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Optoelectronics Letters 2008年第4期4卷 295-298页

作者： YANG jun ruan Shuang-chen ZHANG Min ZHANG We Research Center for Space Optical Engineering Harbin Institute of Technology Harbin 150001 China College of Electronic Science and Technology Shenzhen University Shenzhen 518060 China

Real-time continuous-wave terahertz imaging is demonstrated with a 1.63 THz （184.31 lam） optically-pumped terahertz laser （OPTL） and a 124 × 124 element room-temperature pyroelectric camera. Transmission-mode THz imaging is presented for the samples hidden in various wrapping materials. These experimental results reveal the possibility to construct a simple real-time THz imaging system applied to nondestructive inspection.

关键词：热电照相机光泵浦激光器实时连续波成像太赫成像

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Visualization of big data security： a case study on the KDD99 cup data set

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Digital Communications and Networks 2017年第4期3卷 250-259页

作者： Zichan ruan Yuantian Miao Lei Pan Nicholas Patterson jun Zhang School of Information Technology Deakin University Geelong VIC 3220 Australia

Cyber security has been thrust into the limelight in the modern technological era because of an array of attacks often bypassing tmtrained intrusion detection systems （IDSs）. Therefore, greater attention has been directed on being able deciphering better methods for identifying attack types to train IDSs more effectively. Keycyber-attack insights exist in big data; however, an efficient approach is required to determine strong attack types to train IDSs to become more effective in key areas. Despite the rising growth in IDS research, there is a lack of studies involving big data visualization, which is key. The KDD99 data set has served as a strong benchmark since 1999; therefore, we utilized this data set in our experiment. In this study, we utilized hash algorithm, a weight table, and sampling method to deal with the inherent problems caused by analyzing big data; volume, variety, and velocity. By utilizing a visualization algorithm, we were able to gain insights into the KDD99 data set with a clear iden- tification of ＂normal＂ clusters and described distinct clusters of effective attacks.

关键词： Big data visualization Sampling method MDS PCA

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RGB WGM lasing woven in fiber braiding cavity

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Science China(Information Sciences) 2022年第8期65卷 247-253页

作者： Kun GE Zhiyang XU Dan GUO Ben NIU jun ruan Libin CUI Tianrui ZHAI College of Physics and Optoelectronics Faculty of ScienceBeijing University of Technology

It is critical to realize woven and wearable red-green-blue(RGB) whispering gallery mode(WGM)lasing that is tunable and flexible in the fiber braiding cavity. However, it is still a challenge to achieve tunable full-color lasing with the large color gamut by a facile approach. Here, we design the braiding cavity to realize RGB WGM lasing with high performance. The braiding cavity consists of three optical fibers coated with dye-doped polymer. Each fiber therein serves as a resonant cavity to support multiple lasing modes. There is no interference owing to the air gap between them; therefore, we can achieve full-color WGM lasing. The lasing emission in our fiber braiding cavity covers a color gamut of 86.7% larger than standard RGB *** work may provide a platform for potential applications in white laser and integrated optoelectronic devices.

关键词： RGB whispering gallery mode (WGM) lasing fiber braidingcavity full-color gamut

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Studies of flow field characteristics during the impact of a gaseous jet on liquid–water column

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Chinese Physics B 2019年第6期28卷 293-301页

作者： Jian Wang Wen-jun ruan Hao Wang Li-Li Zhang School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China Harbin Jian Cheng Bloc Limited Company Harbin 150030China

Both experimental and numerical studies were presented on the flow field characteristics in the process of gaseous jet impinging on liquid–water column. The effects of the impinging process on the working performance of rocket engine were also analyzed. The experimental results showed that the liquid–water had better flame and smoke dissipation effect in the process of gaseous jet impinging on liquid–water column. However, the interaction between the gaseous jet and the liquid–water column resulted in two pressure oscillations with large amplitude appearing in the combustion chamber of the rocket engine with instantaneous pressure increased by 17.73% and 17.93%, respectively. To analyze the phenomena, a new computational method was proposed by coupling the governing equations of the MIXTURE model with the phase change equations of water and the combustion equation of propellant. Numerical simulations were carried out on the generation of gas, the accelerate gas flow, and the mutual interaction between gaseous jet and liquid–water *** simulations showed that a cavity would be formed in the liquid–water column when gaseous jet impinged on the liquid–water column. The development speed of the cavity increased obviously after each pressure oscillation. In the initial stage of impingement, the gaseous jet was blocked due to the inertia effect of high-density water, and a large amount of gas gathered in the area between the nozzle throat and the gas–liquid interface. The shock wave was formed in the nozzle expansion section. Under the dual action of the reverse pressure wave and the continuously ejected high-temperature gas upstream, the shock wave moved repeatedly in the nozzle expansion section, which led to the flow of gas in the combustion chamber being blocked, released, re-blocked, and re-released. This was also the main reason for the pressure oscillations in the combustion chamber.

关键词： gaseous jet liquid–water column pressure oscillations shock wave

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Some discussions about the variable separating method for solving nonlinear models

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Chinese Physics B 2010年第5期19卷 21-28页

作者： ruan Hang-Yu Department of Physics Ningbo University

Through analysing the exact solution of some nonlinear models,the role of the variable separating method in solving nonlinear equations is *** find that rich solution structures of some special fields of these equation come from the nonzero seed ***,these nonzero seed solutions is likely to result in the divergent phenomen for the other field component of the same *** convergence and the signification of all field components should be discussed when someone solves the nonlinear equation using the variable separating method.

关键词： variable separating method nonzero seed solution nonlinear equation

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Extracellular vesicles drive tau spreading in Alzheimer's disease

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Neural Regeneration Research 2022年第2期17卷 328-329页

作者： Zhi ruan Department of Pharmacology and Experimental Therapeutics Boston University School of MedicineBostonMAUSA

Alzheimer's disease(AD) is a progressive and irreversible neurodegenerative disorder that is characterized by memory loss and a decline in activities of daily life. More than 50 million people worldwide are affected by AD, and this number will continue to rise over 100 million within next three decades. Its major pathological features are the extracellular plaque deposits of the β-amyloid peptide and the intracellular flame-shaped neurofibrillary tangle-aggregation of hyperphosphorylated tau-proteins(pTau).

关键词： tau Alzheimer amyloid

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