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帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析

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中国肺癌杂志 2021年第9期24卷 I0007-I0016页

作者： Sarah B GOLDBeRG Kurt A SCHALPeR Scott N GeTTINGeR Amit MAHAJAN roy S HeRBST Anne C CHANG Rogerio LILeNBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVeANU Thuy TRAN Kira PAVLIK elin ROWeN Heather GeRRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBeIRO Yuval KLUGeR Geyu ZHOU Wei WeI Veronica L CHANG Harriet M KLUGeR 董晓荣(翻译/校对) Department of Medicine(Medical Oncology) Yale School of MedicineNew HavenCTUSA Department of Pathology Yale School of MedicineNew HavenCTUSA Department of Radiology Yale School of MedicineNew HavenCTUSA Department of Neurosurgery Yale School of MedicineNew HavenCTUSA Department of Therapeutic Radiology Yale School of MedicineNew HavenCTUSA Interdepartmental Program in Computational Biology and Bioinformatics Yale School of MedicineNew HavenCTUSA Department of Biostatistics Yale School of Public HealthNew HavenCTUSA 华中科技大学同济医学院附属协和医院胸部肿瘤科

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(ce... 详细信息

背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(eastern Cooperative Oncology Group,eCOG)ed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1erse events,Aes)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。

关键词：非小细胞肺癌脑转移免疫治疗帕博利珠单抗

习近平访美签下农业大单美国猎人借机进入中国

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商业周刊（中文版） 2012年第6期 35-35页

作者： Jeff Wilson Whitney McFerron Debarati roy Feiwen Rong

美国农业部4月份将带领有史以来最大贸易代表团前往中国“中国国家副主席在美国艾奥瓦的停留，让当地人感觉中国很重要”

关键词：美国农业部中国习近平猎人访美国家副主席代表团大贸易

Chromatin boundary elements organize genomic architecture and developmental gene regulation in Drosophila Hox clusters

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World Journal of Biological Chemistry 2016年第3期7卷 223-230页

作者： Zhibo Ma Mo Li Sharmila roy Kevin J Liu Matthew L Romine Derrick C Lane Sapna K Patel Haini N Cai Department of Cellular Biology University of Georgia

The three-dimensional(3D) organization of the eukaryotic genome is critical for its proper function. evidence suggests that extensive chromatin loops form the building blocks of the genomic architecture, separating genes and gene clusters into distinct functional domains. These loops are anchored in part by a special type of DNA elements called chromatin boundary elements(CBes). CBes were originally found to insulate neighboring genes by blocking influences of transcriptional enhancers or the spread of silent chromatin. However, recent results show that chromatin loops can also play a positive role in gene regulation by looping out intervening DNA and "delivering" remote enhancers to gene promoters. In addition, studies from human and model organisms indicate that the configuration of chromatin loops, many of which are tethered by CBes, is dynamically regulated during cell differentiation. In particular, a recent work by Li et al has shown that the SF1 boundary, located in the Drosophila Hox cluster, regulates local genes by tethering different subsets of chromatin loops: One subset enclose a neighboring gene ftz, limiting its access by the surrounding Scr enhancers and restrict the spread of repressive histones during early embryogenesis; and the other loops subdivide the Scr regulatory region into independent domains of enhancer accessibility. The enhancer-blocking activity of these CBe elements varies greatly in strength and tissue distribution. Further, tandem pairing of SF1 and SF2 facilitate the bypass of distal enhancers in transgenic flies, providing a mechanism for endogenous enhancers to circumvent genomic interruptions resulting from chromosomal rearrangement. This study demonstrates how a network of chromatin boundaries, centrally organized by SF1, can remodel the 3D genome to facilitate gene regulation during development.

关键词： Chromatin boundary element Insulator CTCF Chromatin loop domains Drosophila Hox genes

饮用水日光照射消毒法对于印度南部儿童腹泻的预防

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世界核心医学期刊文摘（儿科学分册） 2006年第9期2卷 6-6页

作者： Rose A. roy S. Abraham V. 张振

Aims: To evaluate the efficacy and acceptability of solar irradiation in the prevention of diarrhoeal morbidity in children under 5 years of age, in an urban slum in Vellore, Tamil Nadu. Methods: A total of 100 children were assigned to receive drinking water that had been subjected to solar disinfection in polyethylene terephthalate bottles. One hundred age and sex matched controls were also selected. Both groups were followed by weekly home visits for a period of six months for any diarrhoeal morbidity. At the end of the follow up period, the acceptability of the intervention was assessed by interviews, questionnaires, and focus group discussions. Results: There was significant reduction in the incidence,duration, and severity of diarrhoea in children receiving solar disinfected water, despite 86% of the children drinking water other than that treated by the intervention. The incidence of diarrhoea in the intervention group was 1.7 per child-year, and among controls 2.7 per child-year, with an incidence rate ratio of 0.64 (95% CI -0.48 to 0.86). The risk of diarrhoea was reduced by 40% by using solar disinfection. In qualitative evaluation of acceptability, most women felt that solar disinfection was a feasible and sustainable method of disinfecting water. Conclusions: Solar disinfection of water is an inexpensive, effective, and acceptable method of increasing water safety in a resource limited environment, and can significantly decrease diarrhoeal morbidity in children.

关键词：儿童腹泻日光照射消毒法印度南部照射消毒腹泻发病率腹泻发生率可接受性小组讨论持续时间

Structure of protein O-mannose kinase reveals a unique active site architecture

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Structure of protein O-mannose kinase reveals a unique activ...

中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）

作者： Qinyu Zhu David Venzke Ameya S.Walimbe Mary e.Anderson Qiuyu Fu Lisa Kinch Wei Wang Xing Chen Nick Grishin Niu Huang Liping Yu Jack e.Dixon Kevin P.Campbell Junyu Xiao The State Key Laboratory of Protein and Plant Gene Research School of Life SciencesAcademy for Advanced Interdisciplinary StudiesPeking-Tsinghua Center for Life SciencesPeking University Howard Hughes Medical Institute Department of Molecular Physiology and BiophysicsDepartment of NeurologyDepartment of Internal MedicineUniversity of Iowa Roy J.and Lucille A.Carver College of Medicine National Institute of Biological Sciences Beijing Department of Biophysics University of TexasSouthwestern Medical Center Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking-Tsinghua Center for Life SciencesSynthetic and Functional Biomolecules CenterKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationPeking University Medical Nuclear Magnetic Resonance Facility University of Iowa Roy J.and Lucille A.Carver College of Medicine Department of Pharmacology Department of Cellular and Molecular MedicineDepartment of Chemistry and BiochemistryUniversity of California

The"pseudokinase"Sg K196 is a protein O-mannose kinase(POMK)that catalyzes an essential phosphorylation step during biosynthesis of the laminin-binding glycan ***,the catalytic mechanism underlying this activity remains *** we present the crystal structure of Danio rerio POMK in complex with Mg ions,ADP,aluminum fluoride,and

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肝细胞移植解决α1抗胰蛋白酶缺乏

中国烧伤创疡杂志 2011年第3期23卷 262-262页

作者： Jianqiang Ding Govardhana R. Yannam Namita roy-Chowdhury

【动态】遗传性的α1抗胰蛋白酶缺乏会引发肝病和肺气肿。肝脏合成的该蛋白的正常功能是抑制降解肺部结缔组织的中性粒细胞弹性蛋白酶。该病的典型形式是突变的α1抗胰蛋白酶低效分泌并积累在肝细胞中，因而降低了蛋白酶抑制剂的活性，... 详细信息

【动态】遗传性的α1抗胰蛋白酶缺乏会引发肝病和肺气肿。肝脏合成的该蛋白的正常功能是抑制降解肺部结缔组织的中性粒细胞弹性蛋白酶。该病的典型形式是突变的α1抗胰蛋白酶低效分泌并积累在肝细胞中，因而降低了蛋白酶抑制剂的活性，导致肝损伤和肺气肿。

关键词：抗胰蛋白酶缺乏肝细胞移植中性粒细胞弹性蛋白酶 α1抗胰蛋白酶蛋白酶抑制剂结缔组织正常功能肺气肿

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他们是来埋葬而不是赞美黄金的

商业周刊（中文版） 2015年第17期 55-55页

作者： Luzi-Ann Javier Debarati roy Joe Deaux 逸思

在金价创出5年低点之际，投资者们不仅仅是在抛售——他们正押注它将继续下跌。7月，投机者持有的黄金空头合约创下了历史最高水平，这意味着他们赌定了金价将进一步下挫。此外，希望从金价下跌中赚取利润的对冲基金的数量也接近了历史... 详细信息

在金价创出5年低点之际，投资者们不仅仅是在抛售——他们正押注它将继续下跌。7月，投机者持有的黄金空头合约创下了历史最高水平，这意味着他们赌定了金价将进一步下挫。此外，希望从金价下跌中赚取利润的对冲基金的数量也接近了历史高位。

关键词：黄金赞美埋葬对冲基金金价投资者投机者历史

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γ辐射贮藏双孢蘑菇

食用菌 1985年第1期9卷 38-38页

作者： M.K.roy Nita Bahl 贾乾义

蘑菇一般在0℃左右的低温及90％的相对湿度下贮藏。由于在14～15℃较高温度下保藏可减少能量消耗,所以它在技术上要优于0℃的低温贮藏. 这对于发展工业需要增加能源的国家具有重要意义。在印度用冷冻保藏的数量有所增加,但成本高,而且... 详细信息

蘑菇一般在0℃左右的低温及90％的相对湿度下贮藏。由于在14～15℃较高温度下保藏可减少能量消耗,所以它在技术上要优于0℃的低温贮藏. 这对于发展工业需要增加能源的国家具有重要意义。在印度用冷冻保藏的数量有所增加,但成本高,而且不易找到能满足冷冻的贮藏室。双孢蘑菇喜欢较低的温度。γ-射线照射可延长蘑菇的寿命。

关键词：子实体蘑菇拉德菌柄开伞

经椎弓根复位固定器治疗胸腰椎骨折的生物力学研究和临床应用

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苏州医学院学报 1994年第3期14卷 177-179页

作者：殷渠东郑祖根苏州医学院附属第二医院骨科

采用经椎弓根复位固定器治疗胸腰椎骨折３２例，经生物力学测试结果表明，较Ｒｏｙ－ｃａｍｉｌｌｅ，ｓｔｅｆｆｅｅ、Ｄｉｃｋ、Ｃ－Ｄ有明显优越性．术前平均椎前高６６．２７％，椎后高９３．３５％，后突角２３．４８，术后分别恢... 详细信息

采用经椎弓根复位固定器治疗胸腰椎骨折３２例，经生物力学测试结果表明，较Ｒｏｙ－ｃａｍｉｌｌｅ，ｓｔｅｆｆｅｅ、Ｄｉｃｋ、Ｃ－Ｄ有明显优越性．术前平均椎前高６６．２７％，椎后高９３．３５％，后突角２３．４８，术后分别恢复到９８．８１％，９９．２９％，４．９４．其中３０例随访（平均１０月），椎前高仍保持９７．５０％，椎后高维持９８．８０％，不全性瘫痪改善１级以上，无严重并发症。

关键词：腰椎骨折椎弓根螺钉胸椎