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Effect of the combination of high-frequency repetitive magnetic stimulation and neurotropin on injured sciatic nerve regeneration in rats

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Neural Regeneration Research 2020年第1期15卷 145-151页

作者： Jie Chen Xian-ju Zhou rong-Bin sun Department of Orthopedics the Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhouJiangsu ProvinceChina Laboratory of Neurological Diseases Department of Neurologythe Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical UniversityChangzhouJiangsu ProvinceChina Department of Neurology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Repetitive magnetic stimulation is effective for treating posttraumatic neuropathies following spinal or axonal *** is a potential treatment for nerve injuries like demyelinating *** study sought to observe the effects of high-frequency repetitive magnetic stimulation,neurotropin and their combined use in the treatment of peripheral nerve injury in 32 adult male Sprague-Dawley *** create a sciatic nerve injury model,a 10 mm-nerve segment of the left sciatic nerve was cut and rotated through 180°and each end restored continuously with interrupted *** rats were randomly divided into four *** control group received only a reversed autograft in the left sciatic nerve with no *** the high-frequency repetitive magnetic stimulation group,peripheral high-frequency repetitive magnetic stimulation treatment(20 Hz,20 min/d)was delivered for 10 consecutive days after *** the neurotropin group,neurotropin therapy(0.96 NU/kg per day)was administrated for 10 consecutive days after *** the combined group,the combination of peripheral high-frequency repetitive magnetic stimulation(20 Hz,20 min/d)and neurotropin(0.96 NU/kg per day)was given for 10 consecutive days after the *** Basso-Beattie-Bresnahan locomotor rating scale was used to assess the behavioral recovery of the injured *** sciatic functional index was used to evaluate the recovery of motor *** blue staining was performed to determine the number of myelinated fibers in the distal and proximal *** staining was used to detect the length of axons marked by neurofilament *** results reveal that the Basso-Beattie-Bresnahan locomotor rating scale scores,sciatic functional index,the number of myelinated fibers in distal and proximal grafts were higher and axon lengths were longer in the high-frequency repetitive magnetic stimulation,neurotropin and combined groups compared with the control ***

关键词： axon myelinated nerve fibers nerve regeneration neurological rehabilitation neurotropin peripheral nerve injury repetitive magnetic stimulation sciatic nerve trauma

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Some convergence theorems of fuzzy concave integral on fuzzyσ-algebra

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 438-447页

作者： sun rong School of Mathematics and Statistics Chongqing Technology and Business UniversityChongqing 400067China Chongqing Key Laboratory of Statistical Intelligent Computing and Monitoring Chongqing Technology and Business UniversityChongqing 400067China

In this paper,we consider the extension of the concave integral from classical crispσ-algebra to fuzzyσ-algebra of fuzzy ***,the concept of fuzzy concave integral on a fuzzy set is ***,some important properties of s... 详细信息

关键词： convergence theorems fuzzy concave integral fuzzyσ-algebra

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Energy Spectrum of La3Lu2Ga3O12：Cr^3＋ and Its Pressure-Induced R-Line-Shift Reversal

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Communications in Theoretical Physics 2005年第6X期44卷 1103-1114页

作者： MA Dong-Ping CHEN ju-rong Department of Applied Physics Sichuan University Chengdu 610065 Chinat International Centre for Materials Physics the Chinese Academy of Sciences Shenyang 110015 China

By means of both the theory for pressure-induced Shifts （PS） of energy spectra and the theory for shifts of energy spectra due to electron-phonon interaction （EPI）, the normal-pressure energy spectra of α and β centers of Cr^3＋ ions for LLGG：Cr^3＋ and the PS＇s of R1 lines and U band of these centers have been calculated at 10 K, respectively. The total calculated results are in very good agreement with the experimental data. For LLGG：Cr^3＋, the pressureinduced low-high crystal-field transition and the reversal of R1-line PS take place. The pressure-dependent variation of Rmix^ei （2E - 4T2） [mixing-degree of （t2^2 （^3T1）e^4T2） and （t2^3 E） base-wavefunctions in the wavefunction of R1 state without EPI] plays a key role for the reversal of R1-line PS. The behavior of the pure electronic PS of R1 line is quite different from that of the PS of R1 line due to EPI. It is the combined effect of them that gives rise to the total PS of R1 line. The comparison between R1-line PS＇s of GSGG：Cr^3＋ and LLGG：Cr^3＋ has been made. It is found that a peak of R1-line PS appears at Rmix^ei （^2E - ^4T2） ≈ 0.08.

关键词： pressure-induced reversal of Rl-line shift low high crystal-field transition electron-phonon interaction mixing of base-wavefunctions

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Hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage

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Neural Regeneration Research 2013年第13期8卷 1220-1227页

作者： Zhichun Feng Jing Liu rong ju Department of Neonatology & Neonatal Intensive Care Unit Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command Department of Neonatology Chengdu Women's & Children's Central Hospital

Hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically for many years, but its effectiveness remains controversial. In addition, the mechanism of this potential neuroprotective effect remains unclear. This study aimed to investigate the influence of hyperbaric oxygen on the proliferation of neural stem cells in the subventricular zone of neonatal Sprague-Dawley rats （7 days old） subjected to hypoxic-ischemic brain damage. Six hours after modeling, rats were treated with hyperbaric oxygen once daily for 7 days. Immunohistochemistry revealed that the number of 5-bromo-2＇-deoxyuridine positive and nestin positive cells in the subventricular zone of neonatal rats increased at day 3 after hypoxic-ischemic brain damage and peaked at day 5. After hyperbaric oxygen treatment, the number of 5-bromo-2＇- deoxyuddine positive and nestin positive cells began to increase at day 1, and was significantly higher than that in normal rats and model rats until day 21. Hematoxylin-eosin staining showed that hyperbaric oxygen treatment could attenuate pathological changes to brain tissue in neonatal rats, and reduce the number of degenerating and necrotic nerve cells. Our experimental findings indicate that hyperbaric oxygen treatment enhances the proliferation of neural stem cells in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage, and has therapeutic potential for promoting neurological recovery following brain injury.

关键词： neural regeneration brain injury neonatal hypoxic-ischemic encephalopathy hypoxic-ischemicbrain damage hyperbaric oxygen neural stem cells neurons proliferation subventricular zone neonatal rats nestin grants-supported paper neuroregeneration

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Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei Zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming Zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

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Mixed Hierarchical Networks for Deep Entity Matching

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Journal of Computer Science & Technology 2021年第4期36卷 822-838页

作者： Chen-Chen sun De-rong Shen Engineering Research Center of Learning-Based Intelligent System(Ministry of Education)Tianjin University of Technology Tianjin 300384China School of Computer Science and Engineering Tianjin University of TechnologyTianjin 300384China School of Computer Science and Engineering Northeastern UniversityShenyang 110819China

Entity matching is a fundamental problem of data *** groups records according to underlying real-world *** is a growing trend of entity matching via deep learning *** design mixed hierarchical deep neural networks(MHN)for entity matching,exploiting semantics from different abstract levels in the record internal hierarchy.A family of attention mechanisms is utilized in different periods of entity ***-attention focuses on internal dependency,inter-attention targets at alignments,and multi-perspective weight attention is devoted to importance ***,hybrid soft token alignment is proposed to address corrupted *** order is for the first time considered in deep entity ***,to reduce utilization of labeled training data,we propose an adversarial domain adaption approach(DA-MHN)to transfer matching knowledge between different entity matching tasks by maximizing classifier ***,we conduct comprehensive experimental evaluations on 10 datasets(seven for MHN and three for DA-MHN),which illustrate our two proposed approaches1 *** apparently outperforms previous studies in accuracy,and also each component of MHN is ***-MHN greatly surpasses existing studies in transferability.

关键词： entity matching attention mechanism mixed hierarchical neural network(MHN) domain adaption data integration

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Effect of selected fungi on the reduction of gossypol levels and nutritional value during solid substrate fermentation of cottonseed meal

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第9期7卷 690-695页

作者： ZHANG Wen-ju XU Zi-rong sun Jian-yi YANG Xia Key Laboratory of Molecular Ammal Nutrition of Ministry of Education. College of Animal Science Zhejiang university Hangzhou 310029 China College of Animal Science and Technology Shihezi University Shihezi 832003 China

The objective of this work was to investigate the effect of six individual strains of fungi on the reduction of gossypol levels and nutritional value during solid substrate fen＇aentation of cottonseed meal （CSM）. Six groups of disinfected CSM substrate were incubated for 48 h after inoculation with either of the fungi C. capsuligena ZD- 1, C. tropicalis ZD-3, S. cerevisae ZD-5, A. terricola ZD-6, A. oryzae ZD-7, or A. niger ZD-8. One not inoculated group （substrate） was used as a control. Levels of initial and final free gossypol （FG）, crude protein （CP）, amino acids （AA） and in vitro digestibility were assayed. The experiment was done in triplicate. The experimental results indicated that microbial fermentation could greatly decrease （P〈0.05） FG levels in CSM. The detoxification efficiency differed between the species of microorganisms applied. From the perspective of reducing CSM potential toxicity, C. tropicalis ZD-3 was most successful followed by S. cerevisae ZD-5 and A. niger ZD-8. They could reduce FG levels of CSM to 29.8, 63.07 and 81.50 mg/kg based on DM （dry matter）, respectively, and their detoxification rates were 94.57%, 88.51% and 85.16%, respectively. If crude protein, amino acids content and their in vitro digestibility were also taken into account, Aniger ZD-8 may be the best choice. The CP content of CSM substrate fermented by C. tropicalis ZD-3 and A. niger ZD-8 were improved by 10.76% and 22.24%; the TAA （total amino acids） contents were increased by 7.06% and 11.46%, and the EAA （essential amino acids） were raised by 7.77% and 12.64%, respectively. Especially, the levels of methionine, lysine and threonine were improved greatly （P〈0.05）. The in vitro CP digestibility of CSM fermented by C. tropicalis ZD-3 and A. niger ZD-8 was improved by 13.42% and 18.22%, the TAA were increased by 17.75% and 22.88%, and the EAA by 16.61% and 21.01%, respectively. In addition, the in vitro digestibility of methionine, lysine and threonine was also improved

关键词： Fungi Free gossypol Solid substrate fermentation Cottonseed meal Detoxification Nutritional value

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A Subclass of Ockham Algebras

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Acta Mathematica Sinica,English Series 2012年第10期28卷 2115-2128页

作者： Jie FANG Zhong ju sun School of Computer Science Guangdong Polytechnic Normal University

Here we introduce a subclass of the class of Ockham algebras （L; f） for which L satisfies the property that for every x ∈ L, there exists n 〉 0 such that fn（x） and f^n＋1（x） are complementary. We characterize the structure of the lattice of congruences on such an algebra （L; f）. We show that the lattice of compact congruences on L is a dual Stone lattice, and in particular, that the lattice Con L of congruences on L is boolean if and only if L is finite boolean. We also show that L is congruence coherent if and only if it is boolean. Finally, we give a sufficient and necessary condition to have the subdirectly irreducible chains.

关键词： Boolean algebra Ockham algebra congruence congruence coherence subdirectly irre-ducible

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Advances in Research on Anticancer Properties of Salidroside

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Chinese Journal of Integrative Medicine 2021年第2期27卷 153-160页

作者： sun An-qi ju Xiu-lian Key Laboratory for Green Chemical Process of Ministry of Education School of Chemical Engineering&PharmacyWuhan Institute of TechnologyWuhan(430073)China The College of Post and Telecommunication Wuhan Institute of TechnologyWuhan(430073)China

Salidroside is a phenolic secondary metabolite present in plants of the genus Rhodiola,and studies investigating its extensive pharmacological activities and mechanisms have recently attracted increasing *** review summarizes the progress of recent research on the antiproliferative activities of salidroside and its effects on breast,ovarian,cervical,colorectal,lung,liver,gastric,bladder,renal,and skin cancer as well as gliomas and ***,it provides a reference for the further development and utilization of salidroside.

关键词： salidroside anticancer mechanism antiproliferative Chinese medicine review

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Finite Abelian Groups with the Strong Endomorphism Kernel Property

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Acta Mathematica Sinica,English Series 2020年第9期36卷 1076-1082页

作者： Jie FANG Zhong ju sun School of Mathematics and Systems Science Guangdong Polytechnic Normal UniversityGuangzhou 510665P.R.China

An endomorphism h of a group G is said to be strong whenever for every congruenceθon G,(x,y)∈θimplies(h(x),h(y))∈θfor every x,y∈G.A group G is said to have the strong endomorphism kernel property if every congruence on G is the kernel of a strong *** this note,we study the strong endomorphism kernel property in the class of Abelian *** particular,we show that a finite Abelian group has the strong endomorphism kernel property if and only if it is cyclic.

关键词： Strong endomorphism kernel property congruence Abelian group cyclic group

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