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Hepatic artery infusion chemotherapy using mFOLFOX versus transarterial chemoembolization for massive unresectable hepatocellular carcinoma:a prospective *** study

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Chinese Journal of Cancer 2017年第12期36卷 704-711页

作者： Min-Ke He Yong Le Qi-Jiong Li Zi-Shan Yu Shao-Hua Li Wei Wei rong-ping Guo Ming Shi Department of Hepatobiliary Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China

Background: Transarterial chemoembolization(TACE) is recommended as the standard care for unresectable hepatocellular carcinoma(HCC) at Barcelona Clinic Liver Cancer(BCLC) stage A-B. However, the efficacy of TACE on large(> 10 cm) stage A-B HCC is far from satisfactory, and it is proposed that hepatic artery infusion chemotherapy(HAIC)might be a better first-line treatment of this disease. Hence, we compared the safety and efficacy of HAIC with the modified FOLFOX(mFOLFOX) regimen and those ofTACE in patients with massive unresectable ***: A prospective, non-randomized, phase II study was conducted on patients with massive unresectable HCC. The protocol involved HAIC with the mFOLFOX regimen(oxaliplatin, 85 mg/m^2 intra-arterial infusion; leucovorin,400 mg/m^2 intra-arterial infusion; and fluorouracil, 400 mg/m2 bolus infusion and 2400 mg/m^2 continuous infusion)every 3 weeks and TACE with 50 mg of epirubicin, 50 mg of lobaplatin, 6 mg of mitomycin, and lipiodol and polyvinyl alcohol particles. The tumor responses, time-to-progression(TTP), and safety were ***: A total of 79 patients were recruited for this study: 38 in the HAIC group and 41 in the TACE group. The HAIC group exhibited higher partial response and disease control rates than did the TACE group(52.6% vs. 9.8%, P < 0.001;83.8% vs. 52.5%, P = 0.004). The median TTPs for the HAIC and TACE groups were 5.87 and 3.6 months(hazard radio[HR] = 2.35,95% confidence interval [CI] = 1.16-4.76, P = 0.015). More patients in the HAIC group than in the TACE group underwent resection(10 vs. 3,P = 0.033). The proportions of grade 3-4 adverse events(AE) and serious adverse events(SAE) were lower in the HAIC group than in the TACE group(grade 3-4 AEs: 13 vs. 27, P = 0.007;SAEs: 6 vs. 15,p = 0.044). More patients in the TACE group than in the HAIC group had the study treatment terminated early due to intolerable treatment-related adverse events or the withdrawal of consent(10 vs. 2,P = 0.026).Conclusion

关键词： Hepatocellular carcinoma Hepatic artery infusion chemotherapy Transarterial chemoembolization mFOLFOX

SYNTHESIS AND CRYSTAL STRUCTURE OF NEODYMIUM COMPLEX OF 1-METHYL-1,4,7,10-TETRAAZACYCLODODECANE

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Chinese Chemical Letters 1991年第11期2卷 871-872页

作者： ping rong WEI Tian Zhu JIN Guang Xian XU Zhong Sheng JIN Research Centre of Rare Earth Chemistry Peking UniversityBeijing 100871 Changchun Institute of Applied Chemistry Academia SinicaChangchun 130022

The complex [Nd(L)(CH_3CN)(CF_3SO_3)_3] has been synthesized, where L=1-methyl-1,4,7,10-tetraazacyclododecane. The crystal structure of the complex has been determined by a fourcircle X-ray diffractometer to a final R value of 0.0370 and Rw value of 0.0385 respectively. The crystal is triclinic system, space group P1 with a=8.738(2), b=12.870(3), c=12.900(3), α=85.63(2), β=87.25(2), γ=78.30(2)°, V=1415.71(60)~3, Z=2, Dc=1.92g/cm^3. The neodymiumion is eight-coordinated, forming a distorted square antiprism.

关键词： SYNTHESIS AND CRYSTAL STRUCTURE OF NEODYMIUM COMPLEX OF 1-METHYL-1,4,7,10-TETRAAZACYCLODODECANE CF CN

A SIMPLIFIED APPROACH TO EMBEDDING PROBLEMS IN NORMAL BORDISM FRAMEWORK

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Systems Science and Mathematical Sciences 1992年第2期5卷 180-192页

作者： LI Banghe LIU rong ZHANG ping (Institute of Systems Science,Academia Sinica,Beijing 100080,China)

The purpose of this paper is to simplify the computations of the nor-mal bordism groups Ωi（Wf,M×P∞;（?））and Ωi（Cf,（?）w;θf）which Salomonsenand Dax introduced respectively to study the existence and isotopy classificationof differential embeddings of manifolds in manifolds in the metastable *** space pair（Kf,M×P∞）is constructed to replace（Wf,M×P∞）.It isshown that（Kf,M×P∞）is homotopy equivalent to（Wf,M×P∞）and homotopy（n-1）-equivalent to（Cf,（?）W）.To demonstrate the efficacy of this simplification,the isotopy groups [Mn（?）RPn+k],if n（?）2k-4 and Mn is a closed（n-k+2）-connected manifold,and[Mn（?）L（p;q1…,qm）],if 3n（?）4m-2,Mn is a closed（2n-2m+1）-connected manifold and L is a （2m+1）-dimensional lens space,arespecifically computed.

关键词： Normal bordism group differential embedding isotopy

Effect of electroacupunture on gastric mucosal intestinal trefoil factor gene expression of stress-induced gastric mucosal injury in rats

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World Journal of Gastroenterology 2006年第12期12卷 1962-1965页

作者： Xi-ping Li Jie Yan Shou-Xiang Yi Xiao-rong Chang Ya-ping Lin Zong-Bao Yang Ai Huang rong Hu Institute of Acupuncture and Moxibustion Hunan College of Traditional Chinese Medicine Chang'sha 410007 Hunan Province China

AIM： To investigate electroacupunture（EA） at the acupoints of Stomach Meridian of Foot-Yangming（SMFY）, Gallbladder Meridian of Foot-Yangming（SMFY） on gastric mucosal intestinal trefoil factor （ITF） gene expression detection in stress-induced rats with gastric mucosal lesion, and to explore the regulatory mechanism and significance of EA-related gastric mucosal protective effect. METHODS： Forty rats were randomly divided into 4 groups： Blank group, Model group, Model group＋EA at acupoints of SMFY group（＂SMFY group＂）, and Model group＋EA at acupoints of GMFY group（GMFY group）. All rats （except blank group） were made model by water immersion and restraint stress （WRS）. Then the gastric mucosa tissue in each rat was taken off alter assessment of gastric mucosal lesion index（GUI）, and the expression of ITF mRNA of the tissues was detected by reverse transcdption-polymerase chain reaction（RT-PCR） method. RESULTS： Compared with Model group（S4.3± 1.34）, the GUI value in SMFY group （31±2.211 decreased significantly（P〈0.01）, so did that in GMFY group （39.8± 1.62, P〈0.05）, meanwhile GUI value in SMFY group was significantly lower than in GMFY group（P〈0.01）. Compared with Model group （0.65±0.01）, EA had a tendency to improve the expression of gastric mucosal ITFmRNA gene： such tendency existed in GMFY group （0.66±0.01） but with no signficant difference（P〉 0.05）, in SMFY group（0.76±0.01） with an extremely obvious difference （P〈0.01）, furthermore the expression in SMFY group was significantly higher than in GMFY group （P〈 0.01）.CONCLUSION： The gastric mucosal protective effect by EA at the acupoints of SMFY and GMFY was related to the expression variance of ITF, indicating certain meridian specificity exists, It could be one proof for the TCM theory ＂Relative pardcularity between SMFY and stomach＂.

关键词： EA Relative particularity between Stomach Meridian of Foot-Yangming, Gastric mucosal damage,Stress Intestinal trefoil factor Gene expression

Hot-embossing fabrication of chalcogenide glasses rib waveguide for mid-infrared molecular sensing

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Chinese Physics B 2017年第2期26卷 274-279页

作者： Ting-Yang Yan Xiang Shen rong-ping Wang Guo-Xiang Wang Shi-Xun Dai Tie-Feng Xu Qiu-Hua Nie Laboratory of Infrared Material and Devices Advanced Technology Research Institute Ningbo University Ningbo 315211 China Key Laboratory of Photoelectric Materials and Devices of Zhejiang Province Ningbo 315211 China The Australian National University Canberra ACT 2600 Australia

Chalcogenide glasses have shown promise in fabricating mid infrared（MIR） photonic sensing devices due to their excellent optical properties in MIR. In addition, the glass transition temperature of chalcogenide glasses are generally low,making them ideal to create the high-throughput patterns of micro-scale structures based on hot embossing that is alternative to the standard lithographic technology. In this paper, we outline the research progress in the chalcogenide waveguide based on the hot embossing method, and discuss the problems remaining to be solved and the possible solutions.

关键词： chalcogenide glasses hot embossing rib waveguides MIR sensing

Study of parity violation inΛ^(+)_(c)→ΦρandΛ^(+)_(c)→ωρdecays

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Chinese Physics C 2023年第5期47卷 49-56页

作者：洪鹏程严芳平荣刚罗涛 Institute of Modern Physics Fudan UniversityShanghai 200433China Institute of High Energy Physics Chinese Academy of ScienceBejing 100049China University of Chinese Academy of Science Chinese Academy of ScienceBeijing 100049China

CP violation in baryonic decays has not been significantly *** large data events accumulated at e+e-colliders or the Large Hadron Collider,charmed baryon decays would provide a promising laboratory to test CP *** this study,we formulateΛ^(+)_(c)→ΦρandΛ^(+)_(c)→ωρdecays for the measurement of their asymmetry parameters in weak decays at the BESII or LHCb *** polarization transfer is analyzed in the two processes of e+e-→Λ^(+)_(c)Λ^(-)_(c)andΛ^(o)_(b)→Λ^(+)_(c)π^(-),and the formulas for the joint angular distribution of these processes are *** sensitivity of the measurement of the asymmetry parameters of the above two decay processes is estimated for future experiments.

关键词： parity violation asymmetry parameters sensitivity spin density matrix angular distribution

Prognostic value of the neutrophil-to-lymphocyte ratio for hepatocellular carcinoma patients with portal/hepatic vein tumor thrombosis

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World Journal of Gastroenterology 2017年第17期23卷 3122-3132页

作者： Shao-Hua Li Qiao-Xuan Wang Zhong-Yuan Yang Wu Jiang Cong Li Peng Sun Wei Wei Ming Shi rong-ping Guo State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineCancer Center of Sun Yat-Sen University Department of Hepatobiliary Surgery Cancer Center of Sun Yat-Sen University Department of Radiation Oncology Cancer Center of Sun Yat-Sen University Department of Head and Neck Surgery Cancer Center of Sun Yat-Sen University Department of Colorectal Surgery Cancer Center of Sun Yat-Sen University Department of Anesthesia Cancer Center of Sun YatSen University

AIM To investigate whether the preoperative neutrophil-tolymphocyte ratio(NLR) could predict the prognosis of hepatocellular carcinoma(HCC) patients with portal/hepatic vein tumor thrombosis(PVTT/HVTT) after *** The study population included 81 HCC patients who underwent hepatectomy and were diagnosed with PVTT/HVTT based on pathological examination. The demographics, laboratory analyses, and histopathology data were *** Overall survival(OS) and disease-free survival(DFS) were determined in the patients with a high(> 2.9) and low(≤ 2.9) NLR. The median OS and DFS duration in the high NLR group were significantly shorter than those in the low NLR group(OS: 6.2 mo vs 15.7 mo, respectively, P = 0.007; DFS: 2.2 mo vs 3.7 mo, respectively, P = 0.039). An NLR > 2.9 was identified as an independent predictor of a poor prognosis of OS(P = 0.034, HR = 1.866; 95%CI: 1.048-3.322) in uni-and multivariate analyses. Moreover, there was a significantly positive correlation between the NLR and the Child-Pugh score(r = 0.276, P = 0.015) and the maximum diameter of the tumor(r = 0.435, P 2.9 indicates poorer OS and DFS.

关键词： Hepatocellular carcinoma Portal/hepatic vein tumor thrombosis Neutrophil-to-lymphocyte ratio Prognosis

黄鳝(Monopterus albus)P450(11β)基因cDNA的克隆和表达分析

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基因组学与应用生物学 2017年第1期36卷 90-98页

作者：荣萍上海海洋大学水产与生命学院上海201306

11β-羟化酶(11β-hydroxylase)由P450(11β)(Cytochrome P450 11β-hydroxylase)基因编码,是一种重要的线粒体酶,指导合成11-羟睾酮,11-羟睾酮是合成硬骨鱼中最重要的雄性激素11-KT的前体物质,参与精子发生过程。本研究首先利用RT-PCR... 详细信息

11β-羟化酶(11β-hydroxylase)由P450(11β)(Cytochrome P450 11β-hydroxylase)基因编码,是一种重要的线粒体酶,指导合成11-羟睾酮,11-羟睾酮是合成硬骨鱼中最重要的雄性激素11-KT的前体物质,参与精子发生过程。本研究首先利用RT-PCR和RACE技术克隆了黄鳝(Monopterus albus)P450(11β)基因c DNA全长序列,然后利用生物信息学进行了分析,最后利用RT-PCR和荧光定量PCR方法对不同组织的表达情况进行了研究。结果显示:黄鳝P450(11β)基因c DNA全长为1 812 bp,开放阅读框1 632 bp共编码544个氨基酸氨基酸,5'非编码区(5'UTR)9个碱基,3'非编码区(3'UTR)168个碱基。黄鳝P450(11β)基因结构的保守性较高,具有细胞色素P450超家族基因的5个特征区域。氨基酸序列同源性分析表明黄鳝与其他鱼类的同源性在64%~76%之间,与舌齿鲈同源性最高为77%,但与人和老鼠的相似度仅为41.9%和37.7%。系统进化树分析以哺乳类为外群,黄鳝与点带石斑鱼、罗非鱼、舌齿鲈等聚为一大支。基因表达显示黄鳝P450(11β)基因在性腺和脑组织中表达,尤其在精巢中高表达,在卵巢中几乎检测不到。表明该基因对精子发生和精巢发育过程起着一定的作用。

关键词：黄鳝 P450(11β) 克隆表达分析

A Temperature-Precipitation Based Leafing Model and Its Application in Northeast China

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A Temperature-Precipitation Based Leafing Model and Its Appl...