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Chemical Composition of Gossypium herbaceum linn and its Antioxidant, Antibacterial, Cytotoxic and Antimalarial Activities

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Clinical Complementary Medicine and Pharmacology 2021年第1期1卷 68-76页

作者： rotimi abisoye larayetan Gideon Ayeni Abdulrazaq Yahaya Abayomi Ajayi Sunday Omale Umar Ishaq Dauda Joseph Abiodun Chijioke Olisah Julius Aigbogun Swesme Enyioma-Alozie Department of Chemistry Kogi State UniversityPMB 1008AnyigbaKogi StateNigeria Department of Pure and Applied Chemistry University of Fort Hare Alice 5700South Africa Department of Biochemistry Kogi State UniversityPMB 1008AnyigbaKogi StateNigeria Department of Biochemistry School of Life SciencesUniversity of KwaZulu-NatalWestville CampusDurban 4000South Africa Department of Anatomy Faculty of Basic Medical SciencesCollege of Health SciencesKogi State University AnyigbaPMB 1008AnyigbaKogi StateNigeria Botany Department Institute for Costal and Marine ResearchNelson Mandela UniversityPort Elizabeth 6031South Africa Jacio Environmental Limited 3 Airoboyi EstatesKM 2RefineryRefinery RoadEffurunDelta StateNigeria Department of Anatomy Faculty of Basic Medical SciencesBaze UniversityPlot 686Cadastral Zone C 00Jabi Airport Road Bypass(Ring Road)Behind National Judicial InstituteAbujaNigeria

Background:Gossypium herbaceum(***),a plant commonly found in the wild in Nigeria,is said to possess some therapeutic ***,there is a dearth of information on its chemical ***,there is a need to investigate its therapeutic ***:To investigate the qualitative and quantitative phytochemical components of the leaf extracts of ***,as well as its antioxidant,antimalarial and cytotoxic ***:Gas chromatography-mass spectrometry(GC-MS)analysis was used to determine the components of ethanol and hexane extracts of *** leaf while 2,2-diphenyl-1-picrylhydrazyl(DPPH)and nitric oxide assays were used to determine the antioxidant *** parasites viability was examined using parasite lactate dehydrogenase(pLDH)technique and HeLa cell was used for the cytotoxicity ***:Bioactive compounds identified in ethanol and hexane extracts of *** were 37 and 30 kinds,respectively,with major components as linoleic acid(36.10%and 33.82%),vitamin E(7.15%and 5.98%)and caryophyllene(4.21%and 5.08%).It also has tannins,saponins,alkaloids,flavonoids steroids,phenols and *** antibacterial test,significant inhibitory potentials against multidrug-resistant bacteria strains were *** vitro antioxidant potentials(IC 50)of ethanol and hexane extracts were 3.33 and 4.12μg/mL for DPPH assays,and 3.87 and 5.00μg/mL for nitric oxide assays,*** activities(IC 50)were 9.99 and 9.76μg/mL for ethanol and hexane extracts,***:*** leaf may provide novel plant-derived therapeutic agents,effective in treating infectious diseases arising from multiple drug-resistant bacteria and a target in the management of oxidative stress.

关键词： Antimalarial Antimicrobial Antioxidant Bioactive components MBC MBF GC-MS Gossypium herbaceum

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