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Energy analysis of face stability of deep rock tunnels using nonlinear Hoek-Brown failure criterion

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Journal of Central South University 2015年第8期22卷 3079-3086页

作者：张佳华李永鑫许敬叔 School of Civil Engineering Central South University

The nonlinear Hoek-Brown failure criterion was introduced to limit analysis by applying the tangent method. Based on the failure mechanism of double-logarithmic spiral curves on the face of deep rock tunnels, the analytical solutions of collapse pressure were derived through utilizing the virtual power principle in the case of pore water, and the optimal solutions of collapse pressure were obtained by using the optimization programs of mathematical model with regard of a maximum problem. In comparison with existing research with the same parameters, the consistency of change rule shows the validity of the proposed method. Moreover, parametric study indicates that nonlinear Hoek-Brown failure criterion and pore water pressure have great influence on collapse pressure and failure shape of tunnel faces in deep rock masses, particularly when the surrounding rock is too weak or under the condition of great disturbance and abundant ground water, and in this case, supporting measures should be intensified so as to prevent the occurrence of collapse.

关键词： tunnel face limit analysis failure criterion pore water pressure collapse pressure

Taxonomic analysis of cryptococcus species complex strain $8012 revealed Cryptococcus gattii with high heterogeneity on the ~enetics

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Chinese Medical Journal 2011年第13期124卷 2051-2056页

作者： CHEN Min LIAO Wan-qing WU Shao-xi YAO Zhi-rong PAN Wei-hua LIAO Yong Shanghai Key Laboratory of Molecular Medical Mycology Institute of Dermatology and Mycosis of Changzheng HospitalSecond Military Medical University Shanghai 200003 China Institute of Dermatology Chinese Academy of Medical ScienceNanjing Jiangsu 210042 China Department of Dermatology Xinhua Hospital Shanghai Jiao TongUniversity Shanghai 200092 China

Background Initially, Cryptococcus （C.） neoformans was previously divided into two varieties comprising C. neoformans var. neoformans and C. neoformans var. gattii. Currently, taxonomic studies defined C. neoformans as C. species complex, which contains C. neoformans var. neoformans （serotype D）, the hybrid isolates （serotype AD）, C. neoformans var. grubfi （serotype A） and C. gattii （serotypes B and C）. However, Liao and his team once isolated a unique C. gattii isolate, namely strain S8012 with unique phenotype from cerebrospinal fluid （CSF） of a 43-year-old male patient in the Shanghai Changzheng Hospital and described as C. neoformans var. shanghaiensis in 1980s. The aim of this study was to explore the genetic background and polymorphism of Chinese clinical C. gattii isolates. Methods S8012 was analyzed as representative strain using the M13-polymerase chain reaction （PC R） fingerprinting pattern and multilocus sequence analysis including internal transcribed spacers of rDNA （ITS region）, the intergenic spacer 1 regions （IGS1）, RPB1, RPB2, CNLACl, and TEF1 genes. Results The PCR fingerprinting pattern results showed strain S8012 belonged to molecular types VGI, and phylogenetic analysis suggested strain S8012 was grouped into the cluster of C. gattii environmental isolates originated from Eucalyptus camaldulensis trees in Australia. Conclusion C. gattii isolates from Chinese patients expresses high polymorphism on the phenotype, and molecular type VGI isolates from China have a close genetic relationship with the C. gattii isolates from Australia.

关键词： cryptococcus neoformans Cryptococcus gattii genetic polymorphism

Comparison of Efficacy between 3D Navigation-Assisted Percutaneous Iliosacral Screw and Minimally Invasive Reconstruction Plate in Treating Sacroiliac Complex Injury

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Current Medical Science 2019年第1期39卷 81-87页

作者： Qi-lin LU Yi-liang ZHU xu-gui LI Wei XIE Xiao-zhen WANG xue-zhen SHAO Xian-hua CAI Xi-ming LIU Department of Orthopaedics Hubei 672nd Orthopaedics Hospital of Integrated Chinese&Western MedicineWuhan 430079China Department of Orthopaedics the PLA General Hospital of Central Theater CommandWuhan 430070China

The clinical efficacy was compared between 3D navigation-assisted percutaneous iliosacral screw(3DPS)and minimally invasive reconstruction plate(MIRP)in treating sacroiliac complex injury and the surgical procedures of 3DPS were introduced.A retrospective analysis was performed on 49 patients with sacroiliac complex injury from March 2013 to May ***-one cases were treated by 3DPS,and 28 cases by *** indexes as operative time,blood loss,incision length,length of hospital stay and postoperative complications were respectively *** of reduction was postoperatively evaluated by Matta radiological criteria,and clinical effect was assessed by Majeed scoring criteria at the last *** time and hospital stay were significantly shortened,and blood loss,and incision length were significantly reduced in 3DPS group as compared with those in MIRP group(P0.05).It was concluded that both 3DPS and MIRP can effectively treat the sacroiliac complex injury,and 3DPS can provide an accurate,safe and minimally invasive fixation with shorter operative time and hospital stay.

关键词： sacroiliac complex injury 3D navigation-assisted system percutaneous iliosacral screw minimally invasive reconstruction plate

高超声速飞行器DSMC/EPSM自适应当地时间步长混合算法

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空气动力学学报 2008年第3期26卷 394-399页

作者：朱荣丽曹义华北京航空航天大学航空科学与工程学院飞机设计研究所北京100083

采用优化的DSMC/EPSM混合算法,研究了高超声速飞行器三维复杂流场在近连续区的气动力热特性。发展了一种DSMC/EPSM自适应当地时间步长混合算法,根据网格内仿真分子的碰撞数,自动调整网格中进行仿真分子运动和碰撞计算的时间步长,有效地... 详细信息

采用优化的DSMC/EPSM混合算法,研究了高超声速飞行器三维复杂流场在近连续区的气动力热特性。发展了一种DSMC/EPSM自适应当地时间步长混合算法,根据网格内仿真分子的碰撞数,自动调整网格中进行仿真分子运动和碰撞计算的时间步长,有效地提高了程序的计算效率和计算精度。用DSMC方法、DSMC/EPSM混合算法和DSMC/EPSM自适应当地时间步长混合算法对比计算了三维复杂飞行器流场压力、热流分布量,飞行器表面气动力、热分布参数,证明了DSMC/EPSM自适应当地时间步长混合算法大幅度缩短了流场稳定所需的CPU时间,并且不降低流场模拟结果的精度。

关键词： DSMC数值模拟三维流场网格标识分子碰撞

Handgrip Strength as a Predictor of Nutritional Status in Chinese Elderly Inpatients at Hospital Admission

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Biomedical and Environmental Sciences 2017年第11期30卷 802-810页

作者： ZHANG Xin Sheng LIU Ying hua ZHANG Yong xu Qing YU Xiao Ming YANG xue Yan LIU Zhao LI Hui Zi LI Feng xuE Chang Yong Department of Nutrition Chinese PLA General Hospital Department of Nutrition Chinese PLA General Hospital of Rocket Forces

Objective To assess nutritional status and define gender-and age-specific handgrip strength（HGS） cut-point values for malnutrition or nutritional risk in elderly inpatients. Methods A cross-sectional study of 1,343 elderly inpatients was conducted in the Chinese PLA General Hospital. Nutrition Risk Screening（NRS 2002） and Subjective Global Assessment（SGA） were administered. Anthropometric measurements and blood biochemical indicators were obtained using standard techniques. The gender-and age-specific receiver operating characteristic（ROC） curves were constructed to evaluate the HGS for nutritional status by SGA and NRS 2002. Sensitivity, specificity, and areas under the curves（AUCs） were calculated. Results According to NRS 2002 and SGA, 63.81% of elderly inpatients were at nutritional risk and 28.22% were malnourished. Patients with higher HGS had an independently decreased risk of malnutrition and nutritional risk. The AUCs varied between 0.670 and 0.761. According to NRS 2002, the optimal HGS cut-points were 27.5 kg（65-74 years） and 21.0 kg（75-90 years） for men and 17.0 kg（65-74 years） and 14.6 kg（75-90 years） for women. According to SGA, the optimal HGS cut-points were 24.9 kg（65-74 years） and 20.8 kg（75-90 years） for men and 15.2 kg（65-74 years） and 13.5 kg（75-90 years） for women. Conclusion Elderly inpatients had increased incidence of malnutrition or nutritional risk. HGS cut-points can be used for assessing nutritional status in elderly inpatients at hospital admission in China.

关键词： Handgrip strength Elderly inpatients Nutrition assessment Nutrition status Malnutrition

Dual-Mode Terahertz Extended Interaction Oscillator Driven by a Pseudospark-Sourced Sheet Electron Beam

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Journal of Electronic Science and Technology 2021年第3期19卷 243-254页

作者： Jie Xie xue-Song Yuan Liang Zhang Adrian W.Cross hua-Bi Yin Qing-Yun Chen Tong-Bin Yang Xiao-Tao xu Yang Yan Lin Meng School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 610054 Department of Physics University of StrathclydeGlasgow G4 0NG

A terahertz dual-mode extended interaction oscillator (EIO) driven by a pseudospark-sourced sheet electron beam (SEB) was *** major advantages of the newly developed circuit include 1) high-density SEB interacting with the TM_(11) and TM_(31) modes,respectively,and 2) high output power of over 1 kW at the subterahertz frequency *** different types of 2π modes and their output characteristics were studied,and the circuit was optimized to ensure efficient outputs of two standing-wave *** three-dimensional (3D) particle-in-cell (PIC) simulation predicts the maximum output power of 1.3 kW with the 3-dB bandwidth of ~0.5 GHz at 303 GHz when operating at the TM_(11)mode,and 3.18 kW with the 3-dB bandwidth of ~0.85 GHz at 364 GHz when operating at the TM_(31)mode.

关键词： Dual-mode operation extended interaction oscillator(EIO) high-power radiation pseudospark-sourced(PS)electron beam sheet electron beam(SEB) terahertz

Single-nucleotide polymorphism screening and RNA sequencing of key messenger RNAs associated with neonatal hypoxic-ischemia brain damage

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Neural Regeneration Research 2020年第1期15卷 86-95页

作者： Liu-Lin Xiong Lu-Lu xue Mohammed Al-Hawwas Jin huang Rui-Ze Niu Ya-Xin Tan Yang xu Ying-Ying Su Jia Liu Ting-hua Wang Department of Anesthesiology National Traditional Chinese Medicine Clinical Research Base and Western Medicine Translational Medicine Research CenterAffiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhouSichuan ProvinceChina School of Pharmacy and Medical Sciences Division of Health SciencesUniversity of South AustraliaAdelaideSouth AustraliaAustralia Department of Animal Zoology Kunming Medical UniversityKunmingYunnan ProvinceChina Institute of Neurological Disease Department of AnesthesiologyTranslational Neuroscience CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina

A single-nucleotide polymorphism(SNP)is an alteration in one nucleotide in a certain position within a *** are associated with disease ***,the influences of SNPs on the pathogenesis of neonatal hypoxic-ischemic brain damage remain ***-day-old rats were used to establish a hypoxic ischemic encephalopathy *** and expression profiles of mRNAs were analyzed in hypoxic ischemic encephalopathy model rats using RNA *** exhibiting SNPs associated with hypoxic ischemic encephalopathy were identified and studied by gene ontology and pathway analysis to identify their possible involvement in the disease *** identified 89 up-regulated genes containing SNPs that were mainly located on chromosome 1 and *** ontology analysis indicated that the up-regulated genes containing SNPs are mainly involved in angiogenesis,wound healing and glutamatergic synapse and biological processing of calcium-activated chloride *** pathway analysis indicated that the differentially expressed genes play a role in glutamatergic synapses,long-term depression and oxytocin ***,intersection analysis of high throughput screening following PubMed retrieval and RNA sequencing for SNPs showed that CSRNP1,DUSP5 and LRRC25 were most relevant to hypoxic ischemic *** up-regulation of genes was confirmed by quantitative real-time polymerase chain reaction analysis of oxygen-glucose-deprived human fetal cortical *** results indicate that CSRNP1,DUSP5 and LRRC25,containing SNPs,may be involved in the pathogenesis of hypoxic ischemic *** findings indicate a novel direction for further hypoxic ischemic encephalopathy *** animal study was approved on February 5,2017 by the Animal Care and Use Committee of Kunming Medical University,Yunnan Province,China(approval ***2019038).Cerebral tissue collection from a human fetus was approved on September 30,2015 by the Eth

关键词： CSRNP1 DUSP5 gene ontology analysis human fetal cortical neurons LRRC25 mRNA neonatal hypoxic ischemic encephalopathy pathogenesis signaling pathway analysis

基于单相级联延时信号消除法的三相基波正序有功电流检测方法

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电网技术 2014年第8期38卷 2231-2236页

作者：徐榕于泳杨荣峰徐殿国哈尔滨工业大学电气工程及自动化学院黑龙江省哈尔滨市150001

快速准确地检测基波正序有功电流,对电能质量控制非常重要。许多传统方法都需使用锁相环、低通滤波器或进行??和dq坐标变换。为此,提出了一种新型检测方法。首先通过扇合矢量变换,将三相系统的电压和电流归一化为单相系统;然后通过构造... 详细信息

快速准确地检测基波正序有功电流,对电能质量控制非常重要。许多传统方法都需使用锁相环、低通滤波器或进行??和dq坐标变换。为此,提出了一种新型检测方法。首先通过扇合矢量变换,将三相系统的电压和电流归一化为单相系统;然后通过构造级联延时信号消除模块对基波正序电压和电流进行快速提取;最后通过简单的数学计算,得到基波正序有功电流。该方法既不需要锁相环,也不需要低通滤波器,还能够省略使用??和dq坐标变换时的复杂计算。仿真结果验证了所提方法的有效性。

关键词：电能质量基波正序有功电流扇合矢量变换级联延时信号消除

Colostomy is a simple and effective procedure for severe chronic radiation proctitis

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World Journal of Gastroenterology 2016年第24期22卷 5598-5608页

作者： Zi-xu Yuan Teng-Hui Ma huai-Ming Wang Qing-hua Zhong Xi-Hu Yu Qi-Yuan Qin Jian-Ping Wang Lei Wang Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-Sen University Clinical Research Division Fred Hutchinson Cancer Research Center University of Washington

AIM: To assess the efficacy and safety of diverting colostomy in treating severe hemorrhagic chronic radiation proctitis(CRP). METHODS: Patients with severe hemorrhagic CRP who were admitted from 2008 to 2014 were enrolled into this study. All CRP patients were diagnosed by a combination of pelvic radiation history, clinical rectal bleeding, and endoscopic findings. Inclusion criteria were CRP patients with refractory bleeding with moderate to severe anemia with a hemoglobin level < 90 g/L. The study group included patients who were treated by diverting colostomy, while the control group included patients who received conservative treatment. The remission of bleeding was defined as complete cessation or only occasional bleeding that needed no further treatment. The primary outcome was bleeding remission at 6 mo after treatment. Quality of life beforetreatment and at follow-up was evaluated according to EORTC QLQ C30. Severe CRP complications were recorded during ***: Forty-seven consecutive patients were enrolled, including 22 in the colostomy group and 27 in the conservative treatment group. When compared to conservative treatment, colostomy obtained a higher rate of bleeding remission(94% vs 12%), especially in control of transfusion-dependent bleeding(100% vs 0%), and offered a better control of refractory perianal pain(100% vs 0%), and a lower score of bleeding(P < 0.001) at 6 mo after treatment. At 1 year after treatment, colostomy achieved better remission of both moderate bleeding(100% vs 21.5%, P = 0.002) and severe bleeding(100% vs 0%, P < 0.001), obtained a lower score of bleeding(0.8 vs 2.0, P < 0.001), and achieved obvious elevated hemoglobin levels(P = 0.003), when compared to the conservative treatment group. The quality of life dramatically improved after colostomy, which included global health, function, and symptoms, but it was not improved in the control group. Pathological evaluation after colostomy found diffused chronic inflammatio

关键词： Chronic radiation proctitis Rectal bleeding Diverting colostomy Quality of life Serious complication