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A community-based prospective cohort study of dengue viral infection in Malaysia: the study protocol

Infectious Diseases of Poverty 2016年第1期5卷 691-699页

作者： Nowrozy Kamar Jahan Mohtar Pungut Ahmad Amreeta Dhanoa Cheong Yuet Meng Lau Wee Ming Daniel D.Reidpath Pascale Allotey Anuar Zaini Maude Elvira Phipps Quek Kia Fatt Aman Bin Rabu rowther sirajudeen Ahmad AbdulBasitz Ahmad Fatan Faidzal Adlee Ghafar Hamdan Bin Ahmad Iekhsan Othman Sharifah SyedHassan Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon SelatanBandar SunwayPetaling Jaya 47500Malaysia Segamat District Public Health Office Ministry of Health MalaysiaPeti Surat 102Jalan Gudang UbatKampung GubahSegamatJohor Darul Takzim 85000Malaysia Infection and Immunity Cluster Tropical Medicine and Biology PlatformMonash University MalaysiaJalan Lagoon SelatanBandar SunwayPetaling Jaya 47500Malaysia South East Asia Community Observatory(SEACO) 146 Jalan Sia Her YamSuite 601-606Wisma CentrepointSegamatJohor Darul Takzim 85000Malaysia Hospital Segamat Ministry of Health MalaysiaKM 6Jalan GenuangSegamatJohor Darul Takzim 85000Malaysia University Sains Malaysia GelugorPenang 11800Malaysia

Background:Globally,dengue infections constitute a significant public health *** recent decades,Malaysia has become a dengue hyper-endemic country with the co-circulation of the four dengue virus *** cyclical dominance of sub-types contributes to a pattern of major *** consequences can be observed in the rising incidence of reported dengue cases and dengue related *** the complex interaction of the dengue virus,its human hosts and the mosquito vectors at the community level may help develop strategies for addressing the ***:A prospective cohort study will be conducted in Segamat district of Johor State in Peninsular *** received approval from the Malaysian Medical Research Ethics Committee and Monash University Human Research Ethics *** study will be conducted at a Malaysian based health and demographic surveillance site over a 1 year period in three different settings(urban,semi-urban and rural).The study will recruit healthy adults(male and female)aged 18 years and over,from three ethnic groups(Malay,Chinese and Indian).The sample size calculated using the Fleiss method with continuity correction is ***-surveillance of participants will be undertaken to identify asymptomatic,otherwise healthy cases;cases with dengue fever who are managed as out-patients;and cases with dengue fever admitted to a hospital.A genetic analysis of the participants will be undertaken to determine whether there is a relationship between genetic predisposition and disease severity.A detailed medical history,past history of dengue infection,vaccination history against other flaviviruses such as Japanese encephalitis and Yellow fever,and the family history of dengue infection will also be *** addition,a mosquito surveillance will be carried out simultaneously in recruitment areas to determine the molecular taxonomy of circulating ***:The research findings will estimate the burden of

关键词： Dengue Community-based Prospective cohort study Health and demographic surveillance site SEACO Protoco

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Seroprevalence of dengue among healthy adults in a rural community in Southern Malaysia:a pilot study

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Infectious Diseases of Poverty 2018年第1期7卷 1-13页

作者： Amreeta Dhanoa Sharifah Syed Hassan Nowrozy Kamar Jahan Daniel D.Reidpath Quek Kia Fatt Mohtar Pungut Ahmad Cheong Yuet Meng Lau Wee Ming Anuar Zaini Zain Maude Elvira Phipps Iekhsan Othman Aman Bin Rabu rowther sirajudeen Ahmad Abdul Basitz Ahmad Fatan Faidzal Adlee Ghafar Hamdan Bin Ahmad Pascale Allotey Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon SelatanBandar Sunway47500 Petaling JayaMalaysia Segamat District Public Health Office Ministry of Health MalaysiaPeti Surat 102Jalan Gudang UbatKampung Gubah85000 SegamatJohor Darul TakzimMalaysia Infection and Immunity Cluster Tropical Medicine and Biology PlatformMonash University MalaysiaJalan Lagoon SelatanBandar Sunway47500 Petaling JayaMalaysia South East Asia Community Observatory(SEACO) 146 Jalan Sia Her YamSuite 601-606Wisma Centrepoint85000 SegamatJohor Darul TakzimMalaysia Hospital Segamat Ministry of Health MalaysiaKM 6Jalan Genuang85000 SegamatJohor Darul TakzimMalaysia Universiti Sains Malaysia 11800 GelugorPenangMalaysia.

Background:The frequency and magnitude of dengue epidemics continue to increase exponentially in Malaysia,with a shift in the age range predominance toward adults and an expansion to rural *** this,information pertaining to the extent of transmission of dengue virus(DENV)in the rural community is *** communitybased pilot study was conducted to establish DENV seroprevalence amongst healthy adults in a rural district in Southern Malaysia,and to identify influencing ***:In this study undertaken between April and May 2015,a total of 277 adult participants were recruited from households across three localities in the Sungai Segamat subdistrict in Segamat *** were tested for immunoglobulin G(IgG)(Panbio®Dengue Indirect IgG ELISA/high-titer capture)and immunoglobulin M(IgM)(Panbio®)*** plaque reduction neutralization test(PRNT)was conducted on random samples of IgGpositive sera for further *** history and a recall of previous history of dengue were collected through interviews,whereas sociodemographic information was obtained from an existing ***:The overall seroprevalence for DENV infection was 86.6%(240/277)(95%CI:83-91%).Serological evidence of recent infection(IgM/high-titer capture IgG)was noted in 11.2%(31/277)of participants,whereas there was evidence of past infection in 75.5%(209/277)of participants(indirect IgG minus recent infections).The PRNT assay showed that the detected antibodies were indeed specific to *** multivariate analysis showed that the older age group was significantly associated with past DENV *** increased with age;48.5%in the age group of45 years(P<0.001).No associations with occupation,study site,housing type,comorbidity,educational level,and marital status were observed,although the latter two were statistically significant in the univariate *** of the studied factors were significantl

关键词： Dengue Dengue virus Rural Community-based study Seroprevalence Subclinical infection Malaysia

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Successful bowel surgery at hemoglobin 2 g/dL without blood transfusion

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World Journal of Gastrointestinal Surgery 2013年第8期5卷 252-255页

作者： Ramakrishnapillai Padmakumar Madhukara Pai Shams Farish Jayadevan Rajeev Thampi Sanjeev Thekke Veetil Sreevalsan Binu Sheetal Yesudas Santhakumari Sooraj Shamna Safar rowther Department of General Surgery Sunrise Hospital Department of Gastroenterology Sunrise Hospital Department of Anesthesiology Sunrise Hospital Department of Critical Care Medicine Sunrise Hospital Department of General Medicine Sunrise Hospital Department of Nephrology Sunrise Hospital Department of Bio-statistics Sunrise Hospital

We were unable to find reports in the published medical literature of any cases of bowel surgery being successfully performed at such a low hemoglobin level,without blood transfusion or blood products pre or post-surgery,with the patient’s uncomplicated *** study is about such a case.A patient presenting with severegastrointestinal bleeding was diagnosed with enteric fever and multiple ileal *** had an extremely low hemoglobin level(2 g/dL) and mild renal and hepatic *** was immediately admitted for right hemicolectomy under general anesthesia though he refused transfusion of blood or blood products prior to,during,or after surgery on religious grounds(Jehovah’ s Witnesses).After the surgery and having survived these potentially life-threatening circumstances,he left the hospital without major *** such circumstances,lives may be saved by prompt clinical decision-making,collaboration and swift surgical intervention coupled with the immediate consultation and input of the patient and family.

关键词： Gastrointestinal bleed Low hemoglobin level Jehovah’ s witnesses Multiple terminal ileal ulceration Enterotomy Right hemicolectomy.

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