检索结果-南通市图书馆

Transfer learning enhanced graph neural network for aldehyde oxidase metabolism prediction and its experimental application

引用

Acta Pharmaceutica Sinica B 2024年第2期14卷 623-634页

作者： Jiacheng Xiong rongrong Cui Zhaojun Li Wei Zhang Runze Zhang Zunyun Fu Xiaohong Liu zhenghao Li Kaixian Chen Mingyue zheng Drug Discovery and Design Center State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China College of Computer and Information Engineering Dezhou UniversityDezhou 253023China AI Department Suzhou Alphama Biotechnology Co.Ltd.Suzhou 215000China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and TechnologyShanghaiTech UniversityShanghai 200031China State Key Laboratory of Pharmaceutical Biotechnology Nanjing UniversityNanjing 210023China

Aldehyde oxidase(AOX)is a molybdoenzyme that is primarily expressed in the liver and is involved in the metabolism of drugs and other ***-mediated metabolism can result in unexpected outcomes,such as the production of toxic metabolites and high metabolic clearance,which can lead to the clinical failure of novel therapeutic *** models can assist medicinal chemists in rapidly evaluating the AOX metabolic risk of compounds during the early phases of drug discovery and provide valuable clues for manipulating AOX-mediated metabolism *** this study,we developed a novel graph neural network called AOMP for predicting AOX-mediated *** integrated the tasks of metabolic substrate/non-substrate classification and metabolic site prediction,while utilizing transfer learning from 13C nuclear magnetic resonance data to enhance its performance on both *** significantly outperformed the benchmark methods in both cross-validation and external *** AOMP,we systematically assessed the AOX-mediated metabolism of common fragments in kinase inhibitors and successfully identified four new scaffolds with AOX metabolism liability,which were validated through in vitro ***,for the convenience of the community,we established the first online service for AOX metabolism prediction based on AOMP,which is freely available at https://***.

关键词： Drugmetabolism Aldehyde oxidase Transferlearning Graph neural network Kinase inhibitor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Leaf nutrient resorption of two life-form tree species in urban gardens and their response to soil nutrient availability

Leaf nutrient resorption of two life-form tree species in ur...

引用

第十二届现代生态学讲座暨林草与环境学科研究生学术论坛

作者：郭晋平 Ruyuan Hu Tairui Liu Yunxiang Zhang rongrong zheng 山西农业大学林学院 College of Forestry Shanxi Agricultural University

Background. Leaf nutrient resorption is a key strategy in plant conservation that minimizes nutrient loss and enhances productivity. However,the differences of the nutrient resorption among garden tree species in urban ecosystems were not clearly understood,especially the differences of nitrogen resorption efficiency(NRE) and phosphorous resorption efficiency(PRE) between evergreen and deciduous ***. We selected 40 most generally used garden tree specie belonged two life forms(evergreen and deciduous) and investigated the nitrogen(N) and phosphorus(P) concentrations in green and senesced leaves and soil nutrient concentrations of nine samples trees for each ***,the nutrient concentrations and resorption efficiency were compared,and the soil nutrients utilization strategies were further ***. The results showed that the N concentration was significantly higher in the green and senesced leaves of deciduous trees than in the leaves of evergreen trees. The two life-form trees were both N limited and evergreen trees were more sensitive to N limitation. The NRE and PRE in the deciduous trees were significantly higher than those in the evergreen trees. The NRE was significantly positively correlated with the PRE in the deciduous trees. As the soil N and P concentrations increased,the nutrient resorption efficiency(NuRE) of the evergreen trees increased,but that of the deciduous trees decreased. Compared with the deciduous trees,the evergreen trees were more sensitive to the feedback of soil N and P concentrations. These findings reveal the N and P nutrient resorption mechanism of evergreen and deciduous trees and fill a gap in the understanding of nutrient resorption in urban ecosystems.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

多跨简支梁桥上无砟轨道无缝线路受力研究

引用

华南理工大学学报（自然科学版） 2019年第10期47卷 81-92页

作者：戴公连葛浩郑榕榕陈国荣中南大学土木工程学院湖南长沙410083 中南大学高速铁路建造技术国家工程实验室湖南长沙410083

为研究多跨简支梁桥上不同无砟轨道对应无缝线路的受力特点,基于梁轨相互作用原理推导了可以考虑非线性阻力的多跨简支梁梁轨相互作用公式,并与有限元法进行了对比.分别建立了32m标准跨度简支梁桥上不同无砟轨道模型,分析对比了实测温... 详细信息

为研究多跨简支梁桥上不同无砟轨道对应无缝线路的受力特点,基于梁轨相互作用原理推导了可以考虑非线性阻力的多跨简支梁梁轨相互作用公式,并与有限元法进行了对比.分别建立了32m标准跨度简支梁桥上不同无砟轨道模型,分析对比了实测温度荷载与制挠力耦合作用下各无砟轨道对应的无缝线路受力规律,同时探讨了简支梁跨数墩顶刚度以及扣件阻力等结构参数的影响.结果表明:对于32m标准跨度简支梁,随着简支梁跨数的增加,钢轨附加应力最大值趋于稳定,且稳定时的最大值均小于规范限值,对于铺设无砟轨道的简支梁桥,其跨数不受钢轨附加应力限制;对于单元板式及双块式无砟轨道,当墩顶纵向刚度大于2000kN/cm时,墩顶刚度的变化对其钢轨附加应力的影响很小;多跨简支梁桥上无砟轨道不建议采用小阻力扣件.

关键词：简支梁桥无砟轨道无缝线路梁轨相互作用钢轨附加应力跨数墩顶刚度

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conjugated and non-conjugated multifunctional electrochromic polymers containing triarylamine blocks

Conjugated and non-conjugated multifunctional electrochromic...

引用

中国化学会第二十次全国电化学大会

作者： Niu Haijun Zhang Xu Lu Qingyi zheng rongrong Yang Caiyu Chen Ye Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education Department of Macromolecular Science and Engineering School of Chemical Chemical Engineering and Materials Heilongjiang University

Electrochromism is known as the alternation of color by the application of a potential. Color changes are commonly occur between a transparent state, where the chromophore only absorbs in the UV region, and a colored state or between two colored states in a given electrolyte *** materials have extensive application prospects as intelligent materials and have been used for smart windows, anti-glass and optical displays.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

课堂环境感知、外语学习无聊与外语成绩的相关性研究

引用

Chinese Journal of Applied Linguistics 2023年第4期46卷 605-624,646页

作者：郑荣荣冯恩昊浙江省杭州第十一中学华中科技大学外国语学院

本文采用混合研究方法探索高中英语学习者的课堂环境感知、外语学习无聊和英语成绩之间的关系。共270名我国高中生参与本研究的问卷调查,其中9名学生参与了半结构化访谈。研究结果显示:1)总体课堂环境感知与无聊负相关,与成绩正相关;课... 详细信息

本文采用混合研究方法探索高中英语学习者的课堂环境感知、外语学习无聊和英语成绩之间的关系。共270名我国高中生参与本研究的问卷调查,其中9名学生参与了半结构化访谈。研究结果显示:1)总体课堂环境感知与无聊负相关,与成绩正相关;课堂环境感知的所有维度中只有任务取向与英语成绩显著相关;课堂环境感知的维度中除学生凝聚力之外的所有维度都与无聊负相关;2)教师支持、任务取向和课堂秩序负面影响无聊,无聊负面影响英语成绩,而课堂环境感知的所有维度都不直接影响英语成绩;3)无聊完全中介了课堂环境感知中的教师支持和任务取向对成绩的影响。学生在访谈中的回答验证了量化研究结果。根据研究发现,英语教师应充分为学生提供支持,并恰当地设置任务取向以降低学生的外语学习无聊水平,提高英语学习成绩。

关键词：课堂环境感知外语学习无聊成绩控制价值理论中介效应

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Facies-controlled prediction of dolomite reservoirs in the Middle Permian Qixia Formation in Shuangyushi,northwestern Sichuan Basin

引用

Energy Geoscience 2024年第2期5卷 21-30页

作者： Chao zheng Benjian Zhang rongrong Li Hong Yin Yufeng Wang Xin Hu Xiao Chen Ran Liu Qi Zeng Zhiyun Sun Rui Zhang Xingyu Zhang Weidong Yin Kun Zhang Exploration and Development Research Institute PetroChina Southwest Oil&Gas Field CompanyChengduSichuan610500China Northwest Sichuan Gas Branch PetroChina Southwest Oil&Gas Field CompanyJiangyouSichuan621709China PetroChina Southwest Oil&Gas Field Company ChengduSichuan610500China School of Geosciences and Technology Southwest Petroleum UniversityChengduSichuan610500China

The Middle Permian Qixia Formation in the Shuangyushi area,northwestern Sichuan Basin,develops shoal-facies dolomite *** pinpoint promising reservoirs in the Qixia Formation,deep thin shoal-facies dolomite reservoirs were predicted using the techniques of pre-stack Kirchhoff-Q compensation for absorption,inverse Q filtering,low-to high-frequency compensation,forward modeling,and facies-controlled seismic meme *** results are obtained in six ***,the dolomite reservoirs mainly exist in the middle and lower parts of the second member of Qixia Formation(Qi2 Member),which coincide with the zones shoal cores are ***,the forward modeling shows that the trough energy at the top and bottom of shoal core increases with increasing shoal-core thickness,and weak peak reflections are associated in the middle of shoal ***,five types of seismic waveform are identified through waveform analysis of seismic ***-Ⅰ and Type-Ⅱ waveforms correspond to promising facies(shoal core microfacies).Fourth,vertically,two packages of thin dolomite reservoirs turn up in the sedimentary cycle of intraplatform shoal in the Qi2 Member,and the lower package is superior to the upper package in dolomite thickness,scale and lateral ***,in plane,significantly controlled by sedimentary facies,dolomite reservoirs laterally distribute with consistent thickness in shoal cores at topographical highs and extend toward the ***,the promising prospects are the zones with thick dolomite reservoirs and superimposition of horstegraben structural traps.

关键词： Reservoir prediction Seismic facies Shoal-facies dolomite Qixia formation Shuangyushi Sichuan basin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arecoline causes cognitive impairment and potential addiction via disturbing Kenyon cells in bumblebee brain

引用

Food Science and Human Wellness 2024年

作者： Huiling Liu Xiaohuan Mu rongrong Fan Jieteng Chen Jie Ma Liang Meng Xiaosong Hu Hao zheng Shanshan Liu Xiaofei Wang College of Food Science and Nutritional Engineering， National Engineering Research Center for Fruit and Vegetable Processing， Key Laboratory of Fruits and Vegetables Processing， Ministry of Agriculture， Engineering Research Centre for Fruits and Vegetables Processing， Ministry of Education， China Agricultural University BGI-Qingdao

Areca nut is the basic ingredient of betel quid， which is chewed by hundreds of millions of people in south-eastern Asia. Chewing of areca nut has been associated with oral cancers potentially due to its specific alkaloids， among which arecoline constitutes about 90% of total fraction. Being the world’s fourth most commonly used psychoactive substance， arecoline evokes stimulation， addiction， and other direct neurological effects， while its misuse correlates to neurotoxic effects. However， what might underlie its neurotoxic mechanisms has been poorly documented. The brain is encoded by a complex network of neuronal and glial cell types， and neurotoxicity of hazardous compounds present transcriptional heterogeneity. Recently， the eusocial bumblebee has been used as a model for studying brain effects， with sophisticated cognitive capability and precisely measured brain architecture. Here， we decipher cell-type-specific mental risks to arecoline using bumblebees. Arecoline induced locomotor hyperactivity and cognitive impairment. Single nucleus RNA sequencing (snRNA-seq) unearthed arecoline-induced cell-specific responses， primarily targeted on Kenyon cells (KC). Moreover， high-dose arecoline induced distinctive cell responses among KC subtypes， particularly class I large Kenyon cell (lKC)， leading to DNA damage， excitatory/inhibitory (E/I) imbalance， and calcium dyshomeostasis， which potentially resulted in cognitive impairment. Given arecoline’s popularity and growing exposure risks to humans， neurological health risks of areca nut warrant serious consideration.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

视频回授法对膀胱结石患者结石知识及疾病管理能力的影响

引用

首都食品与医药 2023年第11期30卷 135-137页

作者：郑荣荣天津市第一中心医院天津300000

目的探讨视频回授法对膀胱结石患者结石知识及疾病管理能力的影响.方法选取2021年1月-2021年12月膀胱结石患者110例,根据随机数字表法将患者分为观察组及对照组,每组各55例.对照组行常规性健康宣教,观察组应用视频回授法进行健康指导,... 详细信息

目的探讨视频回授法对膀胱结石患者结石知识及疾病管理能力的影响.方法选取2021年1月-2021年12月膀胱结石患者110例,根据随机数字表法将患者分为观察组及对照组,每组各55例.对照组行常规性健康宣教,观察组应用视频回授法进行健康指导,比较两组患者干预前后结石知识、疾病管理能力、治疗依从性、结石复发情况等.结果干预后观察组患者结石知识评分、饮食管理评分、饮水管理评分、日常生活管理评分、运动管理评分及疾病管理能力总评分高于对照组(P<0.05).观察组饮食依从率、用药依从率、定期复查依从率高于对照组(P<0.05),而观察组患者结石复发率低于对照组(P<0.05).结论视频回授法能有效提高膀胱结石患者对结石知识的掌握程度,从而提高其疾病管理能力及治疗依从率,降低患者结石复发率.

关键词：视频回授法膀胱结石结石知识疾病管理能力治疗依从率满意率

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

JF标准“Can do”模式在第二外语（日语）教学中的应用初探——以合肥师范学院商务英语专业为例

引用

文化创新比较研究 2020年第22期4卷 73-75+78页

作者：郑荣荣合肥师范学院外国语学院

自2010年日本国际交流基金会公布JF标准以来,近10年内,该标准广泛应用于日语教学的各个专业,对日语的教育工作者和日语的学习爱好者,起到了不可磨灭的推动作用。JF标准"Can do"模式所提出的理念及评价标准与该校培养应用型人才的教学目... 详细信息

自2010年日本国际交流基金会公布JF标准以来,近10年内,该标准广泛应用于日语教学的各个专业,对日语的教育工作者和日语的学习爱好者,起到了不可磨灭的推动作用。JF标准"Can do"模式所提出的理念及评价标准与该校培养应用型人才的教学目标不谋而合。该文中,笔者详细分析了该校商务英语专业第二外语(日语)课程的教学现状,本着实践改革的想法,将JF标准"Can do"模式应用到第二外语(日语)教学中,尝试进行教学改革。

关键词： JF标准 “Can do”模式第二外语(日语) 语言能力任务性

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

品读刺绣艺术与生活美学

引用

现代丝绸科学与技术 2020年第6期35卷 28-30页

作者：郑蓉蓉苏州经贸职业技术学院江苏苏州215009

刺绣,曾经不着痕迹、与我们的生活如影随形•如今它却渐行渐远成为高挂在墙上的艺术。通过讨论刺绣艺术与生活美学的关系.明确其“生活之物”与“艺术之物”的双重属性。当代刺绣艺术不能只是“阳春白雪”,更需要全新的载体和文化土壤助... 详细信息

刺绣,曾经不着痕迹、与我们的生活如影随形•如今它却渐行渐远成为高挂在墙上的艺术。通过讨论刺绣艺术与生活美学的关系.明确其“生活之物”与“艺术之物”的双重属性。当代刺绣艺术不能只是“阳春白雪”,更需要全新的载体和文化土壤助其回归本源、回归生活。

关键词：刺绣艺术苏绣生活美学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：