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Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study

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World Journal of Gastroenterology 2019年第40期25卷 6094-6106页

作者： Gian Luca Colussi Debora Donnini rosario francesco brizzi Silvia Maier Luca Valenti Cristiana Catena Alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo Department of Medicine University of Udine

BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected ***,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well *** To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with *** Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern *** study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be *** The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persi

关键词： Direct-acting antiviral agents Hepatitis C virus Mixed cryoglobulinemia Sustained virologic response Cirrhosis Survival analysis

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超声内镜在胰腺癌中的应用现状与展望

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中国普通外科杂志 2014年第3期23卷 269-277页

作者： Claudio De Angelis rosario francesco brizzi Rinaldo Pellicano 冯铁成李新营意大利都灵大学圣.乔瓦尼巴蒂斯塔医院内镜与超声内镜中心胃肠与肝病科

胰腺疾病的诊治在临床上一直是一个难点。在过去的几年中我们见证了放射学和核医学成像的技术进步。考虑到这一点,我们尝试描述超声内镜(EUS)在胰腺癌(PC)诊断及分期的过程中新的角色。到目前为止对于PC最准确的成像技术是对比增强计算... 详细信息

胰腺疾病的诊治在临床上一直是一个难点。在过去的几年中我们见证了放射学和核医学成像的技术进步。考虑到这一点,我们尝试描述超声内镜(EUS)在胰腺癌(PC)诊断及分期的过程中新的角色。到目前为止对于PC最准确的成像技术是对比增强计算机断层扫描(CT)和EUS。后者在检测微小病灶及评估肿瘤大小和淋巴结情况时具有最高的精度,但对于一个可疑的胰腺病变的患者而言,螺旋CT或最新的磁共振成像(MRI)仍是首要的选择。如在CT、MRI扫描为阴性结果而临床上高度怀疑PC,或是CT/MRI扫描后可疑病变需细胞组织学确认时,可应用EUS。相信在不久的将来用于诊断和治疗胰腺疾病的EUS将有更大的发展空间,并且病理结果将为其提供最好的应用证据。

关键词：胰腺肿瘤超声检查腔内超声检查

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Selective internal radiation therapy segmentectomy:A new minimally invasive curative option for primary liver malignancies?

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World Journal of Gastroenterology 2024年第18期30卷 2379-2386页

作者： Riccardo Inchingolo francesco Cortese Antonio rosario Pisani Fabrizio Acquafredda Roberto Calbi Riccardo Memeo Fotis Anagnostopoulos Stavros Spiliopoulos Unit of Interventional Radiology “F.Miulli”Regional General HospitalBari 70021Italy Interdisciplinary Department of Medicine Section of Nuclear MedicineUniversity of Bari“Aldo Moro”Bari 70121Italy Department of Radiology General Regional Hospital“F.Miulli”Acquaviva delle Fonti 70021Italy Unit of Hepato-Pancreatic-Biliary Surgery “F.Miulli”Regional General HospitalBari 70021Italy The Second Radiology Department National and Kapodistrian University of AthensChaidari Athens 12461Greece

Transarterial radioembolization or selective internal radiation therapy(SIRT)has emerged as a minimally invasive approach for the treatment of *** percutaneous technique involves the local,intra-arterial delivery of radioactive microspheres directly into the *** employed as a palliative measure for liver malignancies,SIRT has gained traction over the past decade as a potential curative option,mirroring the increasing role of radiation *** latest update of the BCLC hepatocellular carcinoma guidelines recognizes SIRT as an effective treatment modality comparable to other local ablative methods,particularly well-suited for patients where surgical resection or ablation is not *** segmentectomy is a more selective approach,aiming to deliver high-dose radiation to one to three specific hepatic segments,while minimizing damage to surrounding healthy *** research efforts in radiation segmentectomy should prioritize optimizing radiation dosimetry and refining the technique for super-selective administration of radiospheres within the designated hepatic segments.

关键词： Transarterial radioembolization Selective internal radiation therapy Radiation segmentectomy Hepatocellular carcinoma Primary liver malignancies Personalised dosimetry

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The identification of wildlife-vehicle collision hotspots: Citizen science reveals spatial and temporal patterns

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Ecological Processes 2021年第1期10卷 99-111页

作者： francesco Valerio Marco Basile rosario Balestrieri Mediterranean Institute for Agriculture Environment and DevelopmentInstituto de Investigação e Formação AvançadaUniversidade deÉvoraPólo da MitraAp.947006-554ÉvoraPortugal. UBC-Unidade de Biologia da Conservação Departamento de BiologiaUniversidade deÉvoraPólo da MitraAp.947002-554ÉvoraPortugal. Associazione per la Ricerca la Divulgazione e l’Educazione Ambientale–ARDEAVia Ventilabro80126 NapoliItaly. Chair of Wildlife Ecology and Management University of FreiburgTennenbacher Str.479106 FreiburgGermany. Stazione Zoologica Anton Dohrn Villa Comunale 180121 NaplesItaly.

Linear infrastructures(e.g.,roads,railways,pipelines,and powerlines)pose a serious threat to wildlife,due to the risk of wildlife-vehicle collisions(roadkills).The placement of mitigation measures,such as crossing structures,should consider species’life cycles and ecological *** an assessment would require data collection over large areas,which may be possible by employing citizen *** this study,we aimed to identify spatiotemporal trends of roadkill occurrence using citizen science data from one of the most urbanized and biodiversityrich regions of *** trends were analyzed using generalized additive models,while landscape patterns were assessed by identifying significant thresholds over land cover gradients,related to increases in relative roadkill abundance,by employing threshold indicator taxa *** approach recorded a total of 529 roadkills,including 33 different species,comprising 13 mammal,10 bird,6 reptile,and 2 amphibian *** analysis indicated significant temporal trends for the red fox,the European hedgehog,the stone marten and the European badger,with peaks in roadkill occurrence between the winter and spring *** roadkill abundance increased mostly in landscapes with anthropogenic land cover classes,such as complex cultivations,orchards,or urban *** results allowed us to develop a map of potential roadkill risk that could assist in planning the placement of mitigation *** science contributions from highly populated areas allowed data collection over a large area and a dense road network,and also directly led to the evaluation of management decisional options.

关键词： Roadkill Land cover Road ecology Seasonal trend Spatial prioritization Urban wildlife

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Protecting artificial intelligence IPs:a survey of watermarking and fingerprinting for machine learning

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CAAI Transactions on Intelligence Technology 2021年第2期6卷 180-191页

作者： francesco Regazzoni Paolo Palmieri Fethulah Smailbegovic rosario Cammarota Ilia Polian University of Amsterdam Amsterdam The Netherlands ALaRI-USI LuganoSwitzerland University College Cork CorkIreland Delft University of Technology The Netherlands Intel Labs San DiegoUSA University of Stuttgart StuttgartGermany

Artificial intelligence(AI)algorithms achieve outstanding results in many applicationdomains such as computer vision and natural language processing The performance ofAl models is the outcome of complex and costly model architecture design and ***,it is paramount for model owners to protect their AI models frompiracy-model cloning,illegitimate distribution and *** protection mechanisms havebeen applied to Al models,and in particular to deep neural networks,to verify themodel ***-of-the-art AI model ownership protection techniques have *** pros and cons of Al model ownership protection have been *** majonity of previous works are focused on watermarking,while more advancedmethods such fingerprinting and attestation are promising but not yet explored *** study has been concluded by discussing possible research directions in thearea.

关键词： artificial computer networks

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Laparo-endoscopic “Rendezvous” to treat cholecysto-choledocolithiasis: Effective,safe and simplifies the endoscopist’s work

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World Journal of Gastroenterology 2008年第18期14卷 2844-2850页

作者： Gaetano La Greca francesco Barbagallo Michele Di Blasi Andrea Chisari rosario Lombardo rosario Bonaccorso Saverio Latteri Andrea Di Stefano Domenico Russello Department of Surgical Sciences Transplantation and Advanced Technologies University of Catania Cannizzaro Hospital Via Messina 829 Catania 95126 Italy Endoscopic Unit Cannizzaro Hospital Via Messina 829 Catania 95126 Italy

AIM: To investigate our clinical experience with combined laparo-endoscopic Rendezvous (RV) for the treatment of patients affected by gallstones and common bile duct (CBD) stones and especially to study the never evaluated opinion of the endoscopist concerning the difficulty of the intraoperative endoscopic procedure during the RV in comparison with standard endoscopic retrograde cholangio-pancreatography (ERCP). METHODS: Eighty consecutive patients affected by cholecystolithiasis and diagnosed or suspected CBD stones were treated with a standardized "tailored" RV. The relevant technical features, the feasibility, the effectiveness in stone clearance, the safety but also the simple evaluation of difficulty and agreement of the endoscopist were analyzed with a questionnaire. RESULTS: The feasibility was 97.5% and the effectiveness 100% concerning CBD clearance and solution of coexisting problems at the papilla. Minor morbidity was 3.3%, the operating time was prolonged by a mean of 14 min, the mean hospital stay was 3.8 d and only one stone’s recurrence occurred. The endoscopist evaluated the procedure to be simpler than standard ERCP-ES in 81.2% of the ***: Simultaneous RV carries higheffectiveness and safety at least comparable to those reported for other options. The endoscopist is very often satisfied with this approach because of the minimization of some steps of the endoscopic procedure and avoidance of relevant iatrogenic risk factors. If the mandatory collaboration between surgeons and endoscopists is guaranteed, this approach can often be preferable for the patient, the surgeon, the endoscopist and the hospital.

关键词： Gallstones Common bile duct Endoscopic retrograde cholangio-pancreatography Endoscopic sphincterotomy Rendezvous Intra-operative cholangiography Laparoscopic cholecystectomy

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Irritable bowel syndrome and food interaction

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World Journal of Gastroenterology 2014年第27期20卷 8837-8845页

作者： rosario Cuomo Paolo reozzi francesco Paolo Zito Valentina Passananti Giovanni De Carlo Giovanni Sarnelli Department Of Clinical Medicine and Surgery Federico Ⅱ University Hospital School of Medicine

Irritable bowel syndrome(IBS) is one of the most common gastrointestinal disorders in Western countries. Despite the high prevalence of this disorders, the therapeutic management of these patients is often unsatisfactory. A number of factors have been suggested to be involved in the pathogenesis of IBS, including impaired motility and sensitivity, increased permeability, changes in the gut microbiome and alterations in the brain-gut axis. Also food seems to play a critical role: the most of IBS patients report the onset or the exacerbation of their symptoms after the meals. Recently, an increasing attention has been paid to the role of food in IBS. In this review we summarize the most recent evidences about the role of diet on IBS symptoms. A diet restricted in fermentable, poorly absorbed carbohydrates and sugar alcohols has beneficial effects on IBS symptoms. More studies are needed to improve our knowledge about the relationship between food and IBS. However, in the foreseeable future, dietary strategies will represent one of the key tools in the therapeutic management of patients with IBS.

关键词： Irritable bowel syndrome Fermentable,poorly absorbed carbohydrates and sugar alcohols Gut microbiota Food intolerance Gluten

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Bow hunter’s syndrome successfully treated with a posterior surgical decompression approach:A case report and review of literature

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World Journal of Clinical Cases 2022年第14期10卷 4494-4501页

作者： NiccolòOrlandi francesco Cavallieri Ilaria Grisendi Antonio Romano Reza Ghadirpour Manuela Napoli Claudio Moratti Matteo Zanichelli rosario Pascarella Franco Valzania Marialuisa Zedde Department of Biomedical Metabolic and Neural SciencesCenter for Neuroscience and NeurotechnologyUniversity of Modena and Reggio EmiliaModena 41121Italy Neurology Unit Neuromotor and Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModena 41121Italy Neurosurgery Unit Neuromotor and Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio Emilia 42123Italy Neuroradiology Unit Department of Diagnostic Imaging and Laboratory MedicineAzienda USL-IRCCS di Reggio EmiliaReggio Emilia 41123Italy

BACKGROUND Bow hunter’s syndrome(BHS)is a rare but surgically treatable cause of vertebrobasilar insufficiency due to dynamic rotational occlusion of the vertebral ***,patients present with posterior circulation transient ischaemic symptoms such as presyncope,syncope,vertigo,diplopia,and horizontal nystagmus,but irreversible deficits,including medullary and cerebellar infarctions,have also been *** SUMMARY A 70-year-old patient presented an acute onset of vertigo and gait instability triggered by right head *** medical history included previous episodes of unilateral left neck and occipital pain followed by light-headedness,sweating,and blurred vision when turning his head,and these episodes were associated with severe degenerative changes in the atlanto-dens and left atlanto-axial facet joints and right rotation of the C2 cervical *** magnetic resonance imaging revealed the presence of acute bilateral cerebellar ischaemic lesions,while static vascular imaging did not reveal any vertebral artery *** ultrasonography and angiography were performed and confirmed the presence of a dynamic occlusion of the vertebral artery V3-V4 segment when the head was rotated to the right secondary to left C1-C2 bone spur *** decompression led to complete resolution of paroxysmal symptoms without neurological *** BHS should be considered in cases of repeated posterior circulation transient ischaemic attack or ischaemic stroke,particularly when associated with high cervical spine abnormalities.

关键词： Bow hunter’s syndrome Stroke Non-invasive duplex ultrasonography Dynamic angiography Neurosurgery Case report

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An Unusual Case of Functional Neurological Disorders and Psychogenic Coma following Physical Assault:Clinical and Medico-Legal Considerations

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Journal of Forensic Science and Medicine 2021年第1期7卷 36-38页

作者： Fiorella Caputo rosario Barranco Pietrantonio Ricci Santo Gratteri Francesca Maria Elena Frigiolini Gabriele Rocca francesco Ventura Department of Legal and Forensic Medicine University of GenovaGenovaItaly Department of Legal and Forensic Medicine Institute of Legal MedicineMagna Grsecia University of CatanzaroCatanzaroItaly

Functional neurological disorders can have different clinical manifestations,including coma,in the setting of an unknown *** this article,we present a case of a young man affected by intellectual disabilities who,after a physical assault reported serious neurological alterations and a functional *** case shows how a stressful psychophysical event can bring acute and variable neurological manifestations of functional significance to a victim with previous intellectual *** the growing interest in this field,research is still very limited and studies in this field could better explain the nature of the psychogenic *** a medico-legal point of view,problems of evaluation may emerge for these disorders emerge as a result of acute psycho-physical stress and without any detectable structural alterations.

关键词： Functional coma functional neurological disorder psychogenic disorders stressful events

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Postmortem Nasopharyngeal Swabs Performed during the COVID-19 Infection:Analysis of Preliminary Clinical Records by the Genoa Institute of Legal Medicine(North-West Italy)

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Journal of Forensic Science and Medicine 2022年第1期8卷 24-31页

作者： Martina Drommi rosario Barranco Arianna Bal bo Stefano Errico Francesca Maria Elena Frigiolini Manuela Mangioni Giulia Molinari Alessandra Zappi Patrizia Caligiuri francesco De Stefano francesco Ventura Department of Forensic and Legal Medicine University of GenovaGenovaItaly Department of Health Sciences University of GenovaGenoaItaly Department of Hygiene San Martino Polyclinic HospitalGenovaItaly

COVID-19,the disease caused by the SARS-CoV-2 virus,is highly *** persistence of the virus after infected individuals die remains *** article reports the findings taken from postmortem nasopharyngeal swabs performed to investigate the presence of SARS-CoV-2 in the corpses transferred to the Genoa District Mortuary from the outset of the Italian lockdown(March 9)to the end of the first emergency phase(July 13).One hundred and eighty swabs were carried out:13 corpses resulted positive for the virus,with the diagnosis being reached only after *** were male and 6 female with an average age of 73.5 years *** most frequent comorbidities recorded were arterial hypertension,diabetes,Alzheimer 5s,and pulmonary *** two cases,the swab tested positive at a distance of 125 h and 165 h from actual *** nasopharyngeal swab results a useful way to screen corpses for COVID-19 and to handle bodies in Legal Medicine Centers where safe autoptic rooms are not *** are also a means of safeguarding forensic pathologists,identifying the presence of breeding grounds in the community and providing information for the Public Prosecutor's Office in legal *** are able to produce reliable results up to at least 7 days following death,provided that the corpse is correctly preserved.

关键词： Autopsy forensic pathology legal medicine managing of the corpses naso-pharyngeal swab SARS-CoV-2

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