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Lactobacillus acidophilus and Bifidobacterium breve alleviate neonatal maternal separation induced visceral hypersensitivity and non-spatial memory impairment in rats by the NGF/TrkA pathway

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Food Science and Human Wellness 2024年

作者： Chi Chen Bowen Li Mengfan Ding Huizhen Li Jianxin Zhao R.Paul ross Catherine Stanton Wei Chen Bo Yang State Key Laboratory of Food Science and Resources Jiangnan University School of Food Science and Technology Jiangnan University International Joint Research Center for Probiotics & Gut Health Jiangnan University APC Microbiome Ireland University College Cork Teagasc Food Research Centre Moorepark National Engineering Research Center for Functional Food Jiangnan University

Irritable bowel syndrome-diarrhea （IBS-D） is a prevalent functional bowel disease severely impairs the quality of life of patients. Visceral hypersensitivity （VH） is the main symptom of IBS-D. Probiotics have been found to effectively alleviate VH. In this study， neonatal maternal separation （NMS） was used to induce VH in 72 rats and investigated the effects of daily gavage of 3*109CFU of Lactobacillus and Bifidobacterium on alleviating the symptoms of IBS-D and behavioral interventions， as well as exploring potential mechanisms. The results demonstrated that Lactobacillus acidophilus and Bifidobacterium breve could alleviate the symptoms of IBS-D such as VH and increased frequency of bowel movements， as well as improving non-spatial memory in NMS rats. These effects were achieved by modulating the composition of gut microbiota and metabolites （including short-chain fatty acids， deoxycholic acid and adenosine）， and by regulating the expression of genes and proteins associated with the NGF/TrkA signaling pathway， tryptophan metabolism， and inflammatory factors in the hippocampus. This finding suggests that Lactobacillus acidophilus and Bifidobacterium breve have promising potential for the alleviation of IBS.

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Bifidobacterium breve CCFM1078 regulates bone development in growing BALB/c mice via gut microbiota and metabolites to balance bone formation and resorption

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Food Science and Human Wellness 2024年

作者： Bowen Li Mengfan Ding Xiaoming Liu Haiqin Chen Jianxin Zhao R.Paul ross Catherine Stanton Shilong Jiang Wei Chen Bo Yang Nutrition and Metabolism Research Division Innovation Center Heilongjiang Feihe Dairy Co. Ltd. National Engineering Research Center for Functional Food Jiangnan University State Key Laboratory of Food Science and Technology Jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development APC Microbiome Ireland University College Cork School of Food Science and Technology Jiangnan University International Joint Research Center for Probiotics & Gut Health Jiangnan University Teagasc Food Research Centre

This study endeavors to investigate the effects of Bifidobacterium breve CCFM1078 on bone formation and resorption balance in growing BALB/c mice. Newborn BALB/c mice were assigned to the control group (administration saline) and the CCFM1078 group (administration B. breve CCFM1078， 3 × 109CFU/day) in 3-， 4-， and 5-week tests. All the groups have male and female distinctions. Our findings demonstrate that B. breve CCFM1078 exerts on the dynamic equilibrium between bone formation and resorption during the critical period of growth in mice by modulating the composition of gut microbiota and metabolites (hexadecanamide， linoleoyl ethanolamide， and palmitoyl ethanolamide)， the genes and proteins expression related to the GH/IGF-1 axis and Gs/PKA/CREB signaling pathways， as well as downstream osteogenic and osteoclastic differentiation factors. The effects of B. breve CCFM1078 were different with age and gender dependent. This finding suggests B. breve CCFM1078 may have potential applications in regulating bone metabolism in the growth period population.

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Bifidobacterium longum subsp. infantis CCFM1269 promotes intestinal barrier and release of IFN-β through TLR4-TRIF dependent way in growing mice

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Food Science and Human Wellness 2024年

作者： Mengfan Ding Bo Yang Bowen Li Haiqin Chen Renqiang Yu R.Paul ross Catherine Stanton Shilong Jiang Jianxin Zhao Wei Chen State Key Laboratory of Food Science and Resources Jiangnan University Teagasc Food Research Centre Nutrition and Metabolism Research Division Innovation Center Heilongjiang Feihe Dairy Co. Ltd. Department of Neonatology Wuxi Maternity and Child Health Care Hospital Affiliated Women's Hospital of Jiangnan University National Engineering Research Center for Functional Food Jiangnan University School of Food Science and Technology Jiangnan University PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development International Joint Research Center for Probiotics & Gut Health Jiangnan University APC Microbiome Ireland University College Cork

Bifidobacterium longum subsp. infantis is a commensal bacterium that predominates in the infant gut， playing a critical role in both preventing foreign infections and facilitating immune development. This study aimed to explore the effects of B. longum subsp. infantis supplementation on interferon-beta (IFN-β) secretion and intestinal barrier improvement in growing mice. Female and male mice were orally administered either saline or B. longum subsp. infantis CCFM1269 or I5TI (1 × 109CFU/mice per day， n = 8) from 1-week-age until 3-， 4-， and 5-week-age. RNA sequencing analysis revealed that CCFM1269 exhibited potential antiviral capacity through increasing 2’-5’ oligoadenylate synthetase (OAS). Additionally， CCFM1269 supplementation significantly increased colonic IFN-β levels which combined with OAS in 3-week-old female and male mice by activating the TLR4-TRIF-dependent signaling pathway. However， this effect was not observed in 4- and 5-week-old mice. Furthermore， both CCFM1269 were found to modulate the gut microbiota composition and enhance the intestinal barrier function in 3-， 4-， and 5-week-old mice. In summary， the results of this study suggested that B. longum subsp. infantis CCFM1269 promoting intestinal barrier and releasing IFN-β in growing mice was in a strain-specific and time-dependent manner.

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小苏打牙膏去除牙菌斑的机理研究

口腔护理用品工业 2024年第4期34卷 22-24页

作者：史运明高兆鑫 ross Strand 北京宝洁技术有限公司北京101312 宝洁新加坡研发中心新加坡

目的:构建人原位牙菌斑生物膜模型,获得48小时菌斑生物膜,通过体外牙膏浆处理来研究小苏打(碳酸氢钠)牙膏去除牙菌斑的工作机理。方法:按纳入标准选取4名志愿者,将刻有凹槽的羟基磷灰石圆片固定于活动夹板,配戴夹板,于48小时后取出圆片... 详细信息

目的:构建人原位牙菌斑生物膜模型,获得48小时菌斑生物膜,通过体外牙膏浆处理来研究小苏打(碳酸氢钠)牙膏去除牙菌斑的工作机理。方法:按纳入标准选取4名志愿者,将刻有凹槽的羟基磷灰石圆片固定于活动夹板,配戴夹板,于48小时后取出圆片,经小苏打牙膏浆或磷酸缓冲液处理后于激光共聚焦显微镜下观察生物膜结构,检测生物膜厚度,以及其中钙离子荧光密度。进行随机区组单因素方差分析,SNK法进行均数两两比较。结果:小苏打牙膏浆处理前和处理后的48小时菌斑生物膜厚度分别为30.8±3.5μm和12.1±2.4μm,二者有显著统计学差异(P<0.05)。此外生物膜经小苏打牙膏浆处理后出现钙离子荧光密度密度明显降低(P<0.05)。结论:本实验通过体内收集自然完整的菌斑生物膜,观察小苏打牙膏对牙菌斑的去除效果。进一步发现菌斑的去除伴随着生物膜里的钙离子密度降低,说明小苏打牙膏不但机械去除菌斑,还能通过减少菌斑中钙离子从而有效化学瓦解牙菌斑。

关键词：牙菌斑模型菌斑生物膜小苏打碳酸氢钠激光共聚焦

Enhanced Flexible Ramping Product Formulation for Alleviating Capacity Shortage in Look-ahead Commitment

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 850-860页

作者： Hyeongon Park Bing Huang ross Baldick Department of Safety Engineering Pukyong National UniversityBusan 48513South Korea Midcontinent Independent System Operator CarmelIN 46032USA Department of Electrical&Computer Engineering at The University of Texas at Austin AustinUSA

The roll-out of a flexible ramping product provides independent system operators(ISOs)with the ability to address the issues of ramping capacity *** procure flexible ramping capability by committing more generating units or reserving a certain amount of headrooms of committed *** this paper,we raise the concern of the possibility that the procured flexible ramping capability cannot be deployed in realtime operations due to the unit shut-down in a look-ahead commitment(LAC)*** a solution to the issues of ramping capacity shortage,we provide a modified ramping product formulation designed to improve the reliability and reduce the expected operating *** trajectories of start-up and shutdown processes are also considered in determining the ramping capability.A new optimization problem is formulated using mixed integer linear programming(MILP)to be readily applied to the practical power system *** performance of this proposed method is verified through simulations using a small-scale system and IEEE 118-bus *** simulation results demonstrate that the proposed method can improve the generation scheduling by alleviating the ramping capacity shortages.

关键词： Flexible ramping product look-ahead commitment(LAC) mixed integer linear programming(MILP) reliability

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True polar wander in the Earth system

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Science China Earth Sciences 2023年第6期66卷 1165-1184页

作者： Chong WANG ross N.MITCHELL State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China

True polar wander(TPW),or planetary reorientation,is the rotation of solid Earth(crust and mantle)about the liquid outer core in order to stabilize Earth’s rotation due to mass *** TPW is well-documented on Earth presently with satellites and for multiple planets and moons in the Solar System,the prevalence of TPW in Earth history remains *** a history of controversy,both the physical plausibility of TPW on Earth and an empirical basis for it are now *** resistance to the old idea likely stems from the fact that,like plate tectonics,TPW may influence much of the Earth system,thus acknowledging its existence requires rethinking how many different datasets are *** review summarizes the development of TPW as a concept and provides a framework for future research that no longer regards TPW like a ghost process that may or may not exist,but as an integral part of the Earth system that can relate shallow and deep processes that are otherwise only mysteriously ***,we focus on the temporal regularity of large TPW,and discuss its relationship with the supercontinent-megacontinent cycle based on previous *** suggest the assembly of megacontinents has a close linkage to large ***,supercontinent tenure and breakup have a close linkage to fast *** effects of TPW on sea level changes,paleoclimate,biological diversity,and other facets of the Earth system are presented and require interdisciplinary tests in the future.

关键词： True polar wander(TPW) Planetary reorientation Apparent polar wander(APW) Mantle convection Supercontinent cycle Megacontinent

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China in the Global Response to Climate Change

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China & World Economy 2023年第1期31卷 44-61页

作者： ross Garnaut Melbourne Institute of Applied Economic and Social Research University of MelbourneAustralia

China has a huge national interest in the success of the international effort to hold human-induced increases in temperature to 1.5 degrees-and therefore in global net emissions falling to net zero by *** is essential to the success of the global effort-as a supplier of competitively priced equipment for the zero emissions world economy and as the world's largest current source of greenhouse gas *** is more likely for China and the world with international specialization in goods production for the zero emissions *** will require open international trade,with China supplying equipment and drawing zero emissions semi-processed goods from *** is more likely and will be achieved at a lower cost if there is close cooperation across national boundaries.

关键词： China climate change international cooperation zero carbon

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维多利亚和阿尔伯特博物馆·邓迪分馆

城市环境设计 2024年第1期147卷 48-53页

作者：池口由纪 Mucciola Maurizio Piccinelli Maria Chiara 垣副正树片桐和也铃木公雄松长知宏珠玖优喜多啓藤原徹平针谷将史平辻里佳斋藤浩章 ross Fraser McLean HuftonCrow

英国维多利亚和阿尔伯特博物馆（伦敦）的新建筑坐落在苏格兰北部城市邓迪的海滨。这是苏格兰第一家设计博物馆，预计将作为推广苏格兰文化的一个基地。建筑用地面向流经邓迪河以南的泰河。建筑物悬挑于水面之上，这是我们为一种融合自...

英国维多利亚和阿尔伯特博物馆（伦敦）的新建筑坐落在苏格兰北部城市邓迪的海滨。这是苏格兰第一家设计博物馆，预计将作为推广苏格兰文化的一个基地。建筑用地面向流经邓迪河以南的泰河。建筑物悬挑于水面之上，这是我们为一种融合自然环境和周围景观的新型建筑提出的创意。我们对苏格兰北部奥克尼岛美丽的悬崖很感兴趣，希望通过建筑来传达其自然性，因此我们提出了将多层不同角度的预制混凝土长板堆叠起来的想法，以实现具有微妙细微差别和动态感的立面。当今先进的参数化设计系统使我们能够实现上述目标。

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Arthroscopic scene segmentation using multispectral reconstructed frames and deep learning

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Intelligent Medicine 2023年第4期3卷 243-251页

作者： Shahnewaz Ali ross Crawford Ajay K.Pandey School of Electrical Engineering and Robotics Faculty of EngineeringQueensland University of TechnologyGardens PointBrisbaneQLD 4000Australia

Background Knee arthroscopy is one of the most complex minimally invasive surgeries,and it is routinelyperformed to treat a range of ailments and injuries to the knee *** complex ergonomic design imposesvisualization and navigation constraints,consequently leading to unintended tissue damage and a steep learningcurve before surgeons gain *** lack of robust visual texture and landmark frame features furtherlimits the success of image-guided approaches to knee arthroscopy Feature-and texture-less tissue structures ofknee anatomy,lighting conditions,noise,blur,debris,lack of accurate ground-truth label,tissue degeneration,and injury make semantic segmentation an extremely challenging *** address this complex research problem,this study reported the utility of reconstructed surface reflectance as a viable piece of information that could beused with cutting-edge deep learning technique to achieve highly accurate segmented *** We proposed an intraoperative,two-tier deep learning method that makes full use of tissue reflectanceinformation present within an RGB frame to segment texture-less images into multiple tissue types from kneearthroscopy video *** study included several cadaver knees experiments at the Medical and EngineeringResearch Facility,located within the Prince Charles Hospital campus,Brisbane *** were collectedfrom a total of five cadaver knees,three were males and one from a *** age range of the donors was 56–93 ***-related tissue degeneration and some anterior cruciate ligament injury were observed in mostcadaver *** arthroscopic image dataset was created and subsequently labeled by clinical *** also included validation of a prototype stereo arthroscope,along with conventional arthroscope,to attainlarger field of view and stereo *** reconstructed surface reflectance from camera responses that exhibiteddistinct spatial features at different wavelengths ranging from 3

关键词： Knee arthroscopy Segmentation Multispectral reconstructed Deep learning