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研究,跨界,哲思采访如恩设计研究室

室内设计与装修 2021年第S2期 112-117页

作者：郭小溪(整理) 郭锡恩胡如珊不详

研究作为设计的工具作为一所多元化设计研究室,研究在如恩(Neri&Hu)的设计过程中起着怎样的作用?在我们看来,设计师、建筑师时常会被设计搞到焦头烂额。因为他们需要在很短的时间里,迅速直观地完成设计,以至于设计师没有充分、足够的时... 详细信息

研究作为设计的工具作为一所多元化设计研究室,研究在如恩(Neri&Hu)的设计过程中起着怎样的作用?在我们看来,设计师、建筑师时常会被设计搞到焦头烂额。因为他们需要在很短的时间里,迅速直观地完成设计,以至于设计师没有充分、足够的时间去思考设计背后的东西。但我们确实需要一定的时间来思考自己的设计。

关键词：多元化设计建筑师设计师研究室思考

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灯笼韩国雪花秀旗舰店

室内设计与装修 2016年第7期 18-21页

作者： lyndon neri rossana hu Anne-Charlotte Wiklander Sela Lim Yinan Li Kailun Sun Brian Lo Nicolas Fardet Christine Neri Haiou Xin Litien Poeng pedro pegenaute(摄影) 无不详如恩设计研究室

全新的亚洲著名护肤品牌雪花秀首家旗舰店,位于韩国首尔江南区一座五层高的大楼内.这座大楼始建于2003年,由韩国建筑师承孝相设计.雪花秀希望借助此次的改造,能更好地发扬雪花秀历史,向消费者传达雪花秀品牌的理念.

关键词：旗舰店雪花韩国灯笼护肤品牌建筑师消费者大楼

Benefit of stem cells and skeletal myoblast cells in dilated cardiomyopathies

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World Journal of Cardiology 2011年第3期3卷 93-97页

作者： Luiz César Guarita-Souza Júlio César Francisco rossana Simeoni Jose Rocha Faria-Neto Katherine Athayde Teixeira de Carvalho Department of Post Graduation Surgery Pontifical Catholic University of Parana The PeléPequeno Príncipe Institute Child and Adolescent Health Research and Pequeno Príncipe Faculty

Although some authors suggest that there is mitotic division in the heart,most cardiomyocytes do not have the capacity to regenerate after myocardial infarction and when this occurs there is a deterioration of contractile function,and if the area of infarction is extensive ventricular remodeling may occur,leading to the development of heart *** transplantation into the myocardium with the goal of recovery of cardiac function has been extensively studied in recent years. The effects of cell therapy are based directly on the cell type used and the type of cardiac *** myocardial ischemia in the hibernating myocardium, bone marrow cells have functional benefits,however these results in transmural fibrosis are not evident. In these cases there is a benefit of implantation with skeletal myoblasts,for treating the underlying cause of disease,the loss of cell contractility.

关键词： Cell transplantation Cardiomyopathy Skeletal myoblasts Stem cells

Implantable(Bio)sensors as new tools for wireless monitoring of brain neurochemistry in real time

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World Journal of Pharmacology 2014年第1期3卷 1-17页

作者： Donatella Farina Maria D Alvau Giulia Puggioni Giammario Calia Gianfranco Bazzu rossana Migheli Ottavio Sechi Gaia Rocchitta Maria S Desole Pier Andrea Serra Department of Clinical and Experimental Medicine Medical School University of Sassari

Implantable electrochemical microsensors are characterized by high sensitivity, while amperometric biosensors are very selective in virtue of the biological detecting element. Each sensor, specific for every neurochemical species, is a miniaturized hightechnology device resulting from the combination of several factors: electrode material, shielding polymers, applied electrochemical technique, and in the case of biosensors, biological sensing material, stabilizers, and entrapping chemical nets. In this paper, we summarizethe available technology for the in vivo electrochemical monitoring of neurotransmitters(dopamine, norepinephrine, serotonin, acetylcholine, and glutamate), bioenergetic substrates(glucose, lactate, and oxygen), neuromodulators(ascorbic acid and nitric oxide), and exogenous molecules such as ethanol. We also describe the most represented biotelemetric technologies in order to wirelessly transmit the signals of the abovelisted neurochemicals. Implantable(Bio)sensors, integrated into miniaturized telemetry systems, represent a new generation of analytical tools that could be used for studying the brain's physiology and pathophysiology and the effects of different drugs(or toxic chemicals such as ethanol) on neurochemical systems.

关键词：微传感器药物治疗治疗方法临床分析

注意力缺陷/多动症和儿童期自闭症与产前暴露于全氟烷基物质之间的关联:丹麦全国出生队列的一项巢式病例对照研究

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环境与职业医学 2015年第10期32卷 920-920页

作者： Zeyan Liew Beate Ritz Ondine S.von Ehrenstein Bodil Hammer Bech Ellen Aagaard Nohr Chunyuan Fei rossana Bossi Tine Brink Henriksen Eva Cecilie Bonefeld-Jφrgensen Jφrn Olsen

[背景]全氟烷基物质(PFASs)是持久性污染物,动物实验中具有内分泌干扰性和神经毒性。一些横断面数据显示PFASs与儿童神经行为的问题之间存在正向关联,但是来自前瞻性研究的结果仍然有限。[目的]研究产前暴露于PFASs是否与儿童中的注意... 详细信息

[背景]全氟烷基物质(PFASs)是持久性污染物,动物实验中具有内分泌干扰性和神经毒性。一些横断面数据显示PFASs与儿童神经行为的问题之间存在正向关联,但是来自前瞻性研究的结果仍然有限。[目的]研究产前暴露于PFASs是否与儿童中的注意力缺陷/多动障碍(ADHD)或儿童期自闭症之间有关联。[方法]在1996—2002年丹麦全国出生队列的83 389对母子中,根据丹麦国家医院登记和丹麦精神病中心登记,确定了890名ADHD病例和301名儿童自闭症病例。从这个队列中,随机各选择220例多动症和自闭症病例,并随机选择550例性别相匹配的对照儿童。测量在妊娠早期或中期采集的母体血浆中16种PFASs,使用广义线性模型计算风险比(RRs),模型中考虑到了抽样权重。[结果]在所有样品中均检测到全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA),在≥90%的样本中可以定量其他4种PFASs。没有发现母亲PFAS血浆水平和ADHD之间关联的一致性证据[浓度(ng/m L)的自然对数值每增加一个单位,PFOS对应的RR=0.87(95%CI:0.74,1.02),PFOA对应的RR=0.98(95%CI:0.82,1.16)],对于自闭症也是如此[浓度(ng/m L)的自然对数每增加一个单位,PFOS对应的RR=0.92(95%CI:0.69,1.22),PFOA对应的RR=0.98(95%CI:0.73,1.31)]。在同时校正所有PFASs的模型中,较高的PFAS分位数和ADHD之间既有阳性关联也有阴性关联,但是这些关联的估计值并不精确。[结论]在这项研究中,没有发现一致性的证据能够提示产前PFAS暴露增加儿童中ADHD或儿童期自闭症儿的风险。

关键词：巢式病例对照研究儿童自闭症注意力缺陷出生队列产前暴露儿童期多动症丹麦

Vocational Training and Basic Knowledge of the Mexican University Coach

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Journal of Sociology Study 2015年第3期5卷 232-244页

作者： Ciria Margarita Salazar Julio Alejandro Gomez Figueroa Martha Patricia Perez Lopez CarmenSilvia Vargas Pena Pedro Julian Flores Moreno rossana Tamara Medina Valencia Jose E. Del RioValdivi Jose Aldo Hernandez-Murua University of Colima Mexico University of Veracruz Mexico Autonomous University of Sinaloa Mexico

This paper shows an overview of the academic and vocational training of the Mexican university coaches. Professional sports in Mexico are not sufficiently organized in all disciplines and the Olympic sporting system does not consider the university sports as a hotbed of world‐class athletes. Coaches" academic and vocational training is one of the variables to analyze university‐sporting level. A quantitative model was used to approach the topic through an adapted and validated version of a questionnaire used in Spanish populations. The sample consisted of 326 participant"s coaches at the 2013 National Student Games. Among the findings, observed there are some aspects revealed related to the training, the domain of knowledge and the existing relationship between an empirical coach and a trained one. In conclusion, therefore, it is important to emphasize that the non‐skilled trainer finds it difficult to achieve the optimum sport development, the fulfillment of the assigned tasks, the selection, the dosage, the linking of different means, and the assessment of achievement. According to the national sport level, the university trainer"s profile neither allows the consolidation of practice nor these ages and sport levels.

关键词：职业培训教练员墨西哥大学知识体育运动运动系统奥林匹克

Clinical epidemiology of chronic viral hepatitis B:A Tuscany real-world large-scale cohort study

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World Journal of Hepatology 2018年第5期10卷 409-416页

作者： Cristina Stasi Caterina Silvestri Roberto Berni Maurizia rossana Brunetto Anna Linda Zignego Cristina Orsini Stefano Milani Liana Ricciardi Andrea De Luca Pierluigi Blanc Cesira Nencioni Donatella Aquilini Alessandro Bartoloni Giampaolo Bresci Santino Marchi Franco Filipponi Piero Colombatto Paolo Forte Andrea Galli Sauro Luchi Silvia Chigiotti Alessandro Nerli Giampaolo Corti Rodolfo Sacco Paola Carrai Angelo Ricchiuti Massimo Giusti Paolo Almi Andrea Cozzi Silvia Carloppi Giacomo Laffi Fabio Voller Francesco Cipriani Observatory of Epidemiology Regional Health Agency of TuscanyFlorence 50141Italy Center for Systemic Manifestations of Hepatitis Viruses(MaSVE) Internal Medicine and Liver UnitDepartment of Experimental and Clinical MedicineCareggi University HospitalFlorence 50134Italy Web Solutions Data Visualization and Scientific DocumentationRegional Health Agency of TuscanyFlorence 50141Italy Hepatology Unit Department of Clinical and Experimental MedicineUniversity Hospital of PisaPisa 56100Italy Gastroenterology Research Unit Department of Experimental and Clinical Biomedical Sciences“Mario Serio”Careggi University HospitalFlorence 50134Italy Infectious Disease Unit Hospital of LuccaLucca 55100Italy Infectious Diseases Unit Department of Medical BiotechnologiesSiena University HospitalSiena 53100Italy Infectious Disease Unit “S.Maria Annunziata”HospitalPonte a Niccheri 50012Italy Infectious Disease Unit Hospital of GrossetoGrosseto 58100Italy Infectious Disease Unit Hospital of PratoPrato 59100Italy Infectious and Tropical Diseases Unit Department of Experimental and Clinical MedicineCareggi University HospitalFlorence 50134Italy Gastroenterology and Metabolic Disorders Department of SurgeryCisanello University HospitalPisa 56100Italy Gastroenterology Unit Department of Translational Research and New Technologies in Medicine and SurgeryCisanello University Hospital of PisaPisa 56100Italy Liver Surgery and Transplantation Unit Department of Surgical PathologyMedicineMolecular and Critical AreaCisanello University HospitalPisa 56100Italy Internal Medicine Unit “San Jacopo”HospitalPistoia 51100Italy Infectious Diseases and Hepatology Unit Department of Internal and Specialized MedicineUniversity Hospital of SienaSiena 53100Italy Gastroenterology Unit San Giuseppe HospitalEmpoli 50053Italy Internal Medicine and Liver Unit Department of Experimental and Clinical MedicineCareggi University HospitalFlorence 50135Italy Department of Prevention Central Tuscany Local UnitFlorence 5

AIM To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus(HBV)-infected patients in the Tuscan public health care *** This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation. RESULTS Of 4015 chronic viral hepatitis patients, 1096(27.3%) were HBV infected. The case report form was correctly completed for only 833 patients(64% males, 36% females; mean age 50.1 ± 15.4). Of these HBV-infected patients, 73% were Caucasian, 21% Asian, 4% Central African, 1% North African and 1% American. Stratifying patients by age and nationality, we found that 21.7% of HBV-infected patients were aged < 34 years(only 2.8% were Italian). The most represented routes of transmission were nosocomial/dental procedures(23%), mother-to-child(17%) and sexual transmission(12%). The most represented HBV genotypes were D(72%) and A(14%). Of the patients, 24.7% of patients were HBe Ag positive, and 75.3% were HBe Ag negative. Of the HBV patients 7% were anti-HDV positive. In the whole cohort, 26.9% were cirrhotic(35.8% aged < 45 years), and 47% were eligible for or currently undergoing treatment, of whom 41.9 % were cirrhotic. CONCLUSION Only 27.3% of chronic viral hepatitis patients were HBV infected. Our results provide evidence of HBV infection in people aged < 34 years, especially in the foreign population not protected by vaccination. In our cohort of patients, liver cirrhosis was also found in young adults.

关键词： Hepatitis B virus infection Liver fibrosis Cirrhosis Public health Epidemiology

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君山美学生活馆

世界建筑导报 2020年第5期35卷 120-124页

作者：郭锡恩胡如珊杨延蕙郭鹏 Utsav Jain Ellen Chen Zoe Gao Wuyahuang Li Josh Murphy Alexandra Heijink Hwajung Song Lara Depedro Jason Jia 鲁永新陈晓雯 Mona He Cindy Sun Jacqueline Yam 不详

“居民们不必因为每天都走在同样的街道而感到无聊…道路的脉络不仅存在于单一的维度,而是沿着上下起伏的梯台、拱桥和悬浮着的街道多维度地编织,结合各种不同的路线,或在高处、或在地面,每一个人每天都可以尝试用新的路线到达同一个目... 详细信息

“居民们不必因为每天都走在同样的街道而感到无聊…道路的脉络不仅存在于单一的维度,而是沿着上下起伏的梯台、拱桥和悬浮着的街道多维度地编织,结合各种不同的路线,或在高处、或在地面,每一个人每天都可以尝试用新的路线到达同一个目的地的乐趣。”——伊塔洛•卡尔维诺,《看不见的城市》阳光城君山美学生活馆坐落于北京市郊群山起伏、河流蜿蜒的密云水库附近。曾经的文化中心只是一栋两层高的普通售楼处,改造后将转变为一个具有会所和销售功能的地标性文化中心。如恩在原有的庭院建筑类型的基础上,设计了两段交错的路线,划分出两段不同的旅程:一段供高尔夫俱乐部的会员使用,另一段用于销售中心的客户。每一个空间设计都紧贴自然为本的概念,主庭院和小花园之间的层次让建筑与自然和谐相融。

关键词：高尔夫俱乐部北京市郊卡尔维诺群山起伏上下起伏庭院建筑销售功能阳光城