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Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage

Neural Regeneration Research 2023年第6期18卷 1308-1315页

作者： Zi-Xian Zhou Qi Cui Ying-Mei Zhang jia-Xin Yang Wen-Jing Xiang Ning Tian Yan-Lin jiang Mei-Ling Chen Bin Yang Qing-Hua Li ru-jia liao Laboratory of Neuroscience Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Neurology Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Guangxi Clinical Research Center for Neurological Diseases Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Pharmacology Affiliated Hospital of Guilin Medical UniversityGuilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina

Recent studies have indicated that suppressing oxidative stress and ferroptosis can considerably improve the prognosis of intracerebral hemorrhage(ICH).Withaferin A(WFA),a natural compound,exhibits a positive effect on a number of neurological ***,the effects of WFA on oxidative stress and ferroptosis-mediated signaling pathways to ICH remain *** this study,we investigated the neuroprotective effects and underlying mechanism for WFA in the regulation of ICH-induced oxidative stress and *** established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of hemin-induced *** was injected intracerebroventricularly at 0.1,1 or 5μg/kg once daily for 7 days,starting immediately after ICH *** markedly reduced brain tissue injury and iron deposition and improved neurological function in a dose-dependent manner 7 days after cerebral *** in vitro experiments,cell viability test showed that WFA protected SH-SY5Y neuronal cells against hemin-induced cell ***-linked immunosorbent assays in vitro and in vivo showed that WFA markedly decreased the level of malondialdehyde,an oxidative stress marker,and increased the activities of anti-oxidative stress markers superoxide dismutase and glutathione peroxidase after *** blot assay,quantitative polymerase chain reaction and immunofluorescence results demonstrated that WFA activated the nuclear factor E2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling axis,promoted translocation of Nrf2 from the cytoplasm to nucleus,and increased HO-1 *** Nrf2 with siRNA completely reversed HO-1 expression,oxidative stress and protective effects of ***,WFA reduced hemin-induced ***,after treatment with an HO-1 inhibitor,the neuroprotective effects of WFA against hemin-induced ferroptosis were *** test results showed that WFA combined with ferrostatin-1

关键词： behavior brain injuries hemorrhagic stroke ferroptosis heme oxygenase-1 neuroprotection nuclear factor E2-related factor 2 nuclear translocator oxidative stress stroke

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-jia Yang Qian-ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-Ming Wang Han-Zhou Li Wei-Quan Xu jia-Bao liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

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Vertical SnS2/Si heterostructure for tunnel diodes

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Science China(Information Sciences) 2020年第2期63卷 189-195页

作者： rundong jia Qianqian HUANG ru HUANG Key Laboratory of Microelectronic Devices and Circuits (MOE) Institute of Microelectronics Peking University

Tunneling FET（TFET） is considered as one of the most promising low-power electronic devices,however, suffers from the low drive current. Heterostructure TFET with low effective tunnel barrier height based on traditional 3D materials can obtain large tunnel current but deteriorated off-state current induced by the lattice mismatch. van der Waals heterostructure TFET based on 2D materials can obtain danglingbond-free interface for suppressed off-state current but face the challenge of controllable and stable doping technology. As the critical building block of the TFET, tunnel diode based on the 2D/3D heterostructure is proposed in this study and experimentally demonstrated. Combination of the pristine interface of 2D materials and matured doping technology in the traditional 3D bulk materials, tunnel diodes based on the 2D/3D heterostructures are expected to realize low leakage current and high on current simultaneously,showing great potential in low-power electronics. The N+SnS2/P+Si heterostructure with effective tunnel barrier of 0.17 eV theoretically is considered for the first time and selected as the optimal material platform for tunnel diodes. The N+SnS2/P+Si tunnel diode demonstrated experimentally shows the high current density of 1 μA/μm2, which is the highest one among the reported tunnel diodes based on the 2D/group IV materials. The tunneling current is also confirmed by low-temperature measurements. This study shows the great potential of the 2D/3D heterostructure for low-power tunneling devices.

关键词： 2D/3D heterostructure SnS2/Si tunnel barrier tunnel diode energy-efficient

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丹酚酸B调控脂质代谢改善非酒精性脂肪肝实验研究

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中国药理学通报 2025年第1期41卷 107-115页

作者：张佳健郭梦茹梅金玉陈明安徽医科大学基础医学院药理学教研室安徽合肥230032 安徽医科大学第二附属医院耳鼻喉科安徽合肥230601

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低... 详细信息

目的探讨丹酚酸B(SalB)可能通过调控Lcn2改善非酒精性脂肪肝的作用。方法体内实验,8周龄♂C57BL/6J小鼠用普通维持饲料喂养,作为对照组,8周龄ApoE-/-小鼠用高脂饲料喂养,随机分为模型组和SalB组。在饲养8周后,SalB组小鼠用SalB灌胃,低剂量为15 mg·kg^(-1)·d^(-1),高剂量为30 mg·kg^(-1)·d^(-1),对照组和模型组用等剂量生理盐水灌胃。肝脏转录组测序结果揭示模型组和SalB组的差异表达基因,HE染色、油红O染色观察肝组织的病理变化,试剂盒检测血清和肝组织的脂质、氧化应激和炎症指标,RT-qPCR检测Lcn2、SREBP-1C以及脂质合成相关酶的mRNA水平。体外实验,用棕榈酸(PA)诱导L02和LX-2细胞24 h建立NAFLD模型,用SalB(30μmol·L^(-1))和PA(0.2 mmol·L^(-1))共孵育检测SalB体外改善NAFLD的情况。试剂盒检测L02细胞TC、TG的含量,细胞油红O染色试剂盒检测L02细胞的脂质积累,RT-qPCR检测LX-2细胞Lcn2、SREBP-1C以及脂质合成相关酶基因的mRNA水平。结果模型组血清、肝脏的生化指标异常,肝组织脂质、炎症和氧化应激水平升高,出现大面积脂肪空泡和大量的脂质沉积,PA诱导的L02细胞也出现大量的脂质积累,在SalB干预后均有明显改善。转录组测序结果表明SalB可以调控肝脏脂质代谢和炎症。肝脏和LX-2细胞mRNA水平显示模型组Lcn2、SREBP-1C以及脂质合成相关酶基因表达明显上调,SalB干预后均能降低这些基因的表达。结论丹酚酸B可以明显改善非酒精性脂肪肝,其机制可能是通过下调Lcn2、SREBP-1C和脂质合成酶的表达。

关键词： SalB 非酒精性脂肪肝脂质代谢 Lcn2 SREBP-1C 脂质合成相关酶

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采用端口阻抗测试的车载充电机传导电磁干扰建模方法研究

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西安交通大学学报 2025年第1期59卷 172-182页

作者：李季风耿宇宇贾晋廖兴林路青洋重庆理工大学电气与电子工程学院重庆400054 重庆理工大学汽车零部件先进制造技术教育部重点实验室重庆400054

针对电动汽车车载充电机的设计过程中普遍存在的电磁干扰频率范围广、干扰源复杂的问题,提出了一种基于端口阻抗测试的等效电路建模和系统级协同仿真方法。首先,通过对车载充电机系统各部件进行阻抗测试和三维电磁仿真,建立了无源器件... 详细信息

针对电动汽车车载充电机的设计过程中普遍存在的电磁干扰频率范围广、干扰源复杂的问题,提出了一种基于端口阻抗测试的等效电路建模和系统级协同仿真方法。首先,通过对车载充电机系统各部件进行阻抗测试和三维电磁仿真,建立了无源器件、端口滤波器和高压屏蔽线缆模型,提取了系统印制电路板关键回路的高频寄生参数。其次,建立了有源器件的仿真电路模拟器等效模型,并通过双脉冲实验验证模型的精度;针对功率因数校正电路控制环节的仿真与建模难以同步实现的问题,采用协同建模的方法构建整个系统的等效电路模型。最后,将各部件模型组合在一起,建立了完整的车载充电机系统传导电磁干扰预测模型,并依据相关测试标准进行了系统传导电磁干扰仿真和实验。结果表明:在150 kHz~30 MHz频率范围内,预测结果与实际结果的误差小于9 dB,具有良好的一致性,表明该模型能够精确预测车载充电机系统高压交流端的传导干扰水平,可以有效指导充电机系统的电磁兼容正向设计。

关键词：车载充电机电磁干扰端口阻抗测试协同仿真

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内皮细胞特异性骨形态发生蛋白2对血管新生的影响:生物信息学分析和实验验证

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中国组织工程研究 2025年第1期29卷 103-110页

作者：燕茹王凯茹张飞燕贾绍斌丛广志宁夏医科大学总医院心内科宁夏回族自治区银川市750004 宁夏医科大学总医院医学研究院宁夏回族自治区银川市750004 宁夏医科大学总医院心血管病研究所宁夏回族自治区银川市750004

背景:血管新生是心血管疾病的主要干预靶点,骨形态发生蛋白2具有调控血管新生作用,但内皮细胞特异性骨形态发生蛋白2对血管新生的调控作用不清楚。目的:探讨内皮细胞特异性骨形态发生蛋白2对血管新生的影响。方法:(1)生物信息学分析:通... 详细信息

背景:血管新生是心血管疾病的主要干预靶点,骨形态发生蛋白2具有调控血管新生作用,但内皮细胞特异性骨形态发生蛋白2对血管新生的调控作用不清楚。目的:探讨内皮细胞特异性骨形态发生蛋白2对血管新生的影响。方法:(1)生物信息学分析:通过Panglao DB公共基因表达数据库单细胞转录组荟萃分析观察骨形态发生蛋白2细胞群表达丰度和定位。血管新生小鼠和内皮(心内膜)过表达骨形态发生蛋白2小鼠转录组测序数据集探索内皮细胞骨形态发生蛋白2对血管新生信号通路的调控作用。(2)体内实验验证:建立小鼠后肢缺血模型,对比模型小鼠患侧与健侧缺血后肢7,14和21 d血流灌注情况,免疫荧光和免疫组织化学染色评估小鼠骨形态发生蛋白2和CD31的表达定位情况。(3)体外实验验证:体外培养人脐静脉内皮细胞,分为对照组、缺氧组和骨形态发生蛋白2抑制剂(Noggin蛋白)干预组,培养24 h,观察各组内皮细胞血管新生情况。结果与结论:(1)内皮细胞是表达骨形态发生蛋白2的重要细胞亚群,在血管新生内皮细胞和骨形态发生蛋白2过表达内皮细胞转录组再分析均发现骨形态发生蛋白2表达明显升高,血管新生通路明显激活。(2)缺血7 d小鼠新生血管周围骨形态发生蛋白2阳性血管明显增加(P<0.05),缺血2周骨形态发生蛋白2阳性血管明显减少(P<0.001)。(3)体外培养人脐静脉内皮细胞,缺氧干预后,内皮细胞迁移能力和血管出芽明显增加,血管新生因子血管内皮生长因子和血小板衍生生长因子的表达明显升高,Noggin明显减少了缺氧诱导的内皮细胞血管新生(P<0.001),并下调血管内皮生长因子和血小板衍生生长因子的表达(P<0.01)。(4)结果证实,内皮细胞特异性骨形态发生蛋白2具有调控血管新生作用,靶向性内皮细胞骨形态发生蛋白2可望改善血管新生。

关键词：内皮细胞骨形态发生蛋白2 血管新生单细胞RNA测序批量RNA测序信号通路后肢缺血模型成管实验

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Limits on sequential sharing of nonlocal advantage of quantum coherence

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Science China(Physics,Mechanics & Astronomy) 2022年第6期65卷 26-35页

作者： Ming-Liang Hu jia-ru Wang Heng Fan School of Science Xi’an University of Posts and TelecommunicationsXi’an 710121China Institute of Physics Chinese Academy of SciencesBeijing 100190China CAS Center for Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

Sequential sharing of nonlocal correlation is inherently related to its *** address the question as to how many observers can share the nonlocal advantage of quantum coherence(NAQC)in a(d×d)-dimensional state,where d is a prime or a power of a *** first analyze the trade-off between disturbance and information gain of the general d-dimensional unsharp *** in a scenario where multiple Alices perform unsharp measurements on one party of the state sequentially and independently and a single Bob measures coherence of the conditional states on the other party,we show that at most one Alice can demonstrate NAQC with *** limit holds even when considering the weak measurements with optimal pointer *** results may shed light on the interplay between nonlocal correlations and quantum measurements on high-dimensional systems and the hierarchy of different quantum correlations.

关键词： quantum coherence quantum correlation unsharp measurement

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Detection of electron-phonon coupling in two-dimensional materials by light scattering

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Nano Research 2021年第6期14卷 1711-1733页

作者： jia-Min Lai Ya-ru Xie Jun Zhang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing100083China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China CAS Center of Excellence in Topological Quantum Computation University of Chinese Academy of SciencesBeijing101408China Beijing Academy of Quantum Information Science Beijing100193China

Electron-phonon coupling affects the properties of two-dimensional(2D)materials significantly,leading to a series of novel *** light scattering provides a powerful experimental tool to explore electron-phonon interaction in 2D *** review gives an overview of the basic theory and experimental advances of electron-phonon coupling in 2D materials detected by Raman and Brillouin scattering,*** the Raman scattering part,we review Raman spectroscopy studies of electron-phonon coupling in graphene,transition metal disulfide compounds,van der Waals heterostructures,strongly correlated systems,and 2D magnetic *** the Brillouin scattering part,we extensively introduce Brillouin spectroscopy in non-van der Waals 2D structures,including temperature sensors for phonons and magnons,interfacial Dzyaloshinsky-Moriya interaction and spin torque in multilayer magnetic structures,as well as exciton-polariton in semiconductor quantum well.

关键词： electron-phonon coupling Raman scattering Brillouin scattering two-dimensional(2D)materials

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Hausdorf Dimension of Quadratic Rational Julia Sets

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Acta Mathematica Sinica,English Series 2014年第2期30卷 331-342页

作者： jia ZHOU Liang Wen liao Department of Mathematics Nanjing University

Suppose a quadratic rational map has a Siegel disk and a parabolic fixed point. If the rotation number of the Siegel disk is an irrational of bounded type, then the Julia set of the map is shallow. This implies that i... 详细信息

关键词： Shallow Julia sets quadratic rational map Hausdorff dimension

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