检索结果-南通市图书馆

FSH dosage effect on conventional sperm parameters:a meta-analysis of randomized controlled studies

Asian Journal of Andrology 2020年第3期22卷 309-316页

作者： rossella cannarella Sandro La Vignera Rosita A Condorelli Laura M Mongioi Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy.

Follicle-stimulating hormone(FSH)represents a therapeutic option in normogonadotropic patients with idiopathic *** aim of this review was to evaluate the possible dose-and drug-dependent efficacy of FSH treatment on conventional sperm *** performed a comprehensive systematic review via a meta-analysis of all available randomized controlled trials,in which FSH administration was compared with placebo or no treatment when administered to normogonadotropic patients with idiopathic *** the 971 articles that were retrieved,5 were fin ally included,in eluding a total of 372 patie nts and 294 ***,FSH treatment was effective in ameliorating the sperm concentration,total count,progressive motility,but not normal *** the basis of the weekly dosage,the studies were classified into those using low(175-262.5 IU per week),intermediate(350-525 IU per week),and high(700-1050 IU per week)*** low doses,FSH improved only sperm *** intermediate doses,FSH ameliorated sperm concentration and *** sperm count and progressive motility showed a trend toward the *** high doses,FSH increased sperm concentration,total sperm count,and progressive *** morphology showed a trend toward the ***,both highly purified FSH(hpFSH)and recombinant human FSH(rhFSH)improved sperm concentration,total sperm count,progressive motility,but not *** different efficacy was observed between these two *** meta-analysis provides evidence in favor of high FSH *** FSH efficacy was not related to the preparation type(recombinant vs highly purified).Further studies are needed to evaluate the effectiveness of Iong-standing treatment regimes.

关键词： follicle-stimulati ng hormone male in fertility oligozoospermia sperm concen tration sperm count

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Anejaculation in a patient with Charcot-Marie-Tooth

引用

Asian Journal of Andrology 2018年第5期20卷 529-530页

作者： rossella cannarella Giovanni Burgio Sandro La Vignera Enzo S Vicari Aldo E Calogero Department of Clinical and Experimental Medicine University of Catania Catania95123 Italy

Dear Editor,The occurrence of delayed ejaculation or ane）aculation has been previously suggested in patients with Charcot-Marie-Tooth （CMT） syndrome.1 Despite this, such disorder is rarely investigated and may be underestimated in patients with this disease. We report the case of a 20-year-old men with CMT 1B due to the presence of a punctiform mutation in the exon 2 of the myelin protein zero （MPZ） gene （ 1 q23.3）（Ser78Leu）, complaining for life-long anejaculation. He inherited this mutation from the mother and it has also been detected in his grandmother. No other components of his family were positive at the genetic testing.

关键词：

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Predictive parameters of the efficacy of varicocele repair: a review

引用

Asian Journal of Andrology 2024年第5期26卷 441-450页

作者： Andrea Crafa rossella cannarella Rosita A Condorelli Laura M Mongioì Sandro La Vignera Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Glickman Urology and Kidney Institute Cleveland ClinicClevelandOH 44195USA

Varicocele has a prevalence of 15%in the population and represents a primary cause of infertility in 40%of cases and a secondary cause in approximately 80%of *** is considered the major correctable cause of male *** its high prevalence in the infertile population,a large number of patients with varicocele do not experience reproductive *** this reason,it is still highly debated which parameters could be used to predict which patients with varicocele will be most likely to benefit from its *** main international and European guidelines state that treatment should only be considered in infertile patients with abnormal sperm ***,these guidelines do not help physicians to identify which of these patients may benefit from the ***,this narrative review collects the evidence in the literature on the usefulness of some factors as predictors of improvement,highlighting how some of them may be effective in an initial selection of patients to be treated,while others are promising but further studies are ***,a brief consideration on the possible role of artificial intelligence is proposed.

关键词： artificial intelligence predictive parameters varicocele varicocele repair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Next-generation sequencing:toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure

引用

Asian Journal of Andrology 2021年第1期23卷 24-29页

作者： rossella cannarella Rosita A Condorelli Stefano Paolacci Federica Barbagallo Giulia Guerri Matteo Bertelli Sandro La Vignera Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy MAGI EUREGIO Bolzano 39100Italy

A large proportion of patients with idiopathic spermatogenic failure(SPGF;oligozoospermia or nonobstructive azoospermia[NOA])do not receive a diagnosis despite an extensive diagnostic *** evidence has shown that the etiology remains undefined in up to 75%of these patients.A number of genes involved in germ-cell proliferation,spermatocyte meiotic divisions,and spermatid development have been called into play in the pathogenesis of idiopathic oligozoospermia or ***,this evidence mainly comes from case ***,this study was undertaken to identify the molecular causes of *** accomplish this,15 genes(USP9Y,NR5A1,KLHL10,ZMYND15,PLK4,TEX15,TEX11,MEIOB,SOHLH1,HSF2,SYCP3,TAF4B,NANOS1,SYCE1,and RHOXF2)involved in idiopathic SPGF were simultaneously analyzed in a cohort of 25 patients with idiopathic oligozoospermia or NOA,accurately selected after a thorough diagnostic *** next-generation sequencing(NGS)analysis,we identified the presence of rare variants in the NR5A1 and TEX11 genes with a pathogenic role in 3/25(12.0%)*** other different variants were identified,and among them,13 have never been reported *** out of 17 variants were likely pathogenic and deserve functional or segregation *** genes most frequently mutated were MEIOB,followed by USP9Y,KLHL10,NR5A1,and *** alterations were found in the SYCP3,TAF4B,NANOS1,SYCE1,or RH0XF2 *** conclusion,NGS technology,by screening a specific custom-made panel of genes,could help increase the diagnostic rate in patients with idiopathic oligozoospermia or NOA.

关键词： azoospermia next-generation sequencing oligozoospermia spermatogenetic failure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Artificial intelligence in andrology-fact or fiction:essential takeaway for busy clinicians

引用

Asian Journal of Andrology 2024年第6期26卷 600-604页

作者： Aldo E Calogero Andrea Crafa rossella cannarella Ramadan Saleh Rupin Shah Ashok Agarwal Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Global Andrology Forum Moreland HillsOH 44022USA Glickman Urological and Kidney Institute Cleveland Clinic FoundationClevelandOH 44195USA Department of Dermatology Venereology and AndrologyFaculty of MedicineSohag UniversitySohag 82524Egypt Ajyal IVF Center Ajyal HospitalSohag 82511Egypt Division of Andrology Department of UrologyLilavati Hospital and Research CentreMumbai 400050India Cleveland Clinic Foundation ClevelandOH 44195USA

Artificial intelligence (AI) is revolutionizing the current approach to medicine. AI uses machine learning algorithms to predict the success of therapeutic procedures or assist the clinician in the decision-making process. To date, machine learning studies in the andrological field have mainly focused on prostate cancer imaging and management. However, an increasing number of studies are documenting the use of AI to assist clinicians in decision-making and patient management in andrological diseases such as varicocele or sexual dysfunction. Additionally, machine learning applications are being employed to enhance success rates in assisted reproductive techniques (ARTs). This article offers the clinicians as well as the researchers with a brief overview of the current use of AI in andrology, highlighting the current state-of-the-art scientific evidence, the direction in which the research is going, and the strengths and limitations of this approach.

关键词： andrology artificial intelligence assisted reproductive technique machine learning male infertility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Testosterone replacement therapy and vascular thromboembolic events: a systematic review and meta-analysis

引用

Asian Journal of Andrology 2024年第2期26卷 144-154页

作者： rossella cannarella Carmelo Gusmano Claudia Leanza Vincenzo Garofalo Andrea Crafa Federica Barbagallo Rosita A Condorelli Sandro La Vignera Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Glickman Urological&Kidney Institute Cleveland Clinic FoundationClevelandOH44195USA

To evaluate the relationship between testosterone replacement therapy(TRT)and arterial and/or venous thrombosis in patients with pre-treatment total testosterone(TT)<12 nmol I^(-1),we performed a meta-analysis following the Population Intervention Comparison Outcome ***:men with TT<12 nmol I^(-1) or clear mention of hypogonadism in the inclusion criteria of patients;intervention:TRT;comparison:placebo or no therapy;outcomes:arterial thrombotic events(stroke,myocardial infarction[MI],upper limbs,and lower limbs),VTE(deep vein thrombosis[DVT],portal vein thrombosis,splenic thrombosis,and pulmonary embolism),and mortality.A total of 2423 abstracts were assessed for ***-four studies,including 14 randomized controlled trials(RCTs),were finally included,with a total of 4027 and 310288 hypotestosteronemic male patients,from RCTs and from observational studies,*** on RCT-derived data,TRT did not influence the risk of arterial thrombosis(odds ratio[OR]=1.27,95%confidence interval[CI]:0.47-3.43,P=0.64),stroke(OR=1.34,95%CI:0.09-18.97,P=0.83),MI(OR=0.51,95%CI:0.11-2.31,P=0.39),VTE(OR=1.42,95%CI:0.22-9.03,P=0.71),pulmonary embolism(OR=1.38,95%CI:0.27-7.04,P=0.70),and mortality(OR=0.70,95%CI:0.20-2.38,P=0.56).Meanwhile,when only observational studies are considered,a significant reduction in the risk of developing arterial thrombotic events,Ml,venous thromboembolism,and mortality was *** risk for DVT remains uncertain,due to the paucity of RCT-based *** in men with TT<12 nmol I^(-1) is safe from the risk of adverse cardiovascular *** studies specifically assessing the risk of DVT in men on TRT are needed.

关键词： hypogonadism testosterone testosterone replacement therapy thromboembolism thrombosis TRT

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

SOX13 gene downregulation in peripheral blood mononuclear cells of patients with Klinefelter syndrome

引用

Asian Journal of Andrology 2021年第2期23卷 157-162页

作者： rossella cannarella Michele Salemi Rosita A Condorelli Laura Cimino Giorgio Giurato Giovanna Marchese Angela Cordella Corrado Romano Sandro La Vignera Aldo E Calogero Department of Clinical and Experimental Medicine University of CataniaCatania 95123Italy Oasi Research Institute-IRCCS Troina(EN)94018Italy Genomix4Life Srl Department of MedicineSurgery and Dentistry“Schola Medica Salernitana”University of SalernoBaronissi(SA)84081Italy

Klinefelter syndrome(KS)is the most common sex chromosome disorder in *** is characterized by germ cell loss and other variable clinical features,including *** sex-determining region of Y(SRY)-box 13(Sox13)gene is expressed in mouse *** addition,it has been identified as islet cell autoantigen 12(ICA12),which is involved in the pathogenesis of autoimmune diseases,including type 1 diabetes mellitus(DM)and primary biliary ***13 expression has never been investigated in patients with *** this age-matched,case-control study performed on ten patients with KS and ten controls,we found that SOX13 is significantly downregulated in peripheral blood mononuclear cells of patients with KS compared to *** finding might be consistent with the germ cell loss typical of patients with ***,the role of SOX13 in the pathogenesis of germ cell loss and humoral autoimmunity in patients with KS deserves to be further explored.

关键词： germ cells intellectual disability Klinefelter syndrome rare disease sex-determining region of Y-box 13(SOX13)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：