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Influence of different second generation antipsychotics on the QTc interval: A pragmatic study

World journal of Psychiatry 2016年第4期6卷 442-448页

作者： roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A j?rgensen Else-Marie L?berg Erik johnsen Division of Psychiatry Haukeland University Hospital Department of Clinical Medicine University of Bergen Department of Addiction Medicine Haukeland University Hospital Department of Clinical Psychology University of Bergen

AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in *** Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups

关键词： Psychosis QTc prolongation Antipsychotics Clinical trial Pragmatic design

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聚四氟乙烯发现和发展的历史

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有机氟工业 1988年第4期 1-4页

作者： roy j.Plunkett 任伟成

值此 PTFE 发现50周年之际,特译刊 PTFE 发现者 roy *** 的第一篇 PTFE 专利和他在一次报告会上的发言,以示纪念,愿有机氟行业界同仁创制出更多性能更好的新型有机氟材料!

关键词：聚四氟乙烯专利含氟高聚物 PTFE 致冷剂制冷剂

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直升飞机齿轮真空渗碳评价

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国外金属热处理 1989年第6期10卷 31-34,58页

作者： roy j. Cunningham 谢敏修吉林省通化石油化工机械厂研究所

对波音直升飞机进行的一项研究,其目的是检验9310钢真空渗碳的有效性,提出所体验到的工艺优点,所遇到的问题以及拟定的解决办法。

关键词：直升飞机齿轮渗碳真空热处理

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Dissociation Constant of N-(2-Acetamido)-Iminodiacetic Acid Monosodium (ADA) from (278.15 to 328.15) K

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Open journal of Physical Chemistry 2014年第2期4卷 73-79页

作者： Rabindra N. roy Lakshmi N. roy john j. Dinga Mathew R. Medcalf Katherine E. Hundley Eric B. Hines Clark B. Summers Lucas S. Tebbe jamie Veliz Drury University Springfield USA

The acidic dissociation constant of N-(2-acetamido)-iminodiacetic acid monosodium (ADA) has been determined at 12 temperatures from 278.15 to 328.15 K by electromotive-force (emf) measurements of hydrogen-silver chloride cells without liquid junction. At 298.15 K, the value of the dissociation constant (pK2) is 6.8416 ± 0.0004. In response to the need for new physiological pH standards, buffer solutions of NaADA and its disodium salt, Na2ADA would be useful for pH control in the biological region of pH 6.5 to 7.5. The pK2 values over the experimental temperature range are given as a function of the thermodynamic temperature (T) by the equation pK2 = 2943.784/T - 47.05762 + 7.72703 ln T. At 298.15 K, standard thermodynamic quantities for the dissociation process have been derived from the temperature coefficients;ΔH° = 12,252 j·mol-1, ΔS° = -89.9 j·K-1·mol-1 and = -148 j·K-1·mol-1. The results are interpreted and compared with those of structurally related derivatives of GLYCINE.

关键词： Dissociation Constant ADA Emf Buffer Thermodynamic Quantity

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The Influence of Various Intervention Types on Treatment Success Rates among Category II Tuberculosis Patients

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journal of Tuberculosis Research 2015年第2期3卷 43-49页

作者： Bandita SenGupta Carla j. Burrus Noor Tirmizi Basab Rooj Hilary S. Moshman Soumen Pandey Gundegmaa jaamaa Khrist roy CARE India Calcutta India CARE USA Atlanta GA USA

Background: Category II tuberculosis (TB) patients (i.e. re-treatment TB patients) are at an increased risk for defaulting on treatment compared to Category I TB patients. Therefore, extra steps need to be taken to help Category II TB patients follow through with their treatment. The goal of this study was to examine the effectiveness of three different types of interventions to help improve treatment success rates among Category II patients. Materials and Methods: Three different interventions that were implemented among Category II TB patients in the Bardhaman, Hugli, Malda and Murshidabad districts in West Bengal, India, were: 1) setting up group patient provider meetings (PPMs), 2) making home visits and reinforcing the message of full course of treatment, and 3) linking poor TB patients to social welfare schemes (SWSs) to incentivize them to complete treatment. Results: PPMs and SWSs improved treatment success rates among Category II patients. The treatment success rates for patients who received PPMs and patients who received SWSs were 94.2% and 90.7%, respectively, compared to the 74.5% treatment success rate of patients who received no intervention. The effectiveness of home visits, however, depended on the number of home visits the patient received. Conclusion: PPMs and SWSs improve treatment success among Category II TB patients and may easily be incorporated in Directly Observed Treatment, Short-Course programming as feasible ways. A conclusion regarding home visits, however, could not be drawn from this study.

关键词： Treatment Default Social Welfare Schemes Group Patient Provider Meetings Home Visits

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商标与牌号研究

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上海包装 1983年第3期 18-20页

作者： roy j. Parcels 柳柏生

随着公司、企业不断发展,生产品种增多,它们与社会的关系越来越密切,接触公众的范围和成员也在增加,以前用以表明企业性质,产品和服务方向的识别符号就显得不够充分了。因此,不断改进商标和得子的问题已变得特别重要。各公司派生出来的... 详细信息

随着公司、企业不断发展,生产品种增多,它们与社会的关系越来越密切,接触公众的范围和成员也在增加,以前用以表明企业性质,产品和服务方向的识别符号就显得不够充分了。因此,不断改进商标和得子的问题已变得特别重要。各公司派生出来的强有力的分

关键词：牌号估价包装企业企业管理商标商品经销

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A spectroscopic study of the interaction of the antioxidant naringin with bovine serum albumin

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journal of Biophysical Chemistry 2010年第3期1卷 141-152页

作者： Atanu Singha roy Debi Ranjan Tripathy Angshuman Chatterjee Swagata Dasgupta 不详

The interaction of naringin with bovine serum albumin has been performed using fluorescence, circular dichroism and fourier transform infrared spectroscopy in 20 mM phosphate buffer of pH 7.0 as well as molecular docking studies. The changes in enthalpy (ΔH°) and entropy (ΔS°) of the interaction were found to be +18.73 kj/mol and +143.64 j mol-1 K-1 respectively, indicating that the interaction of naringin with bovine serum albumin occurred mainly through hydrophobic interactions. Negative values of free energy change (ΔG°) at different temperatures point toward the spontaneity of the interaction. Circular dichroism studies reveal that the helical content of bovine serum albumin decreased after interaction with naringin. According to the F?rster non-radiative energy transfer theory the distance between Trp 213 residue and naringin was found to be 3.25 nm. Displacement studies suggest that naringin binds to site 1 (subdomain IIA) of bovine serum albumin (BSA) which was also substantiated by molecular docking studies.

关键词： Naringin Bovine Serum Albumin Fluorescence Binding Warfarin Docking

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欧洲心血管病一级预防中对血压控制的欠缺：欧洲心血管事件风险日常防范与管理研究结果

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中华高血压杂志 2016年第7期24卷 682-684页

作者： Borghi C Tubach F De Backer G Dallongeville j Guallar E Medina j Perk j roy C Banegas jR Rodriguez-Artalejo F Halcox jP 黄邦邦 Department of Internal Medicine Ageing and Clinical Nephrology University of Bologna Bologna Italy Italy INSERM CIC-EC 1425 and Département d'Epidemiologie et Recherche Clinique Assistance Publique-Hopitaux de Paris Hopital Bichat Paris France Université Paris Diderot UMR 1123 ECEVE Paris France France Department of Public Health University of Ghent Ghent Belgium Belgium INSERM U 744 Institut Pasteur de Lille Université Lille-Nord de France France Departments of Epidemiology and Medicine and Welch Center of Prevention Epidemiology and Clinical Research Johns Hopkins Bloomberg School of Public Health Baltimore MD USA USA Medical Evidence and Observational Research AstraZeneca Madrid Spain Spain Faculty of Health and Caring Sciences Linnaeus University Kalmar Sweden Sweden INSERM CIC-EC 1425 and Département d'Epidemiologie et Recherche Clinique Assistance Publique-Hopitaux de Paris Hopital Bichat Paris France France Department of Preventive Medicine and Public Health School of Medicine Universidad Autónoma de Madrid/IdiPaz and CIBER of Epidemiology and Public Health (CIBERESP) Madrid Spain Spain Institute of Life Sciences 2 Swansea University College of Medicine Swansea UK UK

尽管近年来欧洲心血管病的死亡率有所下降,但每年约47%的死亡仍由心血管病引起。因此,心血管病的一级和二级预防十分重要。发生心血管事件的首要危险因素包括年龄、性别、吸烟、动脉高血压、血脂异常、糖尿病、肥胖及缺乏锻炼。

关键词：心血管病二级预防一级预防血脂异常敏感性分析控制率血清尿酸水平代谢综合征危险评估钙拮抗剂

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智能遥控机器人的应用

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控制工程 1993年第5期 54-56+53页

作者： Charles j. Herget Ema L. Grasz roy D. Merrill 李鑫杰

美国Lawrence Livemore(LL)联邦实验室的遥控机器人实验室,是一个对机器人控制系统的新概念进行开发和试验的研究单位。目前,该单位正在研究和开发的项目有:计算机视觉、自适应控制、实时软件结构、智能控制、人工神经元网络、模糊逻辑... 详细信息

美国Lawrence Livemore(LL)联邦实验室的遥控机器人实验室,是一个对机器人控制系统的新概念进行开发和试验的研究单位。目前,该单位正在研究和开发的项目有:计算机视觉、自适应控制、实时软件结构、智能控制、人工神经元网络、模糊逻辑控制器、遥现技术和路径规化及避碰等。该实验室所具有的设备是:一部带有控制器、手爪、力/力矩传感器的六自由度多关节机器人;一个三维CAD工作站,该工作站的软件可对工作环境进行建模以及对机器人进行动力学仿真;一个六自由度的具有力反应的控制球,该球用来向遥控机器人控制器及机器人仿真系统输入控制指令和一套计算机实时操作系统。不久,该实验室还将增加一套三维视觉系统和一部力反馈手控器。本文对目前所进行的开发和研究工作的部分成果做一介绍。

关键词：机器人实验室人工智能智能遥控实时避碰

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Athermal third harmonic generation in micro‐ring resonators

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Opto-Electronic Advances 2020年第12期3卷 17-27页

作者： Shaohao Wang Yuhua Li Brent ELittle Leiran Wang Xiang Wang roy RDavidson Sai Tak Chu FZU-jinjiang joint Institute of Microelectronics Jinjiang Science and Education ParkFuzhou UniversityJinjiang 362200China Department of Physics City University of Hong KongKowloon TongHong Kong 999077China State Key Laboratory of Transient Optics and Photonics Xi’an Institute of Optics and Precision MechanicsChinese Academy of SciencesXi’an 710119China University of Chinese Academy of Sciences Beijing 100049China QXP Technology Xi’an 710311China Department of Microelectronics Science and Technology Qi Shan CampusFuzhou UniversityFuzhou 350108China Key Laboratory of Optical Field Manipulation of Zhejiang Province Department of PhysicsZhejiang Sci-Tech UniversityHangzhou 310018China

Nonlinear high-harmonic generation in micro-resonators is a common technique used to extend the operating range of applications such as self-referencing systems and coherent communications in the visible ***,the generated high-harmonic emissions are subject to a resonance shift with a change in *** present a comprehensive study of the thermal behavior induced phase mismatch that shows this resonance shift can be compensated by a combination of the linear and nonlinear thermo-optics *** this model,we predict and experimentally demonstrate visible third harmonic modes having temperature dependent wavelength shifts between−2.84 pm/ºC and 2.35 pm/ºC when pumped at the *** providing a new way to achieve athermal operation,this also allows one to measure the thermal coefficients and Q-factor of the visible *** steady state analysis,we have also identified the existence of stable athermal third harmonic generation and experimentally demonstrated orthogonally pumped visible third harmonic modes with a temperature dependent wavelength shift of 0.05 pm/ºC over a temperature range of 12º*** findings promise a configurable and active temperature dependent wavelength shift compensation scheme for highly efficient and precise visible emission generation for potential 2f–3f self-referencing in metrology,biological and chemical sensing applications.

关键词： third-harmonic generation thermodynamics micro-resonators

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