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Advances and applications of genome-edited animal models for severe combined immunodeficiency

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Zoological Research 2025年第01期 249-260页

作者： Xiao Zheng Chun-Hui Huang Sen Yan Ming-deng rong Stomatological Hospital School of Stomatology Southern Medical University Guangdong Key Laboratory of Non-Human Primate Models Guangdong-Hongkong-Macau Institute of CNS Regeneration Jinan University School of medicine Jinan University Department of Neurology Guangzhou Red Cross Hospital Faculty of Medical Science Jinan University

Severe combined immunodeficiency disease(SCID),characterized by profound immune system dysfunction,can lead to life-threatening infections and death. Animal models play a pivotal role in elucidating biological processes and advancing therapeutic strategies. Recent advances in gene-editing technologies, including zincfinger nucleases(ZFNs), transcription activator-like effector nucleases(TALENs), CRISPR/Cas9, and base editing, have significantly enhanced the generation of SCID models. These models have not only deepened our understanding of disease pathophysiology but have also driven progress in cancer therapy, stem cell transplantation, organ transplantation, and infectious *** comprehensive overview of current SCID models generated using novel gene-editing approaches,highlighting their potential applications in translational medicine and their role in advancing biomedical research.

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The composition of magmatic-hydrothermal fluids and their related metal mineralization

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Science China Earth Sciences 2025年第1期68卷 208-225页

作者： Qihai SHU Jun deng State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences and ResourcesChina University of GeosciencesBeijing100083China Frontiers Science Center for Deep-time Digital Earth China University of GeosciencesBeijing100083China

Magmatic hydrothermal deposits are important sources of many bulk,precious,and rare metals,and have attracted interest from both academic and industrial ***,it is still unclear if the major enrichment of the ore-forming metals occurs in the parental magma source region,during the magma evolution,or after the fluid *** inclusions trapped in hydrothermal minerals crystallized in the early,high-temperature stage before metal precipitation record information close to that of the initially exsolved magmatic fluids,which are helpful in revealing whether the metals have been already significantly enriched prior to the hydrothermal *** this study,available compositional data of such early-stage fluid inclusions from magmatic hydrothermal systems globally have been *** results indicate that the concentrations of Cu,Sn,and W respectively from the Cu-,Sn-,and W-mineralized fluids are significantly higher than the hydrothermal systems that do not produce ores with the corresponding *** suggests that Cu,Sn,and W could have already been enriched in the magma source and/or magma evolution *** Mo concentrations show no difference between Mo-mineralized and Mobarren fluid systems,indicating no significant pre-enrichment in the source region or during the magma *** also implies that an efficient collection of Mo from a large volume of magmas is required to account for the formation of a large Mo *** all the hydrothermal fluids contain high concentrations of Fe and Zn-Pb,but only a few of them eventually form Fe or Zn-Pb deposits,reflecting an important role of the hydrothermal evolution process on the selective metal *** above results indicate that different metals are enriched in different stages of a magmatic hydrothermal system,and that the major roles played in the formation of a deposit vary with the metal *** addition to the metal concentrations in the orerelated magmas and fluids

关键词： Magmatic hydrothermal deposits Fluid inclusions LA-ICP-MS Metal enrichment Mineralization mechanism

A Cross-Multi-Domain Trust Assessment Authority Delegation Method Based on Automotive Industry Chain

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Computers, Materials & Continua 2025年第1期82卷 407-426页

作者： Binyong Li Liangming deng Jie Zhang Xianhui deng School of Cybersecurity(Xin Gu Industrial College) Chengdu University of Information TechnologyChengdu610225China Advanced Cryptography and System Security Key Laboratory of Sichuan Province Chengdu610225China SUGON Industrial Control and Security Center Chengdu610225China

To solve the challenges of connecting and coordinating multiple platforms in the automotive industry and to enhance collaboration among different participants,this research focuses on addressing the complex supply relationships in the automotive market,improving data sharing and interactions across various platforms,and achieving more detailed integration of data and *** propose a trust evaluation permission delegation method based on the automotive industry *** proposed method combines smart contracts with trust evaluation mechanisms,dynamically calculating the trust value of users based on the historical behavior of the delegated entity,network environment,and other factors to avoid malicious node attacks during the permission delegation *** also introduce strict control over the cross-domain permission granting and revocation mechanisms to manage the delegation path,prevent information leakage caused by malicious node interception,and effectively protect data integrity and *** analysis shows that this method meets the realtime requirements of collaborative interaction in the automotive industry chain and provides a feasible solution to permission delegation issues in the automotive industry chain,offering dynamic flexibility in authorization and scalability compared to most existing solutions.

关键词： Automotive industry chain cross-domain access block chain delegate authority trust assessment

Reduction of thermal stratification due to global warming in winter and spring

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Journal of Oceanology and Limnology 2025年第1期43卷 1-15页

作者： Jie LIU Jianming deng Xiangming TANG State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China School of Geography and Ocean Science Nanjing UniversityNanjing 210023China

Global warming has been reported to enhance thermal stratification and decrease the mixlayer depth(MLD)in waters due to higher surface water temperatures,especially in *** studies were conducted for individual cases or specific *** present,there is a lack of global assessments on the influence of climate warming in different seasons on thermal *** ECMWF Reanalysis v5(ERA5)dataset was used to estimate the variability of water body mixing and its drivers in different seasons and *** indicate that global warming could enhance thermal stratification and decrease the MLD globally in *** speed was the primary driver of MLD changes,followed by ***,ice melt due to global warming enhanced the mixing in icecovered waters in the Northern Hemisphere,and early ice melt led to early *** depth was the primary driver of MLD changes in the Northern Hemisphere due to delayed ice formation and earlier melting,while wind speed was the primary driver in other regions or during ice-free *** enhanced mixing due to earlier ice melt out in late winter and early spring could promote water circulation and nutrient turnover,and replenish dissolved oxygen in deep water,thereby promoting the maximum biomass of cyanobacteria and advance harmful algal blooms.

关键词： global warming mix-layer depth(MLD) thermal stratification ice depth ECMWF Reanalysis v5(ERA5)dataset

Existence of multi-hump generalized homoclinic solutions for a class of reversible systems

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Science China Mathematics 2025年第2期68卷 299-338页

作者： Shengfu deng Yan Zhou Jinsen Zhuang School of Mathematical Sciences Huaqiao UniversityQuanzhou 362021China

In this paper,we investigate a class of reversible dynamical systems in four *** spectrums of their linear operators at the equilibria are assumed to have a pair of positive and negative real eigenvalues and a pair of purely imaginary eigenvalues for the small parameterμ>0,where these two real eigenvalues bifurcate from a double eigenvalue 0 forμ=*** has been shown that this class of systems owns a generalized homoclinic solution with one hump at the center(a homoclinic solution exponentially approaching a periodic solution with a small amplitude).This paper gives a rigorous existence proof of two-hump *** two humps are far away and are glued by the small oscillations in the middle if some appropriate free constants are *** obtained results are also applied to some classical *** ideas here may be used to study the existence of 2^(k)-hump solutions.

关键词： homoclinic solutions multi-hump periodic solutions reversibility

Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

Correlations of the expression of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in colon cancer tissues

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 207-213页

作者： rong-Gang Luan Ming-Da Liu Zi-Feng deng Cong-Lan Lu Mei-Ling Yu Ming-Yu Zhang rong Liu Ran An You-Liang Yao Dong-Bei Guo Yong-Xing Zhang Lei Zhao Department of Gastrointestinal Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics School of Public HealthXiamen UniversityXiamen 361102Fujian ProvinceChina Trauma Surgery Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina Department of Orthopaedics Air Force Hospital of Eastern TheaterAnhui Medical UniversityNanjing 230032Jiangsu ProvinceChina

BACKGROUND Previous cellular studies have demonstrated that elevated expression of Cx43 promotes the degradation of cyclin E1 and inhibits cell proliferation through ***,reduced expression results in a loss of this capacity to facilitate cyclin E *** ubiquitination and degradation of cyclin E1 may be associated with phosphorylation at specific sites on the protein,with Cx43 potentially enhancing this process by facilitating the phosphorylation of these critical *** To investigate the correlation between expression of Cx43,SKP1/Cullin1/F-box(SCF)FBXW7,p-cyclin E1(ser73,thr77,thr395)and clinicopathological indexes in colon *** Expression levels of Cx43,SCF^(FBXW7),p-cyclin E1(ser73,thr77,thr395)in 38 clinical colon cancer samples were detected by immunohistochemistry and were analyzed by statistical methods to discuss their *** Positive rate of Cx43,SCF^(FBXW7),p-cyclin E1(Ser73),p-cyclin E1(Thr77)and p-cyclin E1(Thr395)in detected samples were 76.32%,76.32%,65.79%,5.26%and 55.26%*** expressions of these proteins were not related to the tissue type,degree of tissue differentiation or lymph node ***43 and SCF^(FBXW7)(r=0.749),p-cyclin E1(Ser73)(r=0.667)and p-cyclin E1(Thr395)(r=0.457),SCF^(FBXW7) and p-cyclin E1(Ser73)(r=0.703)and p-cyclin E1(Thr395)(0.415)were correlated in colon cancer(P<0.05),and expressions of the above proteins were positively correlated in colon *** Cx43 may facilitate the phosphorylation of cyclin E1 at the Ser73 and Thr195 sites through its interaction with SCF^(FBXW7),thereby influencing the ubiquitination and degradation of cyclin E1.

关键词： Colon cancer Cx43 SCF^(FBXW7) Phosphorylation of cyclin E1 Sites of cyclin E1 Correlation analysis

Recycling Fe and improving organic pollutant removal via in situ forming magnetic core-shell Fe_(3)O_(4)@CaFe-LDH in Fe(Ⅱ)-catalyzed oxidative wastewater treatment

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Journal of Environmental Sciences 2025年第1期147卷 523-537页

作者： Ting He Jie Sun Liangwei deng Jialin Ming Changwei Hu Key Laboratory of Green Chemistry and Technology Ministry of EducationCollege of ChemistrySichuan UniversityChengdu 610064China Biogas Institute of Ministry of Agriculture and Rural Affairs Chengdu 610041China Inner Mongolia Key Laboratory of Fine Organic Synthesis Inner Mongolia UniversityHohhot 010021China

Due to its high efficiency,Fe(Ⅱ)-based catalytic oxidation has been one of the most popular types of technology for treating growing organic pollutants.A lot of chemical Fe sludge alongwith various refractory pollutantswas concomitantly produced,whichmay cause secondary environmental problemswithout proper *** here innovatively proposed an effective method of achieving zero Fe sludge,reusing Fe resources(Fe recovery=100%)and advancing organics removal(final TOC removal>70%)simultaneously,based on the in situ formation of magnetic Ca-Fe layered double hydroxide(Fe_(3)O_(4)@CaFe-LDH)***(Ca^(2+)and Fe^(3+))concentration(≥30 mmol/L)and their molar ratio(Ca:Fe≥1.75)were crucial to the success of the *** nano Fe_(3)O_(4)was designed to be involved in the Fe(Ⅱ)-catalytic wastewater treatment process,and was modified by oxidation intermediates/products(especially those with COO-structure),which promoted the co-precipitation of Ca^(2+)(originated from Ca(OH)_(2)added after oxidation process)and byproduced Fe^(3+)cations on its surface to in situ generate core-shell Fe_(3)O_(4)@*** oxidation products were further removed during Fe_(3)O_(4)@CaFe-LDH material formation via intercalation and *** applicable to many kinds of organicwastewater,such as bisphenol A,methyl orange,humics,and biogas *** prepared magnetic and hierarchical CaFe-LDH nanocomposite material showed comparable application performance to the recently reported *** work provides a new strategy for efficiently enhancing the efficiency and economy of Fe(Ⅱ)-catalyzed oxidative wastewater treatment by producing high value-added LDHs materials.

关键词： CaFe layered double hydroxide Fe(Ⅱ)-catalytic oxidation Fe recycling Magnetic nanomaterial in situ formation Fe_(3)O_(4)modification

Adaptive optimal control system design for semi-active suspension system by supposing variable parameters under exogenous road disturbance

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Control Theory and Technology 2025年第1期23卷 64-73页

作者： Viet Nguyen Hoang Feiqi deng Chi Nguyen Van School of Automation Science and Engineering South China University of TechnologyGuangzhou510640GuangdongChina Thai Nguyen University of Technology Thai Nguyen CityVietnam

This article presents an adaptive optimal control method for a semi-active suspension *** model of the suspension system is built,in which the components of uncertain parameters and exogenous disturbance are *** adaptive optimal control law consists of the sum of the optimal control component and the adaptive control ***,the optimal control law is designed for the model of the suspension system after ignoring the components of uncertain parameters and exogenous disturbance caused by the road *** optimal control law expresses the desired dynamic characteristics of the suspension ***,the adaptive component is designed with the purpose of compensating for the effects caused by uncertain parameters and exogenous disturbance caused by the road surface;the adaptive component has adaptive parameter rules to estimate uncertain parameters and exogenous *** exogenous disturbances are eliminated,the system responds with an optimal controller *** separating theoretically the dynamic of a semi-active suspension system,this solution allows the design of two separate controllers easily and has reduced the computational burden and the use of too many tools,thus allowing for more convenient hardware *** simulation results also show the effectiveness of damping oscillations of the proposed solution in this article.

关键词： Quarter car suspension system Semi-active suspension Adaptive control Optimal control Linear-quadratic regulator Exogenous disturbance