检索结果-南通市图书馆

Cdc42 deletion yielded enamel defects by disrupting mitochondria and producing reactive oxygen species in dental epithelium

引用

Genes & Diseases 2024年第5期11卷 335-349页

作者： Jinxuan Zheng rongcheng yu Yiqi Tang Sihui Su Sainan Wang Chenxi Liao Xuecong Li Jiabin Liao Dongsheng yu Tingting Ai Wei Zhao Vicky Yau Chufeng Liu Liping Wu Yang Cao Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong 510055China Guangdong Provincial Key Laboratory of Oral Diseases GuangzhouGuangdong 510055China Department of Cariology and Endodontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijing 100081China Department of Oral and Maxillofacial Surgery University at BuffaloBuffaloNY 14214USA Department of Orthodontics Stomatological HospitalSouthern Medical UniversityGuangzhouGuangdong 510280China

Developmental defects of enamel are common due to genetic and environmental factors before and after ***42,a Rho family small GTPase,regulates prenatal tooth development in ***,its role in postnatal tooth development,especially enamel formation,remains ***,we investigated Cdc42 functions in mouse enamel development and tooth repair after ***42 showed highly dynamic temporospatial patterns in the developing incisors,with robust expression in ameloblast and odontoblast ***,epithelium-specific Cdc42 deletion resulted in enamel defects in *** differentiation was inhibited,and hypomineralization of enamel was observed upon epithelial Cdc42 *** analysis showed that abnormal mitochondrial components,phosphotransferase activity,and ion channel regulator activity occurred in the Cdc42 mutant dental *** oxygen species accumulation was detected in the mutant mice,suggesting that abnormal oxidative stress occurred after Cdc42 ***,Cdc42 mutant mice showed delayed tooth repair and generated less calcified *** dysfunction and abnormal oxygen consumption were evidenced by reduced Apool and Timm8a1 expression,increased Atp5j2 levels,and reactive oxygen species overproduction in the mutant repair ***-specific Cdc42 deletion attenuated ERK1/2 signaling in the labial cervical *** Sox2 expression in the mutant labial cervical loop after clipping might lead to delayed tooth *** findings suggested that mitochondrial dysfunction,up-regulated oxidative stress,and abnormal ion channel activity may be among multiple factors responsible for the observed enamel defects in Cdc42 mutant ***,Cdc42 exerts multidimensional and pivotal roles in enamel development and is particularly required for ameloblast differentiation and enamel matrix formation.

关键词： Cdc42 Enamel defects Mitochondrial dysfunction Rho GTPase Tooth repair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Promotion of osteochondral repair through immune microenvironment regulation and activation of endogenous chondrogenesis via the release of apoptotic vesicles from donor MSCs

引用

Bioactive Materials 2024年第11期41卷 455-470页

作者： Guangzhao Tian Han Yin Jinxuan Zheng rongcheng yu Zhengang Ding Zineng Yan Yiqi Tang Jiang Wu Chao Ning Xun yuan Chenxi Liao Xiang Sui Zhe Zhao Shuyun Liu Weimin Guo Quanyi Guo School of Medicine Nankai UniversityTianjin300071China Institute of Orthopedies Department of OrthopedicsThe Fourth Medical Center of PLA General HospitalNational Clinical Research Center for OrthopedicsSports Medicine&Rehabilitation51 Fucheng RoadHaidian DistrictBeijing100142China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Hospital of Stomatology Guangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhou510055China Department of Orthopaedic Surgery Guangdong Provincial Key Laboratory of Orthopedics and TraumatologyFirst Affiliated Hospital Sun Yat-Sen UniversityGuangzhou510080China

Utilizing transplanted human umbilical cord mesenchymal stem cells(HUMSCs)for cartilage defects yielded advanced tissue regeneration,but the underlying mechanism remain *** after HUMSCs delivery to the defects,we observed substantial *** released apoptotic vesicles(apoVs)of HUMSCs promoted cartilage regeneration by alleviating the chondro-immune *** triggered M2 polarization in macrophages while simultaneously facilitating the chondrogenic differentiation of endogenous ***,in macrophages,miR-100-5p delivered by apoVs activated the MAPK/ERK signaling pathway to promote M2 *** MSCs,let-7i-5p delivered by apoVs promoted chondrogenic differentiation by targeting the eEF2K/p38 MAPK ***,a cell-free cartilage regeneration strategy using apoVs combined with a decellularized cartilage extracellular matrix(DCM)scaffold effectively promoted the regeneration of osteochondral ***,new mechanisms of cartilage regeneration by transplanted MSCs were unconcealed in this ***,we provided a novel experimental basis for cell-free tissue engineering-based cartilage regeneration utilizing *** transplanted human umbilical cord mesenchymal stem cells(HUMSCs)for cartilage defects yielded advanced tissue regeneration,but the underlying mechanism remain *** after HUMSCs delivery to the defects,we observed substantial *** released apoptotic vesicles(apoVs)of HUMSCs promoted cartilage regeneration by alleviating the chondro-immune *** triggered M2 polarization in macrophages while simultaneously facilitating the chondrogenic differentiation of endogenous ***,in macrophages,miR-100-5p delivered by apoVs activated the MAPK/ERK signaling pathway to promote M2 *** MSCs,let-7i-5p delivered by apoVs promoted chondrogenic differentiation by targeting the eEF2K/p38 MAPK ***,a cell-free cartilage regener

关键词： Apoptotic vesicles Cartilage regeneration Human umbilical cord mesenchymal stem cells Macrophage polarization Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

如何做好地区供电局降损增效管理工作

引用

电工技术 2009年第12期 28-29页

作者：于荣成广东电网公司茂名供电局广东茂名525000

为更好地实现降损增效的目标,针对10kV及以下电压等级配网、直属县局降损潜力大的实际情况,从技术和管理两方面,茂名供电局提出了9项降损增效的措施。

关键词：线损管理线损 “四分”

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

物哀美在现代女装设计中的表现研究

引用

服装设计师 2023年第10期 120-125页

作者：于荣成张康夫浙江理工大学

从属性、审美等视角研究物哀美的表现形式,论证物哀美学对人类心理和行为的影响,凝练物哀美学对服装设计创意设计的引导作用。通过梳理物哀美学的基本特征、心理影响,论证物哀美的三大属性及审美特征,深入探索物哀美对服装设计的应用思... 详细信息

从属性、审美等视角研究物哀美的表现形式,论证物哀美学对人类心理和行为的影响,凝练物哀美学对服装设计创意设计的引导作用。通过梳理物哀美学的基本特征、心理影响,论证物哀美的三大属性及审美特征,深入探索物哀美对服装设计的应用思路和方法,探究物哀美对服装精神符号的提升价值。指出“物哀”美中的“欲”、“隐”、“苦”从对心理角度强化了设计者的审美感觉,是直观与感动的相互交融。物哀美对自然的细腻体验及感触可以为服装设计提供启迪和借鉴。

关键词：物哀美服装设计符号价值审美意识

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

巢湖铜绿微囊藻Chao 1910的基因组学和磷代谢通路分析

引用

微生物学通报 2023年第4期50卷 1491-1510页

作者：计欣晔余荣成杜康周丛照李旭中国科学技术大学生命科学与医学部生命科学学院安徽合肥230027

【背景】铜绿微囊藻(Microcystis aeruginosa)广泛分布于温带湖泊,因产生微囊藻毒素且易成为蓝藻水华优势藻株而备受关注。【目的】基于全基因组序列分析和基因转录水平验证,阐明从巢湖新分离的铜绿微囊藻Chao 1910的主要代谢通路和磷... 详细信息

【背景】铜绿微囊藻(Microcystis aeruginosa)广泛分布于温带湖泊,因产生微囊藻毒素且易成为蓝藻水华优势藻株而备受关注。【目的】基于全基因组序列分析和基因转录水平验证,阐明从巢湖新分离的铜绿微囊藻Chao 1910的主要代谢通路和磷营养高效利用机制。【方法】通过第三代测序技术拼接获得Chao 1910的全基因组序列,完成主要代谢通路的基因注释,并对与蓝藻水华优势藻株形成相关的磷代谢通路进行深入分析。【结果】比较基因组学表明,Chao 1910藻株与日本铜绿微囊藻NIES-843的亲缘关系最近,其糖酵解、磷酸戊糖途径和核苷酸合成等代谢通路的基因组成非常保守,同时具有完整的磷转运、磷吸收、多聚磷酸盐合成/分解等磷营养高效利用的通路。不同于其他铜绿微囊藻,Chao 1910藻株不具有微囊藻毒素合成基因簇,推测其主要依靠对磷营养的高效利用获取生存竞争优势。【结论】Chao 1910藻株是巢湖首株完成全基因组测序的铜绿微囊藻,这将有助于揭示其获得生存竞争优势的分子机制,为遏制巢湖蓝藻水华暴发提供依据。

关键词：巢湖铜绿微囊藻Chao 1910 全基因组分析磷代谢通路分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

量子核判别分析算法

引用

郑州大学学报（理学版） 2025年第1期57卷 61-66页

作者：康榕乘余凯张新林崧郭躬德福建师范大学计算机与网络空间安全学院福建福州350117 福建师范大学数字福建环境监测物联网实验室福建福州350117 福建师范大学数学与统计学院福建福州350117

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种... 详细信息

核判别分析法通过核函数扩展了线性判别分析对非线性数据的处理能力,成为模式识别领域中一个重要的分支。然而,随着数据的指数增长,经典核判别分析算法在提取特征时会消耗大量计算资源。针对这一问题,利用量子叠加性和并行性提出了一种量子核判别分析算法。首先,借助量子随机存储器技术与控制旋转操作构造需要的类间矩阵和类内矩阵所对应的密度算子;然后,融入线性方程的求解思路并行获取特征态。理论分析表明,所提算法与经典算法相比具有指数级加速。

关键词：量子机器学习非线性判别分析核函数特征提取量子厄米特链积相位估计

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Abundance and distribution of meiofauna in the Chukchi Sea

引用

Acta Oceanologica Sinica 2014年第6期33卷 90-94页

作者： LIN rongcheng HUANG Dingyong GUO yuqing CHANG yu CAO Yinkun WANG Jianjia Third Institute of Oceanography State Oceanic Administration Key Laboratory of Marine Fishery Resources and Ecological Environment of Fujian Province Fisheries CollegeJimei University

The metazoan meiofauna in the Chukchi Sea were collected from seven shallow water stations （depths rang- ing 46 to 52 m） and five deep sea stations （depths ranging between 393 and 2 300 m） during the 4th Chinese National Arctic Research Expedition in 2010. The results showed that abundance of meiofauna was higher in shallow water sediments （average of 2445 ind./（10 cm2）） than in deep sea sediments （407.06 ind./（10 cm2））. A UNIANOVA test for difference between the two different regions was highly significant （F=10h 15, p〈***）. Nematodes were numerically dominant, representing （96.6±4.6）% of the total meiofaunal abundance at the shallow water stations and （98.90±1.42）% at deep sea stations. The number of higher taxonomic groups and abundance of meiofauna were higher at Stas CC1, CC4, and R06 near the Bering Strait and the continent, than at the rest of the shallow water and deep sea stations. The primary factors causing the differences were concentrations of nutrients P and Si of bottom seawater （R=0.831, p〈0.003）, followed by depth （R=-0.655, p〈0.05） and sand fractions of sediments （R=0.632, p 〈0.05）. The numbers of meiofauna on the 65 lam and 32 llm sieves were significantly higher than those on the rest of the screens. Differences in numbers of meiofauna retained on screens with different mesh openings were highly significant among all sampling stations （F=31.60, p〈0.01）. The highest numbers of individuals on screens with 32 μm mesh openings were found at deep sea stations. The number of meiofauna in the top 6-1, 1-2, and 2-4 cm segments constituted 84.4% of the total and was significantly higher than those in the bottom 4-6 and 6-10 cm segments （F=15, p〈0.01）.

关键词： Chukchi Sea meiofauna abundance vertical distribution size spectra deep sea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

数字化效果模拟器在口腔正畸临床教学中的应用效果评估

引用

中华口腔医学研究杂志（电子版） 2022年第2期16卷 113-117页

作者：郑金绚孟博文余镕丞吴莉萍陈正元刘冠琪曹阳中山大学附属口腔医院光华口腔医学院广东省口腔医学重点实验室广州510055

目的评估数字化效果模拟器在口腔正畸临床教学中的应用效果。方法选取2020—2021年于中山大学附属口腔医院正畸科就诊的安氏Ⅰ类、安氏Ⅱ类和安氏Ⅲ类错牙合畸形病例共6个,完善问诊、临床检查和X线片检查后,提供相应的石膏模型和数字化... 详细信息

目的评估数字化效果模拟器在口腔正畸临床教学中的应用效果。方法选取2020—2021年于中山大学附属口腔医院正畸科就诊的安氏Ⅰ类、安氏Ⅱ类和安氏Ⅲ类错牙合畸形病例共6个,完善问诊、临床检查和X线片检查后,提供相应的石膏模型和数字化模型。中山大学光华口腔医学院口腔正畸学专业的2018~2021级研究生28人通过分层随机抽样法分为两组(每组14人),分别进行传统的石膏模型排牙预测(A组)和数字化效果模拟器预测(B组),并完成正畸诊断和治疗计划。由具有硕士生导师资格的3位教师对其诊断和治疗计划进行评估,同时讲授其依据。两组学生分别对传统石膏排牙预测和数字化效果模拟器预测过程进行评价。结果在“制定方案主动性”和“考虑牙移动细节”方面,B组学生得分高于A组,差异具有统计学意义(P<0.001)。相比于A组,B组中更多学生认为数字化模拟器可提高学习兴趣(A组78.57%、B组100%)、加深对诊断与治疗计划的理解(A组75.00%、B组89.28%)和考虑更多三维牙移动(A组64.28%、B组75.00%)。在教师评价中,B组在治疗计划讲授过程得分高于A组(P<0.001)。结论数字化效果模拟器可锻炼学生的临床思维能力,提高口腔正畸诊断与治疗计划的制定的教学效果。

关键词：正畸学数字化效果模拟器诊断计算机辅助教学教学评价

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of non-cardiovascular co-morbidities on heart failure patients with infection

引用

中国循环杂志 2016年第Z1期31卷 -页

作者： Younan Yao yuhui Zhang rongcheng Zhang Yiran Hu Yiwen yu Xuemei Zhao Nini Liu Jian Zhang Heart Failure Center Fuwai Hospital State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical Colege Beijing China

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Reversible SUMOylation of FHY1 Regulates Phytochrome A Signaling in Arabidopsis

引用

Molecular Plant 2020年第6期13卷 879-893页

作者： Gao-Ping Qu Hong Li Xiao-Li Lin Xiangxiong Kong Zi-Liang Hu Yin Hua Jin yu Liu Hang-Lin Song Dae Heon Kim rongcheng Lin Jigang Li Jing Bo Jin Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China University of the Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Yanbian Academy of Agriculture Sciences Yanji 133001China Department of Biology Sunchon National UniversitySunchon 57922South Korea Key Laboratory of Photobiology Institute of BotanyChinese Academy of SciencesBeijing 100093China

In response to far-red light(FR),FAR-RED ELONGATED HYPOCOTYL 1(FHY1)transports the photoactivated phytochrome A(phyA),the primary FR photoreceptor,into the nucleus,where it initiates FR signaling in *** promotes the 26S proteasome-mediated degradation of FHY1,which desensitizes FR signaling,but the underlying regulatory mechanism remains largely ***,we show that reversible SUMOylation of FHY1 tightly regulates this *** K32(K32)and K103 are major SUMOylation sites of *** found that FR exposure promotes the SUMOylation of FHY1,which accelerates its ***,we discovered that ARABIDOPSIS SUMO PROTEASE 1(ASP1)interacts with FHY1 in the nucleus under FR and facilitates its ***1 was strongly SUMOylated and its protein level was decreased in the asp1-1 loss-of-function mutant compared with that in the wild type under ***,asp1-1 seedlings exhibited a decreased sensitivity to FR,suggesting that ASP1 plays an important role in the maintenance of proper FHY1 levels under *** analysis further revealed that ASP1 regulates FR signaling through an FHY1-and phyA-dependent ***,We found that continuous FR inhibits ASP1 accumulation,perhaps contributing to the desensitization of FR *** together,these results indicate that FR-induced SUMOylation and ASP1-dependent deSUMOylation of FHY1 represent a key regulatory mechanism that fine-tunes FR signaling.

关键词： Arabidopsis photomorphogenesis FHY1 SUMO ASP1

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：