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Retrospective study of HIV drug resistance in Mexican children with vertically transmitted infection

World Journal of Pediatrics 2022年第7期18卷 505-510页

作者： Cristina de Jesus Herrera-Castillo Angelica Maldonado-Rodriguez Othon Rojas-Montes Ana Maria Cevallos JoséGuillermo Vazquez-Rosales rosalia lira Infectious Diseases Department Pediatrics Hospital"Silvestre Frenk Freund"National Medical Center"Siglo ⅩⅪ".Mexican Social Sccurity Instiute(IMSS).Mexico City.Mexico Infectious and Parasitie Dise ases Medical Research Unit Pediatrics Hospital"Silvestre Frenk Freund"National Medical Center“Siglo ⅩⅪ”Mexican Social Security Institute(IMSS).Col.Cuauhtemoc.Av.Cuauhtemoc 33006720 Mexico CityMexico Departament of Molecular Biology and Biotechnology Biomedical Research InstituteNational Autonomous University of MexicoUNAMMexico City.Mexico

According to World Health Organization(WHO)estimates,in 2020,there were 1.8 million human immunodeficiency virus(HIV)-infected children below 15 years old living with HIV and 150,000 children who acquired the infection[1].Every year,110,000 children die as a consequence of acquired immune deficiency syndrome-related causes[2].As in adults,optimal management of infected children depends on early diagnosis and treatment with antiretroviral drugs based on their viral genotype.

关键词： infection diagnosis drugs

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Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients

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World Journal of Gastroenterology 2014年第37期20卷 13530-13537页

作者： Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres rosalia lira Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexicano del Seguro Social Clinica de Hepatitis Hospital de Infectologia Centro Médico Nacional La Raza Hospital General Regional No.72 IMSS Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexi-cano del Seguro Social Hospital Infantil de Mexico "Federico Gomez"

AIM: To determine the frequency of occult hepatitis B infection (OHBI) in a group of human immunodeficiency virus (HIV)-1+/ hepatitis B surface antigen negative (HBsAg)- patients from Mexico.

关键词： Hepatitis B virus Occult hepatitis B virus infection Human immunodeficiency virus Hepatitis B surface antigen negative Risk factors Molecular diagnostics

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Occult hepatitis B virus co-infection in human immunodeficiency virus-positive patients: A review of prevalence, diagnosis and clinical significance

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World Journal of Hepatology 2015年第2期7卷 253-260页

作者： Angelica Maldonado-Rodriguez Ana Maria Cevallos Othon Rojas-Montes Karina Enriquez-Navarro Ma Teresa Alvarez-Mu?oz rosalia lira Unidad de Investigacion Medica en Enfermedades Infecciosas y Parasitarias Hospital de Pediatria Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Departamento de Biologia Molecular y Biotecnologia Instituto de Investigaciones Biomedicas Universidad Nacional Autonoma de Mexico

The prevalence of human immunodeficiency virus(HIV) and hepatitis B virus(HBV) co-infection is high as they share similar mechanisms of transmission. The development and widespread use of highly sensitive tests for HBV diagnosis has demonstrated that a significant proportion of apparently healthy individuals with evidence of exposure to HBV continue to carry fully functional HBV DNA in their hepatocytes, a situation that predisposes them to the development of progressive liver disease and hepatocellular carcinoma. The presence of co-infections frequently influences the natural evolution of each of the participating infections present by either facilitating their virulence or competing for resources. Furthermore, the drugs used to treat these infections may also contribute to changes in the natural course of these infections, making the analysis of the impact of co-infection more difficult. The majority of studies has examined the impact of HIV on overt chronic hepatitis B, finding that co-infection carries an increased risk of progressive liver disease and the development of hepatocellular carcinoma. Although the effect of HIV on the natural history of occult hepatitis B infection(OBI) has not been fully assessed, all available data suggest a persisting risk of repeated flares of hepatitis and progressive liver disease. We describe studies regarding the diagnosis, prevalence and clinical significance of OBI in HIVpositive patients in this short review. Discrepancies in worldwide prevalence show the urgent need for the standardization of diagnostic criteria, as established by the Taormina statements. Ideally, standardized protocols for testing should be employed to enable the comparison of data from different groups. Additional studies are needed to define the differences in risk for OBI without HIV and in HIV-HBV co-infected patients with or without overt disease.

关键词： Hepatitis B virus Occult hepatitis B virus infection Hepatitis C virus Egypt Blood donors Hemodialysis Hepatitis B virus reactivation

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