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Axonal degeneration in the anterior insular cortex is associated with Alzheimer’s co-pathology in Parkinson’s disease and dementia with Lewy bodies

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Translational Neurodegeneration 2022年第1期11卷 129-147页

作者： Yasmine Y.Fathy Laura E.Jonkman John J.Bol Evelien Timmermans Allert J.Jonker Annemieke J.M.Rozemuller Wilma D.J.van de Berg Amsterdam UMC Department of Anatomy and NeurosciencesSection Clinical Neuroanatomy and BiobankingAmsterdam NeuroscienceVrije University AmsterdamO|2 Life Sciences buildingDe Boelelaan 11081081 HZ Amster-damNetherlands Amsterdam Neuroscience Program NeurodegenerationAmsterdamthe Netherlands Amsterdam UMC Department of Pathol-ogyAmsterdam NeuroscienceVrije University AmsterdamDe BoelelaanAmsterdamNetherlands Department of Neurology Erasmus Medical CenterPostbus 20403000 CA RotterdamNetherlands.

Background:Axons,crucial for impulse transmission and cellular trafficking,are thought to be primary targets of neurodegeneration in Parkinson’s disease(PD)and dementia with Lewy bodies(DLB).Axonal degeneration occurs early,preceeding and exceeding neuronal loss,and contributes to the spread of pathology,yet is poorly described outside the nigrostriatal *** insula,a cortical brain hub,was recently discovered to be highly vulnerable to pathology and plays a role in cognitive deficits in PD and *** aim of this study was to evaluate morphological features as well as burden of proteinopathy and axonal degeneration in the anterior insular sub-regions in PD,PD with dementia(PDD),and ***:α-Synuclein,phosphorylated(p-)tau,and amyloid-βpathology load were evaluated in the anterior insular(agranular and dysgranular)subregions of post-mortem human brains(n=27).Axonal loss was evaluated using modified Bielschowsky silver staining and quantified using *** damage was comprehensively studied using immunofluorescent multi-labelling and 3D confocal laser-scanning ***:Compared to PD and PDD,DLB showed significantly higherα-synuclein and p-tau pathology load,argyrophilic grains,and more severe axonal loss,particularly in the anterior agranular ***,the dysgranular insula showed a significantly higher load of amyloid-βpathology and its axonal density correlated with cognitive performance.p-Tau contributed most to axonal loss in the DLB group,was highest in the anterior agranular insula and significantly correlated with CDR global scores for *** and myelin showed degenerative changes including swellings,demyelination,and detachment of the axon-myelin ***:Our results highlight the selective vulnerability of the anterior insular sub-regions to various converging pathologies,leading to impaired axonal integrity in PD,PDD and DLB,disrupting their functional properties and potentially con

关键词： α-Synuclein Insular subregions Axonal length density Alzheimer’s disease pathology Neurofilament Myelin

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THE POTENTIAL OF A GROUND BASED TRANSCEIVERS NETWORK FOR WATER dam DEFORMATION MONITORING

THE POTENTIAL OF A GROUND BASED TRANSCEIVERS NETWORK FOR WAT...

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水电2006国际研讨会

作者： J.B Barnes J.van Cranenbroeck School of Surveying and Spatial Information Systems University of New South WalesSydneyAustralia Leica Geosystems AG-Geosystems Division BA EngineeringHeerbruggSwitzerland

The Global Navigation Satellites Systems （GPS, GLONASS and the future GALILEO） has proven to be a useful tool for precision deformation monitoring applications in structural engineering. For continuous structural deformation monitoring on an epoch-by-epoch basis it is desirable for a measurement system to deliver equal precision in all position components, all the time. However, the quality of GPS position solutions is heavily dependent on the number and geometric distribution of the available satellites. Therefore, the positioning precision varies significantly and is three times less in vertical than horizontal coordinates. This situation becomes worse when the line-of-sight to GPS satellites is obstructed to structures, as it is the case for the big water dams when trying to access other interesting parts than only the crest, reducing the number of visible satellites often to less than four. A new positioning technology developed by Locata Technology Australia, that uses a network of ground-based transceivers that cover a specific area of a water dam with strong signals is becoming part of Leica Geosystems solution. This paper discusses the technology and assesses its suitability for use in structural deformation monitoring applications.

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艺术人类学的三种类型

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内蒙古大学艺术学院学报 2013年第4期10卷 5-10页

作者：威尔弗雷德·范·丹姆[荷兰] 王拥军张周瑞(译) 李修建(校) 荷兰莱顿大学艺术史学系荷兰莱顿市999025 丽水学院浙江丽水323000 兰州文理学院甘肃兰州730000 中国艺术研究院北京10029

本文主要讨论不同的"人类学"理念是如何导致了对"艺术人类学"的不同理解。研究小型非西方社会的通行人类学观念影响下的艺术人类学关注这些社会或文化中的视觉艺术。人类学有时也被视为一种独特的方法,可以适用于任何文化中的社会文化现... 详细信息

本文主要讨论不同的"人类学"理念是如何导致了对"艺术人类学"的不同理解。研究小型非西方社会的通行人类学观念影响下的艺术人类学关注这些社会或文化中的视觉艺术。人类学有时也被视为一种独特的方法,可以适用于任何文化中的社会文化现象,包括其艺术形式。这两种人类学观亦可被作为更具广泛性的跨学科人类学研究的补充。按照这种观念,艺术人类学成为人类存在艺术的全景审视。如此,艺术人类学和世界艺术研究同义,被构建为全球性和跨学科的视觉艺术研究。

关键词：人类学视觉艺术类型

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荷兰的社会混合与城市政策

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国际城市规划 2013年第3期28卷 8-12页

作者：吉迪恩.博尔特罗纳德.凡.肯彭买静罗震东荷兰乌得勒支大学地球科学学院城市与区域研究中心南京大学建筑与城市规划学院

在荷兰的政策讨论与实践中,一个反复出现的主题就是努力创建混合的社区。在二战后的最初几年,基本的问题不是混合群体而是混合功能:通过混合各种不同的功能,诸如居住、工作和娱乐等,使地区内的居民能够开展各种活动而不用被迫离开。20世... 详细信息

在荷兰的政策讨论与实践中,一个反复出现的主题就是努力创建混合的社区。在二战后的最初几年,基本的问题不是混合群体而是混合功能:通过混合各种不同的功能,诸如居住、工作和娱乐等,使地区内的居民能够开展各种活动而不用被迫离开。20世纪60年代,功能分区的理念取代了把地区看作是所有功能和人口混合在一个有限空间里的社会单元的理念,居住、就业和交通职能被分离开。20世纪70年代和80年代,荷兰大城市中建于二战前的贫穷地区开展了大型的城市更新运动。在此期间,居住混合并不是一项明确的目标。到20世纪80年代末,一项新的住房政策开始占据主导。城市重构成为关键词:在社会租赁住房占据主导的地区,大量房屋不得不拆毁或更新,以便为那些价格更高的、通常是个人所有的住房留下空间。通过这种方式就可以抵制低收入家庭的高度集中。自2001年以来,关于社会混合的争论一直在变换论调。在此之前,这场争论和政策都已经在社会经济用语中得到体现和表述。2001年之后,与少数族裔在空间上集聚相关的问题变得尤为突出。

关键词：社会混合城市政策荷兰

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大气负载引起地表位移:对重力和基线测量的影响

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地球物理学进展 1987年第3期 57-57页

作者： T.M.van dam J.M.Wahr 林邦佐

大气质量对地壳加载并使之形变.通过将逐日的全球气压数据和质量负载的格林函数进行摺积求和,我们怡算大气负载(包括那些与短期大气扰动有关的大气负载)对地表刚点定位测量和地表重力观测的时间依赖关系.我们茸出了无海洋地球和具有一... 详细信息

大气质量对地壳加载并使之形变.通过将逐日的全球气压数据和质量负载的格林函数进行摺积求和,我们怡算大气负载(包括那些与短期大气扰动有关的大气负载)对地表刚点定位测量和地表重力观测的时间依赖关系.我们茸出了无海洋地球和具有一负压海洋(inverted barometer ocean)的地球的响应.负压海洋显著地影响近海岸台站的负载响应.峰峰垂直位移常常是15一20mm,伴随有3一6卜Gal的扰动.基线变化可能大到20mm或更大.这种扰动在高纬度区和冬季达到最大.这些振幅的变化与Rabbel和Zs。hau(1985)的结果一致.他们用距某一点半径有关的高斯函数模拟了气压扰动.使用台距约I00okm以内测点的现有气压数据就足以计算地壳的形变.单是局部气压数据是不够的.Rabbel和Zsc五-au为使用局部气压和区域平均气压算得的这些位移位所假设的改正值,对正好在内地的测点证明是精确的,但一般地说在距海岸几百公里之内,改正值是不适当的.

关键词：气压形变地壳地球外壳地球内部

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猪群中耐甲氧西林金黄色葡萄球菌的高流行率

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国外畜牧学（猪与禽） 2007年第4期27卷 57-59,76页

作者：杨智满 A.J.de Neeling M.J.M.vanden Broek E.C.Spalburg M.G.van Santen-Verheuvel W.D.C.dam-Deisz H.C.Boshuizen A.W.vandeGiessen E.vanDuijkeren X.W.Huijsdens 荷兰国家公共卫生与环境研究所荷兰食品和消费品安全委员会荷兰Utrecht大学兽医学院

荷兰研究人员最近从猪农及其猪上分离到耐甲氧西林金黄色葡萄球菌(methicillin resistant Staphylococcus aureus,MRSA)。为了评估MRSA在荷兰猪群中的流行情况,作者检测了9家屠宰场的540头猪,这些屠宰场2005年度的生猪屠宰量占荷兰当年... 详细信息

荷兰研究人员最近从猪农及其猪上分离到耐甲氧西林金黄色葡萄球菌(methicillin resistant Staphylococcus aureus,MRSA)。为了评估MRSA在荷兰猪群中的流行情况,作者检测了9家屠宰场的540头猪,这些屠宰场2005年度的生猪屠宰量占荷兰当年总屠宰量的63%。作者发现,在所测猪群中有209头(占39%)猪的鼻腔中携带MRSA。全部54个检测组(每组10头猪)中44组(81%)携带了MRSA,每个组来自不同的猪场,并且所有屠宰场均被污染。所有MRSA分离株均属于同一个菌群--多位点序列(Multi-Locus Sequence,MLS)398型和与之密切相关的spa基因型(主要是t001、t008和t1254)。发现了金黄色葡萄球菌染色体基因盒(Staphylococcal Chromosome Cassette,SCCmec)的三个型:Ⅲ(3%),Ⅳa(39%)和Ⅴ(57%)。44株(每组1株)对四环素均有耐药性,由此提示猪场普遍使用了四环素类抗生素。其中,同时耐红霉素和克林霉素的分离株占23%,同时耐卡那霉素、庆大霉素和托普霉素的分离株占36%,耐复方新诺明的仅1株,无耐环丙沙星和其它几种抗生素的菌株。各屠宰场间MRSA阳性猪比例显著不同,各试验组间也不相同,表明猪场的猪具有高MRSA流行率,而且屠宰场内存在高交叉感染率。

关键词：猪微生物学金黄色葡萄球菌甲氧西林耐药性四环素耐药性遗传学荷兰

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普伐他汀对脑梗死和白质损伤的作用

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世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 58-58页

作者： Ten dam V.H. van Den Heuvel D.M.J. van Buchem M.A. 史利利 Section of Gerontology and Geriatrics Department of Internal Medicine C2-R Leiden University Medical Center PO Box 9600 2300 RC Leiden NetherlandsDr.

The authors examined the effect of pravastatin 40 mg daily on the progression of ischemic brain lesions using repeated brain MRI. After a mean treatment perio d of 33 months, there was an increase in total ischemic lesion load of 1.1 cm3 ( p < 0.001) in the 270 placebo-treated subjects and 1.1 cm3 (p < 0.001) in the 2 65 pravastatin-treated subjects. There was no difference between the two treatm ent groups (p=0.73).

关键词：普伐他汀缺血损伤安慰剂

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Observations on movements of Double-banded Sandgrouse (Pterocles bicinctus) in Borakalalo National Park, North West province, South Africa

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Chinese Birds 2012年第1期03卷 47-53页

作者： Johann H. van NIEKERK Department of Environmental Sciences College of Agriculture and Environmental SciencesUniversity of South Africa PO Box 392 Pretoria 0003 South Africa

The main purpose of this study was to describe the intrinsic (breeding) and extrinsic factors (rainfall/vegetation) that might trigger movements of Double-banded Sandgrouse (Pterocles bicinctus) in Borakalalo National Park, South Africa. The park is situated 80 km north of Pretoria and 30 km north of Jericho in the North West province. Data collection was based on traversing the reserve for two days per month along a set route (32 km) with a vehicle at 10 km·h 1 during 2010. The mean group size of this Double-banded Sandgrouse was 2.47. The male to female ratio in the population was 1:0.87. They were often observed in the road, on short trampled grass or in burnt thornvelds with green sprouts. Double-banded Sandgrouse were mainly present in the reserve during two relatively dry periods, from February––MMMaaarrrccchhh and again from July––SSSeeepppttteeemmmbbbeeerrr 2010. They wwwwweeeeerrrrreeeee more regularly observed in the hinterland of the park in the mornings and conversely, during the late afternoons they were more regularly observed closer to the edge of the Klipvoor dam. Five possible reasons are discussed that may affect the movement of the Double-banded Sandgrouse: annual rainfall, short spells of high/low rainfall periods within the rainy season, daily flights of 2–4 km to drink water, breeding and veld conditions.

关键词： Double-banded Sandgrouse breeding rainfall vegetation

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非类固醇抗炎药治疗炎症性黄斑囊样水肿的疗效

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 18-18页

作者： van Kooij B. De Boer J. Ten dam N. 潘佳鸿 F.C. Donders Institute Department of Ophthalmology University Medical Center Utrecht P.O Box 85500 3508 GA Utrecht Netherlands Dr

PURPOSE: To assess the role of systemic non-steroidal antiinflammatory drugs (NSAIDs) in the treatment of inflammatory cystoid macular edema (iCME). DESIGN: Pilot study. METHODS: We included 66 patients with iCME and treated them with naproxen (2 × 250 mg daily; n=28) or rofecoxib (1 × 25 mg daily; n=38). After 4 months of therapy, visual acuity and in-flammation activity were measured. We evaluated the grade of CME, retinal vasculitis, and papillary leakage with fluorescein angiography. RESULTS: No clear effect of NSAIDs on iCME, visual acuity, and intraocular inflammation was observed. A beneficial effect was noted in less than 8% of the affected eyes. The drop-out rate after 4 months of treatment was 52% , because of adverse effects or inefficacy of the treatment. Improvement of visual acuity was slightly better in patients who were treated with naproxen compared with rofecoxib (P ≤ .05). CONCLUSION: Systemic NSAIDs have a limited role (if any) in the treatment of iCME.

关键词：黄斑囊样水肿非类固醇抗炎药炎症性疗效

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FAIR Principles:Interpretations and Implementation Considerations

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Data Intelligence 2020年第1期2卷 10-29,293-302,322页

作者： Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes Leiden University Medical Center Leiden2333 ZAThe Netherlands Institute of Data Science Maastricht UniversityUniversiteitssingel 60Maastricht 6229 ERThe Netherlands Department of Computer Science The University of ManchesterOxford RoadManchester M139PLUK Oxford e-Research Centre Department of Engineering SciencesUniversity of OxfordOxford OX13PJUK School of Chemistry Faculty of Engineering and Physical SciencesUniversity of SouthamptonSO171BJUK Amsterdam UMC University of AmsterdamAmsterdam 1000 GGThe Netherlands European Bioinformatics Institute(EMBL-EBI) HinxtonCambridgeCB101SDUK Harvard University CambridgeMassachusetts 02138USA Department of Bioinformatics–BiGCaT NUTRIMMaastricht UniversityMaastricht 6229 ERThe Netherlands Conceptual and Cognitive Modeling Research Group(CORE) Free University of Bozen-BolzanoBolzano 39100Italy Aalborg University Aalborg DK-9220Denmark Insight Centre for Data Analytics National University of Ireland GalwayH91 TK33Ireland Centre for Digital Scholarship Leiden University LibrariesLeiden2333 ZAThe Netherlands Department of Computer Science Vrije Universiteit AmsterdamDe Boelelaan 11051081 HV AmsterdamThe Netherlands Dutch Techcentre for Life Sciences(DTL) UtrechtThe Netherlands SURF Utrecht 3511 EPThe Netherlands Keith G Jeffery Consultants FaringdonUK Castor EDC Paasheuvelweg 25Wing 5D1105 BPAmsterdamThe Netherlands San Diego Supercomputer Center University of California San DiegoLa JollaCalifornia 92093USA Learning and Research Resources Centre(CRAI) Universitat de Barcelona08007 BarcelonaSpain Environment Agency Austria A-1090 ViennaAustria University of Notre dame 75004 ParisFrance Health Research Board(HRB) Dublin 2DO2 H638Ireland Liacs Institute of Advanced Computer Science Leiden University2311 GJ LeidenThe Netherlands Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic GO FAIR International Support&Coordination Office(GFISCO) LeidenThe Netherlands Harvard Catalys

The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in *** intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital *** has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR ***,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible ***,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-*** introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR *** self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the ***,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle.

关键词： FAIR guiding principles FAIR implementation FAIR convergence FAIR communities choices and challenges

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