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The Occupational Symptoms in Bus Driver in Brazil and Psychoanalytic Contribution： A Descriptive Research

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Psychology Research 2013年第8期3卷 475-483页

作者： Alcantara Vanessa Carine Gil Andrade Silva Rose Mary rosa CostaI ramos Eliane Pereira Federal Fluminense University Rio de Janeiro Brazil

Astrocytes, reactive astrogliosis, and glial scar formation in traumatic brain injury

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Neural Regeneration Research 2025年第4期20卷 973-989页

作者： María Belén Cieri Alberto Javier ramos Laboratorio de Neuropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain injury is a global health crisis,causing significant death and disability *** that follows traumatic brain injury has serious consequences for neuronal survival and cognitive impairments,with astrocytes involved in this *** traumatic brain injury,astrocytes rapidly become reactive,and astrogliosis propagates from the injury core to distant brain *** astroglial proteins are downregulated near the traumatic brain injury core,while pro-inflammatory astroglial genes are *** altered gene expression is considered a pathological remodeling of astrocytes that produces serious consequences for neuronal survival and cognitive *** addition,glial scar formed by reactive astrocytes is initially necessary to limit immune cell infiltration,but in the long term impedes axonal reconnection and functional *** therapeutic strategies for traumatic brain injury are focused on preventing acute ***,cannabinoids,progesterone,beta-blockers,and cerebrolysin demonstrate neuroprotective benefits but most of them have not been studied in the context of *** this review,we discuss the cell signaling pathways activated in reactive astrocytes following traumatic brain injury and we discuss some of the potential new strategies aimed to modulate astroglial responses in traumatic brain injury,especially using cell-targeted strategies with miRNAs or lncRNA,viral vectors,and repurposed drugs.

关键词： astrocyte glial scar innate immunity neuroinflammation stab injury Toll-like receptors

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita O.Teodoro Mafalda Ribeiro ramos Lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

High-Resolution Esophageal Manometry in Teenagers with Esophageal Atresia

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Open Journal of Epidemiology 2020年第1期10卷 81-89页

作者： Cecilia Zubiri rosa ramos Cecilia Curvale Raúl Matanó Paula Borobia Anabella Zosi Verónica Garrido Julieta Hernández Lucía Gutierrez Luciana Guzmán María Cristina Arregui Marina Prozzi Sandro Miculan Viviana Bernedo Maximiliano Fernández Rivas Cristina Lorenzo Florencia Recalde Verónica Valdiviezo Darío Fajre Cintia Antonioli Mariana Allende Claudia Losada Teresita Gonzalez Department of Gastroenterology at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Gastroenterology at Hospital de Alta Complejidad El Cruce Florencio Varela Buenos Aires Argentina Posadas Hospital Buenos Aires Argentina Department of Nutrition at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Surgery at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Otorhinolaryngology at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina Department of Pneumonology at Hospital de Niños Sor María Ludovica La Plata Buenos Aires Argentina

Introduction: Children with surgically repaired esophageal atresia (EA) show esophageal dysmotility. Due to the performance of high-resolution manometry (HRM), three motility alteration patterns have been described, which allowed to know the segmental alterations. Objective: To describe the esophageal motility patterns found through HRM in teenagers with EA and to relate these with the associated esophageal pathology and its severity. Materials and Method: Ten teenagers were included with no history of esophageal blockage or dilations in the last six months, who were orally fed and asymptomatic. Through performance of HRM, we found surgical and endoscopic history, as well as of esophageal biopsies and pH monitoring. Results: We found the following patterns: aperistalsis, pressurization and distal contraction. 70% showed distal contraction, and 100% of esophageal endoscopies and biopsies were normal. 57% of the esophageal pH monitoring analyzed was pathologic. In the pressurization and aperistalsis groups, we observed severe esophagitis and requirement of Nissen antireflux procedure in 100% of the cases. Esophageal pH monitoring analyzed was 100% pathologic. Conclusion: We described the esophageal segmental alterations in teenagers with atresia by means of HRM. The distal contraction group showed better development, without severe esophagitis or requirement of antireflux procedure. Therefore, by performing an HRM in teenagers with EA, we could predict the future esophageal behavior, according to the peristaltic pattern, since there are significant differences among the groups in study.

关键词： High-Resolution Manometry Esophageal Atresia Teenagers

Brachioradialis tendon transfer and palmaris longus tendon graft for thumb avulsion:A case report and review of literature

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World Journal of Clinical Cases 2025年第4期13卷 48-55页

作者： Pierre Curings Sonia ramos-Pascual Kinga Michalewska Nicolas Gibert Lionel Erhard Mo Saffarini AlexisNogier Department of Hand Surgery Clinique TrenelSainte-Colombe 69560France Medical Research ReSurg SANyon 1260VaudSwitzerland Department of Hand Surgery Hand and Upper Limb Surgical InstituteVilleurbanne 69100France Department of Orthopaedics Clinique TrenelSainte-Colombe 69560France

BACKGROUND Thumb replantation following complete traumatic avulsion requires complex techniques to restore function,especially in cases of avulsion at the level of the metacarpophalangeal joint(MCP I)and avulsion of the flexor pollicis longus(FPL)at the musculotendinous *** treatments include direct tendon suture or tendon transfer,most commonly from the ring *** optimize function and avoid donor finger complications,we performed thumb replantation with flexion restoration using brachioradialis(BR)tendon transfer with palmaris longus(PL)tendon *** SUMMARY A 20-year-old left-handed male was admitted for a complete traumatic left thumb amputation following an accident while sliding from the top of a *** patient presented with skin and bone avulsion at the MCP I,avulsion of the FPL tendon at the musculotendinous junction(zone 5),avulsion of the extensor pollicis longus tendon(zone T3),and avulsion of the thumb’s collateral arteries and *** patient was treated with two stage thumb *** first intervention consisted of thumb replantation with MCP I arthrodesis,resection of avulsed FPL tendon and implantation of a silicone tendon *** second intervention consisted of PL tendon graft and BR tendon ***-up at 10 months showed good outcomes with active interphalangeal flexion of 70°,grip strength of 45 kg,key pinch strength of 15 kg and two-point discrimination threshold of 4 *** Flexion restoration after complete thumb amputation with FPL avulsion at the musculotendinous junction can be achieved using BR tendon transfer with PL tendon graft.

关键词： Brachioradialis tendon transfer Flexor pollicis longus Palmaris longus tendon graft Replantation Thumb amputation Thumb avulsion Case report

A novel heterozygous SF1/NR5A1 gene variant causes 46,XY DSD-gonadal dysgenesis with hypergonadotropic hypogonadism without adrenal insufficiency

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Genes & Diseases 2024年第4期11卷 128-130页

作者： Luis ramos Department of Reproductive Biology Instituto Nacional de Ciencias Medicas y Nutricion Salvador ZubirdnTlalpanMexico City 14080Mexico

Steroidogenic factor 1(SF1/NR5A1;nuclear receptor subfamily 5 group A member 1)is an essential orphan protein involved in gonadal embryogenesis,sex determination,and reproductive endocrinology.

关键词： insufficiency determination gonadal

Principles of surgical resection in hilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 139-146页

作者： Emilio ramos Department of General Surgery Hospital Universitario de BellvitgeUniversidad de Barcelona08907 BarcelonaSpain

The aim of this article is to describe the surgical techniques for the treatment of hilar cholangiocarcinoma(HC).Resection with microscopically negative margin(R0) is the only way to cure patients with ***,resection of the caudate lobe and part of segment Ⅳ,combined with a right or left hepatectomy,bile duct resection,lymphadenectomy of the hepatic hilum and sometimes vascular resection,is the standard surgical procedure for *** frozen-section examination of proximal and distal biliary margins is necessary to confirm the suitability of *** lymphadenectomy probably has little direct effect on survival,inaccurate staging information may influence post resection treatment *** venous and arterial resections should be undertaken in selected cases to achieve a R0 *** concept of 'no-touch proposed' in 1999 by Neuhaus et al combine an extended right hepatectomy with systematic portal vein resection and caudate lobectomy avoiding hilar dissection and possible intraoperative microscopic dissemination of cancer *** recently minor liver resections have been proposed for treatment of *** the hilar bifurcation of the bile ducts is near to liver segments Ⅳ,Ⅴ and Ⅰ,adequate liver resection of these segments together with the bile ducts can result in cure.

关键词： Cholangiocarcinoma Surgery Technique

Parabolic Trough Collector and Central Receiver Coupled with Fresnel Lens:Experimental Tests

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International Journal of Automation and computing 2020年第4期17卷 572-587页

作者： Angelica Palacios Dario Amaya Olga ramos Universidad Militar Nueva Granada Bogota 110121Colombia

Renewable energies have a high impact on power energy production and reduction of environmental pollution worldwide,so high efforts have been made to improve renewable technologies and research about *** paper presents the thermal performance results obtained by simulation and experimental tests of a parabolic trough collector with central receiver coupled to Fresnel lens,under different configurations on the *** simulation method was computational fluid dynamics(CFD)analysis in SolidWorks(R)soft-ware tool,which works with Naiver-Stokes equations to converge on a *** tests were formed with all configurations proposed and three observations for each one,a total of 12 observations were performed in all *** a result,the best thermal performance in simulation was achieved with the Fresnel lens and black pipe collector,with a maximum temperature of 116℃under 1000 W/m^2 radiation,the same system achieved in experimental tests a maximum temperature of 96℃with a radiation of 983 W/m^2.

关键词： Solar collector parabolic trough collector Fresnel lens thermal conductivity solar power

Nanomechanical hydrodynamic force sensing using suspended microfluidic channels

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Microsystems & Nanoengineering 2023年第3期9卷 95-102页

作者： Alberto Martín-Pérez Daniel ramos Optomechanics Lab Instituto de Ciencia de Materiales de Madrid(ICMMCSIC)3 Sor Juana Inés de la Cruz(Madrid)E-28049 MadridSpain

Microfluidics has demonstrated high versatility in the analysis of in-flow particles and can even achieve mechanical properties measurements of biological cells by applying hydrodynamic ***,there is currently no available technique that enables the direct measurement and tracking of these hydrodynamic forces acting on a flowing *** this work,we introduce a novel method for the direct measurement of the hydrodynamic force actuating on an in-flow particle based on the analysis of the induced resonance changes of suspended microchannel resonators(SMRs).This hydrodynamic force sensitivity depends on the device used;therefore,we considered the geometry and materials to advance this dependency on the SMR resonance frequency.

关键词： hydrodynamic applying flow