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International Journal of Clinical Medicine 2012年第3期3卷 215-219页

作者： Francesca Dini Cristina Tuoni Andrea Nannipieri Sara Lunardi rosa teresa scaramuzzo Laura D’Accavio B. Kuppers A. Valetto A. Bartalena Antonio Boldrini Paolo Ghirri Cytogenetics and Molecular Genetics Unit University Hospital of Pisa Pisa Italy Dermatology Unit University Hospital of Pisa Pisa Italy Neonatology Unit Mother and Child Department University Hospital of Pisa Pisa Italy Scuola Superiore Sant’Anna Pisa Italy Section of Neonatal Endocrinology and Dysmorphology University Hospital of Pisa Pisa Italy.

Adams-Oliver Syndrome (AOS) is a rare genetic disease characterized by combination of aplasia cutis congenita (ACC) and terminal transverse limb defects (TTLD), often accompanied by defects in scalp and skull ossification. Different clinical phenotypes may be related to variable severity both of aplasia cutis and TTLD, and of minor clinical features as cutis marmorata telangiectatica congenita (CMTC), congenital cardiac defect and vascular anomalies. The treatment is multidisciplinary: dermatologic, orthopedic and surgical consult should be required. It still remains unclear how to treat patients with a large skin defect that can‘t be closed primarly and may require both surgical and conservative management. We report two cases of AOS with typical limb defects and an area of aplasia cutis over vertex of the scalp managed conservatively with two different dermatologic devices.

关键词： Adams-Oliver Syndrome Aplasia Cutis Congenita Scalp and Skull Defects Dermal Regeneration Template

Current applications of big data and machine learning in cardiology

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Journal of Geriatric Cardiology 2019年第8期16卷 601-607页

作者： Renato Cuocolo teresa Perillo Eliana De rosa Lorenzo Ugga Mario Petretta Department of Advanced Biomedical Sciences University of Naples “Federico II”NaplesItaly Department of Translational Medical Sciences University of Naples “Federico II”NaplesItaly

Machine learning (ML) is a software solution with the ability of making predictions without prior explicit programming, aiding in the analysis of large amounts of data. These algorithms can be trained through supervised or unsupervised learning. Cardiology is one of the fields of medicine with the highest interest in its applications. They can facilitate every step of patient care, reducing the margin of error and contributing to precision medicine. In particular, ML has been proposed for cardiac imaging applications such as automated computation of scores, differentiation of prognostic phenotypes, quantification of heart function and segmentation of the heart. These tools have also demonstrated the capability of performing early and accurate detection of anomalies in electrocardiographic exams. ML algorithms can also contribute to cardiovascular risk assessment in different settings and perform predictions of cardiovascular events. Another interesting research avenue in this field is represented by genomic assessment of cardiovascular diseases. Therefore, ML could aid in making earlier diagnosis of disease, develop patient-tailored therapies and identify predictive characteristics in different pathologic conditions, leading to precision cardiology.

关键词： Cardiac imaging techniques Cardiology Electrocardiography Machine learning Review

Hepatitis B vaccine by intradermal route in non responder patients:An update

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World Journal of Gastroenterology 2014年第30期20卷 10383-10394页

作者： Martina Filippelli Elena Lionetti Alessia Gennaro Angela Lanzafame teresa Arrigo Carmelo Salpietro Mario La rosa Salvatore Leonardi Department of Medical and Pediatric Science University of Catania95100 CataniaItaly Department of Pediatric Sciences University of Messina98100 MessinaItaly

Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.

关键词： Hepatitis B virus Vaccine Intradermal route Non responders Update

Application of a Non-proportional Odds Model for Setting Multiple Cutoff Scores on a Test

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通讯和计算机（中英文版） 2011年第11期8卷 931-938页

作者： rosa Bersabe teresa Rivas Dept. of Psychobiology and Methodology of the Behavioral Sciences University of M6laga 29071-M61aga Spain

Laboratory markers in ulcerative colitis: Current insights and future advances

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World Journal of Gastrointestinal Pathophysiology 2015年第1期6卷 13-22页

作者： Michele Cioffi Antonella De rosa rosalba Serao Ilaria Picone Maria teresa Vietri Department of Biochemistry Biophysics and General PathologySecond Medical School Naples

Ulcerative colitis(UC)and Crohn’s disease(CD)are the major forms of inflammatory bowel diseases(IBD)in *** some common features,these forms can be distinguished by different genetic predisposition,risk factors and clinical,endoscopic and histological *** aetiology of both CD and UC remains unknown,but several evidences suggest that CD and perhaps UC are due to an excessive immuneresponse directed against normal constituents of the intestinal bacterial *** sometimes invasive are routine for the diagnosis and care of patients with *** of UC is based on clinical symptoms combined with radiological and endoscopic *** employment of non-invasive biomarkers is *** biomarkers have the potential to avoid invasive diagnostic tests that may result in discomfort and potential *** ability to determine the type,severity,prognosis and response to therapy of UC,using biomarkers has long been a goal of clinical *** describe the biomarkers assessed in UC,with special reference to acute-phase proteins and serologic markers and thereafter,we describe the new biological markers and the biological markers could be developed in the future:(1)serum markers of acute phase response:The laboratory tests most used to measure the acute-phase proteins in clinical practice are the serum concentration of C-reactive protein and the erythrocyte sedimentation *** biomarkers of inflammation in UC include platelet count,leukocyte count,and serum albumin and serum orosomucoid concentrations;(2)serologic markers/antibodies:In the last decades serological and immunologic biomarkers have been studied extensively in immunology and have been used in clinical practice to detect specific *** UC,the presence of these antibodies can aid as surrogate markers for the aberrant host immune response;and(3)future biomarkers:The development of biomarkers in UC will be very important in the *** progress of

关键词： Inflammatory bowel diseases Ulcerative colitis Crohn’s disease Serologic markers Acute phase response

The cross-talk between family and pediatrician: The case of bronchial asthma

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Health 2013年第2期5卷 307-312页

作者： Salvatore Leonardi Rossella Pecoraro Maria teresa Garozzo Alfina Coco Mario La rosa Department of Pediatrics Bronchopneumoallergology and Cystic Fibrosis Unit University of Catania Catania Italy

Today the most important challenge facing the pediatrician is the increasing prevalence of chronic diseases. With this regard, pediatricians play a key role in the management of these conditions. The closeness with the family, the knowledge of the clinical case and the care continuity allow the pediatrician to acquire a position of director of every case. When pathological events have a chronic feature, suddenly the quality of life of the whole family changes. For this reason the first communication of chronic disease is very important and the task of the pediatrician should be to provide a positive message to help the family in facing the difficulty of this new challenge. The bronchial asthma is the most common chronic disease worldwide. The incidence, the prevalence, and the mortality of the disease have increased in children over the past decades. These trends are particularly marked above all in preschool children. The success reached by Pediatricians is closely related to the compliance and the implementation of the therapy followed by the little patient and his family. With this regard authors, in this review, focus on the illustration of several strategies, based on the pediatrician’ skills and medicine documents, that can be used for the improvement of communication among pedia- trician-family and child, never forgetting the hu- man aspect of the same doctor, that should con- ciliate with the scientific knowledge in the taking care of a specific chronic disease.

关键词： Cross-Talk Bronchial Asthma Children

Instructors’ caring behaviors, burnout, satisfaction, and academic performance of nursing students in online education and the pandemic era

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Frontiers of Nursing 2022年第4期9卷 431-437页

作者： Ryan Michael F.Oducado Mary Kristine Q.Amboy Ayesha C.Penuela Ronnell D.Dela rosa Maria teresa M.Fajardo Dolly Rose F.Temelo College of Nursing West Visayas State UniversityIlioloIloilo 5000Philippines Bataan Peninsula State University BataanBalanga 2100Philippines University of Pangasinan-PHINMA DagupanPangasinan 2400Philippines

Objective:This study aimed to determine the predictive ability of instructors’online caring behaviors,online learning burnout,and satisfaction with online learning on nursing students’academic ***:This was a cross-sectional study employing the administration of online self-repor t measures among 606 undergraduate students in one large nursing school in the *** analysis involved the use of descriptive statistics,Pearson’s r,and linear ***:The mean scores in the instructors’online caring behaviors scale,online learning burnout scale,online learning satisfaction scale,and self-repor ted academic performance were 3.88±0.70,4.00±0.84,2.51±0.96,and 3.25±0.79 ***(β=0.216,P=0.000),burnout(β=0.-098,P=0.019),and instructors’caring behaviors(β=0.096,P=0.030)explained 11.7%of the variability in the students’academic ***:Instructors’caring behavior and levels of burnout and satisfaction are linked to students’academic success in the vir tual learning *** study calls for nursing instructors to be mindful of signs of burnout,employ proactive measures that promote satisfactory learning,and foster more caring behaviors in this time of global health crisis.

关键词： academic performance academic success burnout distance education nursing education

Percoll Gradient Optimization for Blood CD133+ Stem Cell Recovery

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Stem Cell Discovery 2014年第3期4卷 61-66页

作者： rosa María López-Franco Jorge E. Moreno-Cuevas María teresa González-Garza Servicio de Terapia Celular School of Medicine CITES Tecnológico de Monterrey Monterrey México

Circulating CD133+ stem cells from the peripheral blood have been shown to be able to differentiate into numerous cell lineages. However, adults have only a small number of these circulating stem cells. The aim of the present study was to assess a new isolation and enrichment technique for CD133+ stem cells from peripheral blood with the use of Percoll density gradients. Our results demonstrated the presence of two large mononuclear bands when whole blood was centrifuged with 48% and 50% Percoll concentrations. Flow cytometric analysis (FACS) revealed a major CD133+ enrichment at the 48% Percoll concentration in one of the two bands. Further culture of these cells resulted in the formation of multiple colony-forming units. Our results suggest an advantage from using a simple Percoll gradient for successful CD133+ cell recovery, which could aid in differentiation and transplantation protocols.

关键词： Stem Cells Recovery CD133+ Percoll Density Gradients

Sex effect on presenilins expression in post-natal rat brain

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Advances in Bioscience and Biotechnology 2013年第12期4卷 1086-1094页

作者： Paola Piscopo Sonia Canterini Valentina Carletti Paolo rosa Alessio Crestini Maria teresa Fiorenza Annamaria Confaloni Department of Cellular Biology and Neuroscience Section of Clinics Diagnosis and Therapy of Central Nervous System Diseases Istituto Superiore di Sanità Rome Italy Department of Cellular Biology and Neuroscience Section of Clinics Diagnosis and Therapy of Central Nervous System Diseases Istituto Superiore di Sanità Rome Italy Department of Psychology Section of Neuroscience “Sapienza” University of Rome Rome Italy Department of Psychology Section of Neuroscience “Sapienza” University of Rome Rome Italy

Presenilin 1 and presenilin 2 are widely expressed during brain development. Several mutations in these proteins have been associated with autosomal-dominant inherited forms of Alzheimer disease. Their expression is regulated by various cellular and extracellular factors, which change with age and sex. Both age and sex are key risk factors for Alzheimer’s disease, but the issue of whether the expression of presenilins is influenced by the sex during early postnatal development of the brain has been poorly investigated so far. In this study, we report that transcript levels of presenilins, and the subset of neurons expressing these proteins in various brain areas of the developing post-natal brain are different in male and female rats, suggesting that their function(s) may contribute to sexual dimorphism in the brain, both at morphological and functional levels.

关键词： Development Sex Presenilins γ-Secretase Rats Sexual Dimorphism

The Pattern of Sediment Dispersion in the Front Sector of the Stenhouse and Ajax Glaciers, Visca Anchorage, King George Island, Antarctica

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International Journal of Geosciences 2014年第12期5卷 1509-1520页

作者： Beatriz Ferraz Scigliano Kátia Kellem da rosa Ana teresa Cordeiro Cid Bastos Elisabete de Santis Braga Instituto Oceanográfico da Universidade de Sao Paulo Laboratório de Nutrientes Micronutrientes e Elementos Traco nos Oceanos—Praca do Oceanográfico 191 CEP 055-8-120 Cidade Universitária Sao Paulo Brazil Universidade Federal do Rio Grande do Sul UFRGS Centro Polar e Climático—CPC Departamento de Geografia—Instituto de Geociências Av. Bento Goncalves 9500 Porto Alegre Brazil

This study investigated the dispersal pattern of suspended sediment in the areas near the Stenhouse and Ajax glaciers, Visca Anchorage, Martel Inlet, King George Island, Antarctica. This study was conducted using visible band processing of Quickbird high-resolution spatial images obtained in October 2006. The methodology was also based on the collection and interpretation of data obtained from water samples collected in Admiralty Bay in December 2004. The digital processing of satellite images was performed using a classification method based on the reflectance characteristics of water. The classified images improved visual identification of the dispersion pattern of suspended sediments in the study area. These data were related to the interpretation of analyses conducted on suspended particulate matter (SPM) in the water. The sediment dispersal pattern observed may be associated with glacial erosion processes, their input of meltwater from the front of the glaciers into the study area, detritus flow processes and glaciomarine circulation in the region.

关键词： Remote Sensing Glaciomarine Circulation Suspended Sediment