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Interleukin-17A facilitates tumor progression via upregulating programmed death ligand-1 expression in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 176-198页

作者： Zhong-Xia Yang Li-Ting Zhang xiao-Jun Liu Xue-Bin Peng xiao-rong Mao The First School of Clinical Medicine Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Infectious Diseases The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of Radiotherapy Gansu Provincial HospitalLanzhou 730000Gansu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is an inflammation-associated tumor with a dismal *** has become an important treatment strategy for HCC,as immunity is closely related to inflammation in the tumor *** regulates the expression of programmed death ligand-1(PD-L1)in the immunosuppressive tumor microenvironment and affects im-munotherapy ***-17A(IL-17A)is involved in the remodeling of the tumor microenvironment and plays a protumor or antitumor role in different *** hypothesized that IL-17A participates in tumor progression by affe-cting the level of immune checkpoint molecules in *** upregulation of PD-L1 expression in HCC cells by IL-17A was assessed by reverse transcription PCR,western blotting,and flow *** studies were conducted with gene knockout models and pathway *** function of IL-17A in immune evasion was explored through coculture of T cells and HCC *** effects of IL-17A on the malignant biological behaviors of HCC cells were evaluated in vitro,and the antitumor effects of an IL-17A inhibitor and its synergistic effects with a PD-L1 inhibitor were studied in *** IL-17A upregulated PD-L1 expression in HCC cells in a dose-dependent manner,whereas IL-17A receptor knockout or treatment with a small mothers against decapentaplegic 2 inhibitor diminished the PD-L1 expression induced by ***-17A enhanced the survival of HCC cells in the coculture ***-17A increased the viability,G2/M ratio,and migration of HCC cells and decreased the apoptotic *** D1,VEGF,MMP9,and Bcl-1 expression increased after IL-17A treatment,whereas BAX expression *** combination of IL-17A and PD-L1 inhibitors showed synergistic antitumor efficacy and increased cluster of differentiation 8+T lymphocyte infiltration in an HCC mouse *** IL-17A upregulates PD-L1 expression via the IL-17A receptor/phosphorylation-small mothers against

关键词： Interleukin-17A Programmed death ligand-1 Interleukin-17A receptor Small mothers against decapentaplegic 2 Hepatocellular carcinoma Immunotherapy

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Effects of Ti-and Nb-based transition element from single to multiple compound oxides and carbon-based composite additives on Mg-MgH2 hydrogen storage material

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Tungsten 2025年第1期7卷 32-49页

作者： Li-rong xiao Chen Chen Shuo Wang Zi-Yin Dai Hideo Kimura Cui Ni Chuan-Xin Hou Xue-Qin Sun Si-Jie Guo Wei Du Xiu-Bo Xie School of Environmental and Material Engineering Yantai University Bosch HUAYU Steering Systems (Yantai) Co. Ltd.Ytp/MFE University of Tennessee Knoxville Shandong Key Laboratory of Eco-Environmental Science for the Yellow River Delta Shandong University of Aeronautics

MgH2is considered as a promising hydrogen storage material for its high hydrogen storage capacity,low cost and abundant resource ***,the low kinetics and high enthalpy formation of MgH2limit its wide *** the perspective of adding catalysts to enhance the hydrogen storage properties of Mg-MgH2,this article elaborated the main catalysts based on Ti and Nb transition elements,including single oxide catalysts,binary oxides catalysts（combined with Ni,Na,Sr,V,etc.）,multiple catalysts bound to carbon,and composite catalysts with Ti and Nb elements combined with MXene ***,the main pathways of various catalysts to reduce the reaction activity and broaden the hydrogen desorption channel were also *** Ti-based catalysts can enhance the reactive sites of the matrix by forming multivalent states,while Nb-based catalysts broaden the hydrogen reaction channels by forming tiny *** improving the size structure and enhancing the grain size stability,combined with carbon materials should be the future considerations.

关键词： Catalysts Mg-based hydrogen storage alloys Solid hydrogen storage Transition metal elements

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ILF3 inhibits p-AMPK expression to drive non-alcoholic fatty liver disease progression

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World Journal of Hepatology 2025年第2期17卷 170-181页

作者： Ting Zhan Jia-Xi Liu Min Huang Ming-Tao Chen xiao-rong Tian Xiu-Lin Yang Jie Tan Yan-Li Zou Zheng Han Wei Chen Xia Tian xiao-Dong Huang Department of Gastroenterology Wuhan Third Hospital(Tongren Hospital of Wuhan University)Wuhan 430000Hubei ProvinceChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a disease of increasing global prevalence and an important risk factor for the development of insulin resistance,type 2 diabetes,non-alcoholic steatohepatitis and hepatocellular carcinoma,but the pathogenesis is not *** aim of this study was to explore the role of ILF3 in *** To investigate the molecular processes through which ILF3 facilitates the advancement of NAFLD by inhibiting the expression of *** exploration seeks to provide new insights into the etiology of NAFLD and evaluate the potential of ILF3 as a diagnostic marker and potential treatment focus for future *** In vitro and in vivo experiments were conducted using HepG2 cells and NAFLD animal *** effects of ILF3 knockdown on lipid synthesis and triglyceride(TG)secretion were examined by analyzing the expression levels of ***,the roles of ILF3 and the AMPK signaling pathway were verified using techniques such as Western blotting,quantitative reverse transcription PCR,Oil Red O staining,and *** Investigations revealed an increase in ILF3 Levels within both HepG2 cells and animal models of NAFLD,concurrently with a decrease in p-AMPK *** down ILF3 activated the AMPK pathway,reducing lipid production and TG secretion in hepatocytes,thereby mitigating the advancement of *** ILF3 promotes the evolution of NAFLD by inhibiting the expression of *** knockdown of ILF3 activates the AMPK signaling pathway,alleviating the severity of *** findings underscore the function of ILF3 in the pathogenesis of NAFLD and demonstrate its viability as a treatment focus and diagnostic indicator.

关键词： Non-alcoholic fatty liver disease ILF3 AMPK pathway Lipid metabolism Therapeutic target Molecular mechanism

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Modeling and realization of real time electronic countermeasure simulation system based on SystemVue

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Defence Technology（防务技术） 2020年第2期16卷 470-486页

作者： xiao-rong Tong College of Computer Weinan Normal UniversityWeinan 714099China

In this paper,we proposed a new design scheme of real time electronic countermeasure simulation *** paper mainly expounds the modeling and realization methods of each part of the whole simulation system,and the real-time property of system has been *** countermeasure simulation system is the key part of military training of individuals;it can also allow the realistic evaluation of the performance of modern equipments and *** a proof,we have drawn up a series of simulation scenarios,such as radar electronic reconnaissance simulation scenario,to explain the feasibility and the superiority of our modeling scheme in this paper.

关键词： Electronic countermeasure system Real-time property System modeling SystemVue Simulation Signal processing Transparent computing

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路径可实时定义的物联网传输模型

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小型微型计算机系统 2025年第1期46卷 181-188页

作者：肖融胡以欣陈文龙北京师范大学人工智能学院北京100875 首都师范大学信息工程学院北京100048

计算能力弱、存储容量小是普通物联网节点的典型特征,复杂的部署环境和不稳定的无线链路又会导致物联网网络状态频繁变化.所以,物联网中固定的传输路径无法提供高效的感知及数据传输服务.例如典型的树型路由结构中,靠近树根的节点要提... 详细信息

计算能力弱、存储容量小是普通物联网节点的典型特征,复杂的部署环境和不稳定的无线链路又会导致物联网网络状态频繁变化.所以,物联网中固定的传输路径无法提供高效的感知及数据传输服务.例如典型的树型路由结构中,靠近树根的节点要提供的传输任务较重,能量消耗更快,会导致整个网络部署周期变短.本文提出了一种路径可实时定义的物联网传输模型(IoT Transmission Model with Real-time Path Definition,ITRP),物联子网中所有节点将邻接关系上报给网关设备,由性能占优的有源供电网关设备来定义网络的实时路由树.网关向物联子网节点发送报文时会携带转发标签,后续转发节点只需根据标签完成报文传输,并根据上一跳信息建立其到网关的反向传输路径.ITRP模型可围绕特定的网络服务目标(节能、传输安全、带宽保障等)收集相关网络状态信息,并周期性调整路由拓扑,实现物联网传输服务的优化.实验面向能量均衡目标展开,经过10个信息采集周期,ITRP模型相对确定性路由模型能量最低节点的能耗比为44%~86%,相对自适应多径传输模型能量最低节点的能耗比为63%~86%;而且,ITRP模型只需较小的标签代价,实验环境中报文的平均标签长度不超过5比特.

关键词：路径可定义层级连通树实时路由树转发标签

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吉非替尼联合异基因CD8^(+)自然杀伤T细胞治疗晚期或转移性EGFR突变NSCLC的疗效和安全性

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循证医学 2025年第1期25卷 25-26页

作者：董晓荣华中科技大学同济医学院附属协和医院肿瘤中心胸部肿瘤科武汉430022

清华大学医学院一项前瞻性研究(ChiCTR-IIR-17013471)探索了吉非替尼与异基因CD8^(+)自然杀伤T(natural killer T,NKT)细胞联合治疗晚期或转移性表皮生长因子受体(epidermal growth factor receptor,EGFR)突变型非小细胞肺癌(non-small cell lung cancer,NSCLC)的疗效和安全性[1]。研究结果显示,该联合治疗策略显著延长了患者无进展生存期(progression-free survival,PFS),并且总体安全性良好,为未来的临床应用提供了参考。

关键词： EGFR突变非小细胞肺癌异基因CD8^(+)NKT细胞

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Dynamic properties analysis of a stay cable-damper system in consideration of design and construction factors

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Earthquake Engineering and Engineering Vibration 2014年第2期13卷 317-326页

作者： Dan Danhui Chen Yanyang xiao rong Department of Bridge Engineering Tongji University Henan Provincial Communications Planning Survey & Design Institute Co. Ltd

A numerical solution based on the Steffensen stable point iterative method is proposed to resolve the transcendental frequency equation of a stay cable-damper system. The frequency equation, which considers clamped supports and fl exural rigidity of the cable, is intended to investigate the infl uence of the parameters of the cable damper system on its dynamic characteristics. Two factors involved in the design and construction phases, the damping coeffi cient induced by external dampers and the cable tension, are the focus of this study. Their impact on modal frequencies and damping ratios in these two phases of cable-damper systems are investigated by resolving the equation with the proposed solution. It is shown that the damping coeffi cient and cable tension exert more noticeable effects on the modal damping ratios than on the modal frequencies of stay cable-damper systems, and the two factors can serve as design variables in the design phase and as adjustment factors in the construction phase. On the basis of the results, a roadmap for system-level optimal design of stay cable-damper systems that can achieve global optimal vibration suppression for the entire bridge is proposed and discussed.

关键词： cable damper damping coeffi cient cable tension dynamic property optimal design

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旋毛虫蛋白抑制巨噬细胞炎症反应的作用探索

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中国药理学通报 2025年第2期41卷 250-257页

作者：杨姣姣申晓荣闫欢杨勇樊卫平山西医科大学基础医学院微生物与免疫学教研室山西太原030000

目的探讨旋毛虫(trichinella spiralis,Ts)蛋白对脂多糖(lipopolysaccharide,LPS)诱导巨噬细胞株RAW264.7产生炎症反应的影响及其机制。方法通过LPS刺激RAW264.7细胞建立炎症模型,实验共分为4组:对照(negative control,NC)组、Ts组(Ts 2 mg·L^(-1))、LPS处理组(LPS 1 mg·L^(-1))、Ts+LPS组(Ts 2 mg·L^(-1)+LPS 1 mg·L^(-1))。qRT-PCR检测巨噬细胞极化分子标志物iNOS、Arg1以及炎症因子IL-1β、IL-6的表达,Western blot检测IL-1β、IL-6、BRD2蛋白表达,免疫荧光实验检测BRD2。为探索Ts蛋白抑制炎症是否通过BRD2发挥作用,我们用siRNA靶向敲低BRD2分子,再次分组实验,qRT-PCR检测 iNOS、Arg1、IL-1β、IL-6 的表达,Western blot检测IL-1β、IL-6的表达。结果与对照组相比,LPS促进iNOS、IL-1β、IL-6及BRD2的表达,Ts蛋白干预可降低iNOS、IL-1β、IL-6、BRD2的表达。敲低 BRD2 后,Ts蛋白进一步降低iNOS,而Arg1、IL-1β、IL-6水平有所上升。结论 Ts蛋白通过调控巨噬细胞极化、抑制BRD2从而缓解LPS诱导的巨噬细胞炎症反应。

关键词：旋毛虫蛋白巨噬细胞炎症 BRD2 M1/M2极化 LPS

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中国路域农田土壤多环芳烃污染特征和风险评价

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环境科学 2025年第2期46卷 1076-1088页

作者：赵冰帅吴怡霏李素鑫欧阳秋孙兴牟英高晓蓉大连理工大学生物工程学院智能生物制造教育部重点实验室大连116024

随着交通日益发达和机动车保有量跃升,公路沿线农田土壤多环芳烃(PAHs)污染问题不容忽视.通过搜集近16 a来我国各地路域农田土壤污染的研究数据,对PAHs的整体污染水平、组成特征、主要来源、地域分布以及生态健康风险进行了系统分析.结... 详细信息

随着交通日益发达和机动车保有量跃升,公路沿线农田土壤多环芳烃(PAHs)污染问题不容忽视.通过搜集近16 a来我国各地路域农田土壤污染的研究数据,对PAHs的整体污染水平、组成特征、主要来源、地域分布以及生态健康风险进行了系统分析.结果表明,我国路域农田土壤ω(∑_(16)PAHs)在86.40~3 568.00μg·kg^(-1)范围内,中位值为490.15μg·kg^(-1);PAHs各单体含量(以中位值计)在5.55~47.39μg·kg^(-1)范围内,其中菲的含量最高;PAHs组成以中高环(4~6环)为主,占总PAHs的56.81%,多数省份处于“轻度污染”甚至更高的污染程度.全国范围内PAHs的空间分布差异明显,污染程度从高到低依次为东北和西北地区、中部和东南沿海地区、西南地区.源解析结果表明,路域农田土壤中PAHs污染主要来自石油和天然气等燃料的混合燃烧源,污染程度与当地的石油、煤炭储量之间存在较强的正相关性.通过风险商值法、毒性当量法和健康风险评估模型这3种不同的评价方法对PAHs污染情况进行了生态和健康风险综合分析,结果显示出我国整体路域农田土壤的PAHs生态风险处于中度污染水平,而健康风险较为乐观.

关键词：多环芳烃(PAHs) 路域农田土壤污染特征空间分布风险评价

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Discrete DNA Three-dimensional Nanostructures： the Synthesis and Applications

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Chinese Journal of Polymer Science 2017年第1期35卷 1-1,2-24页

作者： xiao-rong Wu Chen-wei Wu 张川 School of Chemistry and Chemical Engineering State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing Shanghai Jiao Tong University

Structural DNA nanotechnology, an emerging technique that utilizes the nucleic acid molecule as generic polymer to programmably assemble well-defined and nano-sized architectures, holds great promise for new material synthesis and constructing functional nanodevices for different purposes. In the past three decades, rapid development of this technique has enabled the syntheses of hundreds and thousands of DNA nanostructures with various morphologies at different scales and dimensions. Among them, discrete three-dimensional （3D） DNA nanostructures not only represent the most advances in new material design, but also can serve as an excellent platform for many important applications. With precise spatial addressability and capability of arbitrary control over size, shape, and function, these nanostructures have drawn particular interests to scientists in different research fields. In this review article, we will briefly summarize the development regarding the synthesis of discrete DNA 3D nanostructures with various size, shape, geometry, and topology, including our previous work and recent progress by other groups. In detail, three methods majorly used to synthesize the DNA 3D objects will be introduced accordingly. Additionally, the principle, design rule, as well as pros and cons of each method will be highlighted. As functions of these discrete 3D nanostructures have drawn great interests to researchers, we will further discuss their cutting-edge applications in different areas, ranging from novel material synthesis, new device fabrication, and biomedical applications, etc. Lastly, challenges and outlook of these promising nanostructures will be given based on our point of view.

关键词： DNA self-assembly DNA 3D nanostructure Nanocarrier Biosensor Nanomedicine

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