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抗原受体基因重排在儿童T-急性淋巴细胞白血病的表达

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抗原受体基因重排在儿童T-急性淋巴细胞白血病的表达

在非反刍动物饲料中运用单一组分外源性蛋白酶创造最优价值

西北五省（区）第六届儿科学术交流大会

作者：帖利军 Li Aihong Ingela Goransson Gran roos Jeffrey kutok 顾龙君

目的:了解抗原受体基因重排在儿童T-急性淋巴细胞白血病（ALL）的表达形式,为T-ALL患儿寻找合适的微量残留病（MRD）监测标记;方法:采用基因片段分析（Fragment analysis）及基因测序技术筛选进入哈佛医学院Dana-Farber肿瘤中心（DFCI）... 详细信息

目的:了解抗原受体基因重排在儿童T-急性淋巴细胞白血病（ALL）的表达形式,为T-ALL患儿寻找合适的微量残留病（MRD）监测标记;方法:采用基因片段分析（Fragment analysis）及基因测序技术筛选进入哈佛医学院Dana-Farber肿瘤中心（DFCI）ALL协作组05-001方案的所有49例T系-ALL抗原受体基因重排标记;结果:①43例T系-ALL患儿（6例未得到初发时患儿的标本）中,T细胞受体基因重排以TCRVγⅠ阳性最多,22例（占51.62%）;其次为TCRVδ1-Jδ1,14例（32.56%）;继之为FCRVγⅢ（20.51%）、TCRVγⅡ（17.95%）、TCRVγⅣ（15.38%）。T细胞受体基因重排中,双等位基因重排发生阳性率较高;②43例T-ALL中,5例患儿有免疫球蛋白重链（IGH）重排,主要为VH6及VH2,存在系性交叉抗原表达;③同时筛选13例T-ALL患儿初发时外周血及骨髓标本,两例患儿外周血及骨髓抗原受体基因重排不一致。结论:抗原受体基因重排存在于绝大多数的T-ALL患儿中,可作为T-ALL治疗中监测MRD的指标。

关键词：白血病 T淋巴细胞急性儿童抗原受体基因重排

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国外畜牧学（猪与禽） 2018年第1期38卷 65-67页

作者：兰慧(译) 邵建忠(校) Aaron J.Cowieson Franz F.roos 不详 DSM公司

外源性蛋白酶在过去15~20年中已经成为商用混合酶制剂的一部分,但仅在过去5~10年内才作为单一组分的商用酶——蛋白酶——上市。作为混合酶制剂的组成成分(通常还含有各种碳水化合物酶或糖酶和/或植酸酶),很难将各个组分成分的贡献分开... 详细信息

外源性蛋白酶在过去15~20年中已经成为商用混合酶制剂的一部分,但仅在过去5~10年内才作为单一组分的商用酶——蛋白酶——上市。作为混合酶制剂的组成成分(通常还含有各种碳水化合物酶或糖酶和/或植酸酶),很难将各个组分成分的贡献分开,同时每一种成分的功效具有隐性的价值而不是明确的价值。然而,单一组分酶制剂的攻效可以在不同的生产和营养条件下轻松地测定,并且它们与其他酶的互补性也很容易描述清楚。非反刍动物饲料添加外源性蛋白酶的动机是在保持动物生产性能的前提下显著降低饲料成本。这一目标通常是用给最低成本配方中的酶提供的营养基质替换日粮中昂贵的蛋白质/氨基酸源来实现的。最近的重点已经从这种经典的方法转向为蛋白酶应用中的所谓"额外蛋白(extra-proteinaceous)"效应,包括环境效益、垫料管理、肠道恢复力、均匀性和微生物稳定性。虽然这些"次要"效应可能并不是动物生产使用蛋白酶的主要动机,但它们越来越明显,且需要进行解释。此外,如果能够了解这些效应,那么它们可以主动转化成生产优势,如较低的饲料转化率和较高的日增重。本综述的目的是简要总结当前非反刍动物生产中单一组分外源性蛋白酶应用技术的现状,并提出可以解释"额外蛋白"效应的机制。最后将讨论可提高外源性蛋白酶对动物生产性能产生有益作用的日粮/动物因素。

关键词：蛋白酶蛋白质家禽猪氨基酸营养

单纯先天性肺动脉瓣狭窄女性怀孕期间的非心脏并发症

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世界核心医学期刊文摘(心脏病学分册) 2007年第5期 39-40页

作者： Drenthen W. Pieper P.G. roos-Hesselink J.W. 罗亮 Department of Cardiology University Medical Center Groningen University of Groningen Hanzeplein 1 9700 RB Groningen Netherlands

背景:有关肺动脉瓣狭窄患者妊娠结果的资料较少,其中大多数仅限于妊娠期间的心脏并发症。目的:观察单纯肺动脉瓣狭窄女性患者妊娠期间的非心脏并发症风险和胎儿风险的程度及其决定因素。方法:利用全国注册(CONgenital CORvitia)资料,将... 详细信息

背景:有关肺动脉瓣狭窄患者妊娠结果的资料较少,其中大多数仅限于妊娠期间的心脏并发症。目的:观察单纯肺动脉瓣狭窄女性患者妊娠期间的非心脏并发症风险和胎儿风险的程度及其决定因素。方法:利用全国注册(CONgenital CORvitia)资料,将在荷兰6所三级

关键词：肺动脉瓣狭窄女性患者并发症并发病疾病心脏

Ancient DNA of the pygmy marmoset type specimen Cebuella pygmaea(Spix,1823)resolves a taxonomic conundrum

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Zoological Research 2021年第6期42卷 761-771页

作者： Jean P.Boubli Mareike C.Janiak Leila M.Porter Stella de la Torre Liliana Cortes-Ortiz Maria N.Fda Silva Anthony B.Rylands Stephen Nash Fabricio Bertuol Hazel Byrne Felipe E.Silva Fabio Rohe Dorien de Vries Robin M.D.Beck Irune Ruiz-Gartzia Lukas F.K.Kuderna Tomas Marques-Bonet Tomas Hrbek Izeni P.Farias Anneke Hvan Heteren Christian roos School of Science Engineering&EnvironmentUniversity of SalfordSalford M54WTUK Instituto Nacional de Pesquisas da Amazonia ManausAmazonas 69060-001Brazil Department of Anthropology Northern Illinois UniversityDeKalbIL 60115-2828USA College of Biological and Environmental Sciences Universidad San Francisco de QuitoQuito 170901Ecuador Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Re:wild AustinTX 78767USA Laboratorio de Evolução e Genética Animal Universidade Federal do AmazonasManausAmazonas 69080-900Brazil Department of Anthropology University of UtahSalt Lake CityUT 84112USA Research Group on Primate Biology and Conservation MamirauaInstitute for Sustainable DevelopmentTeféAmazonas 69553-225Brazil Experimental and Health Sciences Department(DCEXS) Institut de Biologia EvolutivaUniversitat Pompeu Fabra-CSICBarcelona 08002Spain Department of Biology Trinity UniversitySan AntonioTX 78212USA Bavarian State Collection of Zoology Zoologische Staatssammlung MünchenStaatliche Naturkundliche Sammlungen Bayerns81247 MunichGermany GeoBio-Center Ludwig-Maximilians-Universitat München80333 MunichGermany Department Biologie II Ludwig-Maximilians-Universitat München82152 MunichGermany Gene Bank of Primates and Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate Research37077 GottingenGermany

The pygmy marmoset,the smallest of the anthropoid primates,has a broad distribution in Western *** studies using molecular and morphological data have identified two distinct species separated by the Napo and Solimoes-Amazonas ***,reconciling this new biological evidence with current taxonomy,i.e.,two subspecies,Cebuella pygmaea pygmaea(Spix,1823)and Cebuella pygmaea niveiventris(Lönnberg,1940),was problematic given the uncertainty as to whether Spix’s pygmy marmoset(Cebuella pygmaea pygmaea)was collected north or south of the Napo and Solimoes-Amazonas rivers,making it unclear to which of the two newly revealed species the name pygmaea would ***,we present the first molecular data from Spix’s type specimen of Cebuella pygmaea,as well as novel mitochondrial genomes from modern pygmy marmosets sampled near the type locality(Tabatinga)on both sides of the *** these data,we can confirm the correct names of the two species identified,i.e.,*** for animals north of the Napo and Solimoes-Amazonas rivers and *** for animals south of these two *** analyses of the novel genetic data placed into the context of cytochrome b gene sequences from across the range of pygmy marmosets further led us to reevaluate the geographical distribution for the two Cebuella *** dated the split of these two species to 2.54 million years *** discuss additional,more recent,subdivisions within each lineage,as well as potential contact zones between the two species in the headwaters of these rivers.

关键词： Historic DNA DNA taxonomy Pygmy marmoset Cebuella pygmaea C.niveiventris Amazon Type specimen

孤立肾和双侧肾肿瘤行强制性保肾组织的肿瘤切除术及其长期疗效

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中华泌尿外科杂志 2009年第2期30卷 144-144页

作者： roos FC 李金华(摘译) 陈志强(校)

作者介绍强制性保肾组织的肿瘤切除术及其长期疗效。指征：孤立肾或双侧肾肿瘤，慢性肾功能不全或对侧肾良性病变的肾功能受限。术前CT或MRT三维成像，特别对大的中央型肿瘤手术有很大帮助。胁腹部经第10或11肋间功口，冷／热缺血下手... 详细信息

作者介绍强制性保肾组织的肿瘤切除术及其长期疗效。指征：孤立肾或双侧肾肿瘤，慢性肾功能不全或对侧肾良性病变的肾功能受限。术前CT或MRT三维成像，特别对大的中央型肿瘤手术有很大帮助。胁腹部经第10或11肋间功口，冷／热缺血下手术，钳夹阻断动脉血供，在距肿瘤数mm的安全距离处整块切除肿瘤，肿瘤切除基底部的肾组织及肿瘤切缘作快速冰冻切片检查。血管缝合止血，

关键词：肿瘤切除术长期疗效肾组织强制性肾肿瘤孤立肾双侧快速冰冻切片检查

Mitogenomic phylogeny of the Asian colobine genus Trachypithecus with special focus on Trachypithecus phayrei(Blyth, 1847) and description of a new species

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Zoological Research 2020年第6期41卷 656-669页

作者： Christian roos Kristofer MHelgen Roberto Portela Miguez Naw May Lay Thant Ngwe Lwin Aung Ko Lin Aung Lin Khin Mar Yi Paing Soe Zin Mar Hein Margaret Nyein Nyein Myint Tanvir Ahmed Dilip Chetry Melina Urh EGrace Veatch Neil Duncan Pepijn Kamminga Marcus AHChua Lu Yao Christian Matauschek Dirk Meyer Zhi-Jin Liu Ming Li Tilo Nadler Peng-Fei Fan Le Khac Quyet Michael Hofreiter Dietmar Zinner Frank Momberg Primate Genetics Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Gene Bank of Primates German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Chances for Nature(CfN) Goettingen 37073Germany Australian Museum Research Institute Australian MuseumSydneyNew South Wales 2010Australia Natural History Museum London SW7 BDUK Wildlife Conservation Society(WCS)-Myanmar Program Yangon 11041Myanmar Fauna&Flora International(FFI)-Myanmar Programme Yangon 11201Myanmar Popa Mountain Park Nature and Wildlife Conservation DivisionForest DepartmentPopa 05242Myanmar World Wide Fund for Nature(WWF)-Myanmar Yangon 11191Myanmar Department of Zoology Jagannath UniversityDhaka 1100Bangladesh Primate Research and Conservation Division AaranyakGuwahatiAssam 781028India Department of Anthropology Emory UniversityAtlantaGA 30322USA Department of Anthropology Yale UniversityNew HavenCT 06511USA Department of Mammalogy American Museum of Natural HistoryNew YorkNY 10024USA Naturalis Biodiversity Center Leiden 2333 CRThe Netherlands Lee Kong Chian Natural History Museum National University of SingaporeSingapore 117377Singapore Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030USA Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650223China Cuc Phuong Commune Nho Quan DistrictNinh Binh ProvinceVietnam School of Life Sciences Sun Yat-Sen UniversityGuangzhouGuangdong 510275China Center for Biodiversity Conservation and Endangered Species Ho-Chi-Minh CityVietnam Institute for Biochemistry and Biology University of PotsdamPotsdam 14476Germany Cognitive Ethology Laboratory German Primate CenterLeibniz Institute for Primate ResearchGoettingen 37077Germany Leibniz Science Campus Primate Cognition Goettingen 37077Germany De

Trachypithecus,which currently contains 20 species divided into four groups,is the most speciose and geographically dispersed genus among Asian *** several morphological and molecular studies,however,its evolutionary history and phylogeography remain poorly ***’s langur(Trachypithecus phayrei) is one of the most widespread members of the genus,but details on its actual distribution and intraspecific taxonomy are limited and ***,to elucidate the evolutionary history of Trachypithecus and to clarify the intraspecific taxonomy and distribution of ***,we sequenced 41 mitochondrial genomes from georeferenced fecal samples and museum specimens,including two *** analyses revealed a robustly supported phylogeny of Trachypithecus,suggesting that the *** group branched first,followed by the *** group,and the *** and *** groups most *** four species groups diverged from each other 4.5-3.1 million years ago(Ma),while speciation events within these groups occurred much more recently(1.6-0.3 Ma).Within ***,we found three clades that diverged 1.0-0.9 Ma,indicating the existence of three rather than two *** the phylogenetic species concept and based on genetic,morphological,and ecological differences,we elevate the *** subspecies to species level,describe a new species from central Myanmar,and refine the distribution of the three ***,our study highlights the importance of museum specimens and provides new insights not only into the evolutionary history of *** but the entire Trachypithecus genus as well.

关键词： Colobinae Integrative zoology Mitochondrial genome Museum specimens New species

对侧肾脏正常患者行选择性保肾组织的肾肿瘤切除术及其长期疗效

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中华泌尿外科杂志 2009年第2期30卷 144-144页

作者： roos FC 李金华(摘译) 陈志强(校)

1979年起作者医院扩大了选择性保肾组织的肾肿瘤切除术指征，至1984年此种手术占同期肾肿瘤手术8％，2005至2007年为41％。1969至2004年，该院选择性指征行保肾组织。肾癌（NZK）切除381例，术后10年肿瘤特有存活率96．7％，局部复发率4... 详细信息

1979年起作者医院扩大了选择性保肾组织的肾肿瘤切除术指征，至1984年此种手术占同期肾肿瘤手术8％，2005至2007年为41％。1969至2004年，该院选择性指征行保肾组织。肾癌（NZK）切除381例，术后10年肿瘤特有存活率96．7％，局部复发率4．3％，其中术前多发性病灶者占3．4％。1979至2006年保肾手术治疗NZK474例，其中NZK≤4cm372例，〉4cm102例（21．5％），

关键词：肿瘤切除术肾组织长期疗效肾脏对侧肿瘤手术局部复发率手术治疗

在非反刍动物饲料中运用单一组分外源性蛋白酶创造最优价值(续)

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国外畜牧学（猪与禽） 2018年第5期38卷 65-69页

作者：兰慧韩浩月 Aaron J. Cowieson Franz F. roos(DSM)

2 对氨基酸消化率的影响二次曲线的实线显示最佳拟合曲线,虚线是95%的可信区间.水平的实线表示蛋白酶无作用（资料来自Cowieson和roos,2014）.

关键词：反刍动物饲料蛋白酶外源性价值组分氨基酸消化率拟合曲线二次曲线

Occurrence of seeding metastases in resectable perihilar cholangiocarcinoma and the role of low-dose radiotherapy to prevent this

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World Journal of Hepatology 2020年第11期12卷 1089-1097页

作者： Lotte C Franken Eva roos Job Saris Jeanin E van Hooft Otto M van Delden Joanne Verheij Joris I Erdmann Marc G Besselink Olivier R Busch Geertjan van Tienhoven Thomas M van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Pathology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Gastroenterology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Interventional Radiology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiation Oncology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands

BACKGROUND Preoperative biliary drainage in patients with presumed resectable perihilar cholangiocarcinoma(PHC)is hypothesized to promote the occurrence of seeding *** metastases can occur at the surgical scars or at the site of postoperative drains,and in case of percutaneous biliary drainage,at the catheter *** prevent seeding metastases after resection,we routinely treated PHC patients with preoperative radiotherapy(RT)for over 25 years until January *** To investigate the incidence of seeding metastases following resection of *** All patients who underwent resection for pathology proven PHC between January 2000 and March 2019 were included in this retrospective *** 2000-January 2018,patients received preoperative RT(3×3.5 Gray).RT was omitted in patients treated after January *** A total of 171 patients underwent resection for PHC between January 2000 and March *** 171 patients undergoing resection,111 patients(65%)were treated with preoperative *** bile cytology showed no difference in the presence of viable tumor cells in bile of patients undergoing preoperative RT or ***,two patients(1.2%)with seeding metastases were identified,both in the laparotomy scar and both after preoperative RT(one patient with endoscopic and the other with percutaneous and endoscopic biliary drainage).CONCLUSION The incidence of seeding metastases in patients with resected PHC in our series was low(1.2%).This low incidence and the inability of providing evidence that preoperative low-dose RT prevents seeding metastases,has led us to discontinue preoperative RT in patients with resectable PHC in our center.

关键词： Perihilar cholangiocarcinoma Seeding metastases Preventive radiotherapy