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Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review

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World Journal of Clinical Oncology 2020年第1期11卷 31-42页

作者： rogelio González-González Sandra López-Verdín Jesús Lavalle-Carrasco Nelly molina-Frechero m.rio Isiordia-Espinoza ramón G Carreón-Burciaga ronell Bologna-molina Department of research School of DentistryUniversidad Juárez del Estado de DurangoDurango 34000Mexico research Institute of Dentistry Health Science CenterUniversidad de GuadalajaraGuadalajara 4430Mexico Department of Health Care Xochimilco UnitUniversidad Autónoma Metropolitana XochimilcoMéxico 04960Mexico Department of Clinics Biomedical Sciences DivisionCentro Universitario de los AltosUniversidad de GuadalajaraTepetitlán de Morelos 47620Mexico molecular Pathology Area School of DentistryUniversidad de la RepúblicaMontevideo 11600Uruguay

BACKGrOUND Ameloblastomas are common benign epithelial odontogenic neoplasms that present an aggressive and unpredictable behavior that may modify treatment *** signaling pathways that participate in the progression of these tum.rs have been identified.B-raf proto-oncogene serine/threonine kinase(BrAF)is a protein involved in the behavior of ameloblastomas,and it is related to many cell *** gene mutations have been identified in ameloblastomas,of which the BrAF V600E(valine substituted by glutamic acid at amino acid 600)mutation has been the most common and can be present concomitantly with other mutations that may be involved in its *** therapies have been used as an alternative in the case of resistance or contraindications to conventional *** To document the presence of BrAF V600E and additional mutations,their behavior,and targeted therapies in these *** An electronic literature search was conducted according to PrISmA guidelines in Pubmed/mEDLINE,Cochrane,EmBASE,and SpringerLink using the terms“ameloblastomas”,“BrAF V600E”,“additional mutations”,and“targeted therapies”.Ameloblastomas were classified according to WHO *** criteria were articles in English,published not m.re than 10 years ago,and studies with laboratory works related to BrAF *** were evaluated by two independent reviewers and retrieved for full-text *** EBLIP Critical Appraisal Checklist was used to evaluate the quality of the eligible *** statistical analysis was *** Two independent reviewers,with a substantial concordance indicated by a kappa coefficient of k=0.76,evaluated a total of 19 articles that were included in this *** analysis registered 521 conventional ameloblastomas(Am),81 unicystic ameloblastomas(UA),13 ameloblastic carcinomas(AC),three metastatic ameloblastomas(mA),and six peripheral ameloblastomas(PA),of which the histopathological type,anatom

关键词： Ameloblastoma B-raf proto-oncogene serine/threonine kinase B-raf protooncogene serine/threonine kinase V600E Additional mutations Targeted therapies

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Notes,outline and divergence times of Basidiomycota

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Fungal Diversity 2019年第6期99卷 105-367页

作者： mao-Qiang He rui-Lin Zhao Kevin D.Hyde Dominik Begerow m.rtin Kemler Andrey Yurkov Eric H.C.mcKenzie Olivier raspe makoto Kakishima Santiago Sanchez-ram.rez Else C.Vellinga roy Halling Viktor Papp Ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan Schoutteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladim.r Antonin Teun Boekhout Bianca Denise Barbosa da Silva Eske De Crop Cony Decock Balint Dima Arun Kum.r Dutta Jack W.Fell Jozsef Geml masoomeh Ghobad-Nejhad Adm.r J.Giachini Tatiana B.Gibertoni Sergio P.Gorjon Danny Haelewaters Shuang-Hui He Brendan P.Hodkinson Egon Horak Tamotsu Hoshino Alfredo Justo Young Woon Lim Nelson menolli Jr Armin mesic Jean-m.rc moncalvo Gregory m.mueller La szlo G.Nagy rHenrik Nilsson machiel Noordeloos Jorinde Nuytinck Takamichi Orihara Cheewangkoon ratchadawan m.rio rajchenberg Alexandre G.S.Silva-Filho m.rcelo Aloisio Sulzbacher Zdenko Tkalcec ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felipe Wartchow Tie-Zheng Wei michael WeiB Chang-Lin Zhao Paul m.Kirk State Key Laboratory of mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Department of Entomology and Plant Pathology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal research Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China ruhr-Universitat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibniz Institute DSmZ-German Collection of microorganisms and Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany manaaki Whenua-Landcare research Private Bag 92170AucklandNew Zealand research Department Meise Botanic GardenNieuwelaan 381860 MeiseBelgium Service General de l'Enseignement superieur et de la recherche scientifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium University of Tsukuba TsukubaIbaraki 305-8572Japan Department of Ecology and Evolutionary Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA Institute of Systematic Botany The New York Botanical GardenBronxNY 10458-5126USA Department of Botany Szent Istvan University1518 BudapestHungary Kom.rov Botanical Institute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 Institut pour Systematique Ecologie Biodiversite(ISYEB Umr 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance Institute of microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Department of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium State Key Laboratory of Applied microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Department of Botany Moravian Mu

The Basidiomycota constitutes a major phylum of the kingdom Fungi and is second in species numbers to the *** present work provides an overview of all validly published,currently used basidiomycete genera to date in a single *** outline of all genera of Basidiomycota is provided,which includes 1928 currently used genera names,with 1263 synonyms,which are distributed in 241 families,68 orders,18 classes and four *** provide brief notes for each accepted genus including information on classification,number of accepted species,type species,life mode,habitat,distribution,and sequence ***,three phylogenetic analyses with combined LSU,SSU,5.8s,rpb1,rpb2,and ef1 datasets for the subphyla Agaricomycotina,Pucciniomycotina and Ustilaginomycotina are conducted,*** time estimates are provided to the family level with 632 species from 62 orders,168 families and 605 *** study indicates that the divergence times of the subphyla in Basidiomycota are 406-430 mya,classes are 211-383 mya,and orders are 99-323 mya,which are largely consistent with previous *** this study,all phylogenetically supported families were dated,with the families of Agaricomycotina diverging from 27-178 mya,Pucciniomycotina from 85-222 mya,and Ustilaginomycotina from 79-177 *** times as additional criterion in ranking provide additional evidence to resolve taxonomic problems in the Basidiomycota taxonomic system,and also provide a better understanding of their phylogeny and evolution.

关键词： Classification molecular clock Fungi Systematics Taxonomy

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Observatory science with eXTP

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Science China(Physics,mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.m.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake m.rgarita Hernanz Peter A.Jenke Thomas J.maccarone Simin mahmoodifar Domitilla de m.rtino Alessandra De rosa Elena m.rossi Antonia rowlinson Gloria Sala Giulia Stratta Thomas m.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altam.rano Jean-Luc Atteia Nils A.andersson m.Cristina Baglio David r.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward m.Cackett riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez m.ria Chernyakova ChiChuan Jin riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando massimiliano De Pasquale Nathalie Degenaar melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle maurizio Falanga XiLong Fan robert D.Ferdman m.rco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi mingYu Ge Bruce Gendre ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys malyshev Julien malzac Antonios manousakis Ian mcHardy missagh mehdipour YunPeng men m.riano méndez roberto P.mignani romana mikusincova m.Coleman miller Giovanni miniutti Christian motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo reig SrON Netherlands Institute for Space research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICrEA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAr SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTrON Netherlands Institute for radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ max-Planck-Institut für radioastronomie Dr.Karl-remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IrAP Universitéde ToulouseCNRSUPSCNES mathematical Sciences and STAG research Centre University of Southampton New York University Abu Dhabi Center for relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental research Dipartimento di matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves

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First and Second Law Analysis of a LiBr-Water Absorption Cycle with recovering Condensation Heat for Generation

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Frontiers in Heat and mass Transfer 2024年第6期22卷 1719-1741页

作者： J.L.rodríguez-muñoz J.S.Pacheco-Cedeño J.F.Ituna-Yudonago J.J.ram.rez-minguela I.J.González-Hernández Department of mechanical Engineering Escuela Superior de Ciudad SahagúnUniversidad Autónoma del Estado de HidalgoCiudad SahagúnCarretera Cd.Sahagún-Otumba s/nZona IndustrialHidalgoC.P.43998México Departamento de Ingeniería en Aeronáutica Universidad Politécnica Metropolitana de HidalgoBoulevard Acceso a Tolcayuca 1009Ex Hacienda de San Javier TolcayucaHidalgoC.P.43860México Department of Chemical Engineering University of GuanajuatoDCNECol.Noria Alta s/nGuanajuatoGto.C.P.36050México Department of Industrial Engineering Escuela Superior de Ciudad SahagúnUniversidad Autónoma del Estado de HidalgoCiudad SahagúnHidalgoC.P.43998México

In conventional absorption refrigeration systems(ArS),the heat from the condenser is usually rejected by the environment in place to be used in the system,so recuperating this is a good alternative to enhance the system’s *** instance,in this paper,an alternative ArS in which LiBr/Water is used as a refrigerant mixture,where part of condensing heat is recovered via the solution heat recovery generator absorption cycle(Hr-ArS)was energy and exergy *** influence of generator,condenser and evaporator temperatures,as well as the efficiency of the solution heat exchanger on the coefficient of performance,exergy performance and exergy destroyed of the Hr-ArS system,were analyzed and compared with the traditional ArS system at the same working *** results showed an increase between 5.8%–6.3%on the COP and 3.7%–9.5%in the exergy efficiency when condenser/absorber temperature was reduced from 40℃ to 30℃.However,when the evaporation temperature rose from 5℃ to 15℃,the COP(coefficient of performance)increased by around 8%,although this could be increased by 2.3%–6.3%if the generator temperature decreases from 100℃ to 80℃.m.reover,the COP and exergetic performance for the Hr-ArS is m.re significant at the lowest generator,condenser and evaporator temperatures,as well as at high efficiency in the solution heat exchanger,in comparison to ArS ***,the COP and exergy performance for the Hr-ArS system was im.roved by 2.57%to 3.11%and 0.22%to 0.7%,respectively,while the recovering condensation heat for generation is around 1.51%–3.76%lower than with the *** also was found that for all ranges of evaporator and condenser temperatures,the COP for the Hr-ArS system is around 3%higher than that obtained with the ArS at the three different generator temperatures here analyzed,while when the solution heat exchanger effectiveness was increased from 0.7–1.0,the total exergy destruction for the Hr-ArS resulted be 3.24%–5.01%smaller than the ArS

关键词： Absorption refrigeration system recovery condensation heat energy and exergy analysis LiBr-H_(2)O

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