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Whole-volume histogram analysis of spectral-computed tomography iodine maps characterizes HER2 expression in gastric cancer

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World Journal of Gastroenterology 2024年第38期30卷 4211-4220页

作者： Wei-Ling Zhang Jing Sun rong-fang Huang Yi Zeng Shu Chen Xiao-Peng Wang Jin-Hu Chen Yun-Bin Chen Chun-Su Zhu Zai-Sheng Ye You-Ping Xiao Department of Radiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Pathology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Gastric Surgery Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina Department of Epidemiology Clinical Oncology School of Fujian Medical University&Fujian Cancer Hospital(Fujian Branch of Fudan University Affiliated Cancer Hospital)Fuzhou 350014Fujian ProvinceChina

BACKGROUND Although surgery remains the primary treatment for gastric cancer(GC),the identification of effective alternative treatments for individuals for whom surgery is unsuitable holds ***2 overexpression occurs in approximately 15%-20%of advanced GC cases,directly affecting treatment-related ***-computed tomography(sCT)enables the quantification of material compositions,and sCT iodine concentration parameters have been demonstrated to be useful for the diagnosis of GC and prediction of its invasion depth,angioge-nesis,and response to systemic *** existing report describes the prediction of GC HER2 status through histogram analysis based on sCT iodine maps(IMs).AIM To investigate whether whole-volume histogram analysis of sCT IMs enables the prediction of the GC HER2 *** This study was performed with data from 101 patients with pathologically confirmed GC who underwent preoperative sCT *** parameters were extracted via sCT IM histogram analysis:The minimum,maximum,mean,standard deviation,variance,coefficient of variation,skewness,kurtosis,entropy,percentiles(1st,5th,10th,25th,50th,75th,90th,95th,and 99th),and lesion *** correlations of the parameters with the HER2 status and clinicopathological parameters were *** operating characteristic curves were used to evaluate the parameters’diagnostic *** Values for the histogram parameters of the maximum,mean,standard deviation,variance,entropy,and percentiles were significantly lower in the HER2+group than in the HER2–group(all P<0.05).The GC differentiation and Lauren classification correlated significantly with the HER2 status of tumor tissue(P=0.001 and 0.023,respectively).The 99th percentile had the largest area under the curve for GC HER2 status identification(0.740),with 76.2%,sensitivity,65.0%specificity,and 67.3%*** sCT IM histogram parameters correlated positively with the GC HER2 status(r=0.

关键词： Gastric cancer Spectral computed tomography Iodine map Histogram analysis

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Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis:a nationwide retrospective study in China

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World Journal of Pediatrics 2024年第5期20卷 506-516页

作者： Li-Wen Tan Jun-Li Wan Chun-Hua Zhu Hong Xu Zheng-Kun Xia Li-Zhi Chen Xiao-Chuan Wu fang Wang Xiao-rong Liu Cheng-Guang Zhao Xiao-Zhong Li Jian-Hua Mao Xiao-Wen Wang Wen-Yan Huang Yu-Hong Li Jian-Jiang Zhang Shi-Pin Feng Jun Yang Jiao-Jiao Liu Chun-Lin Gao Li-Ping rong Lan-Jun Shuai Ke Xu He-Jia Zhang Qiu Li Ai-Hua Zhang Mo Wang Department of Nephrology Children’s Hospital of Chongqing Medical UniversityZhongshan 2nd Rd.136Chongqing400014China Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Pediatrics Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Nephrology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing210008China Department of Nephrology Children’s Hospital of Fudan UniversityNational Paediatric Medical Center of ChinaShanghaiChina Department of Pediatrics Jinling HospitalNanjing Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Department of Pediatrics The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Nephrology Beijing Children’s HospitalCapital Medical UniversityBeijing100045China National Center for Children’s Health BeijingChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology and Immunology Children’s Hospital of Soochow UniversitySuzhouChina Department of Nephrology Children HospitalZhejiang University School of MedicineHangzhouChina Department of Nephrology Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina Department of Nephrology and Rheumatology Shanghai Children’s HospitalSchool

Background Pediatric antineutrophil cytoplasmic antibody-associated vasculitis(AAV)is a life-threatening systemic vasculitis featured by liability to renal ***,there are few studies on the risk factors and predictive models for renal outcomes of AAV in *** Data from 179 AAV children in multiple centers between January 2012 and March 2020 were collected *** risk factors and predictive model of end-stage renal disease(ESRD)in AAV were *** Renal involvement was the most typical manifestation(95.5%),and the crescent was the predominant pathological lesion(84.9%).The estimated glomerular filtration rate(eGFR)was evaluated in 114 patients,of whom 59.6%developed ESRD,and the median time to ESRD was 3.20 *** eGFR[P=0.006,odds ratio(OR)=0.955,95%confidence interval(CI)=0.924–0.987]and the percentages of global glomerulosclerosis(pGGS;P=0.018,OR=1.060,95%CI=1.010–1.112)were independent risk factors for ESRD of renal *** on the pGGS and eGFR at renal biopsy,we developed three risk grades of ESRD and one predictive *** Kaplan‒Meier curve indicated that renal outcomes were significantly different in different risk grades(P<0.001).Compared with serum creatinine at baseline,the predictive model had higher accuracy(0.86 versus 0.58,P<0.001)and a lower coefficient of variation(0.07 versus 0.92)in external *** Renal involvement is the most common manifestation of pediatric AAV in China,of which more than half deteriorates into *** predictive model based on eGFR at renal biopsy and the pGGS may be stable and accurate in speculating the risk of ESRD in AAV children.

关键词： Antineutrophil cytoplasmic antibody End-stage renal disease Glomerulonephritis Pediatric nephrology Vasculitis

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Treatment of fat-poor renal angiomyolipoma with ectopic blood supply by fluorescent laparoscopy:A case report and review of literature

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World Journal of Clinical Oncology 2024年第11期15卷 1435-1443页

作者： Jian-Er Tang rong-Jiang Wang Zhi-Hai fang Ping-Ya Zhu Jian-Xiang Yao Hua Yang Department of Urology First Affiliated Hospital of Huzhou Normal CollegeHuzhou 313000Zhejiang ProvinceChina Department of Andrology Huzhou Women and Children's HospitalHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Renal angiomyolipoma and renal cell carcinoma are the most common benign and malignant tumors of the kidney respectively,and the preoperative differential diagnosis is crucial due to the wide difference in treatment ***-poor renal angiomyolipoma is a relatively rare type of in renal *** fat imaging features are not obvious,and it is easily misdiagnosed as renal cell *** SUMMARY We report the case of a 41-year-old man who complained of *** abdominal computed tomography scans revealed that a heterogeneous mass was seen in the lower pole of the right kidney,with the size of about 53 mm×47 *** showed two right renal arteries,with the mass supplied by an ectopic vessel from the abdominal *** laparoscopic blockade of the right renal heterotopic artery and partial nephrectomy was *** on histological and immunohistochemical findings,the tumor was diagnosed as fatpoor renal *** The use of fluorescent laparoscopy can effectively help intraoperative management,and the fluorescence pattern provided by intravenous indocyanine green can help suggest the final diagnosis,effectively guide the surgical decisionmaking,and avoid preoperative imaging diagnosis leading to nephrectomy for benign renal tumors,through fluorescent navigation of tumor supply vessel precise block,minimize the loss of renal function.

关键词： Renal angiomyolipoma Renal cell carcinoma Ectopic blood supply luorescent laparoscopic Partial nephrectom Case report

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Exploring the mechanism of active ingredients of Smilacis Glabrae Rhizoma in treating migraine headache through network pharmacology and animal experiments

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Integrative Medicine Discovery 2024年第18期8卷 1-10页

作者： Dao-Xian Shu Yan-Yan Chen Jiao-rong Wang Ying Wang Yong-fang Gu Yan-Xin Wang Department of Brain DiseaseⅡ The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230031China

Background:To explore the potential mechanism of action of the active ingredients of Smilacis Glabrae Rhizoma(SGR)in the treatment of migraine using network pharmacology and in vivo ***:Through the search of Traditional Chinese Medicines Systems Pharmacology Database and Analysis Platform,Genecards,Drugbank and other databases,we obtained active ingredients,targets of SGR and related disease targets of migraine,and took the intersection for protein-protein interactions *** constructing the network diagram,network topology analysis was performed to derive the core targets and key active ingredients,and Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were ***,molecular docking was performed and validated by in vivo *** vivo experiments,18 male BALB/c mice were selected,and the SGR group was fed with SGR drinking tablet concentrate,and nitroglycerin injection was used to construct a mouse model of ***-linked immunosorbent assay test was used to detect the levels of TNF-α,IL-1β,IL-6,and AKT1 in ***:The results showed that the core targets of SGR for the treatment of migraine were TNF-α,IL-1β,IL-6,and *** core targets and key active ingredients had better binding *** with the blank group,the number of head scratching in the model group *** with the model group,there was a significant reduction of the number of head scratching in the SGR *** comparison with the blank group,the protein level in the plasma in the model group was markedly *** with the model group,the protein level in the SGR group was significantly ***:SGR has the characteristics of improving migraine based on multi-targets,multi-components and multi-pathways,and the mechanism of action may be related to the inhibition of the release of inflammatory factors,neuron protection,and interference with apoptosis and other processes.

关键词： migraine Smilacis Glabrae Rhizoma network pharmacology molecular docking mechanism of effect

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World Federation of Acupuncture-Moxibustion Societies(WFAS)Technical Benchmark of Acupuncture and Moxibustion:Filiform Needle

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World Journal of Acupuncture-Moxibustion 2024年第3期34卷 231-236页

作者： Liang ZHOU Si-qi ZHANG Meng fang Gui-rong DONG Hong-sheng DONG Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese MedicineShanghai 200437China Shanghai Research Institute of Acupuncture and Meridian Shanghai 200030China

On December 31,2023,World Federation of Acupuncture-Moxibustion Societies(WFAS)officially issued Technical Benchmark of Acupuncture and Moxibustion:Filiform *** technical benchmark clarifies terms and definitions,operating procedures and requirements,safety requirements,*** promulgation and implementation of this technical benchmark would provide a standard for acupuncture practitioners to apply filiform needle in clinical practice,and may play a positive role in the safe use and promotion of filiform needle.

关键词： Acupuncture Filiform needle Academicorganization International standards Technicaloperation Specification

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A methodology for laser tool setters calibration and its precise mathematical model

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Chinese Journal of Aeronautics 2024年第7期37卷 564-581页

作者： Tao fang Zixi fang Ze Zhong CHEN Zhiyong CHANG School of Mechanical Engineering Northwestern Polytechnical UniversityXi’an 710072China Gina Cody School of Engineering and Computer Science Concordia UniversityMontrealQuebec H3G 1M8Canada Changsha Optimum CNC Corporation Changsha 410221China Institute for Aero-engine Smart Assembly of Shaanxi Province Xi’an 710072China

On-machine tool setting is a pivotal approach in achieving intelligent manufacturing,and laser tool setters have become a crucial component of smart machine *** tool setters play a crucial role in precisely measuring the dimensions of cutting tools during the part machining process,focusing on tool length and *** a measuring instrument,the positions of the laser axis of the laser tool setter need to be accurately calibrated before ***,in actual calibration scenarios,traditional calibration methods face challenges due to installation errors in the tool setter and geometric errors in the measuring *** address this issue,this study proposes a novel calibration ***,the calibration mechanism of the laser beam axis is *** on the accurate mathematical model of the laser beam and the measuring rod,and using the polygon clipping algorithm,the mathematical mechanism of the laser tool setter’s work is ***,a novel method is introduced to calculate the compensation distance between the laser beam reference point and the rod bottom center point at each moment during ***,by utilizing the kinematic chain of the tool setter calibration system,a new calibration method is developed to accurately calibrate the position of the laser beam axis in the machine tool coordinate ***,the accuracy of the calibration method is verified through simulation experiments and calibration *** method improves the calibration accuracy of the tool setter,and the mathematical model of the laser tool setter can be extended to the measurement of tools,thereby improving the precision of tool *** research significantly improves the efficient production performance of smart machine tools.

关键词： On-machine tool setting Smart machine tools Mathematical model Calibration method Laser tool sette

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Direct observation of shock-induced phase transformation in polycrystalline iron via in situ x-ray diffraction

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Chinese Physics B 2024年第10期33卷 337-342页

作者： Fan Zhang Jia-Qin Dong Zhi-Yong Xie Zhi-Yu He Hua Shu Rui-rong Wang Jun Xiong Guo Jia Zhi-Heng fang Wei Wang Da-Wu Xiao An-Le Lei Jie Chen Xiu-Guang Huang Collaborative Innovation Center of IFSA(CICIFSA) School of Physics and AstronomyCenter for Ultrafast Science and TechnologyKey Laboratory for Laser Plasmas(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200240China Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghai 201800China Institute of Materials China Academy of Engineering PhysicsMianyang 621700China

Phase transition of polycrystalline iron compressed along the Hugoniot is studied by combining laser-driven shock with in situ x-ray diffraction *** is suggested that polycrystalline iron changes from an initial body-centered cubic structure to a hexagonal close-packed structure with increasing pressure(i.e.,a phase transition fromαtoε).The relationship between density and pressure for polycrystalline iron obtained from the present experiments is found to be in good agreement with the gas-gun Hugoniot *** results show that experiments with samples at lower temperatures under static loading,such as in a diamond anvil cell,lead to higher densities measured than those found under dynamic *** means that extrapolating results of static experiments may not predict the dynamic responses of materials *** addition,neither the face-centered cubic structure seen in previous molecular-dynamics simulations or twophase coexistence are found within our experimental pressure range.

关键词： in situ x-ray diffraction phase transition polycrystalline iron

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直流电压下局部放电数值模拟方法研究综述

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绝缘材料 2024年第4期57卷 1-12页

作者：陈芳荣娜胡晓贵州大学电气工程学院贵州贵阳550025 浙江大学电气工程学院浙江杭州310027 浙江天际互感器股份有限公司浙江衢州324100

本文分别介绍了直流电压下局部放电数值模拟的三电容模型、电导模型以及等离子体模型的建模方法和优缺点,梳理了近年来国内外学者运用这3种模型取得的研究成果。对近年来直流电压下局部放电测试方面的研究进行了归纳整理,总结了温度、... 详细信息

本文分别介绍了直流电压下局部放电数值模拟的三电容模型、电导模型以及等离子体模型的建模方法和优缺点,梳理了近年来国内外学者运用这3种模型取得的研究成果。对近年来直流电压下局部放电测试方面的研究进行了归纳整理,总结了温度、绝缘材料、电压谐波、大气压以及绝缘缺陷等因素对直流电压下局部放电特性的影响。最后讨论了当前数值模拟方法研究中仍然存在的不足,展望了今后研究需要继续深入的方向。

关键词：直流电压局部放电三电容模型电导模型等离子体模型

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患者视角下多重制度逻辑对医患关系的作用机制研究

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中国医院管理 2024年第3期44卷 62-67页

作者：傅蓉陆方南京医科大学医政学院江苏南京211166

目的探究多重制度逻辑对医患关系的作用机制。方法通过梳理多重制度逻辑理论,提出患者视角下多重制度逻辑对医患关系作用机制的概念模型,并对江苏省2家三级公立医院住院患者进行问卷调查,分析患者视角下多重制度逻辑对医患关系影响的作... 详细信息

目的探究多重制度逻辑对医患关系的作用机制。方法通过梳理多重制度逻辑理论,提出患者视角下多重制度逻辑对医患关系作用机制的概念模型,并对江苏省2家三级公立医院住院患者进行问卷调查,分析患者视角下多重制度逻辑对医患关系影响的作用路径,验证概念模型。结果构建了多重制度逻辑对医患关系作用机制的概念模型,验证了患者视角下多重制度逻辑对医患关系有明显影响,市场逻辑和社会逻辑的交互在一定程度上影响医患关系,患者关注焦点在多重制度逻辑对医患关系的影响作用中起到中介效应,多重制度逻辑和患者信息配置能力的交互对患者关注焦点影响明显。结论多重制度逻辑对医患关系的影响存在两条路径:一是多重制度逻辑对医患关系发挥作用的直接效应路径;二是患者关注焦点的中介效应路径,该路径受到患者个体信息配置能力的调节。

关键词：多重制度逻辑医患关系患者视角作用机制

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患者视角下多重制度逻辑对医患关系的作用路径研究

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中华医院管理杂志 2024年第2期40卷 142-147页

作者：傅蓉陆方盐城市第一人民医院团委盐城224000 南京医科大学医政学院南京211166

目的探究患者视角下多重制度逻辑对医患关系的作用路径, 为推动我国公立医院深化医改及完善现代医院管理制度提供依据。方法基于多重制度逻辑理论, 提出多重制度逻辑对医患关系作用路径的研究假设;通过随机抽样, 于2022年3—6月对江苏省... 详细信息

目的探究患者视角下多重制度逻辑对医患关系的作用路径, 为推动我国公立医院深化医改及完善现代医院管理制度提供依据。方法基于多重制度逻辑理论, 提出多重制度逻辑对医患关系作用路径的研究假设;通过随机抽样, 于2022年3—6月对江苏省2家三级公立医院的住院患者进行问卷调查, 问卷包括由政府逻辑、社会逻辑、市场逻辑和专业逻辑4个维度组成的多重制度逻辑量表, 以及由满意、承诺和信任3个维度构成的医患关系量表两部分。基于问卷调查结果, 运用结构方程模型分析患者视角下多重制度逻辑及其交互对医患关系的作用路径。结果共有效调查住院患者308人。结构方程模型分析结果显示, 多重制度逻辑对医患关系有直接影响, 路径系数为0.331(P<0.05);市场逻辑、社会逻辑以及专业逻辑分别对医患关系有直接影响, 路径系数为0.139、0.289和0.236(P<0.05);市场逻辑与社会逻辑的交互在一定程度上直接影响医患关系, 路径系数为0.257(P<0.05)。结论患者视角下多重制度逻辑及其交互作用会影响医患关系的发展, 政府及公立医院可聚焦市场逻辑、社会逻辑及专业逻辑采取相应措施, 同时关注制度逻辑交互, 加强多主体协同治理, 提升患者就医体验, 推动公立医院高质量发展及医患关系健康发展。

关键词：医患关系多重制度逻辑患者认知结构方程模型作用路径

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