检索结果-南通市图书馆

Spatial association between landslides and environmental factors over Guizhou Karst Plateau,China

Journal of Mountain Science 2018年第9期15卷 1987-2000页

作者： YUE Xi-liu wu Shao-hong HUANG Mei GAO Jiang-bo YIN Yun-he FENG Ai-qing GU Xiao-ping Institute of Geographical Sciences and Natural Resources Research Chinese Academy of SciencesBeijing 10010lChina Post-doctoral Workstation China Reinsurance GroupBeijing 100033China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100190China National Climate Center China Meteorological AdministrationBeijing 100081China Guizhou Key Laboratory of Mountainous Climate and Resource Guiyang 550002China

Guizhou Karst Plateau is located at the center of the karst region in Asia, where landslides are a typical disaster. Affected by the local karst environment, the landslides in this region have their own characteristics. In this study, 3975 landslide records from inventories of the Guizhou karst plateau are studied. The geographical detector method is used to detect the dominant casual factor and predominant multi-factor combinations for the local landslides. The results show that landslides are prone to areas on slopes between 10° and 35°, of clay rock, in close proximity to gullies, and especially in areas of moderate vegetation, dryland, and mild rocky desertification. Continuous precipitation over 10 days has a great effect on landslide occurrence. Compared with the individual factors, the impact of two-factor interaction has greater explanatory power for landslide volume. The volume of earthquake-induced landslides is predominantly controlled by the interactions of faults and slopes, while that of humaninduced landslides is affected by the interactions of land cover and hydrological conditions. For rainfallinduced landslides, the dominant interactions vary in different regions. In the central karst basin, the interactions between faults and precipitation can explain over 90% of the variations in landslide volumes. In the southern hilly karst region, the interactions between lithology and slope can explain over 71% of the variations in landslide volume and those between fault and land-use can explain 50% of the variations of the landslide volumes in the northeastern mountainous karst region.

关键词： Landslides Karst Combined impact Geographical detector method Environmental factor Guizhou

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

超声心动图诊断胎儿单纯肺动脉瓣狭窄的价值

引用

中华医学超声杂志（电子版） 2024年第2期21卷 158-162页

作者：李博彭芳华孔德璇张欢欢曲东辉王锟阚长利聂明辉刘天鑫吴文瑛承德医学院附属医院超声科 067000

目的探讨超声心动图在诊断胎儿单纯肺动脉瓣狭窄(PVS)中的价值。方法回顾性分析2019年1月至2022年12月在天津市中心妇产科医院超声科和承德医学院附属医院南区超声科产前经超声心动图诊断为单纯PVS的胎儿35例。胎儿心脏超声检查获取四... 详细信息

目的探讨超声心动图在诊断胎儿单纯肺动脉瓣狭窄(PVS)中的价值。方法回顾性分析2019年1月至2022年12月在天津市中心妇产科医院超声科和承德医学院附属医院南区超声科产前经超声心动图诊断为单纯PVS的胎儿35例。胎儿心脏超声检查获取四腔心切面、左心室及右心室流出道切面、三血管切面等。测量各心腔横径,观察房室瓣启闭及反流情况。出生的胎儿均于产后24 h内行超声心动图检查,测量肺动脉速度和肺动脉跨瓣压差,评估肺动脉瓣狭窄程度。分析产前和产后超声心动图检查结果,采用Pearson相关分析产前PVS分组(正向组、逆向组)与产后PVS分度(轻、中、重度)之间的相关性。结果35例单纯PVS胎儿引产8例,出生27例。产前动脉导管(DA)正向组15例,逆向组20例,2组病例肺动脉流速、肺动脉狭窄后扩张和三尖瓣反流程度差异具有统计学意义(P0.05)。27例出生后新生儿期超声心动图检查均证实有不同程度PVS,轻度15例,中度8例,重度4例。产前PVS不同分组与产后PVS不同分度之间具有相关性(Pearson相关系数=0.58,P<0.05),产前正向组病例产后大部分为轻度PVS(12/14,85.71%),逆向组病例产后中度和重度PVS居多(10/13,76.92%)。结论胎儿单纯PVS肺动脉流速快,三尖瓣反流程度重,DA逆灌产后可能中度以上PVS的可能性大,狭窄后扩张是胎儿PVS的一个重要间接征象。胎儿单纯PVS可以在产前进行诊断,超声心动图是诊断胎儿单纯PVS并预估其产后分度的重要手段。

关键词：超声心动图胎儿肺动脉瓣狭窄产前产后

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pig macrophages with site-specific edited CD163 decrease the susceptibility to infection with porcine reproductive and respiratory syndrome virus

引用

Journal of Integrative Agriculture 2023年第7期22卷 2188-2199页

作者： XU Kui ZHOU Yan-rong SHANG Hai-tao XU Chang-jiang TAO Ran HAO Wan-jun LIU Sha-sha MU Yu-lian XIAO Shao-bo LI Kui State Key Laboratory of Animal Nutrition/Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural AffairsInstitute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193P.R.China Shenzhen Kingsino Technology Co. Ltd.Shenzhen 518106P.R.China State Key Laboratory of Agricultural Microbiology/Key Laboratory of Preventive Veterinary Medicine in Hubei Province College of Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070P.R.China Precision Medicine Institute The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080P.R.China

Porcine reproductive and respiratory syndrome(PRRS)is recognized as one of the most infectious viral diseases of *** Cluster of differentiation 163(CD163)is identified as an essential receptor for mediating PRRS virus(PRRSV)infection,the important residues involved in infection on CD163 are still ***,it is very important to identify these key residues to study the mechanism of PRRSV infection and to generate anti-PRRSV *** this study,we first generated immortalized porcine alveolar macrophage(IPAM)cell lines harboring 40-residues(residues 523-562,including R561(arginine(R)at position 561))deletion of *** infection experiments showed that these IPAM cell lines were completely resistant to PRRSV *** then generated cloned pigs carrying CD163-R561A(an arginine(R)to alanine(A)substitution at position 561 of CD163).PRRSV challenge experiments in porcine alveolar macrophages(PAMs)isolated from the CD163-R561A pigs showed significantly lower susceptibility to PRRSV than that of CD163-R561 *** this study,we show that CD163523-562 contains essential residues for mediating PRRSV infection,and that CD163 R561 significantly contributes to PRRSV infection but is not essential for *** functional sites can therefore serve as new targets for understanding the mechanism of PRRSV ***,CD163-R561A pigs can be used as an important model for improving pig germplasm with resistance against PRRSV.

关键词： pigs porcine alveolar macrophages dual-sgRNA homology-directed repair PRRSV CD163

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

9个燕麦品种的种带细菌多样性及其促生功能定性分析

引用

草原与草坪 2024年第2期44卷 13-24页

作者：李向阳张玉娟贾倩英张宏姚博黄荣张振粉甘肃农业大学草业学院草业生态系统教育部重点实验室甘肃省草业工程实验室中-美草地畜牧业可持续发展研究中心甘肃兰州730070

【目的】探究燕麦(Avena sativa)种带细菌及其促生功能多样性。【方法】采用传统培养方法分离纯化9个燕麦品种种带细菌,并定性分析其固氮、溶磷、产IAA能力和分解纤维素功能。【结果】共分离到34株细菌分离物,结合其形态特征及16S rDNA... 详细信息

【目的】探究燕麦(Avena sativa)种带细菌及其促生功能多样性。【方法】采用传统培养方法分离纯化9个燕麦品种种带细菌,并定性分析其固氮、溶磷、产IAA能力和分解纤维素功能。【结果】共分离到34株细菌分离物,结合其形态特征及16S rDNA分析,分离出的细菌隶属于原核生物界的4门19属,其中优势门为厚壁菌门(Firmicutes),占比56.00%;优势属为芽孢杆菌属(Bacillus),占比41.18%;34株燕麦种带细菌均具不同的促生功能,其中分属于芽孢杆菌属、埃希氏菌属(Escherichia)、假单胞菌属(Pseudomonas)、志贺氏菌属(Shigella)和大西洋杆菌属(Atlantibacter)的9株细菌同时具备固氮、溶磷、产吲哚乙酸和分解纤维素功能。【结论】本试验共分离到34株细菌分离物,均具备不同的促生功能,其中9株细菌兼具固氮、溶磷、产吲哚乙酸和分解纤维素功能,志贺氏菌属LFt4综合能力最强。

关键词：种带细菌燕麦细菌多样性植物促生

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats

引用

World Journal of Gastroenterology 2018年第30期24卷 3384-3397页

作者： Dan Zhang Yan-bo Ren Kai Wei Jue Hong Yan-Ting Yang Li-Jie wu Ji Zhang Zheng Shi Huan-Gan wu Xiao-Peng Ma Laboratory of Acupuncture-moxibustion and Immunology Shanghai Research Institute of Acupuncture and MeridianShanghai University of Traditional Chinese Medicine Department of Integrated Traditional Chinese Medicine and Western Medicine North Branch of Huashan HospitalFudan University Key Laboratory of Systems Biomedicine (Ministry of Education) Shanghai Center for Systems BiomedicineShanghai Jiao Tong University Yueyang Clinical Medicine School Shanghai University of Traditional Chinese Medicine

AIM To observe the effect of herb-partitioned moxibustion(HPM) on expression of colonic cytokines in ulcerative colitis(UC) *** A UC rat model was established by protein immunization in combination with topical chemical *** in the HPM group(n = 8) received HPM at bilateral Tianshu(ST25) *** gross injury and pathological scores of the colon were *** expression profile of colonic cytokines was assayed using the protein microarray *** differential cytokines were selected and verified by *** corresponding Uni Prot Accessions of the differentially expressed cytokines were retrieved in the Uni Prot *** pathways involved were analyzed with the help of the KEGG PATHWAY *** DAVID database was used for functional cluster and pathway *** HPM improved colon injuries in UC rats,manifested by accelerated repair of ulcers and alleviation of inflammation,and the gross injury and pathological scores both significantly decreased(P 1.3 or < 0.77 was taken as the screening *** were 77 down-regulated and 9 up-regulated differentially expressed colonic cytokines in the HPM group compared with the model group,and expression of 20 differed significantly(P < 0.05).Twelve of the 20 significantly differentially expressed cytokines [β-catenin,interleukin-1 receptor 6(IL-1 R6),IL-1β,B7-1,nerve growth factor receptor,AMP-activated protein kinase-α1,neuropilin-2,orexin A,adipocyte differentiation-related protein,IL-2,Fas and Fas L] were up-regulated in the model group(n = 3,compared with the normal group) but downregulated in the HPM group(n = 3,compared with the model group).Functional cluster analysis showed that the differentially expressed colonic cytokines in the HPM group regulated apoptosis and protein *** pathway analysis showed that 52 down-regulated and 7 up-regulated differentially expressed colonic cytokines in the HPM group had *** pathw

关键词： Cytokine expression profile Ulcerative colitis Protein microarray Rats Herb-partitioned moxibustion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Outcomes of laparoscopic bile duct exploration for choledocholithiasis with small common bile duct

引用

World Journal of Clinical Cases 2021年第8期9卷 1803-1813页

作者： Xiao-Xiao Huang Jia-Yi wu Yan-Nan Bai Jun-Yi wu Jia-Hui Lv Wei-Zhao Chen Li-Ming Huang rong-Fa Huang Mao-Lin Yan Department of Hepatobiliary and Pancreatic Surgery Shengli Clinical Medical College of Fujian Medical UniversityFujian Provincial HospitalFuzhou 350001Fujian ProvinceChina

BACKGROUND Laparoscopic cholecystectomy(LC)combined with laparoscopic common bile duct(CBD)exploration(LCBDE)is one of the main treatments for choledocholithiasis with CBD diameter of larger than 10 ***,for patients with small CBD(CBD diameter≤8 mm),endoscopic sphincterotomy remains the preferred treatment at present,but it also has some drawbacks associated with a series of complications,such as pancreatitis,hemorrhage,cholangitis,and duodenal *** date,few studies have been reported that support the feasibility and safety of LCBDE for choledocholithiasis with small *** To investigate the feasibility and safety of LCBDE for choledocholithiasis with small *** A total of 257 patients without acute cholangitis who underwent LC+LCBDE for cholecystolithiasis from January 2013 to December 2018 in one institution were *** clinical data were retrospectively collected and *** to whether the diameter of CBD was larger than 8 mm,257 patients were divided into large CBD group(n=146)and small CBD group(n=111).Propensity score matching(1:1)was performed to adjust for clinical *** demographics,intraoperative data,short-term outcomes,and long-term follow-up outcomes for the patients were recorded and *** In total,257 patients who underwent successful LC+LCBDE were enrolled in the study,146 had large CBD and 111 had small *** median follow-up period was 39(14-86)*** small CBD patients,the median CBD diameter was 0.6 cm(0.2-2.0 cm),the mean operating time was 107.2±28.3 min,and the postoperative bile leak rate,rate of residual CBD stones(CBDS),CBDS recurrence rate,and CBD stenosis rate were 5.41%(6/111),3.60%(4/111),1.80%(2/111),and 0%(0/111),respectively;the mean postoperative hospital stay was 7.4±3.6 *** large CBD patients,the median common bile duct diameter was 1.0 cm(0.3-3.0 cm),the mean operating time was 115.7±32.0 min,and the postoperative bile leak rate,rate of residual CBDS,CBDS recurre

关键词： Common bile duct stones Laparoscopic common bile duct exploration Endoscopic sphincterotomy Bile leak Choledochal stenosis Recurrence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Persistent truncus arteriosus with intact ventricular septum diagnosed by echocardiography

引用

Chinese Medical Journal 2009年第22期122卷 2798-2800页

作者： ZHANG Yu-qi SHEN rong SUN Kun ZHONG Shu-wen wu Yu-rong Department of Pediatric Cardiology Shanghai Children's Medical Center Shanghai Jiao Tong University Shanghai 200127 China

Persistent truncus arteriosus （PTA） is a rare congenital cardiac anomaly, and has an incidence of about 0.5 to 0.9 per 10 000 live births, Almost all cases described in the literatures had a large ventricular septal defect, only few rare cases were reported with intact ventricular septum.2-5 From June 1998 to December 2008, cardiac angiography were performed in 10 880 patients with congenital heart disease in our hospital, 47 patients with PTA were diagnosed, one case with tricuspid atresia, hvooolastic right ventricle,

关键词： persistent truncus arteriosus echocardiography

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Deubiquitinase JOSD2 stabilizes YAP/TAZ to promote cholangiocarcinoma progression

引用

Acta Pharmaceutica Sinica B 2021年第12期11卷 4008-4019页

作者： Meijia Qian Fangjie Yan Weihua Wang Jiamin Du Tao Yuan Ruilin wu Chenxi Zhao Jiao Wang Jiabin Lu bo Zhang Nengming Lin Xin Dong Xiaoyang Dai Xiaowu Dong bo Yang Hong Zhu Qiaojun He Zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 310058China Department of Clinical Pharmacology Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou First People’s HospitalCancer CenterZhejiang University School of MedicineHangzhou 310006China Second Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310009China Cancer Center of Zhejiang University Hangzhou 310058China

Cholangiocarcinoma(CCA)has emerged as an intractable cancer with scanty therapeutic *** aberrant activation of Yes-associated protein(YAP)and transcriptional co-activator with PDZ-binding motif(TAZ)are reported to be common in CCA ***,the underpinning mechanism remains poorly ***(DUB)is regarded as a main orchestrator in maintaining protein ***,we identified Josephin domain-containing protein 2(JOSD2)as an essential DUB of YAP/TAZ that sustained the protein level through cleavage of polyubiquitin chains in a deubiquitinase activity-dependent *** depletion of JOSD2 promoted YAP/TAZ proteasomal degradation and significantly impeded CCA proliferation in vitro and in *** analysis has highlighted the positive correlation between JOSD2 and YAP abundance in CCA patient ***,this study uncovers the regulatory effects of JOSD2 on YAP/TAZ protein stabilities and profiles its contribution in CCA malignant progression,which may provide a potential intervention target for YAP/TAZ-related CCA patients.

关键词： Cholangiocarcinoma Deubiquitinase JOSD2 YAP/TAZ

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cataclysmic variables based on the stellar spectral survey LAMOST DR3

引用

Research in Astronomy and Astrophysics 2018年第6期18卷 67-88页

作者： Xianming L.Han Li-Yun Zhang Jian-rong Shi Qing-Feng Pi Hong-Peng Lu Li-bo Zhao Rachel K.Terheide Lin-Yang Jiang College of Physics/Department of Physics and Astronomy & Guizhou Provincial Key Laboratory of Public Big Data Guizhou University Dept.of Physics and Astronomy Butler University Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences National Astronomical Observatories Chinese Academy of Sciences Department of Astronomy Beijing Normal University

Big data in the form of stellar spectra from the spectroscopic survey associated with the Large Sky Area Multi-object Fiber Spectroscopic Telescope(LAMOST) are important for studying properties of cataclysmic variables(CVs). By cross matching the catalogs of CVs compiled with LAMOST DR3,acquired from October 2011 to July 2015, we obtained the first spectroscopic catalog for CVs observed by LAMOST with high signal to noise ratio, above 8. By integrating line profiles, their equivalent widths(EWs) of the Hα, Hβ, Hγ and Hδ, as well as He I 5876 and 6678 A? lines, were calculated. There were74 stellar spectra from 48 known CVs and three spectra from three new CV candidates. At the same time, we also collected their previously published EWs. Thirty-three objects had repeated spectra and30 stars showed spectral variability in the Hα line. Moreover, we carried out photometric follow-up studies for five CVs(UU Aqr, TT Tri, PX And, BP Lyn and RW Tri). We obtained nine new light curves and revised their linear ephemerides. For RW Tri, there is a possible oscillation with an amplitude of0.0031(2) days and a period of 47.6±0.4 years, which might be caused by a third body(brown dwarf)or magnetic activity cycle.

关键词： stars: cataclysmic variables stars: spectroscopic stars: variable

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210

引用

Cancer Biology & Medicine 2019年第1期16卷 173-180页

作者： Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei wu bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu State Key Laboratory of Molecular Oncology and Department of Medical Oncology National Cancer Center National Clinical Research Center for Cancer Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College-Medical Oncology Department of Gastroenterology Tumor Hospital Affiliated to Xinjiang Medical University Tumor Hospital Affiliated to Xinjiang Medical University Department of Diagnostic Radiology National Cancer Center National Clinical Research Center for Cancer Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College-Medical Oncology Department of Pathology National Cancer Center National Clinical Research Center for Cancer Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College-Medical Oncology

Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor ***: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, ***: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without ***: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events.

关键词： Reactive capillary hemangiomas SHR-1210 skin toxicity anti-tumor efficacy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：