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World Journal of Radiology 2024年第6期16卷 232-240页

作者： zhan-rong zhang Feng Chen Hui-Juan Chen Department of Radiology The Affiliated Hainan Hospital of Hainan Medical University(Hainan General Hospital)Haikou 570311Hainan ProvinceChina

BACKGROUND Langerhans cell histiocytosis(LCH)is characterized by diabetes insipidus and is an uncommon occurrence.Pathological biopsies still have a certain degree of diagnostic probability.We present a case in which LCH initially affected the pituitary gland.This resulted in a misdiagnosis of chronic inflammation upon pathological examination.CASE SUMMARY A 25-year-old female exhibited symptoms of diabetes insipidus.Magnetic resonance imaging revealed an enhanced foci in the pituitary gland.After surgical resection of the pituitary lesion,the pathological diagnosis was chronic inflam-mation.However,the patient later experienced bone destruction in the skull and lower limb bones.After the lower limb bone lesion was compared with the initial pituitary lesion,the final diagnosis was modified to LCH.The patient was treated with multiple chemotherapy courses.However,the patient’s condition gradually worsened,and she eventually passed away at home.CONCLUSION LCH should be considered when patients exhibit diabetes insipidus and absence of high signal intensity in the pituitary gland on sagittal T1-weighted image and abnormal enhancement in the pituitary region.

关键词： Langerhans cell histiocytosis Pituitary gland Diabetes insipidus Multi-system Misdiagnosis Magnetic resonance imaging Case report

Efficacy and safety of tandem autologous stem cell transplantation in multiple myeloma:a retrospective single-center analysis

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Chinese Medical Journal 2023年第15期136卷 1873-1875页

作者： Shunquan Wu Zongjian Qiu Ting Lin Zhijuan Zhu Xiaofan Li Xianling Chen Ping Chen Yiting Wang rong zhan Nainong Li Department of Hematology Hematopoietic Stem Cell Transplantation CenterFujian Institute of HematologyFujian Provincial Key Laboratory on HematologyFujian Medical University Union HospitalFuzhouFujian 350001China Translational Medicine Center on Hematology Fujian Medical UniversityFuzhouFujian 350001China

To the Editor:Upfront autologous stem cell transplantation(ASCT)has been an integral part of the management of young and eligible older patients with newly diagnosed multiple myeloma(NDMM)for over three decades.Tandem stem cell transplantation was defined as two planned sequential ASCTs within 3 to 6 months.More than two decades after its introduction,trials exploring the utility of tandem transplants have yielded mixed results.The role of tandem ASCT in multiple myeloma(MM)remains unclear and controversial.In the EMN02/HOVON95 study.

关键词： myeloma analysis stem

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TL1A作为炎症性肠病治疗靶点的研究进展

世界华人消化杂志 2024年第6期32卷 397-404页

作者：战蓉蓉王冬张晓岚河北医科大学第二医院消化内科河北省消化病学研究所消化内科重点实验室河北省石家庄市050000

肿瘤坏死因子超家族成员(TNF superfamily member,TNFSF)和肿瘤坏死因子受体超家族蛋白由多种分子组成,对免疫系统的发育和功能起着关键作用.TNFSF15基因编码的肿瘤坏死因子样配体1(tumor necrosis factor-like ligand 1 aberrance,TL1A... 详细信息

肿瘤坏死因子超家族成员(TNF superfamily member,TNFSF)和肿瘤坏死因子受体超家族蛋白由多种分子组成,对免疫系统的发育和功能起着关键作用.TNFSF15基因编码的肿瘤坏死因子样配体1(tumor necrosis factor-like ligand 1 aberrance,TL1A)是一种Ⅱ型跨膜蛋白,有可溶性或膜结合两种存在形式,通过结合其功能性受体-死亡受体3[(death receptor 3,DR3)或TNFFRSFf25]为下游信号通路提供刺激信号,调节效应细胞的增殖、激活、凋亡以及细胞因子、趋化因子的产生.TL1A/DR3细胞因子系统已成为黏膜免疫的重要模块,参与维持肠道稳态,促进慢性炎症反应的发生和发展,因此,在炎症性肠病的发生发展过程中也发挥重要作用.

关键词： TL1A 炎症性肠病肠纤维化治疗靶点专家述评

Effect of arsenic trioxide on proliferation and apoptosis of U266 cells and its relationship with the expression variation of VEGF

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Frontiers of Medicine 2008年第4期2卷 356-360页

作者： rong zhan Qinghong YU Haobo HUANG Fujian Institute of Hematology Department of HematologyThe Affiliated Union HospitalFujian Medical UniversityFuzhou 350001China

The aim of this article is to explore the effect of arsenic trioxide(As2O3)on the proliferation and apopto-sis of myeloma cell line U266 and its relationship with the expression variation of vascular endothelial growth factor(VEGF).The viability and apoptosis of U266 cells were observed by methylthiazolyl-tetrazolium(MTT)assay and terminal-deoxynucleotidyl transferase mediated nick end labeling(TUNEL).The effect of As2O3 on the VEGF expression of U266 cells were tested by enzyme linked immunosorbent assay(ELISA)and reverse transcrip-tion-polymerase chain reaction(RT-PCR)analysis.We found that As2O3 could significantly inhibit the growth of U266 cells,and the concentration for 50%growth inhibition(IC50)was 2 mmol/L.After treatment with 2,5,10 mmol/L As2O3 for 36 hours,dose-dependent apop-tosis of U266 cells was observed.After treatment with 2,5,10 mmol/L As2O3 for 72 hours,a dose-dependent reduc-tion of VEGF in the supernatant of U266 cells culture was found.As far as single cells are concerned,nevertheless,the expression of VEGF mRNA did not vary.So we draw the conclusion that As2O3 could induce the apoptosis of U266 cells and inhibit their proliferation,decrease the tumor load,and lead to the reduction of VEGF in the culture supernatant,but not change the expression of VEGF in single U266 cells.

关键词： arsenic trioxide myeloma proliferation apoptosis vascular endothelial growth factor

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某船舶餐厅振动噪声分析及治理

噪声与振动控制 2024年第3期44卷 177-182,208页

作者：高处詹蓉苏元凯高晓磊司南中国船舶及海洋工程设计研究院上海200011 三沙市船务管理局海南三沙570102

某船舶大餐厅与机舱公用部分钢围壁导致餐厅噪声水平超标,严重影响船员就餐舒适性。基于统计能量分析法和经验分析法,对餐厅所在舱段进行声学仿真,通过对比数值计算结果与实测数据,分析餐厅噪声来源及组成,确定在外部控制振源,在内部敷... 详细信息

某船舶大餐厅与机舱公用部分钢围壁导致餐厅噪声水平超标,严重影响船员就餐舒适性。基于统计能量分析法和经验分析法,对餐厅所在舱段进行声学仿真,通过对比数值计算结果与实测数据,分析餐厅噪声来源及组成,确定在外部控制振源,在内部敷设浮筑地板、吸隔声材料的综合治理方案,最终有效控制餐厅噪声。从工程实践角度为毗邻主要声源的船舶舱室噪声治理提供一种参考方法,并提出一些建议。

关键词：振动与波统计能量分析船上餐厅声能量降噪设计

Effects of vitamin D supplementation on glucose and lipid metabolism in patients with type 2 diabetes mellitus and risk factors for insulin resistance

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World Journal of Diabetes 2023年第10期14卷 1514-1523页

作者： Li-Jie Sun Ji-Xuan Lu Xin-Yu Li Tian-Sheng Zheng Xiao-rong zhan Department of Endocrinology First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Endocrinology Southern University of Science and Technology HospitalShenzhen 518071Guangdong ProvinceChina

BACKGROUND Type 2 diabetes mellitus(T2DM)is a chronic metabolic disease featured by insulin resistance(IR)and decreased insulin secretion.Currently,vitamin D deficiency is found in most patients with T2DM,but the relationship between vitamin D and IR in T2DM patients requires further investigation.AIM To explore the risk factors of IR and the effects of vitamin D supplementation on glucose and lipid metabolism in patients with T2DM.METHODS Clinical data of 162 T2DM patients treated in First Affiliated Hospital of Harbin Medical University between January 2019 and February 2022 were retrospectively analyzed.Based on the diagnostic criteria of IR,the patients were divided into a resistance group(n=100)and a non-resistance group(n=62).Subsequently,patients in the resistance group were subdivided to a conventional group(n=44)or a joint group(n=56)according to the treatment regimens.Logistic regression was carried out to analyze the risk factors of IR in T2DM patients.The changes in glucose and lipid metabolism indexes in T2DM patients with vitamin D deficiency were evaluated after the treatment.RESULTS Notable differences were observed in age and body mass index(BMI)between the resistance group and the non-resistance group(both P<0.05).The resistance group exhibited a lower 25-hydroxyvitamin D_(3)(25(OH)D_(3))level,as well as notably higher levels of 2-h postprandial blood glucose(2hPG),fasting blood glucose(FBG),and glycosylated hemoglobin(HbA1c)than the non-resistance group(all P<0.0001).Additionally,the resistance group demonstrated a higher triglyceride(TG)level but a lower high-density lipoprotein-cholesterol(HDL-C)level than the non-resistance group(all P<0.0001).The BMI,TG,HDL-C,25(OH)D_(3),2hPG,and HbA1c were found to be risk factors of IR.Moreover,the posttreatment changes in levels of 25(OH)D_(3),2hPG,FBG and HbA1c,as well as TG,total cholesterol,and HDL-C in the joint group were more significant than those in the conventional group(all P<0.05).CONCLUSION Patients with IR exhibit significant abnormalities i

关键词： Vitamin D Type 2 diabetes mellitus Glucose and lipid metabolism Insulin resistance Risk factors

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多源频率域地震勘探技术及应用

物探与化探 2024年第3期48卷 618-628页

作者：孙红林刘铁华刘铁张占荣陈支兴中铁第四勘察设计院集团有限公司

在城市地球物理勘探中，因受到城市中各种强电磁机械干扰和交通建筑阻隔，诸多地球物理勘探技术勘探效果不佳。本文基于瞬态面波、微动台阵和微动谱比，采用多点三分量低频传感器获取的多源频率域地震数据，综合提取两种特征曲线后进行... 详细信息

在城市地球物理勘探中，因受到城市中各种强电磁机械干扰和交通建筑阻隔，诸多地球物理勘探技术勘探效果不佳。本文基于瞬态面波、微动台阵和微动谱比，采用多点三分量低频传感器获取的多源频率域地震数据，综合提取两种特征曲线后进行联合反演，实现融合3种技术的多源频率域地震勘探。其中，提出了双源综合频散谱提取技术、双源特征曲线联合反演技术和基于非均匀介质的等效均匀介质正演技术，勘探成果的精度和效率均得到了提高，在工程实践中得到验证。

关键词：多源频率域地震勘探瞬态面波微动台阵微动谱比

An Open-Label Study of Pegylated Liposomal Doxorubicin,Vincristine, and Reduced-Dose Dexamethasone Combination Therapy in Newly Diagnosed Multiple Myeloma Patients in the Chinese Population

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Clinical oncology and cancer resexreh 2009年第6期6卷 394-400页

作者： Yang Shen Zhixiang Shen Bin Jiang Jian Hou rong zhan Lugui Qiu Daobin Zhou Jie Jin Juan Li Fanyi Meng Ping Zou Ting Liu Jianyong Li Chun Wang Depei Wu Jun Ma Department of Hematology Ruijin Hospital Shanghai Jiaotong University Medical School Shanghai China Department of Hematology People's Hospital Affiliated to Beijing University Beijing China Department of Hematology Shanghai Changzheng Hospital Shanghai China Department of Hematology Affiliated Union Hospital of Fujian Medical Uni- versity Fujian Fuzhou Province China Department of Hematology Institute of Hematology and Blood Disease Hospital of Chinese Academy of Medical Sciences Beijing China Department of Hematology Peking Union Medical College Hospital Bei- jing China Department of Hematology 1st Affiliated Hospital of Zhejiang University Han.qzhou Zheiing Province China Department of Hematology The First Affiliated Hospital Sun Yat-Sen Uni- versity Guangzhou Guangdong Province China Department of Hematology Nanfang Medical University Affiliated Nanfang Hospital Guangzhou Guangdong ProvinceChina Department of Hematology Wuhan Union Hospital Wuhan Hubei Province. China Department of Hematology West China Hospital of Sichuan University Chengdu Sichuan Province China Department of Hematology The People's Hospital of Jiangsu Province Nanjing Jiangsu Province China Department of Hematology Shanghai First People's Hospital Shanghai China Department of Hematology the First Affiliated Hospital of Suzhou University Suzhou Zhejing Province China Department of Hematology Harbin Institute of Hematology & Oncology Harbin Heilongjiang Province China

OBJECTIVE Though doxorubicin is highly activein the treatment of multiple myeloma, its toxicityprofile limits its therapeutic index. We performed thisstudy to evaluate the efficacy and safety of pegylatedliposomal doxorubicin (PLD, Caelyx^(?)), vincristine,and reduced-dose dexamethasone combinationtherapy in newly diagnosed multiple myeloma (MM)patients in a Chinese population.METHODS This was an open-label, single-armstudy in which newly diagnosed patients with MMreceived PLD 40 mg/m^2 intravenously on Day 1,vincristine 1.4 mg/m^2 intravenously (maximum 2 mg)on Day 1, and 40 mg of dexarnethasone (intravenouslyor orally) from Day 1 to Day 4. Treatment wasrepeated every 28 days for at least 4 cycles.RESULTS In the intent-to-treat (ITT) analysis, theoverall response rate was 68.29%, and the completeremission rate was 10.98%. The incidence of alladverse events was 46.34%. The most commonnon-hematologic toxicities were palmar-plantarerythrodysesthesia (13.4%) and stomatitis (6.1%).CONCLUSION PLD, vincristine, and a reduceddosedexamethasone combination (DVd) is aneffective and safe regimen in newly diagnosed MMpatients in a Chinese population.

关键词：多发性骨髓瘤联合治疗长春新碱地塞米松中国人口聚乙二醇阿霉素脂质体

Emerging neurotropic features of SARS-CoV-2

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Journal of Molecular Cell Biology 2021年第10期13卷 705-711页

作者： Wen-rong zhan Jing Huang Peng-Ming Zeng Wei-Ya Tian Zhen-Ge Luo School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China

The prevailing coronavirus disease-19(COVID-19)caused by a novel severe acute respiratory syndrome coronavirus(SARS-CoV-2)has presented some neurological manifestations including hyposmia,hypogeusia,headache,stroke,encephalitis,Guillain-Barre syndrome,and some neuropsychiatric disorders.Although several cell types in the brain express angiotensin-converting enzyme-2(ACE2),the main SARS-CoV-2 receptor,and other related proteins,it remains unclear whether the observed neurological manifestations are attributed to virus invasion into the brain or just comorbidities caused by dysregulation of systemic factors.Here,we briefly review the neurological manifestations of SARS-CoV-2,summarize recent evidence for the potential neurotropism of SARS-CoV-2,and discuss the potential mechanisms of COVID-19-associated neurological diseases.

关键词： SARS-CoV-2 ACE2 brain invasion neurological manifestations

硫酸多粘菌素B对血液病中性粒细胞缺乏伴发热患者的临床疗效观察

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中国实验血液学杂志 2022年第5期30卷 1596-1600页

作者：吴顺泉战榕福建省血液病研究所福建省血液病学重点实验室福建医科大学附属协和医院福建福州350001

目的:探究硫酸多粘菌素B对血液病中性粒细胞缺乏伴发热患者的临床疗效与安全性。方法:收集2019年10月-2020年9月在福建医科大学附属协和医院血液科住院的50例患者的临床资料,所有患者均接受联合或大剂量化疗或造血干细胞移植后出现中性... 详细信息

目的:探究硫酸多粘菌素B对血液病中性粒细胞缺乏伴发热患者的临床疗效与安全性。方法:收集2019年10月-2020年9月在福建医科大学附属协和医院血液科住院的50例患者的临床资料,所有患者均接受联合或大剂量化疗或造血干细胞移植后出现中性粒细胞缺乏伴发热,经验性抗感染治疗疗效不佳,病原学检查阳性并根据药敏结果更改为硫酸多粘菌素B为主的方案进行抗感染治疗。结果:50例患者总共发生85例次感染,感染部位分别为肺部、血流、肠道、口腔、肛周、软组织以及鼻腔,致病菌以革兰阴性菌为主。根据病原学及药敏结果更改为硫酸多粘菌素B抗感染治疗,总有效率为68%,特别是用药>7 d有效率明显上升,自动出院及死亡患者分别占24%及8%。碳青霉烯类抗菌素使用时间在14 d内或是7 d内更改为硫酸多粘菌素B治疗的有效率分别为80%及70.6%,2周后再更改的患者有效率仅为33.3%;替加环素使用时间在14 d内或是7 d内更改为硫酸多粘菌素B治疗的有效率分别为80%及66.7%。硫酸多粘菌素B不良反应发生率低,多数轻微,仅1例患者出现横纹肌溶解。结论:硫酸多粘菌素B对于血液病中性粒细胞缺乏伴发热患者临床疗效好,且安全性高。

关键词：硫酸多粘菌素B 血液病中性粒细胞缺乏并发热