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The challenge of molecular selection in liver-limited metastatic colorectal cancer for surgical resection: a systematic review and meta-analysis in the context of current and future approaches

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Oncology Research 2024年第9期32卷 1407-1422页

作者： rossana RONCATO JERRY POLESEL FEDERICA TOSI ELENA PERUZZI ERIKA BRUGUGNOLI CLAUDIA LAURIA PANTANO MARIA FURFARO FILIPPO DI GIROLAMO ALESSANDRO NANI ARIANNA PANI NOEMI MILAN ELENA DE MATTIA ANDREA SARTORE-BIANCHI ERIKA CECCHIN Experimental and Clinical Pharmacology Unit Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Medicine(DMED) University of UdineUdine33100Italy Unit of Cancer Epidemiology Centro di Riferimento Oncologico di Aviano(CRO)IRCCSAviano33081Italy Department of Oncology and Hemato-Oncology Universitàdegli Studi di MilanoMilan20122Italy Department of Hematology Oncologyand Molecular MedicineGrande Ospedale Metropolitano NiguardaMilan20122Italy Oncology Pharmacy Unit IRCCS Istituto Romagnolo per lo Studio dei Tumori Dino AmadoriMeldola47014Italy Pharmacy Unit Fondazione IRCCS Istituto Tumori di MilanoMilan20122Italy Department of Pharmacy Ca’Foncello Treviso Regional HospitalPiazzale Ospedale 1Treviso31100Italy Department of Medical Surgical and Health Sciences University of TriesteTrieste34127Italy Hospital Pharmacy Cattinara HospitalAzienda Sanitaria Universitaria Giuliano IsontinaTrieste34148Italy Department of Oncology and Onco-Hematology Postgraduate School of Clinical Pharmacology and ToxicologyUniversity of MilanMilan20122Italy

Objectives:Treatment of metastatic colorectal cancer(mCRC)includes resection of liver metastases(LM),however,no validated biomarker identifies patients most likely to benefit from this *** meta-analysis aimed to assess the impact of the most relevant molecular alterations in cancer-related genes of CRC(i.e.,RAS,BRAF,SMAD4,PIK3CA)as prognostic markers of survival and disease recurrence in patients with mCRC surgically treated by LM ***:A systematic literature review was performed to identify studies reporting data regarding survival and/or recurrence in patients that underwent complete liver resection for CRC LM,stratified according to RAS,BRAF,PIK3CA,and SMAD4 mutational *** ratios(HRs)from multivariate analyses were pooled in the meta-analysis and various adjustment strategies for confounding factors were *** search was conducted in numerous databases,including MEDLINE(PubMed),Embase,Cumulative Index to Nursing and Allied Health Literature(CINAHL)(EBSCO host),and WHO Global Index Medicus,through March 18th,***-analyses,editorials,letters to the editor,case reports,studies on other primary cancers,studies with primary metastatic sites other than the liver,studies lacking specific oncological outcome variables or genetic data,non-English language studies,and studies omitting residual disease data from liver metastasectomy were *** remaining 47 studies were summarized in a descriptive table which outlines the key characteristics of each study and final results were graphically ***:RAS mutation status was negatively associated with overall survival(OS)(HR,1.68;95%CI,1.54–1.84)and recurrence free survival(RFS)(HR,1.46;95%CI,1.33–1.61).A negative association was also found for BRAF regarding OS(HR,2.64;95%CI,2.15–3.24)and RFS(HR,1.89;95%CI,1.32–2.73)and SMAD4 regarding OS(HR,1.93;95%CI,1.56–2.38)and RFS(HR,1.95;95%CI,1.31–2.91).For PIK3CA only three studies were eligible and no significant associati

关键词： Metastasectomy Liver metastases RAS BRAF SMAD4 PIK3CA Colorectal

Using Optical Tweezers to Study the Friction of the Red Blood Cells

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Advances in Bioscience and Biotechnology 2024年第2期15卷 100-111页

作者： Edoukoua Jean Michel Konin Pavel Yale abadê Ange-Boris N’guessan Kouassi Benoit Kouakou Abaka Michel Kouacou Eugene Megnassan Département des Sciences et Techniques Université Alassane Ouattara Bouaké C&#244te d’Ivoire Laboratoire d’Instrumentation Image et Spectroscopie (L2IS) Institut National Polytechnique Félix Houphou&#235t-Boigny (INPHB) Yamoussoukro C&#244te d’Ivoire Classes préparatoires aux grandes Ecoles Université de San Pedro San Pedro C&#244te d’Ivoire Laboratoire de Physique Fondamentale et Appliquée Université Nangui Abrogoua (UNA) Abidjan C&#244te d’Ivoire

In the last two decades the study of red blood cell elasticity using optical tweezers has known a rise appearing in the scientific research with regard to the various works carried out. Despite the various work done, no study has been done so far to study the influence of friction on the red blood cell indentation response using optical tweezers. In this study, we have developed a new approach to determine the coefficient of friction as well as the frictional forces of the red blood cell. This approach therefore allowed us to simultaneously carry out the indentation and traction test, which allowed us to extract the interfacial properties of the microbead red blood cell couple, among other things, the friction coefficient. This property would be extremely important to investigate the survival and mechanical features of cells, which will be of great physiological and pathological significance. But taking into account the hypothesis of friction as defined by the isotropic Coulomb law. The experiment performed for this purpose is the Brinell Hardness Test (DB).

关键词： Friction Indentation Optical Tweezers Tribology Red Blood Cells

Association between Helicobacter pylori infection,mismatch repair,HER2 and tumor-infiltrating lymphocytes in gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2487-2503页

作者： Carlos A Castaneda Miluska Castillo Luis A Bernabe Joselyn Sanchez Matteo Fassan Katherine Tello Ignacio Ivan Wistuba Ivan Chavez Passiuri Eloy Ruiz Juvenal Sanchez Fernando Barreda Daniel Valdivia Yaqueline Bazan Milagros abad-Licham Claudio Mengoa Hugo Fuentes Paola Montenegro Ebert Poquioma Raul Alatrista Claudio J Flores Luis Taxa Faculty of Health Sciences Universidad Cientifica del SurLima 15038Peru GECO PERU Grupo de Estudios Clinicos Oncologicos del PeruLima 15038Peru Department of Research Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Faculty of Human Medicine Universidad Ricardo PalmaLima 15039Peru Department of Medicine Surgical Pathology&Cytopathology UnitUniversity of PaduaPadua 35121Italy Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTX 77030United States Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Specialties Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Regional de Enfermedades Neoplasicas del NorteTrujillo 13001Peru Faculty of Human Medicine Universidad Privada Antenor OrregoTrujillo 13008Peru Department of Surgery Instituto Regional de Enfermedades Neoplasicas del SurArequipa 04002Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Epidemiology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unidad de Investigación Básica y Traslacional Oncosalud-AUNALima 15038Peru Faculty of Medicine Universidad San Martin de PorresLima 15008Peru

BACKGROUND The influence of Helicobacter-pylori(***)infection and the characteristics of gastric cancer(GC)on tumor-infiltrating lymphocyte(TIL)levels has not been extensively *** of infiltrating-immune-cell subtypes as well as survival is necessary to obtain comprehensive *** To determine the rates of deficient mismatch-repair(dMMR),HER2-status and *** infection and their association with TIL levels in *** Samples from 503 resected GC tumors were included and TIL levels were evaluated following the international-TILs-working-group recommendations with assessment of the intratumoral(IT),stromal(ST)and invasive-border(IB)*** density of CD3,CD8 and CD163 immune cells,and dMMR and HER2-status were determined by immunohistochemistry(IHC).*** infection was evaluated by routine histology and quantitative PCR(qPCR)in a subset of *** dMMR was found in 34.4%,HER2+in 5%and ***-positive in 55.7%of *** IT-TIL was associated with grade-3(P=0.038),while ST-TIL with grade-1(P<0.001),intestinal-histology(P<0.001)and no-recurrence(P=0.003).dMMR was associated with high TIL levels in the ST(P=0.019)and IB(P=0.01)compartments,and STCD3(P=0.049)and ST-CD8(P=0.05)***2-was associated with high IT-CD8(P=0.009).*** was associated with high IT-TIL levels(P=0.009)when assessed by routine-histology,and with high TIL levels in the 3 compartments(P=0.002-0.047)and CD8 density in the IT and ST compartments(P=0.001)when assessed by qPCR.A longer overall survival was associated with low IT-CD163(P=0.003)and CD8/CD3(P=0.001 in IT and P=0.002 in ST)and high IT-CD3(P=0.021),ST-CD3(P=0.003)and CD3/CD163(P=0.002).CONCLUSION TIL levels were related to dMMR and *** CD8/CD3 and high CD163/CD3 were associated with lower recurrence and longer survival.

关键词： Lymphocytes Macrophages Gastric cancer Helicobacter pylori HER2 Mismatch repair

Human Eosinophil Cell Manipulation by Optical Tweezers

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Open Journal of Biophysics 2024年第3期14卷 330-338页

作者： Pavel Yale Jean Michel Edoukoua Konin abadê Ange-Boris N’guessan Michel Abaka Kouacou Jérémie T. Zoueu Laboratoire dInstrumentation Image et Spectroscopie (L2IS) Institut National Polytechnique Houphout-Boigny (INPHB) Yamoussoukro Cte dIvoire Laboratoire de Chimie et de Physique Appliques Sciences et Techniques Universit Alassane Ouattara Bouak Cte dIvoire

In this work, lateral deformation of human eosinophil cell during the lateral indentation by an optically trapped microbead of diameter 4.5 µm is studied. The images were captured using a CCD camera and the Boltzmann statistics method was used for force calibration. Using the Hertz model, we calculated and compared the elastic moduli resulting from the lateral force, showing that the differences are important and the force should be considered. Besides the lateral component, the setup also allows us to examine the lateral cell-bead interaction. The mean values of the properties obtained, in particular the elastic stiffness and the shear stiffness, were Eh = (37.76 ± 2.85) µN/m and Gh = (12.57 ± 0.32) µN/m. These results show that the lateral indentation can therefore be used as a routine method for cell study, because it enabled us to manipulate the cell without contact with the laser.

关键词： Optical Tweezers Human Eosinophil Cell Indentation Shear Stiffness

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建筑学报 2024年第7期 76-81页

作者：无郭锡恩胡如珊陈颢(摄影) 如恩设计研究室不详

Static Analysis of Doubly-Curved Shell Structures of Smart Materials and Arbitrary Shape Subjected to General Loads Employing Higher Order Theories and Generalized Differential Quadrature Method

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Computer Modeling in Engineering & Sciences 2022年第12期133卷 719-798页

作者： Francesco Tornabene Matteo Viscoti rossana Dimitri Department of Innovation Engineering School of EngineeringUniversity of SalentoLecce73100Italy

The article proposes an Equivalent Single Layer(ESL)formulation for the linear static analysis of arbitrarily-shaped shell structures subjected to general surface loads and boundary conditions.A parametrization of the physical domain is provided by employing a set of curvilinear principal *** generalized blendingmethodology accounts for a distortion of the structure so that disparate geometries can be *** layer of the stacking sequence has an arbitrary orientation and is modelled as a generally anisotropic *** addition,re-entrant auxetic three-dimensional honeycomb cells with soft-core behaviour are considered in the *** unknown variables are described employing a generalized displacement field and pre-determined through-the-thickness functions assessed in a unified ***,a weak assessment of the structural problem accounts for shape functions defined with an isogeometric approach starting fromthe computational *** has been proposed to define two-dimensional distributions of static surface *** the same way,boundary conditions with three-dimensional features are implemented along the shell edges employing linear *** fundamental relations are obtained from the stationary configuration of the total potential energy,and they are numerically tackled by employing the Generalized Differential Quadrature(GDQ)method,accounting for nonuniform computational *** the post-processing stage,an equilibrium-based recovery procedure allows the determination of the three-dimensional dispersion of the kinematic and static *** case studies have been presented,and a successful benchmark of different structural responses has been performed with respect to various refined theories.

关键词： 3D honeycomb anisotropic materials differential quadrature method general loads and constraints higher order theories linear static analysis weak formulation

Static Analysis of Anisotropic Doubly-Curved Shell Subjected to Concentrated Loads Employing Higher Order Layer-Wise Theories

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Computer Modeling in Engineering & Sciences 2023年第2期134卷 1393-1468页

作者： Francesco Tornabene Matteo Viscoti rossana Dimitri Department of Innovation Engineering School of EngineeringUniversity of SalentoLecce73100Italy

In the presentmanuscript,a Layer-Wise(LW)generalizedmodel is proposed for the linear static analysis of doublycurved shells constrained with general boundary conditions under the influence of concentrated and surface *** unknown field variable is modelled employing polynomials of various orders,each of them defined within each layer of the *** a particular case of the LW model,an Equivalent Single Layer(ESL)formulation is derived *** approaches are outlined for the assessment of external forces,as well as for non-conventional *** doubly-curved shell is composed by superimposed generally anisotropic laminae,each of them characterized by an arbitrary *** fundamental governing equations are derived starting from an orthogonal set of principal ***,generalized blending functions account for the distortion of the physical *** implementation of the fundamental governing equations is performed bymeans of the Generalized Differential Quadrature(GDQ)method,whereas the numerical integrations are computed employing theGeneralized IntegralQuadrature(GIQ)*** the post-processing phase,an effective procedure is adopted for the reconstruction of stress and strain through-the-thickness distributions based on the exact fulfillment of three-dimensional equilibrium equations.A series of systematic investigations are performed in which the static response of structures with various curvatures and lamination schemes,calculated by the present methodology,have been successfully compared to those ones obtained fromrefined finite element three-dimensional *** though the present LW approach accounts for a two-dimensional assessment of the structural problem,it is capable of well predicting the three-dimensional response of structures with different characteristics,taking into account a reduced computational cost and pretending to be a valid alternative to widespread numerical implementations.

关键词： Concentrated load doubly-curved shells generalized differential quadrature laminated anisotropic materials layer-wise theory mapping technique

Bio-mathematical models of viral dynamics to tailor antiviral therapy in chronic viral hepatitis

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World Journal of Gastroenterology 2009年第5期15卷 531-537页

作者： Maurizia rossana Brunetto Piero Colombatto Ferruccio Bonino UO Epatologia Azienda Ospedaliero-Universitaria Pisana 56100 Pisa Italy Direzione Scientifica Fondazione IRCCS Ospedale Maggiore Policlinico Mangiagalli and Regina Elena di Milano 20122 Milano Italy

The simulation of the dynamics of viral infections by mathematical equations has been applied successfully to the study of viral infections during antiviral therapy. Standard models applied to viral hepatitis describe the viral load decline in the f irst 2-4 wk of antiviral therapy, but do not adequately simulate the dynamics of viral infection for the following period. The hypothesis of a constant clearance rate of the infected cells provides an unrealistic estimation of the time necessary to reach the control or the clearance of hepatitis B virus (HBV)/ hepatitis C virus (HCV) infection. To overcome the problem, we have developed a new multiphasic model in which the immune system activity is modulated by a negative feedback caused by the infected cells reduction, and alanine aminotransferase kinetics serve as a surrogate marker of infected-cell clearance. By this approach, we can compute the dynamics of infected cells during the whole treatment course, and find a good correlation between the number of infected cells at the end of therapy and the long-term virological response in patients with chronic hepatitis C. The new model successfully describes the HBV infection dynamics far beyond the third month of antiviral therapy under the assumption that the sum of infected and non-infected cells remains roughly constant during therapy, and both target and infected cells concur in the hepatocyte turnover. In clinical practice, these new models will allow the development of simulators of treatment response that will be used as an "automatic pilot" for tailoring antiviral therapy in chronic hepatitis B as well as chronic hepatitis C patients.

关键词： Viral hepatitis Bio-mathematical models Hepatitis B virus Hepatitis C virus Viral dynamics

Compositional characteristics and oxidative stability of chia seed oil(Salvia hispanica L)

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食物生产加工与营养(英文) 2020年第1期2卷 83-90页

作者： Abrehem abad Fereidoon Shahidi Department of Biochemistry Memorial University of NewfoundlandSt.John’sNL A1B 3X9Canada

Fatty acid composition and triacylglycerols(TAG)profile of chia seed oil were *** main fatty acids present in the tested oil wereα-linolenic acid(Ln,61.1%)>linoleic acid(L,16.6%)>palmitic acid(P,6.7%)>oleic acid(O,6.0%)>stearic acid(S,3.2%).Five major triacylglycerols in chia oil were LnLnLn,LnLLn,LnLnP,LnOLn,and LLLn and these contributed more than 76%to the *** oxidative stability under autoxidative and photooxidative conditions before and after the removal of their minor components was also *** addition,tocols,chlorophylls and carotenoids were measured in the *** samples were stripped of their minor components by using a facile silicic acid and charcoal in one pot rather than in a *** under Schaal oven condition and photooxidation were also monitored for both crude oil(non-stripped)and stripped oil using stationary phase *** tocopherol contents were in the order ofβ−/γ-282.68,δ-47.44,andα-tocopherols 10.94 mg/kg of *** removed all the minor components including tocopherols,chlorophylls and *** stability of the tested seed oil was primarily affected by its composition of fatty acids,triacylglycerols,minor components,and storage conditions.

关键词： Chia seed oil Fatty acids Triacylglycerols Tocopherols Pigments Chlorophylls Carotenoids Oxidative stability