检索结果-南通市图书馆

维普期刊数据库

Predictors of Adverse Pregnancy Outcomes Following Traumatic Injuries

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第3期44卷 642-647页

作者： wan-rong LU Ping WU Gong SONG Mei-qi GU Zhe XU Li HE National Clinical Research Center for Gynecology and Obstetrics Cancer Biology Research CenterTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Traumatic Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective After traumatic injury in pregnant women,providing timely and appropriate management for high-risk patients is crucial for both pregnant women and *** study aimed to identify risk factors that predict adverse pregnancy outcomes after traumatic *** A retrospective cohort study including 317 pregnant patients who experienced trauma was *** collected data included general demographics,injury mechanisms and adverse pregnancy *** were divided into two subgroups based on the absence or presence of trauma-related adverse pregnancy *** and multivariate logistic regressions were conducted to estimate the associations between clinical variables and adverse pregnancy *** A total of 41(12.93%)patients experienced adverse pregnancy outcomes within the first 24 h *** study revealed that age>35 years(OR=14.995,95%CI:5.024–44.755,P<0.001),third trimester trauma(OR=3.878,95%CI:1.343–11.204,P=0.012),abdominal pain(OR=3.032,95%CI:1.221–7.527,P=0.017),vaginal bleeding(OR=3.226,95%CI:1.093–9.523,P=0.034),positive scan in focused assessment with sonography for trauma(FAST)positive(OR=8.496,95%CI:2.825–25.555,P<0.001),9≤injury severity score(ISS)<16(OR=3.039,95%CI:1.046–8.835,P=0.041)and ISS≥16(OR=5.553,95%CI:1.387–22.225,P=0.015)increased the probability of posttraumatic adverse pregnancy *** age,gestational age at delivery,vaginal bleeding and positive FAST results were risk factors for abnormal *** Advanced maternal age,third trimester,and positive FAST results should alert multidisciplinary trauma teams to closely monitor patients to prevent adverse pregnancy outcomes.

关键词： adverse pregnancy outcomes predictive factors abnormal delivery trauma

The prognostic and immunological impacts of DCX expression:a pan-cancer analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Advances 2024年第14期7卷 1-8页

作者： Xin Li wan-rong Li Hao Jin Tianjin Cancer Hospital Airport Hospital Tianjin 300060China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China.

Background:Doublecortin(DCX),a microtubule-associated protein,is best known for its critical role in neuronal migration during neural development,where it stabilizes microtubules and guides neurons to their proper ***,DCX has been implicated in various cancer processes,suggesting it may influence tumor progression and the tumor *** evidence indicates that DCX can modulate cell migration,invasion,and interaction with immune cells,making it a potential player in ***,the role of DCX across different cancer types and its potential as a prognostic biomarker remain underexplored,necessitating a comprehensive ***:We utilized The Cancer Genome Atlas to extract data on DCX expression in tumor and adjacent normal tissues across diverse cancer *** expression analysis was conducted using differential expression sequencing *** analysis was performed with Kaplan-Meier estimates and Cox proportional hazards *** between DCX expression and tumor mutational burden,microsatellite instability,and immune infiltration were examined using Spearman’s ***:DCX showed variable expression across cancer types,with significant overexpression in certain tumors such as liver and lung cancer and downexpression in others like breast *** DCX expression was correlated with poor prognosis in adrenocortical carcinoma but with better outcomes in low-grade ***,DCX expression was significantly associated with various immune markers and chemokines,suggesting a role in modulating the immune ***:Our findings highlight the complex role of DCX in cancer,underlining its potential as a prognostic marker and its involvement in immune-related *** DCX could represent a novel approach to modulating tumor behavior and enhancing immune response in cancer therapy.

关键词： pan-cancer analysis tumor microenvironment prognostic biomarker immune infiltration chemokine signaling cancer genomics

Pan-Cancer dissection of ORAI1:prognostic implications and immune landscapecorrelation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Advances 2024年第9期7卷 1-10页

作者： wan-rong Li Jian wang Xin Li Tianjin Cancer Hospital Airport Hospital National Clinical Research Center for CancerTianjin 300308China Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin 300060China.

Background:The ORAI1 gene,central to store-operated calcium entry(SOCE),is increasingly recognized for its pivotal role in cancer progression and patient prognosis across a broad spectrum of *** its critical involvement in calcium signaling pathways that are essential for cellular functions such as proliferation,migration,and apoptosis,the comprehensive impacts of ORAI1 within the tumor microenvironment(TME)and its modulation across various cancers have not been fully ***:We conducted a pan-cancer analysis leveraging data from The Cancer Genome Atlas(TCGA)and Genotype-Tissue Expression(GTEx)to assess ORAI1 *** expression analyses were performed,complemented by correlative studies with tumor mutation burden(TMB),microsatellite instability(MSI),immune infiltration,and key biological processes and ***:Our results demonstrate that ORAI1 is consistently upregulated in a range of cancer types,associated with aggressive tumor characteristics and poor patient ***,ORAI1 upregulation correlates with increased tumor mutation burden(TMB)and microsatellite instability(MSI),markers of genomic instability that are predictive of response to immunotherapy,underscoring its potential utility in clinical stratification and treatment ***1's influence extended to the immune landscape,showing associations with immune cell infiltration and both immunosuppressive and immunostimulatory gene sets,thereby affecting the TME and possibly the efficacy of immunotherapeutic ***:The multifaceted nature of ORAI1's involvement in cancer pathophysiology positions it as a prospective biomarker and therapeutic *** expression dynamics and correlative significance with prognostic and immune regulatory elements underscore its potential in guiding therapeutic strategies and improving clinical *** study lays a foundation for future research,aiming to leverage ORAI1's biol

关键词： ORAI1 Pan-Cancer analysis tumor microenvironment immunotherapy tumor mutation burden microsatellite instability

Identification and validation of a pyroptosis-related prognostic model for colorectal cancer based on bulk and single-cell RNA sequencing data

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2024年第2期15卷 329-355页

作者： Li-Hua Zhu Jun Yang Yun-Fei Zhang Li Yan wan-rong Lin Wei-Qing Liu Department of Surgical Oncology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Internal Medicine-Oncology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Department of Oncology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Pyroptosis impacts the development of malignant tumors,yet its role in colorectal cancer(CRC)prognosis remains *** To assess the prognostic significance of pyroptosis-related genes and their association with CRC immune *** Gene expression data were obtained from The Cancer Genome Atlas(TCGA)and single-cell RNA sequencing dataset GSE178341 from the Gene Expression Omnibus(GEO).Pyroptosis-related gene expression in cell clusters was analyzed,and enrichment analysis was conducted.A pyroptosis-related risk model was developed using the LASSO regression algorithm,with prediction accuracy assessed through K-M and receiver operating characteristic analyses.A nomo-gram predicting survival was created,and the correlation between the risk model and immune infiltration was analyzed using CIBERSORTx ***,the differential expression of the 8 prognostic genes between CRC and normal samples was verified by analyzing TCGA-COADREAD data from the UCSC *** An effective pyroptosis-related risk model was constructed using 8 genes-CHMP2B,SDHB,BST2,UBE2D2,GJA1,AIM2,PDCD6IP,and SEZ6L2(P<0.05).Seven of these genes exhibited differential expression between CRC and normal samples based on TCGA database analysis(P<0.05).Patients with higher risk scores demonstrated increased death risk and reduced overall survival(P<0.05).Significant differences in immune infiltration were observed between low-and high-risk groups,correlating with pyroptosis-related gene *** We developed a pyroptosis-related prognostic model for CRC,affirming its correlation with immune *** model may prove useful for CRC prognostic evaluation.

关键词： Colorectal cancer Pyroptosis Single-cell RNA sequencing Immune infiltration Prognostic model

基于GNSS水汽和地面假相当位温观测的短时强降水阈值预报方法研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

气象 2024年第5期50卷 603-615页

作者：余洋万蓉付志康向怡衡中国气象局武汉暴雨研究所、中国气象局流域强降水重点开放实验室/暴雨监测预警湖北省重点实验室武汉430205

基于2019年和2020年6—7月GNSS水汽监测网大气可降水量(PWV)资料和并址气象站的地面雨量、温、压、湿等同步观测数据,利用临界成功指数(CSI)和命中率(POD)两个检验指标,探索建立了基于PWV、6小时水汽增量(PWV*)及假相当位温距平(θ_(se... 详细信息

基于2019年和2020年6—7月GNSS水汽监测网大气可降水量(PWV)资料和并址气象站的地面雨量、温、压、湿等同步观测数据,利用临界成功指数(CSI)和命中率(POD)两个检验指标,探索建立了基于PWV、6小时水汽增量(PWV*)及假相当位温距平(θ_(se)*)的短时强降水阈值预报方法,并利用2021年6—7月降水样本对该预报方法进行检验,结果显示CSI和POD分别为0.167和0.593,其评分高于目前常规业务方法对短时强降水的客观预报评分,其中约48%的短时强降水发生在预警之后的24小时内,约78%发生于48小时内。研究区域内78.6%的短时强降水样本发生在连续15小时PWV*的累积值(∑PWV*)≥75 mm且连续24小时θ_(se)*累积值(∑θ_(se)*)≥30 K的条件下;PWV高值区叠加∑PWV*和∑θ_(se)*的大值区对梅雨期短时强降水以及暴雨发生区域有较好的指示性。

关键词：短时强降水 GNSS 大气可降水量假相当位温客观预报

维普期刊数据库

在线全文

学校读者我要写书评

暂无评论

化学职前教师手持技术TPACK调查研究

化学教育（中英文） 2024年第4期45卷 60-66页

作者：蓝宛榕邓峰张丽凡朱峻灏华南师范大学化学学院广东广州510006 佛山市顺德区乐从第一实验学校广东佛山528315

设计了《化学职前教师手持技术TPACK量表式问卷》,对223名化学职前教师进行问卷调查,采取探索性因子分析与验证性因子分析检验问卷的信度、效度以及七因子模型的合理性,同时通过结构方程模型构建并讨论化学职前教师手持技术TPACK的发展... 详细信息

设计了《化学职前教师手持技术TPACK量表式问卷》,对223名化学职前教师进行问卷调查,采取探索性因子分析与验证性因子分析检验问卷的信度、效度以及七因子模型的合理性,同时通过结构方程模型构建并讨论化学职前教师手持技术TPACK的发展路径。研究结果表明:(1)问卷具有良好的信效度;(2)TPACK七因子模型具有一定的合理性;(3)化学职前教师手持技术TPACK的发展路径中除CK对PCK无直接影响外,均支持TPACK的变革观点。文末据此对手持技术TPACK基础研究与化学教师发展两方面提出相应的建议。

关键词：化学职前教师手持技术 TPACK 结构方程模型

维普期刊数据库

共轭亚油酸对肉牛肌内前脂肪细胞增殖与分化的影响

在线全文

学校读者我要写书评

暂无评论

农业生物技术学报 2024年第3期32卷 559-567页

作者：万荣农斯伟周振明孟庆翔百色学院农业与食品工程学院/亚热带特色农业产业学院中国农业大学肉牛研究中心

前脂肪细胞广泛存在于牛肉的肌纤维中，同时，在肌束间也分布有大量前脂肪细胞，其增殖以及分化水平在牛肉大理石花纹的形成过程中影响较大，可直接影响牛肉品质。本研究旨在探究共轭亚油酸(conjugated linoleic acid, CLA)对鲁西黄牛(B... 详细信息

前脂肪细胞广泛存在于牛肉的肌纤维中，同时，在肌束间也分布有大量前脂肪细胞，其增殖以及分化水平在牛肉大理石花纹的形成过程中影响较大，可直接影响牛肉品质。本研究旨在探究共轭亚油酸(conjugated linoleic acid, CLA)对鲁西黄牛(Bos taurus)肌内前脂肪细胞增殖与分化的影响，通过构建体外细胞模型，设计0、50、100和150μmol/L CLA处理培养于基础培养基中的肉牛肌内前脂肪细胞4 d，研究CLA对肉牛肌内前脂肪细胞增殖的影响。流式细胞术分析显示，与对照组相比，100μmol/L CLA显著增加了S期细胞比例(P0.05)，表明100μmol/L CLA显著促进肉牛肌内前脂肪细胞的增殖(P<0.05)。不同剂量的CLA处理培养细胞6 d，细胞内脂肪含量测定和qRT-PCR分析表明，100和150μmol/L CLA显著增加了肌内前脂肪细胞胞质内脂肪含量(P<0.05)；其中，50、100和150μmol/L CLA可使得过氧化物酶体增殖物激活受体(peroxisome proliferator-activated receptor γ, PPARγ)、增强子结合蛋白(CCAAT/enhancer binding protein α, C/EBPα)的表达显著提升(P<0.05)，其中，100μmol/L CLA处理组同对照组相比，PPARγ基因的表达水平升高幅度约3倍，C/EBPα基因的表达水平升高幅度约2倍。设计CLA (100μmol/L)、胰岛素(10μg/mL)和地塞米松(0.25μg/mL) 4种组合的分化培养基诱导培养细胞6 d,CLA、胰岛素和地塞米松同时加入培养基时，处理细胞的胞质中脂肪含量显著增加，而当分别去除地塞米松、胰岛素或CLA后，细胞质中脂肪的含量分别下降了74%、68%和31%。以上结果表明，CLA可有效促进肉牛肌内前脂肪细胞增殖，诱导细胞胞质内脂滴的生成，且能升高PPARγ和C/EBPα基因的表达水平，从而刺激肉牛肌内前脂肪细胞的分化。本研究为优良肉质地方黄牛培育及营养调控肉牛肌内脂肪沉积提供理论基础。

关键词：肉牛肌内前脂肪细胞增殖分化共轭亚油酸(CLA)

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

计算机与机械电子技术的融合发展思考

办公自动化 2024年第15期29卷 67-69页

作者：程丽琴万茸西安理工大学高科学院西安713700 西安高新科技职业学院西安713700

计算机与机械电子技术的融合发展,是在信息化和智能化浪潮下的一项重要创新。这一融合过程不仅将两种技术的优势相结合,推动各自领域的进步,更为整个社会的生产力和科技进步提供新的动力。文章探讨计算机与机械电子技术的融合发展,分析... 详细信息

计算机与机械电子技术的融合发展,是在信息化和智能化浪潮下的一项重要创新。这一融合过程不仅将两种技术的优势相结合,推动各自领域的进步,更为整个社会的生产力和科技进步提供新的动力。文章探讨计算机与机械电子技术的融合发展,分析两者结合在工业生产、智能制造和科学研究中的重要性。通过分析和趋势展望,阐述融合发展所带来的机遇和挑战,为促进技术创新与产业升级提供思路和参考。

关键词：计算机机械电子技术融合发展智能制造技术创新

中西太平洋金枪鱼延绳钓钓钩深度分布及其影响因素

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

上海海洋大学学报 2024年第4期33卷 1020-1030页

作者：刘志强郭绍健王禹程周成吴峰万荣上海海洋大学海洋生物资源与管理学院国家远洋渔业工程技术研究中心大洋渔业资源可持续开发教育部重点实验室

为掌握中西太平洋金枪鱼延绳钓作业中钓钩深度分布及其影响因素，根据2021年8—10月随“淞航”号调查船在中西太平洋海域调查时采集的作业参数、钓钩深度和环境数据等信息，利用支持向量回归模型（Support vector machine,SVR）和广义... 详细信息

为掌握中西太平洋金枪鱼延绳钓作业中钓钩深度分布及其影响因素，根据2021年8—10月随“淞航”号调查船在中西太平洋海域调查时采集的作业参数、钓钩深度和环境数据等信息，利用支持向量回归模型（Support vector machine,SVR）和广义加性模型（General additive model,GAM）分析不同作业参数和环境因素下钓钩深度的分布情况，探讨各因素对钓钩深度的影响。结果表明：（1）钓钩深度的计算值中1号钓钩深度最小，为（130.03±3.32） m;8号钓钩深度最大，为（363.25±36.52） m。实测值中1号钓钩深度最小，为（130.81±17.94） m;7号钓钩深度最大，为（329.91±54.37） m。（2）1号钓钩的SVR模型整体拟合度最小（R2=0.38）;6号钓钩的整体拟合度最大（R2=0.77）。SVR模型训练值的均方差中6号钓钩最小，为0.138;8号钓钩最大，为0.309。测试值的均方差中4号钓钩最小，为0.086;5号钓钩最大，为0.282。（3）GAM分析显示0～64 m、128～192 m水层平均流速和投绳速度与各钓钩深度相关性最高，其次分别为64～128 m、192～256 m、256～320 m水层平均流速和船速。320～384 m水层平均流速和风速与各钓钩深度均无显著相关性。（4）SVR和GAM的钓钩深度预测值与实测值平均差异分别为1.75%和6.38%。SVR预测值与实测值随钓钩位置变化趋势一致，吻合性较好。研究结果有助于了解作业中金枪鱼延绳钓钓钩分布规律，进而为优化钓具性能提供基础参考依据。

关键词：中西太平洋金枪鱼延绳钓钓钩深度支持向量回归机模型广义加性模型