检索结果-南通市图书馆

Polyethylene glycol fusion repair of severed sciatic nerves accelerates recovery of nociceptive sensory perceptions in male and female rats of different strains

引用

Neural Regeneration Research 2025年第9期20卷 2667-2681页

作者： Liwen zhou Karthik Venkudusamy Emily A.Hibbard Yessenia Montoya Alexa Olivarez Cathy z.Yang Adelaide Leung Varun Gokhale Guhan Periyasamy zeal Pathak Dale R.Sengelaub George D.Bittner Department of Neuroscience University of TexasAustinTXUSA Program in Neuroscience Indiana UniversityBloomingtonINUSA Department of Molecular Biosciences University of TexasAustinTXUSA

Successful polyethylene glycol fusion(PEG-fusion)of severed axons following peripheral nerve injuries for PEG-fused axons has been reported to:(1)rapidly restore electrophysiological continuity;(2)prevent distal Wallerian Degeneration and maintain their myelin sheaths;(3)promote primarily motor,voluntary behavioral recoveries as assessed by the Sciatic Functional Index;and,(4)rapidly produce correct and incorrect connections in many possible combinations that produce rapid and extensive recovery of functional peripheral nervous system/central nervous system connections and reflex(e.g.,toe twitch)or voluntary *** preceding companion paper describes sensory terminal field reo rganization following PEG-fusion repair of sciatic nerve transections or ablations;howeve r,sensory behavioral recovery has not been explicitly explored following PEG-fusion *** the current study,we confirmed the success of PEG-fusion surgeries according to criteria(1-3)above and more extensively investigated whether PEG-fusion enhanced mechanical nociceptive recovery following sciatic transection in male and female outbred Sprague-Dawley and inbred Lewis *** nociceptive responses were assessed by measuring withdrawal thresholds using von Frey filaments on the dorsal and midplantar regions of the *** von Frey filament tests were a more reliable method than plantar von Frey filament tests to assess mechanical nociceptive sensitivity following sciatic nerve *** withdrawal thresholds of the sciatic-mediated lateral dorsal region differed significantly across strain but not *** thresholds did not change significantly from baseline in chronic Unoperated and Sham-operated *** sciatic transection,all rats exhibited severe hyposensitivity to stimuli at the lateral dorsal region of the hindpaw ipsilateral to the ***,PEG-fused rats exhibited significantly earlier return to baseline withdrawal thresholds than Negative

关键词： autophagia axotomy collateral sprouting neuropathic pain peripheral nerve repair polyethylene glycol fusion(PEG-fusion) saphenous nerve sensory neurons sex and strain Wallerian degeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

钙通道阻滞剂与癌症的危险

引用

美国医学会杂志（中文版） 1999年第2期18卷 63-68页

作者： rose.,L 林仲翔

背景:最近的流行病学研究引起了人们对钙通道阻滞剂的关注。研究表明使用钙通道阻滞剂有可能使总癌症及其些特殊癌症的危险性升高。目的:确定钙通道阻滞剂的应用是否使总癌症和特殊癌症的危险升高。设计:对1983-1996年收集的资料进行病... 详细信息

背景:最近的流行病学研究引起了人们对钙通道阻滞剂的关注。研究表明使用钙通道阻滞剂有可能使总癌症及其些特殊癌症的危险性升高。目的:确定钙通道阻滞剂的应用是否使总癌症和特殊癌症的危险升高。设计:对1983-1996年收集的资料进行病例-对照药物监测研究。地点:美国马里兰州巴尔的摩市、纽约州纽约市以及宾夕法尼亚州费城的各家医院。病例-共计9513例不同部位的偶发癌症患者,年龄40-69岁。对照患者6492例,年龄40-69岁,因非恶性疾病入院。主要观察指标:癌症总数和23种特殊癌症。结果:钙通道阻滞剂的使用与总癌症的危险无关(相对危险性[RR]为1.1;95%可信区间[CI],0.9-1.3)。药物应用与个别癌症的危险亦无显著联系,包括那些以前受到注意的癌症,只有肾癌例外(RR为1.8;95%CI,1.1-2.7)。近期用药的患者、用药5年或5年以上者以及只用一种钙通道阻滞剂者,也与癌症发病无关联。使用β-阻滞剂和血管紧张素-转移酶抑制剂者,一般与癌症总发病率或单种癌发病无关,但两种药物都与肾癌相关(RR分别为1.8[95%CI,1.3-2.5]及1.9(95%CI,1.2-3.0)。结论:研究提示钙通道阻滞剂的使用与总癌症或具体某种癌的发病危险无关。肾癌是个例外。以往的研究表明肾癌的发生与高血压或治疗高血压的药物有关。

关键词：钙通道阻滞剂癌流行病学危险因素

来源：

维普期刊数据库评论