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Effects of transcranial direct current stimulation on movement function of Parkinson's disease model mice

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Effects of transcranial direct current stimulation on moveme...

面向输电线路监测网络混合MAC协议改进方法

中国神经科学学会第十二届全国学术会议

作者： peng-Yu Wang Ya-Xin Deng Jie fang Meng-Ya Wang Hong-Ping Huang Ring Star group Wannan medical college Department of physiology and neurobiology Wannan medical college

Objective Parkinson’s disease(PD) is a common degenerative disorder of the central nervous system in elderly people. At present, the main methods to treat PD are drug therapy, surgical treatment, cell transplantation, diet guidance, life and psychological care. Transcranial direct current stimulation(t DCS) has been widely used in recent years due to its non-invasive and effective properties. However, the mechanism of the optimal stimulation pattern of t DCS on neuroregulation for PD therapy is unclear. Methods Male C57 BL/6 J mice were intraperitoneal injected by 1-methyl-4 phenyl-1,2,3,6-tetrahydropyridine hydrochloride(MPTP,30 mg/kg/2 h, continuously for 4 times, 2 h interval for each time) to establish PD model mice. Behavioral observation and lower limb electromyography(EMG) signals were recorded. t DCS treatment(stimulation current intensity: 1 m A, duration: 1 min per time, for 4,8,12 times, interval: 5 min) was performed 24-48 h after the establishment of the mice model. Results PD model mice showed climbing pole time extension(P < 0.01)in pole test, decreased vertical and horizontal scores(P < 0.01)in open-field test, and increased total power and average cycle amplitude of EMG signal(P < 0.05). t DCS treatment can reverse increased total power and average cycle amplitude of EMG signal(P < 0.05), which can be more effective in the 12 times t DCS treatment group mice among the 3 different t DCS patterns treatment. Conclusion The experiment data provides evidences to study the mechanism of the optimal stimulation pattern of t DCS treatment of PD.

关键词： Parkinson’s disease transcranial direct current stimulation mice electromyography

来源： cnki会议评论

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小型微型计算机系统 2014年第5期35卷 1031-1036页

作者：朱宝晖林俊如曾鹏汪扬张延宇匡方军中国科学院沈阳自动化研究所工业控制网络与系统研究室沈阳110016 中国科学院大学北京100049

非均衡网络流量、局部密集网络拓扑等应用特征以及低能耗、高实时通信等应用需求给应用于输电线路监测网络的MAC设计提出了挑战.针对原应用与输电线路监测网络低流量时段的X-MAC协议的不足,通过引入同步操作、精确预估唤醒时刻,提出了SX... 详细信息

非均衡网络流量、局部密集网络拓扑等应用特征以及低能耗、高实时通信等应用需求给应用于输电线路监测网络的MAC设计提出了挑战.针对原应用与输电线路监测网络低流量时段的X-MAC协议的不足,通过引入同步操作、精确预估唤醒时刻,提出了SX-MAC协议.SX-MAC最大限度地减少网络中前导码报文的长度,节省了网络能量.通过分析SX-MAC协议的网络能耗,得出最优同步周期的理论值.又提出了占空比交错调度机制,优化上行数据的实时性.采用了OPNET进行了仿真验证,结果表明,在此应用背景下,SX-MAC协议比X-MAC协议能够更好地节约网络能量和满足网络实时性要求.仿真条件下最优的同步周期为15分钟.

关键词：输电线路监测无线传感器网络 MAC SX—MAC 前导码报文

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淋巴特异性酪氨酸磷酸酶抑制剂的研究进展

药学学报 2017年第5期52卷 699-705页

作者：朱鹏举侯旭奔方浩山东大学药学院药物化学研究所山东济南250012

淋巴特异性酪氨酸磷酸酶(lymphoid-specific tyrosine phosphatase,LYP)主要分布于淋巴系统,是由PTPn22基因编码的非受体蛋白酪氨酸磷酸酶。正常生理条件下,该酶与CSK结合后,可抑制T细胞受体信号传导并维持免疫系统自身稳定。病理条件下... 详细信息

淋巴特异性酪氨酸磷酸酶(lymphoid-specific tyrosine phosphatase,LYP)主要分布于淋巴系统,是由PTPn22基因编码的非受体蛋白酪氨酸磷酸酶。正常生理条件下,该酶与CSK结合后,可抑制T细胞受体信号传导并维持免疫系统自身稳定。病理条件下,该酶会发生突变而无法正常结合CSK,导致其功能亢进并诱发各种免疫疾病。因此淋巴特异性酪氨酸磷酸酶也被认为是治疗I型糖尿病、风湿性关节炎以及格雷夫斯病等自身免疫疾病的新型靶标。本文将综述其研究进展,并总结已报道的抑制剂的结构类型及活性。

关键词：淋巴特异性酪氨酸磷酸酶自身免疫病抑制剂

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一种新型支持QoS的光缓存结构

光通信技术 2010年第9期34卷 1-4页

作者：吴大鹏王汝言张杰重庆邮电大学光互联网及无线信息网络研究中心重庆400065

提出了一种新型的、用于光分组交换网络的光纤缓存结构。该结构采用光纤分段式共享的机制,充分提高光纤延迟线的利用率,能实现服务区分功能。仿真结果表明,这种新型结构能有效提高分组传送概率,降低光分组平均延迟参数;相比于输出端口... 详细信息

提出了一种新型的、用于光分组交换网络的光纤缓存结构。该结构采用光纤分段式共享的机制,充分提高光纤延迟线的利用率,能实现服务区分功能。仿真结果表明,这种新型结构能有效提高分组传送概率,降低光分组平均延迟参数;相比于输出端口缓存结构,文中所提出的输出式循环共享光缓存结构减少了所使用的光纤延迟线单元数量,简化了核心节点结构。

关键词：光分组交换端口竞争光纤延迟线服务质量

药对防风-羌活与其单味药挥发油共有组分的分析

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中南大学学报（自然科学版） 2010年第2期41卷 440-445页

作者：陈帅华余莲芳李晓如梁逸曾江西科技师范学院化学化工学院江西南昌330013 中南大学化学化工学院湖南长沙410083

利用气相色谱-质谱法分离检测药对防风-羌活、单味药防风和羌活的挥发油成分,采用交互移动窗口因子分析法对药对与单味药挥发油成分的共有组分进行分析,用质谱库结合保留指数进行定性,并采用总体积积分法定量。研究结果表明:防风、羌活... 详细信息

利用气相色谱-质谱法分离检测药对防风-羌活、单味药防风和羌活的挥发油成分,采用交互移动窗口因子分析法对药对与单味药挥发油成分的共有组分进行分析,用质谱库结合保留指数进行定性,并采用总体积积分法定量。研究结果表明:防风、羌活和药对防风-羌活的挥发油分别定性79,70和74个成分,占总含量的85.81%,87.35%和86.76%;药对防风-羌活与防风、羌活的共有组分分别为44和53个;药对挥发油组分主要来自于单味药羌活。

关键词：防风羌活药对气相色谱/质谱交互移动窗口因子分析法

Pilot HI survey of Planck Galactic Cold Clumps with FAST

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Research in Astronomy and Astrophysics 2020年第5期20卷 181-192页

作者： Ning-Yu Tang Pei Zuo Di Li Lei Qian Tie Liu Yue-fang Wu Marko Krco Meng-Ting Liu You-Ling Yue Yan Zhu Hong-Fei Liu Dong-Jun Yu Jing-Hai Sun peng Jiang Gao-Feng Pan Hui Li Heng-Qian Gan rui Yao Shu Liu FAST Collaboration National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030ChinaShanghai 200030China East Asian Observatory HI 96720USA Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China

We present a pilot HI survey of 17 Planck Galactic Cold Clumps(PGCCs)with the Five-hundred-meter Aperture Spherical radio Telescope(FAST).HI Narrow Self-Absorption(HINSA)is an effective method to detect cold HI being mixed with molecular hydrogen H2 and improves our understanding of the atomic to molecular transition in the interstellar *** was found in 58%PGCCs that we *** column density of HINSA was found to have an intermediate correlation with that of 13CO,following log(N(HINSA))=(0.52±0.26)log(N13CO)+(10±4.1).HI abundance relative to total hydrogen[HI]/[H]has an average value of 4.4×10-3,which is about 2.8 times of the average value of previous HINSA surveys toward molecular *** clouds with total column density NH>5×1020 cm-2,an inverse correlation between HINSA abundance and total hydrogen column density is found,confirming the depletion of cold HI gas during molecular gas formation in more massive *** line width of 13CO is about 0-0.5 kms-1 larger than that of *** possible explanation of narrower non-thermal width of HINSA is that HINSA region is smaller than that of *** on an analytic model of H2 formation and H2 dissociation by cosmic ray,we found the cloud ages to be within 106.7-107.0 yr for five sources.

关键词： ISM:clouds ISM:evolution ISM:molecules

The atomic parameter model for the fifth and sixth transition metal quasicrystal alloys(Mc=0.5)

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Science China(Physics,Mechanics & Astronomy) 2009年第10期52卷 1593-1600页

作者： LIAO ShuZhi GUI XuChun ZHANG Chun peng HaoJun XIE HaoWen OUYANG Yifang ZHANG BangWei Key Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of PhysicsHunan Normal UniversityChangsha 410081China College of Mathematics and Computer Science Hunan Normal UniversityChangsha 410081China Department of Physics Guangxi UniversityNanning 530004China Department of Applied Physics Hunan UniversityChangsha 410081China International Centre for Materials Physics Chinese Academy of SciencesShenyang 110015China

The forming ability of quasicrystal phase has a relationship with the atomic bond factors based on differences in atom size and electron ***,those factors or their combination are used to describe the forming ability,stability of alloys,*** this paper,the quasicrystal alloy forming abilities for the fifth and sixth transition metals(Y,Zr,Nb,Mo,ru,Rh,Pd and La,Hf,Ta,W,Re,Os,Ir,Pt) based alloys have been studied by the size factor and the atomic parametric *** has been found that an ellipse curve can be used to separate the quasicrystal formed area from the informed area in the size factor and atomic parameters functional *** ellipse curve can be defined by an equation(x-m)2/c2+(y?n)2/d2=*** overall reliabilities for the model are up to 97.4% and 95.5% for the fifth and the sixth transition metals based quasicrystal alloys,***,the ellipse parameters m,n,c and d can be paraphrased by some appropriate parameters for each host metal.

关键词： quasicrystal transition metal atomic parametric model ellipse model

5-PSS/UPU并联机构的多目标性能参数优化

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浙江大学学报（工学版） 2019年第4期53卷 654-663页

作者：李研彪郑航徐梦茹罗怡沁孙鹏浙江工业大学机械工程学院浙江杭州310032

在并联机构多目标参数优化方面,针对5-PSS/UPU并联机构,提出基于空间模型技术与主成分分析法相结合的多目标性能参数优化方法.推导出机构的位置反解、运动传递平衡方程,对单个驱动分支进行螺旋分析,给出多个全域性能指标;应用空间模型技... 详细信息

在并联机构多目标参数优化方面,针对5-PSS/UPU并联机构,提出基于空间模型技术与主成分分析法相结合的多目标性能参数优化方法.推导出机构的位置反解、运动传递平衡方程,对单个驱动分支进行螺旋分析,给出多个全域性能指标;应用空间模型技术,研究各全域性能评价指标与机构结构参数之间的分布规律,绘制了各项全域性能图谱;应用主成分分析(PCA)法,研究各全域性能指标之间的相关性,得到综合性能评价指标函数并绘制综合性能图谱;基于综合性能图谱,选取多组结构参数并计算综合性能指标在机构工作空间下的分布规律.研究结果表明,空间模型技术结合PCA法能够综合考虑机构的各项性能,对结构参数进行优化设计,该优化方法同样适用于其他并联机构.

关键词：并联机构运动学分析性能指标主成分分析(PCA)

Phytoplankton community composition in the surrounding waters of Changli, Hebei, China

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Marine Science Bulletin 2016年第2期18卷 79-96页

作者： ZHANG peng ru-yan LI De-liang LIU Xian-bin ZHAO Xing-gui LIU Zhan-guang Tianjin Marine Environmental Protection and Restoration Technology Engineering Center Tianjin Key Laboratory of Marine Resources and Chemistry Tianjin University of Science and Technology Tianjin 300457 China

The seasonal and spatial variations of phytoplankton abundance weresupported with microscopic analyses in the surrounding waters of Changli in the spring(May) and summer (August) of 2015. Nineteen sampling stations were selected in thisstudied area (39°26′30"-39°39′ N, 119°17′30"-119°34′03"). During the survey period, atotal of 27 species of phytoplankton have been documented in spring and 63 species insummer. In terms of the community composition at the seasonal level and the spatialdistribution, Dinoflagellates was absolutely dominant in spring and Bacillariophyta wasdominant in summer. The average phytoplankton cell density of phytoplankton speciesshowed substantial seasonal differences. In addition, the dominant species in differentseasons were different. The average values of Shannon-Wiener diversity index (H')were 0.99 in spring and 3.25 in summer, which implied that species diversity in summeris higher than that in spring. Redundancy analysis (RDA) revealed that ammonium(NH4+-N) and nitrites nitrate nitrogens (NO3--N) were the important environmentalfactors influencing the phytoplankton distribution. N is the main environmental drivingfactor result from environmental indicators and RDA analysis.

关键词： phytoplankton community seasonal changes environmental factors Changlicostal zone RDA