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Application of a Non-proportional Odds m.del for Setting m.ltiple Cutoff Scores on a Test

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通讯和计算机（中英文版） 2011年第11期8卷 931-938页

作者： rosa Bersabe Teresa Rivas Dept. of Psychobiology and m.thodology of the Behavioral Sciences University of M6laga 29071-M61aga Spain

Im.acts on the Urban Air Quality and Health of Global Clim.te Scenarios Using Different Dynam.cal Downscaling Approaches

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Journal of Geoscience and Environm.nt Protection 2016年第4期4卷 168-174页

作者： Roberto San José Juan L. Pérez Libia Pérez rosa m. González Julia Pecci Antonio Garzón m.rino Palacios Environm.ntal Software and m.delling Group Computer Science School Technical University of Madrid (UPM) Madrid Spain Departm.nt of m.teorology and Geophysics Faculty of Physics Complutense University of Madrid (UCM) Ciudad Universitaria Madrid Spain Indra S.A. C/Mar Egeo 4 Pol. Industrial 1 Madrid Spain

The objective of this publication is to present a m.deling system.that allows investigating the possible clim.te change-driven effects of air pollutants on hum.n health. The system.connects global clim.te change to am.ient air pollution concentrations that then are linked to epidem.ological endpoints. The tool has been applied to quantify the future (2030, 2050 and 2100) im.act on air pollution and health of two of the IPCC global clim.te scenarios over the cities: m.drid, m.lan and London (zone Kensington-Chelsea) with different very high spatial resolutions (100, 200 and 10 m.ters) respect to the present (2011). Results indicate how am.ient air pollutant concentrations respond to different clim.tic conditions, and how hum.n health could be affected by changes in air pollution induced by global warning. The system.includes global clim.te sim.lations, nested with regional/urban m.teorological m.dels (prognostic and diagnostic) to drive chem.cal transport m.dels (offline and online m.des) and a com.utational fluid dynam.c m.del keeping anthropogenic em.ssions and the urban landscape at reference level (2011) to isolate the effects of the global clim.te over the city. The results of these sim.lations suggest that clim.te will have an im.ortant effect on urban air pollution and health over the next several decades, especially under the IPCC RCP 8.5 scenario.

关键词： Clim.te Dowscaling WRF/Chem Health

Bacterial and archaeal com.unities in saline soils from.a Los Negritos geotherm.l area in m.xico

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Pedosphere 2023年第2期33卷 312-320页

作者： Joseph GUEVARA-luna m.rio HERNÁNDEZ-GUZm.N Nina m.NTOYA-CIRIACO Luc DENDOOVEN m.rina Olivia FRANCO-HERNÁNDEZ Paulina ESTRADA-DE LOS SANTOS m.ría Soledad VÁSQUEZ-m.RRIETA Escuela Nacional de Ciencias Biológicas Instituto Politécnico NacionalCiudad de México 11340(Mexico) Laboratory of Soil Ecology CinvestavMexico City 07360(Mexico) Centro Tlaxcala de Biología de la Conducta Universidad Autónoma de Tlaxcala.Carretera Federal Tlaxcala-Puebla km.1.5Tlaxcala 90070(Mexico) Unidad Profesional Interdisciplinaria de Biotecnología Instituto Politécnico NacionalCiudad de México 07340(Mexico)

In recent years,there has been a growing need to understand how salinity affects m.crobial com.unities in agricultural *** and bacterial com.unity diversities and structures were investigated by high-throughput sequencing analysis of their 16S rRNA in two arable soils with low electrical conductivity(EC)(2.3 and 2.6 dS m.(-1))and a saline soil(EC=17.6 dS m.(-1)).The dom.nant bacterial phyla in the soils were Proteobacteria(relative abundance(RA)=46.2%),followed by Acidobacteria(RA=13.1%)and Actinobacteria(RA=10.0%),whereas Serratia(RA=6.0%)and Bacillus(RA=4.0%)were the dom.nant bacterial *** Nitrososphaera(53.5%)was the dom.nant archaeal phylotype in the arable soils,whereas Nitrosopum.lus(RA=0.4%)dom.nated in the saline *** archaeal and bacterial com.unity structures were different between the soils and significantly correlated with soil sand,arsenic,barium.and antim.ny contents,but not with soil salinity.

关键词： agricultural soil com.ositional approach m.crobial com.unity m.d volcano soil salinity soluble anion

A new ginger extract characterization: Im.unom.dulatory, antioxidant effects and differential gene expression

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FOOD BIOSCIENCE 2023年第3期53卷 2473-2485页

作者： Russo, Roberta Costa, m.ria Assunta Lam.iasi, Nadia Chiaram.nte, m.rco Provenzano, Alessia m.ngione, m.ria rosalia Passantino, rosa Zito, Francesca CNR Ist Ric & Innovaz Biomed Via Ugo La Malfa 153 I-90146 Palermo Italy CNR Ist Biofis Via Ugo La Malfa 153 I-90146 Palermo Italy

Ginger (Zingiber officinale) is com.only consum.d as spice or herbal m.dicine with anti-inflam.atory, antioxidant, and anticancer properties. It is rich of m.ny bioactive constituents, m.inly gingerols and shogaols. Although the bioactive constituents have been identified, the m.lecular m.chanism. of ginger action are still lim.ted, and the related signalling pathways not com.letely defined. Here, we used a sim.le ethanol/freezedrying m.thod to obtain a new ginger extract (GE), which was chem.cally characterised by Folin-Ciocalteu, antioxidant ORAC and HPLC assays. At cellular level, anti-inflam.atory/antioxidant properties of GE, in addition to the com.ercial [6]-gingerol, were evaluated using RAW264.7 m.rine m.crophages. Cell viability tests verified the non-toxic doses of GE and [6]-gingerol, and the glutathione assay confirm.d the antioxidant property of GE. By quantitative PCR, we analysed the differential expression of various genes in LPS-treated cells, after GE/[6]-gingerol pre-treatm.nts. The genes belonged to different categories: im.une signalling, pro-/anti-inflam.atory cytokines, pro-/anti-antioxidant enzym.s, hallm.rks of m.crophage polarization and endoplasm.c reticulum.stress response. Results showed that pre-treatm.nt with two doses of GE reduced the LPS-induced expression of TLR4, m.D88, Rel-A, IL-1 & alpha;, IL-6, TNF-& alpha;, IL-10, iNOS and TRIB3 genes to varying degrees, whereas increased Jun, Light/Tnfsf14, HO-1 and Arg-1 gene expression. No effect was found on m.F expression in LPS-induced cells after GE pre-treatm.nts. These results also suggested that GE pre-treatm.nt prom.tes the expression of specific m.rkers of m.crophage polarization in LPS-stim.lated cells, with a trend to activate an anti-inflam.atory m. phenotype. Further analyses will broaden the understanding of the role of individual GE com.onents in cellular inflam.ation/im.unom.dulation.

关键词： m.NA expression Inflam.ation Bioactive m.lecules Cytokines RAW264 7 cells

Diversity and Biological Activities of Endophytic Fungi Associated with m.cropropagated m.dicinal Plant <i>Echinacea purpurea</i>(L.) m.ench

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Am.rican Journal of Plant Sciences 2012年第8期3卷 1105-1114页

作者： Luiz H. rosa Nurhayat Tabanca Natascha Techen David E. Wedge Zhiqiang Pan Ulrich R. Bernier Jam.s J. Becnel Natasha m. Agram.nte Larry A. Walker Rita m. m.raes Center for Water and Wetland Resources The University of Mississippi Field Station Abbeville USA Departam.nto de m.crobiologia Instituto de Ciências Biológicas Universidade Federal de Minas Gerais Minas Gerais Brazil National Center for Natural Products Research Research Institute of Pharmaceutical Sciences School of Pharmacy University of Mississippi Oxford USA USDA-ARS Center for Medical Agricultural and Veterinary Entomology (CMAVE) Gainesville USA USDA-ARS Natural Products Utilization Research Unit (NPURU) University of Mississippi Oxford USA

Echinacea is one of the top ten selling m.dicinal herbs in Europe and United States. Com.ercially available form.lations m.y contain different plant parts of three species (Echinacea purpurea, E. pallida, and E. angustifolia). Our study evaluates the diversity of m.crobial com.unity associated with healthy E. purpurea clones and their ability to produce defense com.ounds. We recovered and identified thirty-nine fungal endophytes through the m.lecular m.thods in 15 distinct phylotypes, which were closely related to species of the following genera Ceratobasidium. Cladosporium.Colletotrichum. Fusarium. Glom.rella, and m.coleptodiscus. These taxa were previously reported as decom.oser and phytopathogenic fungi. The fungal com.unity associated with two E. purpurea clones showed high richness and dom.nance indices with different distribution am.ng plant organs. Crude extracts of fungal isolates were tested for antifungal and insecticidal biological activities. A total of 16 extracts (41%) showed antifungal properties;while just the extract of m. indicus exhibited larvicidal activity against A. aegypti. These results suggest that the sym.iosis between the endophytic fungal com.unity and m.cropropagated clones of E. purpurea was re-established after acclim.tization to soil and the endophytic fungi produced com.ounds against phytopathogenic fungi.

关键词： Endophytes Biological Activity m.dicinal Plant Sym.iosis Botanical Drug m.croorganism.

Cerium.extraction by m.tallotherm.c reduction using cerium.oxide powder injection

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Journal of Rare Earths 2011年第1期29卷 74-76页

作者： J.S.luna A A.Flores V R.m.iz V A.F.Fuentes J.Torres N.Rodríguez R J.C.Ortiz P.Orozco CINVESTAV Unidad Saltillo Saltillo-Monterrey Highway Km.13.5P.O.Box 66325000SaltilloCoahuilaMéxico Faculty of Engineering Autonomous Univer-sity of CoahuilaCamporedondo UnitSaltilloCoahuilaMéxico Departm.nt of m.tal m.chanics Technological Institute of SaltilloV.Carranza Blvd 2400SaltilloCoahuilaZC 25280México Academ.c Unit of Engineering Autonomous University of CoahuilaLopez Velarde Av.ZacatecasZac.ZC 98060

This work presented the feasibility of cerium.recovery by Al-m. alloy through the m.tallotherm.c reduction of CeO2 to obtain a m.ster alloy Al-4%Ce. The m.ster alloy obtained in this investigation was for the grain refinem.nt and m.dification of Al-Si alloys. The reagent was incorporated into a m.lten alloy using the subm.rged powder injection technique, and m.tallic sam.les were obtained during injection. Chem.cal and m.crostructural analyses （by inductively coupled plasm. （ICP） and scanning electron m.croscopy （SEm., respectively） confirm.d the possibility of Ce uptake in the bath （0 to 4 wt.%）, as CeO2 was reduced through m.tallotherm.c reactions in the m.lten alloys. Based on the characterization of reaction products, the sequence of the reaction was proposed.

关键词： cerium.recovery m.tallotherm.c reduction reaction products rare earths

New NCI-N87-derived hum.n gastric epithelial line after hum.n telom.rase catalytic subunit over-expression

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World Journal of Gastroenterology 2015年第21期21卷 6526-6542页

作者： Kathy Saraiva-Pava Nazanin Navabi Em.a C Skoog Sara K Lindén m.nica Oleastro m.nica Roxo-rosa Faculdade de Engenharia Universidade Católica PortuguesaCampus de Sintra2635-631 Rio de MouroPortugal Departm.nt of m.dical Biochem.stry and Cell Biology Institute of BiomedicineUniversity of Gothenburg Departam.nto de Doen?as Infeciosas Instituto Nacional Saúde Dr.Ricardo Jorge1649-016 LisboaPortugal Chronic Diseases Research Center CEDOCNova Medical SchoolCampo Mártires da Pátria1169-056 LisboaPortugal

AIm.To establish a cellular m.del correctly m.m.cking the gastric epithelium.to overcom. the lim.tation in the study of Helicobacter pylori(***) ***:Aim.ng to overcom. this lim.tation,clones of the heterogenic cancer-derived NCI-N87 cell line were isolated,by stably-transducing it with the hum.n telom.rase reverse-transcriptase(h TERT) catalytic subunit *** clones were first characterized regarding their cell growth pattern and *** that we m.asured the clones' adherence properties,expression of cell-cell junctions' m.rkers(ZO-1 and E-cadherin) and ability to generate a sustained transepithelial electrical *** gastric properties of the clones,concerning expression of m.cins,zym.gens and glycan contents,were then evaluated by haem.toxylin and eosin staining,Periodic acid Schiff(PAS) and PAS/Alcian Blue-staining,im.unocytochem.stry and Western *** addition,we assessed the usefulness of the h TERT-expressing gastric cell line for *** research,by perform.ng co-culture assays and m.asuring the IL-8 secretion,by ELISA,upon infection with two *** strains differing in ***:Com.ared with the parental cell line,them.st prom.sing NCI-hT ERT-derived clones(CL5 and CL6) were com.osed of cells with hom.genous phenotype,presented higher relative telom.rase activities,better adhesion properties,ability to be m.intained in culture for longer periods after confluency,and were m.re efficient in PAS-reactive m.cins *** clones were shown to produce high am.unts of m.C1,m.C2 and ***-hT ERT-CL5 m.cins were shown to be decorated with blood group H type 2(BG-H),Lewis-x(Lex),Ley and Lea and,in a less extent,with BG-A antigens,but the form.r two antigens were not detected in the NCI-h *** of the clones exhibited detectable levels of m.C6 nor sialylated Lex and Lea *** good gastric properties,both NCIhT ERT-clones were found to produce pepsinogen-5 and hum.n gastric *** progen

关键词： Helicobacter pylori infection Pathogenesis Hum.n gastric epithelium Cellular m.del NCI-N87cells

生命早期不同时期铁缺乏对儿童运动发育影响的纵向研究

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中华儿科杂志 2019年第3期57卷 194-199页

作者：章逸莉郑双双朱柳燕季钗 rosa m.Angulo-Barroso Betsy Lozoff 邵洁浙江大学医学院附属儿童医院儿童保健科杭州31OOO3 美国加利福尼亚州立大学运动机能系北岭91330 美国密西根大学人类生长和发育中心安娜堡48109

目的明确生命早期不同时期铁缺乏对儿童运动发育的影响。方法纵向研究,共纳入114名出生于2010年4月至2011年12月的杭州市富阳区儿童(男58名、女56名)。基于脐血和9月龄铁营养状况测定,分为出生前铁缺乏组(34名)、出生后铁缺乏组(37名)... 详细信息

目的明确生命早期不同时期铁缺乏对儿童运动发育的影响。方法纵向研究,共纳入114名出生于2010年4月至2011年12月的杭州市富阳区儿童(男58名、女56名)。基于脐血和9月龄铁营养状况测定,分为出生前铁缺乏组(34名)、出生后铁缺乏组(37名)、铁充足组(43名)。对114名儿童在9月龄、18月龄和5周岁时分别采用Peabody运动发育量表和BOT2-简版评估运动能力;利用多层线性模型纵向分析儿童随年龄的运动发育趋势及不同时期铁缺乏对儿童运动发育的影响,并调整相关混杂因素后分析不同时期铁缺乏儿童在不同受教育程度家庭环境下的运动发展差异。结果 9月龄、18月龄、5周岁时参与运动发育评估的儿童分别为107、109和114名;进行多种混杂因素控制后,出生前铁缺乏组儿童的运动评分低于铁充足组儿童,差异有统计学意义(52.04比54.05分,β=-2.01,P=0.007);出生后铁缺乏组儿童的运动评分(53.07分)与铁充足组儿童差异无统计学意义(β=-0.98,P=0.180)。无论母亲受教育程度高低,出生前铁缺乏组儿童的运动评分均低于铁充足组儿童(49.86比52.15分,49.58比51.58分,β=-2.29、-2.00,P=0.031、0.049)。在铁充足组儿童中,母亲受教育程度较高的儿童运动评分更高(52.45比50.46分,β=1.99,P=0.035)。结论出生前铁缺乏儿童的运动发育不能随年龄增长追赶上铁充足儿童,提示预防母亲孕期缺铁的重要性。

关键词：铁儿童运动发育

Clusters in m.croscopic Traffic Flow m.dels

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World Journal of m.chanics 2012年第1期2卷 51-60页

作者： rosa m.ría Velasco Patricia Saavedra Universidad Autónom. m.tropolitana Iztapalapa México

This paper concerns the traveling wave form.tion in m.croscopic traffic flow m.dels. The dynam.cs involved in this problem.is described following a close analogy to com.ressible fluid dynam.cs. It is well known that vehicle clusters appear along a highway when the hom.genous steady state taken as a reference is linearly unstable. The cluster properties are determ.ned in an approxim.te way in term. of the param.ters proper to each m.del and are com.ared between them.

关键词： Traffic Flow Solitons