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食管癌组织miR-21、miR-182表达与临床病理特征及预后的关系

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现代生物医学进展 2021年第3期21卷 506-510页

作者：刘晓铃肖继业赵力威郑虹蕾徐蓉生四川省肿瘤医院核医学科四川成都610041 四川现代医院急诊科四川成都610045

目的:探讨食管癌组织微小RNA-21(miR-21)、微小RNA-182(miR-182)表达与临床病理特征及预后的关系。方法:选择2010年10月至2014年2月期间在我院治疗的120例食管癌患者为研究对象,采集患者的食管癌组织及癌旁组织,采用荧光定量PCR检测组织... 详细信息

目的:探讨食管癌组织微小RNA-21(miR-21)、微小RNA-182(miR-182)表达与临床病理特征及预后的关系。方法:选择2010年10月至2014年2月期间在我院治疗的120例食管癌患者为研究对象,采集患者的食管癌组织及癌旁组织,采用荧光定量PCR检测组织中miR-21、miR-182表达量,采用Kaplan-Meier法分析患者生存情况。结果:与癌旁组织相比,食管癌组织中miR-21、miR-182表达量明显升高(P<0.05)。食管癌组织中miR-21、miR-182表达均与TNM分期和淋巴结转移相关(P<0.05)。miR-21低表达患者的5年生存率明显高于高表达患者(P<0.05),miR-182低表达患者的5年生存率明显高于高表达患者(P<0.05)。结论:miR-21、miR-182表达量在食管癌中上调,与食管癌TNM分期和淋巴结转移相关。miR-21高表达以及miR-182高表达患者5年生存率下降,检测miR-21、miR-182表达量在食管癌患者预后预测中具有一定临床意义。

关键词：食管癌微小RNA-21 微小RNA-182 生存率 TNM分期淋巴结转移

FACT:An Air-Ground Communication Framework for Seeding Quality Control of Aircraft

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Computer Systems Science & Engineering 2022年第5期41卷 539-555页

作者： Dequan Li Jiming Li xu Zhou Jin rong Hu Xin Wang Jing Duan State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing100081China Key Laboratory for Cloud Physics of China Meteorological Administration Beijing100081China Chengdu University of Information Technology Chengdu610225China Curacloud Corporation SeattleWA98104USA

A new type of air-ground communication application framework named FACT(framework for air-ground communication technology with weather-modification aircraft)is presented to track and command weather-modification aircraft to perform ideal cloud *** provides a set of solutions from three perspectives,namely,onboard,onground and air-to-ground,with the core purpose of solving the problems of the rapid exchange of information,contract analysis and identifying potential seeding areas when flight plans and meteorological conditions *** board,the observed data are processed centrally and transmitted downward through air-to-ground *** real-time application and sharing of aircraft detection data are strengthened on the ground,and potential areas of operation are automatically identified based on ground *** communication between the air and the ground achieves a technical breakthrough by realizing double satellite links,adaptive data transmission and VPN channel ***,an application based on FACT is designed and implemented for the real-time command of weather-modified *** approach has become the key air-to-ground communication system support for more than 40 Chinese aircraft and the big data service support center of airborne data to ensure improved operation of weather-modification aircraft in China.

关键词： Air-ground communication application framework aircraft operation data transmission and analysis

寻常型银屑病血热证患者免疫血清学标志物的系统评价

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上海医药 2016年第9期37卷 20-27页

作者：李欣肖青青李福伦徐蓉范斌彭世光李斌上海中医药大学附属岳阳中西医结合医院皮肤科上海200437 上海市中医药研究院皮肤病研究所上海201203 首都医科大学附属北京朝阳医院皮肤科北京100020

目的:系统评价寻常型银屑病血热证患者免疫血清学标志物γ-干扰素(interferon-γ,IFN-γ)、白介素(interleukin,IL)-4、IL-17、IL-23、IL-6、α-肿瘤坏死因子(tumor necrosis factor-α,TNF-α)和IL-10水平的变化。方法:完整检索7个数据库中的近30年相关文献,纳入17篇文献,共包括768例受试者(443例寻常型银屑病血热证患者和325例健康对照者)。评价被纳入文献的研究质量并提取有效数据,然后采用随机效应模型合并受试组和对照组受试者的免疫血清学标志物水平效应量。结果:总效应量分析结果显示,受试组患者的血清IFN-γ水平(均数差24.90 pg/ml,95%CI:12.36~37.43)、IL-17水平(均数差28.92 pg/ml,95%CI:17.44~40.40)、IL-23水平(均数差310.60 pg/ml,95%CI:4.96~616.24)和TNF-α水平(均数差19.84 pg/ml,95%CI:13.80~25.87)显著高于对照组,IL-4水平(均数差-13.5 pg/ml,95%CI:-17.74^-9.26)和IL-10水平(均数差-10.33 pg/ml,95%CI:-12.03^-8.63)显著低于对照组,IL-6水平没有显著变化。结论:寻常型银屑病血热证患者的血清IFN-γ、IL-17、IL-23和TNF-α水平显著升高,而IL-4和IL-10水平显著降低。该结论尚需得到高质量、大样本量临床研究的进一步证实。

关键词：银屑病血热证 γ-干扰素白介素-17 白介素-23 α-肿瘤坏死因子白介素-4 白介素-10 白介素-6

A novel model to assess soil productivity in the dry-hot valleys of China

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Journal of Mountain Science 2017年第4期14卷 705-715页

作者： DUAN Xing-wu HAN xu HU Jin-ming FENG De-tai rong Li Institute of International Rivers and Eco-security Yunnan UniversityKunming 60095China Yunnan Key Laboratory of International Rivers and Trans-boundary Eco-security Yunnan UniversityKunming 60095China China Institute of Water Resources and Hydropower Research Beijing 100038China

Accurate evaluation of soil productivity has been a long-standing challenge. Although numerous models for productivity assessment exist, most are cumbersome to use and require substantial parameter inputs. We developed a new empirical soil productivity model based on field investigations of soil erosion, soil physieoehemieal properties, and crop yields in the dry-hot valleys （DHVs） in China. We found that soil pH, and organic matter and available potassium contents significantly affected crop yields under eroded conditions of the DHVs. Moreover, available potassium content was the key factor affecting soil productivity. We then modified an existing soil productivity model by adding the following parameters： contents of effective water, potassium, organic matter, and clay, soil pH, and root weighting factor. The modified soil productivity model explained 63.5% of the crop yield. We concluded that the new model was simple, realistic, and exhibited strong predictability. In addition to providing an accurate assessment of soil productivity,our model could potentially be applied as a soil module in comprehensive crop models.

关键词： Soil productivity Productivity indexmodel Redundancy analysis Dry-hot valleys

The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B

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Protein & Cell 2014年第11期5卷 837-850页

作者： Yan Zhang Huirong Yang xue Guo Naiyan rong Yujiao Song Youwei xu Wenxian Lan xu Zhang Maili Liu Yanhui xu Chunyang Cao State Key Laboratory of Bio-organic and Natural Product Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 China Institutes of Biomedical Sciences Fudan University 130 Dong-An Road Shanghai 200032 China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China

KDM5B is a histone H3K4me2/3 demethylase. The PHD1 domain of KDM5B is critical for demethylation, but the mechanism underlying the action of this domain is unclear. In this paper, we observed that PHDIKDMSB interacts with unmethylated H3K4me0. Our NMR structure of PHDIKDMSB in complex with H3K4me0 revealed that the binding mode is slightly different from that of other reported PHD fingers. The disruption of this interaction by double mutations on the residues in the interface （L325A/D328A） decreases the H3K4me2/3 demethylation activity of KDM5B in cells by approximately 50% and increases the transcriptional repression of tumor suppressor genes by approximately twofold. These findings imply that PHDIKDMSB may help maintain KDM5B at target genes to mediate the demethylation activities of KDM5B.

关键词： KDM5B PHD1 H3K4me0 demethylase,repression structure

银杏酮酯联合常规抗血小板方案在急性冠脉综合征患者经皮冠脉介入术后氯吡格雷抵抗的应用价值

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世界中医药 2019年第7期14卷 1892-1897页

作者：王宇平郭金成苏平冯玉宝徐荣蔡宜婷首都医科大学附属北京潞河医院心内科北京101199 内蒙古自治区鄂尔多斯市中心医院心内科鄂尔多斯017000

目的:评价银杏酮酯联合常规双联抗血小板方案在急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术后氯吡格雷抵抗时的应用价值。方法:选取2017年1月至12月在首都医科大学附属北京潞河医院共有1 560例ACS患者行PCI手术,按就诊顺序纳入... 详细信息

目的:评价银杏酮酯联合常规双联抗血小板方案在急性冠脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)术后氯吡格雷抵抗时的应用价值。方法:选取2017年1月至12月在首都医科大学附属北京潞河医院共有1 560例ACS患者行PCI手术,按就诊顺序纳入489例经血栓弹力图证实存在氯吡格雷抵抗的患者进行临床观察,根据不同抗血小板方案将其分为A组(n=127)、B组(n=209)和C组(n=153)。A组采用阿司匹林+氯吡格雷强化的抗血小板治疗方案,B组采用阿司匹林+替格瑞洛的抗血小板治疗方案,C组采用阿司匹林+氯吡格雷+银杏酮酯的抗血小板治疗方案。调整用药后2周复查TEG,观察3组腺苷二磷酸抑制率(ADP%)、花生四烯酸抑制率(AA%),比较用药期间药物不良反应发生率(ADR)、3组抗血小板治疗的药物总费用(元),考察随访6个月时主要不良心血管事件(MACE)发生率。结果:调整用药后2周复查TEG发现,3组ADP%、AA%均较其调整用药前明显改善(P0.05),其中C组改善最佳(P0.05)。结论:银杏酮酯联合常规阿司匹林和氯吡格雷双联抗血小板治疗可有效改善ACS患者PCI术后出现的氯吡格雷抵抗,可显著降低血小板的聚集活性、降低出血率及近期MACE事件,且不会增加药物费用,故推荐这一方案在临床合理应用。

关键词：氯吡格雷抵抗非ST段抬高心肌梗死 PCI术经皮冠状动脉介入治疗银杏酮酯抗血小板药物

Prediction of different stages of rectal cancer: Texture analysis based on diffusion-weighted images and apparent diffusion coefficient maps

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World Journal of Gastroenterology 2020年第17期26卷 2082-2096页

作者： Jian-Dong Yin Li-rong Song He-Cheng Lu xu Zheng Department of Radiology Shengjing Hospital of China Medical UniversityShenyang 110003Liaoning ProvinceChina College of Medicine and Biological Information Engineering Northeastern UniversityShenyang 110036Liaoning ProvinceChina Department of Clinical Oncology Shengjing Hospital of China Medical UniversityShenyang 110011Liaoning ProvinceChina

BACKGROUND It is evident that an accurate evaluation of T and N stage rectal cancer is essential for treatment *** has not been extensively investigated whether texture features derived from diffusion-weighted imaging(DWI)images and apparent diffusion coefficient(ADC)maps are associated with the extent of local invasion(pathological stage T1-2 vs T3-4)and nodal involvement(pathological stage N0 vs N1-2)in rectal *** To predict different stages of rectal cancer using texture analysis based on DWI images and ADC *** One hundred and fifteen patients with pathologically proven rectal cancer,who underwent preoperative magnetic resonance imaging,including DWI,were enrolled,*** ADC measurements(ADCmean,ADCmin,ADCmax)as well as texture features,including the gray level co-occurrence matrix parameters,the gray level run-length matrix parameters and wavelet parameters were calculated based on DWI(b=0 and b=1000)images and the ADC *** sample t-tests or Mann-Whitney U tests were used for statistical *** logistic regression analysis was conducted to establish the *** predictive performance was validated by receiver operating characteristic curve *** Dissimilarity,sum average,information correlation and run-length nonuniformity from DWIb=0 images,gray level nonuniformity,run percentage and run-length nonuniformity from DWIb=1000 images,and dissimilarity and run percentage from ADC maps were found to be independent predictors of local invasion(stage T3-4).The area under the operating characteristic curve of the model reached 0.793 with a sensitivity of 78.57%and a specificity of 74.19%.Sum average,gray level nonuniformity and the horizontal components of symlet transform(SymletH)from DWIb=0 images,sum average,information correlation,long run low gray level emphasis and SymletH from DWIb=1000 images,and ADCmax,ADCmean and information correlation from ADC maps were identified as independent pr

关键词： Rectal cancer Diffusion weighted imaging Apparent diffusion coefficient Texture analysis

Tunable and Linewidth-Reduced Laser Diode Stack for Rubidium Laser Pumping

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Chinese Physics Letters 2013年第11期30卷 88-90页

作者： LI Zhi-Yong TAN rong-Qing xu Cheng LI Lin Department of High Power Gas Laser Institute of ElectronicsChinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049

Linewidth of a laser diode stack with 5 bar is reduced to 0.2 nm from 1.8 nm through the use of an external volume Bragg grating(VBG)*** temperature of the VBG is controlled efficiently to make the central wavelength *** linewidth changes little in the wavelength-tuning *** the tunable range covers the rubidium D2 absorption line,the stack can be used to pump the rubidium laser efficiently.

关键词： tunable tuning pump

Proteomic characteristics of the liver and skeletal muscle in the Chinese tree shrew(Tupaia belangeri chinensis)

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Protein & Cell 2012年第9期3卷 691-700页

作者： rongxia Li Wei xu Zhen Wang Bin Liang Jia-Rui Wu rong Zeng Key Laboratory of Systems Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological ScienceChinese Academy of SciencesShanghai 200031China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyKunming 650223China

Valid animal models are useful for studying the pathophysiology of specific disorders,such as neural disease,diabetes and *** molecular phylogeny studies indicate that the tree shrew is in the same order as(or a close sister to)primates,and thus may be an ideal model in which to study human *** this study,the proteome of liver and muscle tissue in tree the shrew was identified by combining peptide fractionation and LC-MS/MS *** total,2146 proteins were detected,including 1759 proteins in liver samples and 885 proteins in skeletal muscle samples from the tree *** sub-source analysis revealed that nearly half of the identified proteins(846 proteins and 418 proteins)were derived from human *** this study,we are the first to describe the characteristics of the proteome from the liver and skeletal muscle of the tree *** tree analysis based on these proteomic data showed that the tree shrew is closer to primates(human)than to glires(the mouse and rat).

关键词： proteome Chinese tree shrew phylogenetic tree liver muscle