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Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis

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World Journal of Gastroenterology 2021年第11期27卷 1064-1075页

作者： José Carlos Rodrigues Nascimento Lianna C pereira Juliana Magalhães C Rêgo ronaldo p dias paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen pierluigi Toniutto Reinaldo B Oriá Department of Anesthesia and Surgery Liver Transplantation Fortaleza General HospitalFortaleza 60150-160CEBrazil Laboratory of the Biology of Tissue Healing Ontogeny and NutritionDepartment of Morphology and Institute of BiomedicineSchool of MedicineFederal University of CearáFortaleza 60430-270CEBrazil Department of Dental Clinic Federal University of CearáFortaleza 60430-270CEBrazil Department of Surgery Liver Transplant Unit of Federal University of CearáFortaleza 60430-270CEBrazil Transplantation Division Hospital Geral de FortalezaFortaleza 60175-742CEBrazil Institute of Virology CharitéUniversitätsmedizin BerlinBerlin 10117Germany UCL Medical School Royal Free CampusLondon NW32PFUnited Kingdom Department of Specialized Medicine Hepatology Liver Transplantation UnitAzienda Sanitaria Universitaria Integrata of UdineUdine I-33100Italy

BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular *** E(protein:ApoE,gene:ApOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and ApOE polymorphisms may influence HCV-induced liver *** To determine whether ApOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)*** injury severity was assessed using different criteria,including METAVIR and models for endstage liver *** polymorphisms were analyzed by quantitative real-time polymerase chain *** The ApOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)p=0.048,in patients carrying the ApOE4 allele when compared to *** addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;p=0.043)and(A1F4,57.4%vs A3F4,0.0%;p=0.024)in ApOE4 patients when compared to ApOE3 *** fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(p=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients.

关键词： Apolipoprotein E polymorphism Liver cirrhosis Hepatitis C virus Hepatocellular carcinoma Liver transplantation

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Time-Series Embeddings from Language Models:A Tool for Wind Direction Nowcasting

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Journal of Meteorological Research 2024年第3期38卷 558-569页

作者： Decio ALVES Fabio MENDONCA Sheikh Shanawaz MOSTAFA Fernando MORGADO-dias University of Madeira Campus Universitário da Penteada9020-105FunchalPortugal Interactive Technologies Institute/Laboratory for Robotics and Engineering Systems and Agência Regional para o Desenvolvimento da Investigação Tecnologia e InovaçãoEdif.Madeira TecnopoloCaminho da Penteada piso-29020-105FunchalPortugal

Wind direction nowcasting is crucial in various sectors,particularly for ensuring aviation operations and *** this context,the TELMo(Time-series Embeddings from Language Models)model,a sophisticated deep learning architecture,has been introduced in this work for enhanced wind-direction *** by using three years of data from multiple stations in the complex terrain of an international airport,TELMo incorporates the horizontal u(east-west)and v(north-south)wind components to significantly reduce forecasting *** a day with high wind direction variability,TELMo achieved mean absolute error values of 5.66 for 2-min,10.59 for 10-min,and 14.79 for 20-min forecasts,processed within a swift 9-ms/step *** degree-based analysis,in comparison,yielded lower performance,emphasizing the effectiveness of the u and v *** contrast,a Vanilla neural network,representing a shallow-learning approach,underperformed in all analyses,highlighting the superiority of deep learning methodologies in wind direction *** is an efficient model,capable of accurately forecasting wind direction for air traffic operations,with an error less than 20°in 97.49%of the predictions,aligning with recommended international *** model design enables its applicability across various geographical locations,making it a versatile tool in global aviation meteorology.

关键词： wind nowcasting wind components wind direction time series prediction deep learning

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Seasonal variation and host sex affect bat–bat fly interaction networks in the Amazonian savannahs

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Integrative Zoology 2024年第3期19卷 400-416页

作者： paulo MEJIA Gustavo Lima URBIETA Bruna da Silva XAVIER IsaíJorge de CASTRO JoséJúlio DE TOLEDO Gustavo GRACIOLLI Lucio AndréVIANA dias William Douglas CARVALHO programa de pós-Graduação em Biodiversidade Tropical Universidade Federal do Amapá(UNIFAP)MacapáAPBrazil programa de pós-Graduação em Ecologia Instituto de BiologiaCentro de Ciências da SaúdeUniversidade Federal do Rio de Janeiro(UFRJ)Rio de JaneiroRJBrazil Laboratório de Mamíferos Instituto de Pesquisas Científicas e Tecnológicas do Estado do Amapá(IEPA)MacapáAPBrazil programa de pós-Graduação em Biologia Animal Laboratório de SistemáticaEcologia e Evolução(LSEE)Instituto de BiociênciasUniversidade Federal de Mato Grosso do Sul(UFMS)Campo GrandeMTBrazil Terrestrial Ecology Group(TEG-UAM) Departamento de EcologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridMadridSpain

Bats are the second-most diverse group of mammals in the world,and bat flies are their main ***,significant knowledge gaps remain regarding these antagonistic interactions,especially since diverse factors such as seasonality and host sex can affect their network ***,we explore the influence of such factors by comparing species richness and composition of bat flies on host bats,as well as specialization and modularity of bat–bat fly interaction networks between seasons and adult host *** captured bats and collected their ectoparasitic flies at 10 sampling sites in the savannahs of AmapáState,northeastern region of the Brazilian *** female bats being more parasitized and recording greater bat fly species richness in the wet season,neither relationship was statistically *** pooled network could be divided into 15 compartments with 54 links,and all subnetworks comprised>12 *** total number of links ranged from 27 to 48(for the dry and wet seasons,respectively),and female and male subnetworks had 44 and 41 links,*** values were very low for the pooled network and for all *** results revealed higher bat fly species richness and abundance in the wet season,whereas specialization and modularity were higher in the dry ***,the subnetwork for female bats displayed higher specialization and modularity than the male ***,both seasonality and host sex contribute in different ways to bat–bat fly network *** studies should consider these factors when evaluating bat–bat fly interaction networks.

关键词： Amapá Amazon biome bat flies bats interaction networks

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山药多糖对地塞米松诱导IR-3T3-L1脂肪细胞的降血糖作用及机制研究

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中国比较医学杂志 2024年第4期34卷 73-83页

作者：刘昕玥王凤忠郑涵文 Alberto Carlos pires dias 范蓓王琼中国农业科学院农产品加工研究所/农业农村部农产品加工质量安全风险评估实验室/农业农村部农产品质量安全收贮运管控重点实验室北京100193 西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的探究山药多糖(Chinese yam polysaccharide,CYpS)在地塞米松(dexamethasone,DEX)诱导的3T3-L1胰岛素抵抗(IR-3T3-L1)细胞模型中的降血糖作用。方法将IR-3T3-L1脂肪细胞随机分为对照组(Con)、DEX组(DEX)、Met组(Met,阳性药组)、CYpS组(0.05、0.15、0.45 mg/mL),通过DEX(1μmol/L)诱导建立IR-3T3-L1细胞模型,进行给药后细胞对葡萄糖的消耗量和细胞中血脂(总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C))与丙二醛(malondialdehyde,MDA)和谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-px)、己糖激酶(hexokinase,HK)、丙酮酸激酶(pyruvate kinase,pK)含量的检测,并采用qRT-pCR对AMpK-pI3K/Akt信号通路中相关基因表达进行检测。结果DEX组与Con组相比,1μmol/L DEX处理48 h显著降低了IR-3T3-L1细胞的葡萄糖消耗量(ppS处理IR-3T3-L1细胞显著增加了细胞中葡萄糖的消耗(ppK、GSH-px酶活性(pppppS可以显著回调pI3K、Akt、GLUT-4、AMpK、IRS-2、ppARa、Adiponectin的mRNA水平(pppS能够改善DEX诱导的IR-3T3-L1细胞对葡萄糖的消耗,调节脂代谢紊乱,缓解氧化应激,其作用机制可能通过调控IR-3T3-L1脂肪细胞的AMpK-pI3K/Akt信号通路来实现糖脂代谢紊乱和胰岛素抵抗调节来实现。

关键词：山药多糖胰岛素抵抗地塞米松 3T3-L1细胞二甲双胍 AMpK-pI3K/Akt信号通路

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黄花菜醇提物对斑马鱼抑郁样行为的改善作用研究

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中国比较医学杂志 2024年第4期34卷 20-27页

作者：郑涵文王梓航刘昕玥于佳玮 Alberto Carlos pires dias 王凤忠王琼西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 中国农业科学院农产品加工研究所北京100193 中国农业大学食品科学与营养工程学院北京100083 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的探究黄花菜醇提物(Hemerocallis citrina Baroni,HCE)在利血平(reserpine)诱导的斑马鱼幼鱼(Danio rerio)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜... 详细信息

目的探究黄花菜醇提物(Hemerocallis citrina Baroni,HCE)在利血平(reserpine)诱导的斑马鱼幼鱼(Danio rerio)模型中对抑郁行为的改善作用。方法将斑马鱼幼鱼分为对照(Con)组、利血平组、氟西汀组、黄花菜低剂量组(1.5 mg/L)、黄花菜中剂量组(3 mg/L)、黄花菜高剂量组(4.5 mg/L)。采用斑马鱼声音刺激和光刺激进行抑郁样行为学分析。利用RT-qpCR研究黄花菜醇提物对抑郁症有关的星状胶质细胞标志物及其衍生物基因(GFAp、C3、C4B、EMp-1和S100α-10)以及神经营养因子(BDNF)及其自身受体转录基因(p75、TrkB)的调节功能。结果与对照组相比,模型组在440 Hz声音刺激与8000 Lux光照刺激下运动距离缩短、运动时间减少(pppppppp75、TrkB下调(pp75、TrkB表达显著上调(pp<0.0001)。表明黄花菜醇提物抑制了星形胶质细胞激活诱发的炎症表现,同时促进了神经营养因子及其受体基因的生成,对抑郁起到了改善作用。结论黄花菜醇提物可以改善利血平诱导的斑马鱼幼鱼的抑郁样行为变化,斑马鱼脑中星形胶质细胞标志物的表达量减少,同时促进神经营养因子及其受体基因的生成,起到抗抑郁作用。

关键词：黄花菜抑郁症利血平斑马鱼

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ON THE UNIQUENESS OF THE WEAK SOLUTIONS OF A QUASILINEAR HYpERBOLIC SYSTEM WITH A SINGULAR SOURCE TERM

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Chinese Annals of Mathematics,Series B 2002年第3期23卷 317-324页

作者： J.p.dias M.FIGUEIRA Dedicated to the memory of Jacques-Louis Lions Dedicated to the memory of Jacques-Louis Lions

This paper is a continuation of the authors' previous paper [1]. In this paper the authors prove, assuming additional conditions on the initial data, some results about the existence and uniqueness of the entropy weak... 详细信息

关键词： Cauchy problem Weak solution Quasilinear hyperbolic system

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基于网络药理学和实验验证探究酸枣仁复方治疗抑郁症的作用机制

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中国实验动物学报 2024年第7期32卷 901-912页

作者：郑涵文刘昕玥赵海燕王佳音罗福龙范蓓 Alberto Carlos pires dias 王凤忠王琼中国农业科学院农产品加工研究所北京100193 西南医科大学附属中医医院中葡中医药国际合作中心四川泸州646000 西南医科大学附属中医医院脾胃病科四川泸州646000 首都医科大学宣武医院急诊科北京100053 葡萄牙米尼奥大学生物系中葡药食植物资源研究中心葡萄牙布拉加4710-057

目的通过网络药理学技术预测酸枣仁复方(Ziziphi spinosae semen formula, ZSSF)对于抑郁症的关键作用靶点,并通过利血平诱导的抑郁斑马鱼模型验证酸枣仁复方治疗抑郁症的作用机制。方法通过TCMSp数据库检索酸枣仁复方的药物作用靶点... 详细信息

目的通过网络药理学技术预测酸枣仁复方(Ziziphi spinosae semen formula, ZSSF)对于抑郁症的关键作用靶点,并通过利血平诱导的抑郁斑马鱼模型验证酸枣仁复方治疗抑郁症的作用机制。方法通过TCMSp数据库检索酸枣仁复方的药物作用靶点,利用Uniprot数据库对靶点名称进行校正。采用GeneCards、OMIM、NCBI数据库检索抑郁症相关靶点,并对3个数据库的靶点结果进行汇总去比重。利用STRING数据库预测了交集靶点的蛋白质-蛋白质相互作用(protein-protein interaction, ppI)信息,利用Metascape数据库构建进行富集研究,并利用微生信对KEGG和GO的富集结果实现了可视化。通过利血平诱导的斑马鱼抑郁模型进行行为学实验和RT-qpCR实验,验证酸枣仁复方对抑郁症的治疗作用。结果筛选出抑郁症与酸枣仁复方的交集靶点188个,蛋白质-蛋白质相互作用结果显示,酸枣仁复方抗抑郁主要作用于肿瘤坏死因子-α(TNF-α)、血清白细胞介素2(IL-2)、血清白细胞介素6(IL-6)、血清白细胞介素1β(IL-1β)、血清白细胞介素10(IL-10)等靶点,KEGG通路富集分析表明,酸枣仁复方通过TNF信号通路、pI3K-Akt信号通路、cGMp-pKG信号通路等多种信号通路发挥其治疗抑郁症的作用。动物实验结果显示,与利血平组相比,酸枣仁复方高、中、低剂量组斑马鱼在声光刺激下的运动距离显著延长(pppCR结果显示,与利血平组相比,酸枣仁复方高、中、低剂量给药组斑马鱼脑组织中TNF-α、IL-2、IL-6、IL-1β、IL-10 mRNA表达水平上调(p<0.001)。结论酸枣仁复方通过多成分、多靶点发挥抗抑郁作用,且其抗抑郁作用可能与抑制炎症因子的表达有关。

关键词：网络药理学酸枣仁复方抑郁症炎症因子

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Comparison between Care Strategies for patients with Osteoarthritis of the Hands Based on the Use of Joint protection, Assistive Technology and Exercises

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Open Journal of Orthopedics 2024年第7期14卷 295-311页

作者： Daniele dos Santos Scarcella Talita dias da Silva Victoria Yanara Hernandes da Silva Maria Cândida de Miranda Luzo Selma Lancman Marcia Uchoa de Rezende Carlos Bandeira de Mello Monteiro Instituto de Ortopedia e Traumatologia Hospital das Clnicas HCFMUSP Faculdade de Medicina Universidade de So Paulo So Paulo Brazil programa de ps-Graduao em Cincias da Reabilitao Faculdade de Medicina Universidade de So Paulo So Paulo Brazil Escola de Artes Cincias e Humanidades Universidade de So Paulo So Paulo Brazil

Background: Osteoarthritis (OA) is a disabling disease that can affect 6% to 12% of the adult population and more than a third of people over 65 years of age. purpose: To assess whether a group of people with hand osteoarthritis (hOA) who received different types of treatment improved their function after two years of follow-up. Method: The entire sample (n = 97) underwent three follow-up assessments regarding anthropometric parameters of the upper limbs and ability to perform functional activities. Subsequently, the sample was divided into two groups for the intervention periods, called the First period (n = 73) and the Second period (n = 24);the First period kept the same protocol with orientations, and the Second period went to an intervention with orientation strength exercises and use of orthosis. Findings: In the separate analysis of the three questions of the DASH pain module, no differences were found between the assessment moments for groups of guidelines, treatment, or symptoms. Significant effects were observed for F(2, 162) = 3.5, p = 0.033, η2 = 0.04, and interaction for moments and intervention F(2, 162) = 4.3, p = 0.016, η2 = 0.05. Implications: It can be concluded that only guidance treatment does not benefit patients with hand osteoarthritis. In contrast, guidance, exercise, and orthosis treatment can significantly improve the disease.

关键词： Hand Osteoarthritis Hand Deformities Occupational Therapy

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Biomass-glycerol briquettes are not necessarily mechanically stable and energetically effective

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Waste Disposal and Sustainable Energy 2020年第4期2卷 291-303页

作者： Bruno Rafael de Almeida Moreira ronaldo da Silva Viana Samuel dias Moreira Monique dos Santos Lima Anderson Chagas Magalhães Celso Tadao Miasaki JoséClaudio Caraschi Department of phytosanitary Rural Engineering and SoilsSchool of EngineeringSão Paulo State University(Unesp)Ilha SolteiraSão PauloBrazil Department of plant production College of Agricultural and Technological SciencesSão Paulo State University(Unesp)DracenaBrazil São paulo State University(Unesp) ItapevaSão PauloBrazil

The re-use of glycerol from biodiesel industry as an alternative lubricant for making high-performance briquettes is ***,the technical performance of this agro-industrial residue is not *** study outlines,accordingly,the real risk of introducing glycerol into the co-briquetting of highly caloric by-products of *** production of hybrid briquettes consisted of pressing mixtures of residues of sugarcane and sorghum with the liquid additive at 10,20,and 30 wt.%in bench-scale hydraulic piston presser *** of the blend,briquettes containing the supplement at the highest level as part of their composition ended up being much more hygroscopic(20.10%)and less energetic(3.15 GJ m^(−3)).The explanation for the negative impact of glycerol on the thermomechanical behavior of briquettes would be overconcen-tration of additive capable of effectively defying compacting *** degree of compaction during co-briquetting has likely gone down quickly with a maximizing level of *** long as the additive is not able to lubricate the feedstock suitably,improbability of biomass particles to successfully bond together to form themselves into mechanically stable and energetically effective briquettes is *** lower density(273.80 kg m^(−3))and higher relaxation(22.75%),briquettes with glycerol at 30 wt.%generally were aesthetically ***,these products resisted no longer to handling,transportation,and *** lost their shape easily during emptying and shifting them,thus,releasing larger quanti-ties of biomass to the *** evidence of high-viscosity glycerol capable of limiting safe and effective production of high-performance briquettes for heating and power exists.

关键词： Additive Agro-residues Densification Biosolids Waste-to-energy

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A Quasilinear System Related with the Asymptotic Equation of the Nematic Liquid Crystal’s Director Field

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Chinese Annals of Mathematics,Series B 2021年第2期42卷 163-172页

作者： João-paulo dias Departamento de Matemática and CMAFcIO Faculdade de Ciências da Universidade de LisboaCampo GrandeEdificio C61749-016 LisboaPortugal

In this paper, the author studies the local existence of strong solutions and their possible blow-up in time for a quasilinear system describing the interaction of a short wave induced by an electron field with a long wave representing an extension of the motion of the director field in a nematic liquid crystal’s asymptotic model introduced in[Saxton, R. A., Dynamic instability of the liquid crystal director. In: Current progress in Hyperbolic Systems(Lindquist, W. B., ed.), Contemp. Math., Vol.100, Amer. ***., providence, RI, 1989, pp.325–330] and [Hunter, J. K. and Saxton, R. A., Dynamics of director fields, SIAM J. Appl. Math., 51, 1991, 1498–1521] and studied in [Hunter, J. *** Zheng, Y., On a nonlinear hyperbolic variational equation I, Arch. Rat. Mech. Anal.,129, 1995, 305–353], [Hunter, J. K. and Zheng, Y., On a nonlinear hyperbolic variational equation II, Arch. Rat. Mech. Anal., 129, 1995, 355–383] and in [Zhang, p. and Zheng,Y., On oscillation of an asymptotic equation of a nonlinear variational wave equation,Asymptotic Anal., 18, 1998, 307–327] and, more recently, in [Bressan, A., Zhang, p. and Zheng, Y., Asymptotic variational wave equations, Arch. Rat. Mech. Anal., 183, 2007,163–185].

关键词： Benney system Conservation law Schrödinger equation Nematic liquid crystal Director field

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