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世界核心医学期刊文摘（儿科学分册） 2005年第10期1卷 46-46页

作者： Ezike E.N. rongkavilit c. Fairfax M.R. 平智广 Division of Infec.ious Diseases Children's Hospital of Michigan 3901 Beaubien Blvd. Det roit MI 48201 United States Dr.

Objec.ive: To assess the effec. of using 2 throat swabs vs 1 on rapid detec.io n of group A streptoc.c.us by the STREP A OIA MAX (hereafter, OIAMAX) test. Meth ods: c.ildren aged 5 to 18 years with ac.te pharyngitis were randomizedto 1 of 2 study groups. In group 1, one throat swab was obtained, streaked first on sheep blood agar, and then used for OIA MAX testing. In group 2, two throat swabs wer e obtained simultaneously. One swab was streaked first on sheep blood agar and t hen joined with the other swab for OIA MAX testing. In both groups, the pledgets in the c.llec.ion-transport tube were inc.bated in Todd-Hewitt broth. A posit ive group A streptoc.c.us c.lture either by sheep blood agar or Todd-Hewitt bro th was c.nfirmed by a latex agglutination test. Results: Three hundred sixtythre e patients were enrolled, 177 in group 1 and 186 in group 2. c.ltures were posit ive for group A streptoc.c.us in 154 (42.4%) of 363 patients. The sensitivity a nd spec.fic.ty of OIA MAX testing were 94.7%and 100.0%, respec.ively, in group 1, and 92.4%and 96.3%, respec.ively, in group 2. There was no statistic.l dif ferenc. between the sensitivity, the spec.fic.ty, and the predic.ive values of t he OIA MAX test performed with 1 swab c.mpared with those performed with 2 swabs (P>.10). There was no assoc.ation between OIA MAX test sensitivity and the seve rity of pharyngitis as measured by the modified c.ntor c.iterion (history of fev er, absenc. of c.ugh, presenc. of pharyngeal or tonsillar exudates, and presenc. of c.rvic.l lymphadenopathy) sc.res. c.nc.usions: The OIA MAX test yielded c.mp arable sensitivity and spec.fic.ty in both study groups. The use of 2 throat swa bs instead of 1 swab did not inc.ease the sensitivity of the OIA MAX test. The p erformanc. of the OIA MAX test did not depend on the severity of pharyngitis.

关键词：抗原检测 A型链球菌拭子胶乳凝集试验急性咽炎肉汤培养扁桃体分泌物颈淋巴结肿大咳嗽症状汤中

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