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Anti-scattering light focusing by fast wavefront shaping based on multi-pixel encoded digital-micromirror device

Light(Science & Applications) 2021年第8期10卷 1527-1535页

作者： Jiamiao Yang Qiaozhi He Linxian Liu Yuan Qu rongjun shao Bowen Song Yanyu Zhao Department of Instrument Science and Engineering School of Electronic Information and Electrical EngineeringShanghai Jiao Tong University200240 ShanghaiChina. Shanghai Center for Brain Science and Brain-Inspired Technology 200031 ShanghaiChina. School of Automation and Software Engineering Shanxi University030006 TaiyuanChina. Beijing Advanced Innovation Center for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Engineering MedicineBeihang University100191 BeijingChina

Speed and enhancement are the two most important metrics for anti-scattering light focusing by wavefront shaping(WS),which requires a spatial light modulator with a large number of modulation modes and a fast speed of *** the commercial modulators,the digital-micromirror device(DMD)is the sole solution providing millions of modulation modes and a pattern rate higher than 20 ***,it has the potential to accelerate the process of anti-scattering light focusing with a high ***,modulating light in a binary mode by the DMD restricts both the speed and enhancement ***,we propose a multi-pixel encoded DMD-based WS method by combining multiple micromirrors into a single modulation unit to overcome the drawbacks of binary *** addition,to efficiently optimize the wavefront,we adopted separable natural evolution strategies(SNES),which could carry out a global search against a noisy *** with the state-of-the-art DMD-based WS method,the proposed method increased the speed of optimization and enhancement of focus by a factor of 179 and 16,*** our demonstration,we achieved 10 foci with homogeneous brightness at a high speed and formed W-and S-shape patterns against the scattering *** experimental results suggest that the proposed method will pave a new avenue for WS in the applications of biomedical imaging,photon therapy,optogenetics,dynamic holographic display,etc.

关键词： mirror light overcome

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Large dynamic range Shack-Hartmann wavefront sensor based on adaptive spot matching

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Light(Advanced Manufacturing) 2024年第1期5卷 40-49页

作者： Jiamiao Yang Jichong Zhou Lirong Qiu rongjun shao Linxian Liu Qiaozhi He School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China Beijing Key Lab for Precision Optoelectronic Measurement Instrument and Technology School of OptoelectronicsBeijing Institute of TechnologyBeijing 100081China School of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China

The Shack-Hartmann wavefront sensor(SHWS)is widely used for high-speed,precise,and stable wavefront ***,conventional SHWSs encounter a limitation in that the focused spot from each microlens is restricted to a single microlens,leading to a limited dynamic ***,we propose an adaptive spot matching(ASM)-based SHWS to extend the dynamic *** approach involves seeking an incident wavefront that best matches the detected spot distribution by employing a Hausdorff-distance-based nearest-distance matching *** ASM-SHWS enables comprehensive spot matching across the entire imaging plane without requiring initial spot ***,due to its global matching capability,ASM-SHWS can maintain its capacity even if a portion of the spots are *** showed that the ASM-SHWS could measure a high-curvature spherical wavefront with a local slope of 204.97 mrad,despite a 12.5%absence of *** value exceeds that of the conventional SHWS by a factor of 14.81.

关键词： Wavefront sensing Large dynamic range Shack-Hartmann sensor

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Complex transmission matrix retrieval for a highly scattering medium via regional phase differentiation

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Photonics Research 2024年第5期12卷 876-883页

作者： QIAOZHI HE rongjun shao YUAN Qu LINXIAN LIU CHUNXU DING JIAMIAO YANG School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China School of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China

Accurately measuring the complex transmission matrix(CTM) of the scattering medium(SM) holds critical significance for applications in anti-scattering optical imaging, phototherapy, and optical neural networks. Noninterferometric approaches, utilizing phase retrieval algorithms, can robustly extract the CTM from the speckle patterns formed by multiple probing fields traversing the SM. However, in cases where an amplitude-type spatial light modulator is employed for probing field modulation, the absence of phase control frequently results in the convergence towards a local optimum, undermining the measurement accuracy. Here, we propose a high-accuracy CTM retrieval(CTMR) approach based on regional phase differentiation(RPD). It incorporates a sequence of additional phase masks into the probing fields, imposing a priori constraints on the phase retrieval algorithms. By distinguishing the variance of speckle patterns produced by different phase masks, the RPD-CTMR can effectively direct the algorithm towards a solution that closely approximates the CTM of the SM. We built a prototype of a digital micromirror device modulated RPD-CTMR. By accurately measuring the CTM of diffusers, we achieved an enhancement in the peak-to-background ratio of anti-scattering focusing by a factor of 3.6, alongside a reduction in the bit error rate of anti-scattering image transmission by a factor of 24. Our proposed approach aims to facilitate precise modulation of scattered optical fields, thereby fostering advancements in diverse fields including high-resolution microscopy, biomedical optical imaging, and optical communications.

关键词： matrix phase holds

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Full-polarization angular spectrum modeling of scattered light modulation

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Photonics Research 2024年第3期12卷 485-490页

作者： rongjun shao CHUNXU DING YUAN QU LINXIAN LIU QIAOZHI HE YUEJUN WU JIAMIAO YANG School of Electronic Information and Electrical Engineering Shanghai Jiao Tong UniversityShanghai 200240China Institute of Marine Equipment Shanghai Jiao Tong UniversityShanghai 200240China School of Automation and Software Engineering Shanxi UniversityTaiyuan 030006China

The exact physical modeling for scattered light modulation is critical in phototherapy,biomedical imaging,and free-space optical *** particular,the angular spectrum modeling of scattered light has attracted considerable attention,but the existing angular spectrum models neglect the polarization of photons,degrading their ***,we propose a full-polarization angular spectrum model(fpASM)to take the polarization into *** model involves a combination of the optical field changes and free-space angular spectrum diffraction,and enables an investigation of the influence of polarization-related factors on the performance of scattered light *** establishing the relationship between various model parameters and macroscopic scattering properties,our model can effectively characterize various depolarization *** a demonstration,we apply the model in the time-reversal data transmission and anti-scattering light *** method allows the analysis of various depolarization scattering events and benefits applications related to scattered light modulation.

关键词： scattered angular spectrum

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基于小波变换的共焦拉曼图像去噪方法

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光学技术 2019年第3期45卷 330-335页

作者：方松琼邵荣君邱丽荣王允北京理工大学光电学院精密光电测试仪器及技术北京市重点实验室

针对现有共焦拉曼光谱显微图像噪声去除不足的问题,提出一种基于小波变换的拉曼图像全面去噪方法。首先对拉曼光谱图像进行小波变换处理,然后再对拉曼图像进行双边滤波处理,进而实现拉曼光谱显微图像中噪声干扰的抑制。理论分析和实验表... 详细信息

针对现有共焦拉曼光谱显微图像噪声去除不足的问题,提出一种基于小波变换的拉曼图像全面去噪方法。首先对拉曼光谱图像进行小波变换处理,然后再对拉曼图像进行双边滤波处理,进而实现拉曼光谱显微图像中噪声干扰的抑制。理论分析和实验表明:与现有拉曼光谱显微图像去噪方法相比,所提方法使拉曼光谱显微图像的峰值信噪比和结构相似度分别改善了92.99%和197%,其有效提高了拉曼光谱图像的信噪比和物质成分分析的准确率。

关键词：拉曼光谱拉曼图像小波变换

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Czerny-Turner型光栅光谱仪光学系统优化设计

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光学技术 2018年第4期44卷 395-399页

作者：刘佳畅李书成邵荣君王允赵维谦北京理工大学光电学院精密光电测试仪器及技术北京市重点实验室

为提高光栅光谱仪分辨力,设计了基于球面反射物镜、工作波段范围500~800nm、焦长800mm的非对称式C-T型光栅光谱仪系统,给出了在消像差条件下系统中元件参数和结构尺寸的计算方法,运用光学设计软件Zemax对系统进行仿真分析与优化设计,研... 详细信息

为提高光栅光谱仪分辨力,设计了基于球面反射物镜、工作波段范围500~800nm、焦长800mm的非对称式C-T型光栅光谱仪系统,给出了在消像差条件下系统中元件参数和结构尺寸的计算方法,运用光学设计软件Zemax对系统进行仿真分析与优化设计,研制了光谱仪样机。设计和实验结果表明,系统在工作光谱范围内的理论分辨力优于0.01nm、实际分辨力优于0.04nm,满足光谱测量需求;整个光学系统具有结构简单、元件数量少、成本低、分辨力高、稳定性好等优点。

关键词：应用光学光谱仪 Czerny-Turner 光学设计 Zemax 高分辨力

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同步放化疗治疗中晚期宫颈癌临床效果观察

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中国基层医药 2018年第15期25卷 1968-1971页

作者：叶瑞智朱玲刚邵荣军台州市肿瘤医院肿瘤放疗科浙江省台州317502

目的探讨同步放化疗治疗中晚期宫颈癌的临床效果.方法选择2010年1月至2011年1月台州市肿瘤医院中晚期宫颈癌患者60例,采用随机数字表法分为两组,对照组30例,给予单纯放射治疗;观察组30例,给予同步放化疗治疗;比较两组近期疗效及不良反... 详细信息

目的探讨同步放化疗治疗中晚期宫颈癌的临床效果.方法选择2010年1月至2011年1月台州市肿瘤医院中晚期宫颈癌患者60例,采用随机数字表法分为两组,对照组30例,给予单纯放射治疗;观察组30例,给予同步放化疗治疗;比较两组近期疗效及不良反应,随访5年,比较两组远期疗效.结果观察组近期总有效率93.33%,显著高于对照组的73.33%,差异有统计学意义（χ2＝14.397,P＜0.05）,观察组5年生存率76.67%,显著高于对照组的53.33%,差异有统计学意义（χ2＝11.922,P＜0.05）;观察组局部复发率及远处转移率分别为16.67%、13.33%,显著低于对照组相应指标,差异均有统计学意义（χ2＝7.401,5.115,均P＜0.05）.对照组不良反应发生率13.33%,与观察组的23.33%比较,差异无统计学意义（χ2＝3.340,P＞0.05）.结论对中晚期宫颈癌患者采取同步放化疗治疗的疗效较好,提高患者生存率,且耐受性较好.

关键词：宫颈肿瘤放射疗法计算机辅助化学疗法辅助

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多维康复健康教育对胶质母细胞瘤术后同步放化疗患者日常生活能力、运动功能和生存质量影响

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浙江医学 2022年第3期44卷 299-302页

作者：孙玲琴邵荣军张君丽毛斌英台州市肿瘤医院肿瘤放疗一科 317502

目的探讨多维康复健康教育对胶质母细胞瘤术后同步放化疗患者日常生活能力(ADL)、运动功能和生存质量影响。方法选取2018年3月至2021年3月台州市肿瘤医院收治的胶质母细胞瘤术后放化疗患者82例,采用随机数字表法分为观察组与对照组各41... 详细信息

目的探讨多维康复健康教育对胶质母细胞瘤术后同步放化疗患者日常生活能力(ADL)、运动功能和生存质量影响。方法选取2018年3月至2021年3月台州市肿瘤医院收治的胶质母细胞瘤术后放化疗患者82例,采用随机数字表法分为观察组与对照组各41例。观察组在常规健康教育基础上结合多维康复健康教育,对照组仅采用常规健康教育。两组干预时间均为1个月。比较两组干预前与干预1个月后ADL、运动功能评定量表(FMA)、卡氏功能状态(KPS)评分、焦虑自评量表(SAS)、抑郁自评量表(SDS)评分以及满意度变化。结果两组干预1个月后ADL评分较干预前均明显增加(均P<0.05);观察组干预1个月后ADL评分明显高于对照组(P<0.05)。两组干预1个月后FMA上肢和下肢评分较干预前均明显增加(均P<0.05);观察组干预1个月后上肢和下肢评分均明显高于对照组(均P<0.05)。两组干预1个月后KPS评分较干预前均明显增加(均P<0.05);观察组干预1个月后KPS评分明显高于对照组(P<0.05)。两组干预1个月后SAS评分和SDS评分较干预前均明显降低(均P<0.05);观察组干预1个月后SAS评分和SDS评分均明显低于对照组(均P<0.05)。观察组干预1个月后总满意率(97.56%)明显高于对照组(80.49%),差异有统计学意义(P<0.05)。结论多维康复健康教育可改善胶质母细胞瘤术后同步放化疗患者ADL、运动功能和生存质量,同时还可以减轻患者负面情绪,提高患者满意度。

关键词：多维康复健康教育胶质母细胞瘤放化疗运动功能生存质量

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局部姑息性放疗与口服阿片类药物治疗肿瘤骨转移患者疼痛的疗效比较

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中国民康医学 2016年第10期28卷 22-24页

作者：郑琳刘丽丹邵荣军朱玲刚胡青青台州市肿瘤医院浙江温岭317500

目的:比较局部姑息性放疗与口服阿片类药物治疗肿瘤骨转移患者疼痛的临床疗效。方法:选取200例肿瘤骨转移患者作为研究对象,随机分为对照组和观察组,每组各100例。对照组患者使用短效阿片类药物滴定后改成长效缓释阿片类药物口服镇痛治... 详细信息

目的:比较局部姑息性放疗与口服阿片类药物治疗肿瘤骨转移患者疼痛的临床疗效。方法:选取200例肿瘤骨转移患者作为研究对象,随机分为对照组和观察组,每组各100例。对照组患者使用短效阿片类药物滴定后改成长效缓释阿片类药物口服镇痛治疗;观察组患者进行6MV-X线直线加速器调强放射治疗。结果:治疗后,观察组患者的疼痛完全缓解8例,部分缓解86例,无效6例,总有效率为94%;对照组患者的疼痛完全缓解7例,部分缓解85例,无效8例,总有效率为92%;两组患者临床治疗有效率比较无统计学意义(P>0.05);观察组患者不良反应发生率低于对照组(P<0.05),具有统计学意义。结论:肿瘤骨转移疼痛患者采用局部姑息性放射治疗和口服阿片类药物均具有镇痛的效果,但局部姑息性放射治疗不良反应少,可改善患者生活质量。

关键词：骨转移肿瘤疼痛阿片类药物姑息性放疗

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Co-Seismic Surface Rupture and Recurrence Interval of Large Earthquakes along Damaoyaba-Litang Segment of the Litang Fault on the Eastern Margin of the Tibetan Plateau in China

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Journal of Earth Science 2021年第5期32卷 1139-1151页

作者： Shiyuan Wang rongjun Zhou Mingjian Liang shao Liu Nina Liu Jianyu Long Sichuan Earthquake Agency^Chengdu 610041 China School of Geological Engineering and Geomatics Chang'an UniversityXi'an 710054China

The Litang fault is a left-lateral secondary shear zone in the Sichuan-Yunnan active block that accommodates the tectonic deformation associated with the eastward extrusion of the upper crust of the Tibetan Plateau. Based on 1 : 50 000 geological mapping of active faults, the Litang fault consists of three geometric segments, the Cuopuhu, Damaoyaba, and Litang segments, in the west of Litang, which are divided by the of Haizi Mountain uplift and the wide-angle bending and branching of the fault near Jinchanggou. This study also identifies the surface rupture of the A.D. 1890 earthquake, which is distributed intermittently along the ~28 km long Damaoyaba segments and ~25 km long Litang segments. The maximum horizontal displacement is 4.1 m along Damaoyaba segments, and 4 m along Litang segments. The rupture involves typical left-lateral shear movement. The two ruptures are divided by discontinuous segments or gaps that are ~18 km long;thus, the total surface rupture is approximately 71 km long. The estimated moment magnitude was M_(w)7.3±0.1. A comprehensive analysis of data obtained from 5 trenches excavated along the Damaoyaba and Litang segments and the trench data by Xu et al.(2005) identifies age constraints of the 4 most recent paleoseimic events occurred B.C. 1468±54–1340±25, B.C. 52±25–A.D. 76±47, A.D. 1115±90, and A.D. 1890, respectively. The recurrence intervals are 1 415±80, 1 104±104, and 775±90 a, which are consistent with quasi-periodic earthquake recurrence behavior. The average recurrence interval is 1 098±112 a.

关键词： Litang fault surface rupture active fault recurrence intervals paleoearthquake eastern Tibetan Plateau

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