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Creation of Molecular Vortex

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量子光学学报 2006年第B8期12卷 62-63页

作者： Weiping Zhang h. Y. Ling S. Yi h. Pu d. Grochowski Key Laboratory of Optical and Magnetic Resonance Spectroscopy （Ministry of Education） Department of Physics East China Normal University Shanghai 200062 P. R. China department of Physics and Astronomy and Rice Quantum Institute Rice University Houston TX 77251-1892 USA department of Physics and Astronomy Rowan University Glassboro New Jersey 08028-1700 USA

human Milk Oligosaccharides Enhance Innate Immunity to Respiratory Syncytial Virus and Influenza <i>in Vitro</i>

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Food and Nutrition Sciences 2014年第14期5卷 1387-1398页

作者： Geralyn duska-McEwen Albert P. Senft Teah L. Ruetschilling Edward G. barrett Rachael h. Buck discovery R & d Abbott Nutrition Columbus USA Lovelace Respiratory Research Institute Albuquerque USA

human milk oligosaccharides (hMO) contribute to innate immunity by enhancing growth of beneficial bacteria, epithelial cell maturation and mucosal barrier integrity. They have immunomodulatory effects and can block pathogen binding to host cell surface glycans or receptors. We investigated the effects of 2’-fucosyllactose (2’FL), 6’-sialyllactose (6’SL), 3’-sialyllactose (3’SL) and lacto-N-neoTetraose (LNnT) on human respiratory epithelial cell lines or peripheral blood mononuclear cells (PBMCs) following respiratory viral infectionin vitro. Expression of cytokines and viral load were monitored in infected cells. These biomarkers of innate immunity were selected since viral load and cytokine levels (IP-10, MIP-1α, IL-6, IL-8, TNF-α) have been correlated with disease severity in respiratory syncytial virus (RSV) and influenza (IAV) virus infectionin vivo. 2’FL significantly decreased RSV viral load and cytokines associated with disease severity (IL-6, IL-8, MIP-1α) and inflammation (TNF-α, MCP-1) in airway epithelial cells. LNnT and 6’SL significantly decreased IAV viral load in airway epithelial cells. 6’SL dose-dependently down-regulated IP-10 and TNF-α in RSV infected PBMCs. hMO at or below levels found in breast milk enhance innate immunity to respiratory viruses in vitro and may interact directly with cells to modulate biomarkers of innate immunity.

关键词： human Milk Oligosaccharides Respiratory Syncytial Virus Influenza Virus Inflammation Innate Immunity

前列腺T1加权MRI所见的出血除外征对前列腺癌检出的价值

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国际医学放射学杂志 2012年第4期 384-385页

作者： T. barrett h.A. Vargas O. Akin d.A. Goldman h. hricak 唐光健 department of Radiology Memorial Sloan -Kettering Cancer Center1275 York Ave New York NY 10065 USA

摘要目的回顾性确定T1加权MRI上所见的出血除外征结合T2加权影像表现在前列腺癌检出中的出现率与阳性预期值(PPV),采用前列腺切除全量逐层切片病理标本作为参考标准。材料与方法此项回顾性研究由学院审查委员会批准,免除知情同意通知。... 详细信息

摘要目的回顾性确定T1加权MRI上所见的出血除外征结合T2加权影像表现在前列腺癌检出中的出现率与阳性预期值(PPV),采用前列腺切除全量逐层切片病理标本作为参考标准。材料与方法此项回顾性研究由学院审查委员会批准,免除知情同意通知。292例活检证实为前列腺癌的病人接受了直肠

关键词：前列腺癌 T1 检出 MRI

Macrophage-specific inhibition of the histone demethylase JMJd3 decreases STING and pathologic inflammation in diabetic wound repair

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Cellular & Molecular Immunology 2022年第11期19卷 1251-1262页

作者： Christopher O.Audu William J.Melvin Amrita d.Joshi Sonya J.Wolf Jadie Y.Moon Frank M.davis Emily C.barrett Kevin d.Mangum hongping deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler M.Bauer James Shadiow Matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany BMoore Johann EGudjonsson Andrew MSmith Katherine A.Gallagher department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA department of Microbiology and Immunology University of MichiganAnn ArborMIUSA department of Medicinal Chemistry University of MichiganAnn ArborMIUSA department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA department of dermatology University of MichiganAnn ArborMIUSA department of Pathology University of MichiganAnn ArborMIUSA department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

Macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic wounds,we identified increased JMJd3 in diabetic wound macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,JMJd3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JMJd3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JMJd3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an h3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with JMJd3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JMJd3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of JMJd3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of JMJd3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.

关键词： wound healing epigenetics diabetes JMJd3 STING

肿瘤干细胞分析及CA125检测用于卵巢癌之处理

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癌症 1988年第1期 27-30页

作者：谭道彩,C.Welander,h.d.homesley,M.Berens,R.barrett 中山医科大学肿瘤医院美国Wake Forest大学医学院妇产科美国Wake Forest大学医学院妇产科美国Wake Forest大学医学院妇产科美国Wake Forest大学医学院妇产科

1984年1月至1985年7月,103例卵巢癌进行治疗。属Ⅰ期者11例,Ⅱ期15例,Ⅲ期45例,Ⅳ期7例,复发癌25名;浆液性腺癌70例。患者先行腹式全宫附件及大网切除术,并切除盆、腹腔之肿瘤。残余癌体积的直径超2厘米,是henckhoff管于腹腔。103患者... 详细信息

1984年1月至1985年7月,103例卵巢癌进行治疗。属Ⅰ期者11例,Ⅱ期15例,Ⅲ期45例,Ⅳ期7例,复发癌25名;浆液性腺癌70例。患者先行腹式全宫附件及大网切除术,并切除盆、腹腔之肿瘤。残余癌体积的直径超2厘米,是henckhoff管于腹腔。103患者中49例作肿瘤干细胞分析及CA 125检测,54名为对照组。据肿瘤干细胞分析以选择抗癌药,研究组采用15种不同化疗方案;对照患者用12种。患者经手术及化疗达完全缓解或部分缓解伴有顽固难消的癌块则行再剖腹手术。本文103例患者中72人生存12至30个月,生存率为69.90％;研究组49例有43例生存,生存率为87.76％,对照组生存29例,占53.70％,二组之生存率比较,P值≤0.113,有差异。对照组25例死亡,平均生存5.5个月,6例研究组死亡者,平均生13.2月。

关键词：卵巢癌 CA125 患者卵巢恶性肿瘤肿瘤干细胞生存期

ACId-Functionalized Porphyrazines Exhibit ANTI-Tumor Behavior in head and Neck Squamous Cell Carcinomas

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ACID-Functionalized Porphyrazines Exhibit ANTI-Tumor Behavio...

验证PI-RAdS 2.0版本中的主要序列和动态对比增强成像的作用

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Benjamin J. Vesper Neal d. hammer Sangwan Lee Kim Elseth Anthony G. M. barrett Brian M. hoffman James A. Radosevich Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA department of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA department of Chemistry Imperial College of Science Technology and MedicineExhibition RoadSouth KensingtonLondonSW7 2AZUK department of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA

＜正＞Background/Aims: The porphyrin drug Photofrin is used in photodynamic therapy applications to clinically treat oral and upper aerodigestive tract tumors;however, this drug is limited by its inadequate tumor selectivity and poor optical properties-common problems for members of the porphyrin family. We are currently studying a class of porphyrin derivatives, the porphyrazines （pzs）, which possess superior optical properties and greater synthetic flexibility than the porphyrins and show promise as both PdT agents and traditional anti - tumor agents. Previous work in our laboratory has shown that a subfamily of acid - functionalized pzs exhibit selective anti - tumor activity in A549 human lung adenocarcinoma cells. We here expand this study to test these same pzs in a number of head and neck squamous cell carcinoma （SCC） cell lines. Methods: MTT proliferation/viability assays were used to test the toxicity of three h2[pz（ An;B4-n） ] pzs, where n = 4, 3, or 2 （ in a trans conformation）, A is [S（Ch2）3COOh], and B is a fused β,β’ - diisopropyloxybenzo ring. Five SCC cell lines were exposed to the pzs at concentrations of 12.5 - 50 μM, for periods of 24, 48, and 72 hours. Results: As the number of terminal acid groups on the pzs was increased, the amount of toxicity observed in the SCC cell lines upon 72 hour exposure also increased-a trend which was also observed previously in the A549 adenocarcinoma cell line. Additionally, at any given concentration, each compound was found to kill a greater percentage of tumor cells than normal cells. Normal cells were found to be unaffected by the h2A2B2 pz （four acid groups） at concentrations of 25 μM and below, whereas all five SCC cell lines exhibited toxicity in the presence of each of the three pzs at all concentrations studied （12.5 - 50 μM）. Conclusion: The acid - appended pzs were found to exhibit the same structure - function relationship in both adeno-carcinomas and squamous cell carcinomas. The selective tumor toxicity

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国际医学放射学杂志 2018年第1期 102-102页

作者： M.d.Greer J.h.Shih N.Lay T.barrett L.K.Bittencourt S.Borofsky 周波 Molecular Imaging National Cancer InstituteNational Institutes of Health

摘要目的采用多阅片者间研究数据验证前列腺成像报告和数据系统(PI-RAdS)2.0版中主要脉冲序列和动态对比增强(dCE)MRI的有限作用。材料与方法本回顾性研究

关键词：动态对比增强 dCE 检出率 PI-RAdS 2.0 dWI

遗传性血色病进行缺铁治疗后,二价金属离子转运体1(dMT1)增加,而铁调节基因1(IREG1)和hFE基因mRNA表达不增加

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 44-45页

作者： Kelleher T. Ryan E. barrett S. J. Crowe 马卉 Centre for Liver disease Mater Misericordiae Univ. HospitalDublin 7 Ireland

Background and aims: While upregulation of divalent metal transporter 1 (dMT1) and iron regulated gene 1 (IREG1)within duodenal enterocytes is reported in patients with hereditary haemochromatosis (hh), these findings are controversial. Furthermore,the effect of hFE, the gene mutated in hh, on expression of these molecules is unclear. This study examines duodenal expression of these three molecules in hh patients(prior to and following phlebotomy), in patients with iron deficiency (Id), and in controls. Methods: dMT1, IREG1, and hFE mRNA were measured in duodenal tissue of C282Y homozygous hh patients, in Id patients negative for the C282Y mutation with a serum ferritin concentration less than 20 μ g/l,and in controls negative for C282Y and h63d mutations with normal iron indices, using real time polymerase chain ***: dMT1 and IREG1 mRNA levels were not significantly different in non-phlebotomised (untreated) hh patients compared with controls. dMT1 expression was significantly increased in hh patients who had undergone phlebotomy therapy(treated) and in patients with Id compared with ***1 was significantly increased in Id patients relative to controls, and while IREG1 expression was 1.8-fold greater in treated hh patients, this was not statistically *** mRNA expression was not significantly different in any of the groups investigated relative to controls. Conclusions:These findings demonstrate that untreated hh patients do not have increased duodenal dMT1 and IREG mRNA, but rather phlebotomy increases expression of these molecules, reflecting the effect of phlebotomy induced erythropoiesis. Finally, hFE appears to play a minor role in the regulation of iron absorption by the duodenal enterocyte.

关键词：遗传性血色病 dMT1 hFE基因mRNA IREG1 调节基因缺铁二价金属离子基因突变血清铁蛋白纯合子

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Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg h.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky d.M.Asner h.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin d.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi d.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin h.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury d.Cinabro L.Corona L.M.Cremaldi S.Cunliffe T.Czank F.dattola E.de La Cruz-Burelo G.de Nardo M.de Nuccio G.de Pietro R.de Sangro M.destefanis S.dey A.de Yta-hernandez F.di Capua S.di Carlo J.dingfelder Z.doležal I.domínguez Jiménez T.V.dong K.dort S.dubey S.duell S.Eidelman M.Eliachevitch T.Ferber d.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani d.Greenwald C.hadjivasiliou S.halder K.hara T.hara O.hartbrich K.hayasaka h.hayashii C.hearty M.T.hedges I.heredia de la Cruz M.hernández Villanueva A.hershenhorn T.higuchi E.C.hill h.hirata M.hoek S.hollitt T.hotta C.-L.hsu Y.hu K.huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs d.E.Jaffe E.-J.Jang h.B.Jeon S.Jia Y.Jin C.Joo J.Kahn h.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki h.Kichimi C.Kiesling B.h.Kim C.-h.Kim d.Y.Kim S.-h.Kim Y.K.Kim Y.Kim T.d.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar d.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.S.Lange K.Lautenbach I.-S.Le Beihang University Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba University Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 deutsches Elektronen–Synchrotron 22607 Hamburg duke University DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu University Gifu 501-1193 The Graduate University for Advanced Studies(SOKENdAI) Hayama 240-0193 Gyeongsang National University Jinju 52828 department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 high Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana University BloomingtonIndiana 47408 Institute for high Energy Physics Protvino 142281 Institute of high Energy Physics Vienna 1050 Institute of high Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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