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与17号染色体有关的前额颞疾病及帕金森综合征最新研究进展

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世界医学杂志 2002年第24期6卷 6-8,5页

作者： SoniaM.rosso 王伊龙 Depar.mentofNeur.logy UniversityHospital－DijkzigtDr.Molewaterplein403015GDRotterdamTheNetherlands. Depar.mentofNeur.logy UniversityHospital－DijkzigtDr.Molewaterplein403015GDRotterdamTheNetherlan

可喜的是，现经证实的遗传缺陷及其相关蛋白方面的研究，将有助于我们进一步理解tau蛋白在前额颞疾病所引起的神经功能退化过程中所起的作用。

关键词： 17号染色体前额颞疾病帕金森疾病 tau蛋白基因突变

Use of chondr.l fr.gments for.one stage car.ilage r.pair. A systematic r.view

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Wor.d Jour.al of Or.hopedics 2015年第11期6卷 1006-1011页

作者： Davide Edoar.o Bonasia Antongiulio Mar.otti Feder.ca rosso Gianluca Collo r.ber.o r.ssi Depar.ment of Or.hopaedics and Tr.umatology University of TorinoAO Mauriziano "Umberto I" Hospital

AIM: To investigate the state of the ar. r.gar.ing Car.ilage Autogr.ft Implantation System(CAIS) or.Par.iculated Juvenile Allogr.ft Car.ilage(PJAC).METHODS: The author. sear.hed the English liter.tur. r.gar.ing CAIS and PJAC. The sear.h str.tegy was:(par.iculated car.ilage) Or.autologous car.ilage fr.gments. All basic science ar.icles wer. included. Clinical ar.icles with less than 10 patients tr.ated and less than 6 mo of follow-up wer. excluded. With these cr.ter.a, a total of 17 ar.icles wer. available for.the pr.sent r.view. r.SULTS: PJAC and CAIS ar. r.latively novel techniques for.car.ilage r.pair. Good basic science evidence was descr.bed to suppor. the concept. Although the pr.liminar. clinical r.por.s show encour.ging r.sults, clinical data ar. still limited, especially for.CAIS. The indications for.both techniques need to be pr.cisely defined(age of the patients, size of the lesion, and involvement of the subchondr.l bone), together.with other.debated issues. CONCLUSION: In conclusion, the author. can state that encour.ging pr.liminar. r.sults ar. available for.both techniques. However. fur.her.studies ar. necessar. to pr.cisely deter.ine the indications, sur.ical techniques, and long ter. outcomes for.PJAC and CAIS.

关键词： Car.ilage Juvenile Chondr.l fr.gments Adult Par.iculated car.ilage

Extr.me Events Assessment Methodology Coupling Debr.s Flow,Flooding and Tidal Levels in the Coastal Floodplain of the Sao Paulo Nor.h Coast(Br.zil)

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Inter.ational Jour.al of Geosciences 2013年第5期4卷 30-38页

作者： r.fael de Oliveir. Sakai Diego Lour.nco Car.acho Emilia Ar.saki Paolo Alfr.dini Alessandr. Pezzoli Wilson Cabr.l de Sousa Junior.Maur.zio rosso Luca Magni Polytechnic School of Sao Paulo Univer.ity Department of Hydraulic and Environmental EngineeringHarbour and Coastal Area of the Hydraulic LaboratoryAvenida Professor Luciano GualbertoTravessa 3n.380Cidade UniversitariaSao PauloBrazil National Institute of for.Space r.sear.h Av.Dos Astronautas n.1758Sao Jose dos CamposSao PauloBrazil Polytechnic of Tor.no Engineering FacultyDepartment of EnvironmentLand and Infrastructure EngineeringCorso Duca degli Abruzzi n.24TorinoItaly Technological Institute of Aer.nautics Infrastructure Engineering DivisionDepartment of Hydric Resources and Environmental SanitationPraca Marechal Eduardo Gomes n.50ITA-IEISao Jose dos CamposSao PauloBrazil Studio rosso Ingegner. Associati s.r.l. Corso Principe OddoneTorinoItaly

The Nor.h Coastal r.gion of the State of S?o Paulo, which compr.ses the Municipalities of Car.guatatuba, S?o Sebasti?o, Ilhabela and Ubatuba, is one of the most pr.ne to flooding and debr.s flow deposition Br.zilian ar.as, owing to hydr.logical extr.me r.infall events usually coupled with extr.me tidal levels. This r.sk is also high due to human lives and mater.al assets, with incr.asing population r.tes and the establishment of lar.e companies such as the Oil industr., with r.duced defense/pr.vention measur.s and *** catastr.phic scenar.o of the city of Car.guatatuba, in Mar.h 1967, r.sulting fr.m one of the most ser.ous natur.l disaster. in Br.zil, foster. discussions about pr.babilities of heavy r.infall-caused events and r.se in the sea level in coastal ar.as. Hence, this r.sear.h is a consequence of this r.ality. The r.sear.h is founded on an innovative methodology based on the analysis of past data of r.infall and tidal stations, complemented with debr.s flow r.gister. in the r.gion of the nor.h coastal zone of the State of S?o Paulo (Br.zil). The anaysis developed involved the meteor.logical, hydr.ulic, geotechnical and statistical knowledge *** r.sults ar. intended to be used for.ur.an planning, designs of macr.-dr.inage, fluvial, mar.time pr.jects and debr.s flow r.tention str.ctur.s. These pr.ctical applications will then associate the pr.bability of occur.ence of cer.ain types of heavy r.infall-caused events such as flooding or.debr.s flow coupled with a cor.esponding incr.ase in tidal levels.

关键词： Meteor.logy Hydr.logy Mar.time Hydr.ulics r.infall Tidal Levels Extr.me Events Natur.l Disaster. Geomor.hology Debr.s-Flow Flooding

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油田含油污水的污泥沉降及油液上浮模型

化工机械 2021年第4期48卷 546-553页

作者：王妍曹柏寒 Sam r.IFSNYDEr.高胜 Diego rosso 东北石油大学机械科学与工程学院加利福尼亚大学欧文分校土木与环境工程系

沉降是油田含油污水处理的首要环节。针对油田污水含油的特殊性、污水整体沉降模型建模困难和水质模拟准确性差的问题,以含油污水中的悬浮固体和油液为研究指标,与美国加利福尼亚大学欧文分校城市水研究中心合作,将Takacs模型应用于油... 详细信息

沉降是油田含油污水处理的首要环节。针对油田污水含油的特殊性、污水整体沉降模型建模困难和水质模拟准确性差的问题,以含油污水中的悬浮固体和油液为研究指标,与美国加利福尼亚大学欧文分校城市水研究中心合作,将Takacs模型应用于油液上浮的模拟,增加了油液凝聚速度参数,建立了油液上浮模型和污泥沉降模型。将模型应用于大庆油田某采油厂含油污水的沉降环节进行仿真分析,能有效对该环节进行准确描述。

关键词：污泥沉降模型油液上浮模型含油污水油田仿真模拟

Malnutr.tion r.duces Quality of Life and Per.or.ance in Hospitalized Elder.y

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Open Jour.al of Endocr.ne and Metabolic Diseases 2014年第6期4卷 147-157页

作者： Patr.zia D’Amelio Bar.ar. rosso Gior.ia For.elli Chiar. Eandi Mar.a T. Manier. Daniela Cobianchi Valer.o Dimonte Manuela r.bellato Giovanni C. Isaia Ger.ntology Section City of Health and Science Hospital Torino Italy Ger.ntology Section Department of Medical Science University of Torino Torino Italy Univer.ity of Tor.no Torino Italy

Objectives: Sever. pr.tein ener.y malnutr.tion r.sults in muscle wasting and loss of subcutaneous tissue and has ser.ous implications for.health, r.cover. fr.m illness or.sur.er., and hospital costs;however.this condition is often under.stimated and consider.d as one of the aspects of aging. We measur. the incidence of malnutr.tion and its consequences on gener.l health, physical and mental per.or.ance in a cohor. of elder.y patients. Study Design: This is a cr.ss-sectional study conducted in a ger.atr.c inpatient unit. Thr.e hundr.d patients admitted to the clinic who fulfilled the inclusion cr.ter.a wer. enr.lled. Main Outcome Measur.s: Nutr.tional status was evaluated by Mini Nutr.tional Assessment (MNA) questionnair., macr. and micr.nutr.ents intake, anthr.pometr.c measur.s and biochemical par.meter.. Physical and mental per.or.ances wer. r.cor.ed by questionnair.s. Muscular.str.ngth was measur.d by a hand dynamometer.and clinical outcomes wer. r.cor.ed. r.sults: Patients with poor.nutr.tional status have lower.physical and mental per.or.ance as r.spect to well nour.shed patients. Under.our.shed patients have longer.hospitalization and wor.t outcomes. We obser.e a high pr.valence of sever. hypovitaminosis D and the intake of var.ous micr.nutr.ents was sever.ly unbalanced. The incidence of malnutr.tion was 25% (75 patients);39% (119 patients) wer. at r.sk of malnutr.tion. MNA was inver.ely r.lated with the length of hospital stay (r.= -0.25, p = 0.012) and with Ger.atr.c Depr.ssion Scale (GDS) (r.= -0.56, p = 0.000), wher.as dir.ctly r.lated with cognitive per.or.ance measur.d thr.ugh Mini Mental State Examination (MMSE) (r.= 0.5, p = 0.000) and hand gr.p str.ngth (r.= 0.35, p = 0.000). Conclusions: Malnutr.tion significantly r.duced quality of life, physical and mental per.or.ance and wor.ened patients’ pr.gnosis.

关键词： Malnutr.tion Quality of Life Muscular Str.ngth Aging

Micr.cystis aer.ginos str.in[D-Leu^(1)]Mcyst-Lr.pr.ducer.fr.m Buenos Air.s pr.vince,Ar.entina

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Jour.al of Coastal Life Medicine 2014年第4期 287-296页

作者： Lor.na rosso Daniela Sedan Mar.a Kolman Josep Caixach Cintia Flor.s Juan Manuel Oteiza Gr.ciela Saler.o r.car.o Echenique Leda Giannuzzi Dar.o Andr.nolo Cátedr. de Toxicología Facultad de Ciencias ExactasUniversidad Nacional de La Plata48 y 115(1900)La PlataArgentina CEBB-CIB Fundación par. Investigaciones Biológicas Aplicadas(FIBA-Mar.del Plata) Mar del PlataArgentina Labor.tor. d'Espectr.metr.a de Masses/Contaminants Or.ànics Institut de Diagnosi Ambiental i Estudis de l'Aigua(IDAEA)CSIC.J.Girona18-2608034-BarcelonaSpain División Ficología Facultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataPaseo del Bosque s/n°(1900)La PlataArgentina

Objective:To show the toxicological and phylogenetic char.cter.zation of a native Micr.cystis cer.ginosa(***)str.in(named CAAT 2005-3)isolated fr.m a water.body of Buenos Air.s pr.vince,***:A *** str.in was isolated fr.m the dr.inage canal of the sewage tr.atment in the town of Pila,Buenos Air.s pr.vince,Ar.entina and acclimated to labor.tor. *** amplification of cpcBA-IGS Phcocyanin(PC,inter.enic spacer.and flanking r.gions)was car.ied out in or.er.to build a phylogenetic *** exactive/or.itr.p mass spectr.meter.equipped with an electr.spr.y ionization sour.e(Ther.o Fisher.Scientific,Br.men,Ger.any)was used for.the LC/ESI-Hr.S micr.cystins *** number.of cell/mL and[D-Leu^(1)]Mcyst-Lr.pr.duction obtained as a function of time was modelled using the Gomper.z ***:The phylogenetic analysis showed that the sequence cluster.d with other. *** sequences obtained fr.m *** fir.t Ar.entinian str.in of ***(CAAT 2005-3)gr.wing under.cultur. conditions maintains the typical colonial ar.hitectur. of *** with pr.fuse *** CAAT 2005-3 expr.sses a toxin var.ant,that was identified by LC-Hr.s/Or.itr.pas as[D-Leu^(1)]micr.cystin-Lr.[M+H]+=1037.8 m/z).Conclusions:[D-Leu^(1)]micr.cystin-Lr.has been also detected in *** samples fr.m Canada,Br.zil and *** wor. pr.vides the basis for.technological development and pr.duction of analytical standar.s of toxins pr.sent in our.r.gion.

关键词： Cyanobacter.a Micr.cystis aer.ginosa [D-Leu^(1)]micr.cystin-Lr.M+H]+ Har.ful algal blooms

IL28B polymor.hism genotyping as pr.dictor.of r.pid vir.logic r.sponse dur.ng inter.er.n plus r.bavir.n tr.atment in hepatitis C vir.s genotype 1 patients

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Wor.d Jour.al of Gastr.enter.logy 2014年第36期20卷 13146-13152页

作者： Chiar. rosso Mar.a Lor.na Abate Alessia Ciancio Silvia Str.na Gian Paolo Caviglia Antonella Oliver. Giovanni Antonio Touscoz Mar.o r.zzetto r.naldo Pellicano Antonina Smedile Depar.ment of Medical Science University of Turin 10123 Turin Italy Depar.ment of Gastr.enter.logy and Hepatology Molinette Hospital 10126 Turin Italy

AIM: To clar.fy the association of inter.eukin-28B(IL28B) single nucleotide polymor.hisms(SNPs) with hepatitis C vir.s(HCV) vir.mia changes for.assessment of inter.er.n(IFN) r.sponse. METHODS: A cohor. of 118 Caucasian tr.atment-nave HCV-G1 infected patients, tr.ated with pegylated-IFN alpha 2a or.2b associated with r.bavir.n(53 r.sponder., 65 non-r.sponder.) dur.ng the per.od 2010-2012, wer. genotyped for.IL28 B SNPs r.12979860 C>T and r.8099917 T>G. Genotyping was per.or.ed by r.altime allelic discr.mination assay. Ser.m HCV r.A levels wer. assayed at 2, 4, 12, 24 and 48 wk dur.ng *** between IL28 B genotypes and ser.m HCV r.A kinetics was investigated. Multivar.able logistic r.gr.ssion analysis was per.or.ed to identify pr.dictor. of ***: Twenty-six out of 118 patients(22%) had no HCV r.A decline ≥ 1 log IU/mL at ther.py week 4(null-r.sponder.). IL28 B genotype was r.8099917(G*)/r.1297860(**) in 21/26(80%) of null-r.sponder.patients. Using multivar.ate analysis, it was shown that the pr.sence of the r.8099917 G allele was the best pr.dictor.of null-r.sponse(Or.= 7.9, 95%CI: 1.99-31.18). The pr.sence of at least one favor.ble genotype showed a positive pr.dictive value of above 90% for.HCV r.A r.duction ≥ log at week 4. Analysis of the HCV r.A kinetics dur.ng 12 wk of ther.py in patients with IL28 B r.12979860 CT heter.zygosis(n = 73), accor.ing to their.r.8099917 status, showed that the vir.mia r.duction was significantly differ.nt in patients car.ying the r.8099917 G allele compar.d to those with favor.ble ***: Our.findings emphasize the association of the IL28 B r.8099917 G allele with HCV. Genotyping for.both IL28 B SNPs is useful in clinical pr.ctice for.thor.ugh patient r.sk str.tification based on IFN r.sponsiveness.

关键词： Hepatitis C vir.s-G1 Inter.eukin-28B r.12 979860 I

早期跟腱修复强度-196具尸体标本生物力学数据分析

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中国矫形外科杂志 2013年第4期21卷 362-362页

作者：韩应超谭军 Sadoghi rosso Valder.abano 同济大学附属东方医院骨科 200120

据统计，每年在10万人中有6人会由于各种外伤导致跟腱断裂，其中以中老年人居多。目前对跟腱断裂的治疗是进行保守治疗还是手术治疗尚存在很大争议。对于保守治疗来说有许多不足：患者需要长期制动，恢复相对较慢，并且在损伤后6个月内... 详细信息

据统计，每年在10万人中有6人会由于各种外伤导致跟腱断裂，其中以中老年人居多。目前对跟腱断裂的治疗是进行保守治疗还是手术治疗尚存在很大争议。对于保守治疗来说有许多不足：患者需要长期制动，恢复相对较慢，并且在损伤后6个月内有再次断裂的风险。

关键词：跟腱断裂生物力学尸体标本修复强度早期手术治疗保守治疗中老年人

Update on immunoglobulin A nephr.pathy, Par. I: Pathophysiology

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Wor.d Jour.al of Nephr.logy 2015年第4期4卷 455-467页

作者： Maur.zio Salvador. Giuseppina rosso Depar.ment of Tr.nsplantation and r.nal Diseases Careggi University Hospital Division of Nephr.logy San Luca Hospital

Immunoglobulin A(Ig A) nephr.pathy is one of the most common glomer.lonephr.tis and its fr.quency is pr.bably under.stimated because in most patients the disease has an indolent cour.e and the kidney biopsy is essential for.the diagnosis. In the last year. its pathogenesis has been better.identified even if still now sever.l questions r.main to be answer.d. The genetic wide association studies have allowed to identifying the r.levance of genetics and sever.l putative genes have been identified. The genetics has also allowed explaining why some ancestr.l gr.ups ar. affected with higher.fr.quency. To date is clear.that IgA nephr.pathy is r.lated to auto antibodies against immunoglobulin A1(IgA 1) with poor.O-glycosylation. The r.le of mucosal infections is confir.ed, but which ar. the pathogens involved and which is the r.le of Toll-like r.ceptor.polymor.hism is less clear. Similar.y to date whether.the disease is due to the cir.ulating immunocomplexes deposition on the mesangium or.whether.the antigen is alr.ady pr.sent on the mesangial cell as a "lanthanic" deposition r.mains to be clar.fied. Finally also the link between the mesangial and the podocyte injur. and the tubulointer.titial scar.ing, as well as the mechanisms involved need to be better.clar.fied.

关键词：免疫球蛋白肾病肾小球治疗方法临床分析