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Myocardial ischemic changes of electrocardiogram in intracerebral hemorrhage: A case report and review of literature

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World Journal of Clinical Cases 2019年第21期7卷 3603-3614页

作者： Xue-Qi Lin liang-rong Zheng Department of Cardiovascular The First Affiliated Hospital of Zhejiang University

BACKGROUND Cardiac injury may occur after acute pathology of central nervous system(CNS)without any evidence of primary cardiac *** resulting structural and/or functional changes are called cerebrocardiac syndrome(CCS).The great majority of studies have been performed in patients with subarachnoid hemorrhage(SAH),while CCS data after intracerebral hemorrhage(ICH)are *** may cause diagnostic and therapeutic pitfalls for the clinician due to a lack of specific clinical manifestations and diagnostic *** the underlying pathophysiological and molecular mechanism(s)following cerebrovascular incidents will help to implement prevention and treatment strategies to improve the *** SUMMARY A 37-year-old man with a history of hypertension presented to our department on an emergency basis because of a sudden dizziness and left limb *** computed tomography(CT)suggested ICH in the occipital and parietal lobes,and the chosen emergency treatment was hematoma *** ventricular(LV)dysfunction occurred after the next 48 h and the electrocardiogram(ECG)showed non-ST elevation myocardial *** was suspected first in the context of ICH due to the negative result of the coronary CT *** Misinterpretation of ischemic-like ECGs may lead to unnecessary or hazardous interventions and cause undue delay of rehabilitation after *** objective is to highlight the clinical implications of CCS and we hope the differential diagnoses will be considered in patients with acute CNS diseases.

关键词： Stroke Intracerebral hemorrhage Cerebrocardiac syndrome Cardiac insufficiency Non-ST elevation myocardial infraction Case report Neurogenic stunned myocardium

Potentiometric sensor for sensitive and selective detection of heparin

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Chinese Chemical Letters 2012年第2期23卷 233-236页

作者： Yan Chen rong Ning liang Wei Qin CAS and Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes Yantai Institute of Coastal Zone Research Chinese Academy of Sciences Yantai 264003 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

A polymeric membrane ion-selective electrode for determination of heparin is described in this *** is incorporated into the organic membrane phase and functions as sensing element for selective recognition of *** proposed membrane electrode exhibits high selectivity for heparin over lipophilic anions such as thiocyanide and *** potentiometric response to the concentration of heparin is Unear in the range of 0.01-0.4 U/mL and a lower detection limit of 0.005 U/mL can be achieved.

关键词： Potentiometry Sensing element Heparin Protamine Polyion sensor

A theoretical study of the influence of dopants on the dehydrogenation properties of VH_2

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Science China Chemistry 2011年第9期54卷 1510-1517页

作者： LI rong LUO XiaoLing liang GuoMing FU WenSheng College of Chemistry Chongqing Normal University Chongqing 400047 China

Using the plane wave ultrasoft pseudopotential method based on the first-principles density functional theory(DFT),the influence on the electronic structure and dehydrogenation properties of VH2 doped with Zr,Cu and Zn has been *** results show that the negative heat of formation increases and the valence electron number at the Fermi level EF,N(EF) decreases in the Zr-doped model,indicating the higher stability of VH2 after Zr *** the other hand,the negative heat of formation of VH2 decreases and the N(EF) increases in Cu-or Zn-doped systems,suggesting the lower stability of VH2 after Cu or Zn *** calculated overlap populations and electron densities of the V-H bond demonstrate that the bonding is strengthened by Zr doping and weakened by Cu or Zn *** results predict that the maximum capacity to absorb and desorb hydrogen can be raised by the introduction of Zr and reduced by the introduction of Cu or Zn,while the dehydrogenation properties will be poorer in Zr-doped systems and enhanced in Cu-or Zn-doped *** predictions are consistent with the experimental *** populations were also calculated and it was found that the Mulliken population of the V 3d orbitals decreased as a result of Zr doping,and increased after Cu or Zn doping.

关键词： element-doped electronic structure dehydrogenation properties first principles calculation

Synthesis and Crystal Structure of 1-(4-Chlorophenyl)-2-cyano-3-amino-3a-hydroxy- 3a,3b,6,7-tetrahydrobenzo[4,5]indene

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Chinese Journal of Structural Chemistry 2005年第12期24卷 1393-1396页

作者： SHI Da-Qing SHI Chun-Ling rong liang-Ce Department of Chemistr） Xuzhou Normal University Xuzhou 221116 China The Key Laboratory of Biotechnology on Medical Plants of Jiangsu Province Xuzhou 221116 China

The title compound 1-（4-chlorophenyl）-2-cyano-3-amino-3a-hydroxy-3a,3b,6,7- tetrahydro-benzo[4,5]indene 2, has been synthesized by the reductive cyclization of 2-cyano-3- （4-chlorophenyl）-3-（1-tetralon-2-yl） propionitrile 1 induced by low-valent titanium reagent and its structure was determined by single-crystal X-ray diffraction. The crystal belongs to monoclinic, space group C2/c with a = 28.244（7）, b = 14.401（3）, c = 21.245（3）A,β= 115.71（2）°, V = 7786（3）A^3, Mr= 696.13, Dc = 1.188 g/cm^3, Z = 8,μ（MoKα） = 0.208 mm^-1, F（000） = 2916, R = 0.0783 and wR = 0.2350. X-ray analysis reveals that the five-membered ring （C（7）～C（l l）） adopts an envelop conformation, while the six-membered ring （C（10）～C（14）, C（19）） has a half-chair conformation. Meanwhile, intermolecular H-bond interactions result in the formation of polymer.

关键词： tetrahydrobenzoindene synthesis crystal structure low-valent titanium

混合有机磷阻燃剂污染物的微生物降解特性及途径

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中国环境科学 2024年第6期44卷 3434-3441页

作者：罗雅嫣汤蕙齐李翼远欧阳浩民黄鸿陈烁娜仇荣亮华南农业大学资源环境学院广东广州510642 岭南现代农业科学与技术广东省实验室河源分中心广东河源517000 广东省农业农村污染治理与环境安全重点实验室广东广州510642

为了获得更多高效降解有机磷阻燃剂(OPFRs)的菌种资源,探明OPFRs微生物降解途径和作用机制,本研究以一株从广州某污水处理厂剩余污泥中筛选获得的对多种典型OPFRs具有降解能力的太平洋芽孢杆菌(Bacillus pacificus)为研究材料,选取环境... 详细信息

为了获得更多高效降解有机磷阻燃剂(OPFRs)的菌种资源,探明OPFRs微生物降解途径和作用机制,本研究以一株从广州某污水处理厂剩余污泥中筛选获得的对多种典型OPFRs具有降解能力的太平洋芽孢杆菌(Bacillus pacificus)为研究材料,选取环境中检出率高的磷酸三(2-氯乙基)酯(TCEP)、磷酸三(2-氯丙基)酯(TCPP)、磷酸三甲苯酯(TCP)、磷酸三苯酯(TPhP)作为OPFRs典型代表污染物,开展OPFRs混合污染物微生物降解研究.结果表明:Bacillus pacificus能以4种OPFRs(TCEP、TCPP、TCP、TPhP)作为磷源生长代谢.在投菌量为1.0g/L,污染物初始浓度为1.0mg/L时,Bacillus pacificus对TCP的降解效果显著,在第9d的降解率达96.1%,另外3种OPFRs的降解率为23%~34%.4种OPFRs的主要降解途径均是通过磷酯键断裂,最终生成氯乙醇、氯丙醇、磷酸和苯类等小分子化合物.其中,TCEP和TCPP还可以通过末端脱氯进行分解,生成磷酸三丙酯和磷酸三(2-乙基丙基)酯,而TCP则还可以通过甲氧基化而被分解为磷酸三甲酯.研究表明:Bacillus pacificus能耐受并有效降解4种常见的OPFRs混合污染物,可为环境OPFRs污染治理提供新思路和优质的微生物菌种资源.

关键词：有机磷阻燃剂微生物降解混合污染降解途径太平洋芽孢杆菌

经皮超声造影引导下穿刺活检诊断腋窝转移性淋巴结假阴性的风险模型构建与评估

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中国临床医学影像杂志 2024年第10期35卷 685-689,693页

作者：林文金林振湖梁荣喜陈聪薛恩生福建医科大学附属协和医院超声科福建福州350001

目的:构建经皮超声造影引导下细针穿刺活检(pCEUS-FNAC)诊断乳腺癌腋窝转移性淋巴结假阴性的预测模型,探讨该模型在降低pCEUS-FNAC假阴性率的临床可行性及实用性。方法:回顾性收集2020年10月—2023年1月在我院术前行p CEUS-FNAC的浸润... 详细信息

目的:构建经皮超声造影引导下细针穿刺活检(pCEUS-FNAC)诊断乳腺癌腋窝转移性淋巴结假阴性的预测模型,探讨该模型在降低pCEUS-FNAC假阴性率的临床可行性及实用性。方法:回顾性收集2020年10月—2023年1月在我院术前行p CEUS-FNAC的浸润性乳腺癌伴腋窝淋巴结转移患者261例,以腋窝淋巴结手术病理结果为金标准,将病例分为腋窝淋巴结p CEUS-FNAC阳性组和pCEUS-FNAC阴性组,对比分析两组病例临床病理特征、超声征象的差异,采用单因素分析及多因素Logistic回归分析确定pCEUS-FNAC假阴性的危险因素。根据筛选出的危险因素建立列线图预测模型,通过受试者工作特征(ROC)曲线、校准曲线对、临床决策曲线分析(DCA)对模型进行评价。结果:pCEUS-FNAC诊断乳腺癌腋窝转移性淋巴结假阴性率为14.6%。多因素回归分析结果显示,肿瘤d_(最大径)>5 cm、呈多灶、pCEUSⅠ/Ⅱ型为pCEUS-FNAC假阴性的独立危险因素(P5 cm、呈多灶、腋窝淋巴结pCEUSⅠ/Ⅱ型为pCEUS-FNAC假阴性的危险因素,据此构建的预测模型具有较好的区分度和校准度,并展现出良好的临床实用价值。

关键词：乳腺肿瘤淋巴转移超声检查介入性

外水相组成对醋酸戈舍瑞林PLGA微球理化性质的影响

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中南药学 2024年第4期22卷 960-966页

作者：郑明秀刘磊梁荣财烟台大学药学院烟台大学新型制剂与生物技术药物研究山东省高校协同创新中心分子药理和药物评价教育部重点实验室(烟台大学)山东烟台264005 山东绿叶制药有限公司长效和靶向制剂国家重点实验室山东烟台264003

目的采用W/O/W和O/W乳化溶剂挥发法制备醋酸戈舍瑞林PLGA微球,考察在外部水相中加入不同浓度的氯化钠和甘露醇对所制备微球理化性质的影响。方法醋酸戈舍瑞林PLGA微球采用W/O/W和O/W乳化溶剂挥发法制备,以微球的表面形态、内部形态、... 详细信息

目的采用W/O/W和O/W乳化溶剂挥发法制备醋酸戈舍瑞林PLGA微球,考察在外部水相中加入不同浓度的氯化钠和甘露醇对所制备微球理化性质的影响。方法醋酸戈舍瑞林PLGA微球采用W/O/W和O/W乳化溶剂挥发法制备,以微球的表面形态、内部形态、粒径、载药量、体外累计释放行为、结构和晶型来评价不同浓度的添加剂对两种制备方法所制得微球的影响。结果采用W/O/W制备的微球增加外水相中氯化钠的浓度,微球载药量增加、粒径减小、突释量降低、微球表面及内部孔洞减少;增加外水相中甘露醇的浓度,微球载药量增加、粒径减小,突释量降低、微球表面孔洞减少,内部孔洞未减少;O/W法制备的微球增加水相中氯化钠和甘露醇的浓度,微球载药量增加、粒径减小、突释量降低、微球表面及内部孔洞减少。结论通过增加外部水相中添加剂的浓度,有效改善了醋酸戈舍瑞林PLGA微球的结构和性质。

关键词：醋酸戈舍瑞林PLGA微球氯化钠甘露醇乳化溶剂挥发法

经尿道前列腺切除术对前列腺增生患者尿流动力学和前列腺症状评分的影响

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中国现代医学杂志 2024年第16期34卷 62-67页

作者：袁庆梁荣兴袁鹏飞武警四川总队医院泌尿外科四川乐山614000

目的探讨经尿道前列腺切除术对前列腺增生(BPH)患者的尿流动力学和前列腺症状评分的影响。方法选取2021年6月—2023年2月武警四川总队医院收治的93例BPH患者,通过随机数字表法分为观察组和对照组,分别有47和46例。对照组接受传统的经尿... 详细信息

目的探讨经尿道前列腺切除术对前列腺增生(BPH)患者的尿流动力学和前列腺症状评分的影响。方法选取2021年6月—2023年2月武警四川总队医院收治的93例BPH患者,通过随机数字表法分为观察组和对照组,分别有47和46例。对照组接受传统的经尿道前列腺电切术,观察组接受经尿道前列腺切除术。评价两组手术指标(手术时间、术中出血量、造瘘管留置时间、尿管留置时间),术前和术后3、6和12个月的尿动力学参数[最大射尿流率(MFR)、残余尿量(RUV)]、美国国立卫生研究院慢性前列腺炎症状指数(NIH-CPSI)评分、国际前列腺症状(IPSS)评分及术后性功能状况。结果对照组术中出血量多于观察组,造瘘管留置时间、尿管留置时间均长于观察组(P0.05)。两组术前和术后3、6和12个月MFR、RUV水平比较,经重复测量设计的方差分析,结果:①不同时间点MFR、RUV水平比较,差异均有统计学意义(均P<0.05);②两组MFR、RUV水平比较,差异均有统计学意义(均P<0.05),观察组术后MFR较对照组高,RUV较对照组低;③两组MFR、RUV水平变化趋势比较,差异均有统计学意义(均P<0.05)。两组术前和术后3、6和12个月NIH-CPSI评分比较,经重复测量设计的方差分析,结果:①不同时间点NIH-CPSI评分比较,差异有统计学意义(P<0.05);②两组NIH-CPSI评分比较,差异有统计学意义(P<0.05),观察组术后较对照组低;③两组NIH-CPSI评分变化趋势比较,差异有统计学意义(P<0.05)。两组术前和术后3、6和12个月IPSS评分比较,经重复测量设计的方差分析,结果显示:①不同时间点IPSS评分比较,差异有统计学意义(P<0.05);②两组IPSS评分比较,差异有统计学意义(P<0.05),观察组术后较对照组低;③两组IPSS评分变化趋势比较,差异有统计学意义(P<0.05)。观察组性功能恢复优于对照组(P<0.05)。结论经尿道前列腺切除术治疗BPH患者,能够显著改善患者的尿流动力学参数和前列腺症状评分,为慢性前列腺炎合并勃起功能障碍患者提供了一种有效的治疗选择。

关键词：前列腺增生经尿道前列腺切除术尿流动力学前列腺症状评分

Effects of low-dose heavy ion irradiation on male germ cell adaptation and genetics

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Nuclear Science and Techniques 2005年第4期16卷 209-213页

作者： ZHANG Hong LI Wen-Jian ZHENG rong-liang Institute of Modern Physics the Chinese Academy of Sciences Lanzhou 730000 Department of Biologv Lanzhou University Lanzhou 730000

The heavy ions with high linear energy transfer and high relative biological effectiveness are much more deleterious on the male germ cells, ones of the most radiosensitive cells of the body,than low-LET ionizing radiation such as X-ray or gamma-ray. The effects of low-dose heavy ion irradiation on male germ cell adaptation and genetics and the possible mechanism of this adaptation are summarized in our laboratory. Our results showed that the heavy ion irradiation significantly increased the frequencies of chromosomal aberrations in spermatogonia and spermato-cytes of mice, the low dose heavy ion irradiation could induce significant adaptative response on mouse testes and human sperm, and pre-exposure of mouse testes with low-dose heavy ion can markedly alleviate damage effects in-duced by subsequent high-dose irradiation. The increase of SOD activity and decrease of lipid peroxidation levels induced by low-dose ionizing radiation may be involved in this adaptative response mechanism. These studies may provide useful theoretical and clinical bases for radioprotection of reproductive potential and assessment of genetic risks for human exposed to heavy ions in radiotherapy and in outer space environment.

关键词：重离子放射物精液男性辐射防护放射性疗法组织结构