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World Journal of Gastroenterology 2000年第6期6卷 789-792页

作者： Pankaj Singh Anant Indaram ronald greenberg Vernu Visvalingam Simmy Bank Division of Gastroenterology Albert Einstein Colege of MedicineLong Island Jewish Medical CenterNew Hyde ParkNew York

AIM To evaluate the long-term safety ofomeprazole in patients of gastroesophagealreflux disease resistant to treatment with H2receptor *** We prospectively followed 33patients on omeprazole therapy for severeerosive esophagitis for 5-8 years,with periodicgastrin levels,*** infection,gastricbiopsies for incidence of ECL cell hyperplasia,carcinoids,gastric atrophy and *** 185 patient follow-up years and 137 gastricbiopsies were *** Among the 33 patients,36% reachedtheir peak gastrin levels in an average of 8months to one year,then drifted Down slowlyover 1-2 year period to just above their baselinelevel,24% of the patients had a peak gastrinlevel above 400ng·L^1 and one patient had apeak level above 1000 ng·L^*** patient had amild ECL cell hyperplasia which was self limitingand did not show any dysplastic *** percent of patients were positive *** *** gastric biopsies did notshow gastric atrophy,intestinal metaplasia orneoplastic *** In a series of 33 patients followed for 5 - 8 years on omeprazole therapy for severe reflux esophagitis, we did not observe any evidence of significant ECL cell hyperplasia, gastric atrophy, intestinal metaplasia, dysplasia or neoplastic changes.

关键词： gastroesophageal reflux proton pump inhibitors enterochromaffin cell hypergastrinemia carcinoid tumor biopsy

Research evolution of metal organic frameworks: A scientometric approach with human-in-the-loop

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Journal of Data and Information Science 2024年第3期9卷 44-64页

作者： Xintong Zhao Kyle Langlois Jacob Furst Yuan An Xiaohua Hu Diego Gomez Gualdron Fernando Uribe-Romo Jane greenberg Drexel University 3141 Chestnut StPhiladelphiaPAUSA University of Central Florida 4000 Central Florida BlvdOrlandoFLUSA Colorado School of Mines 1500 Illinois StGoldenCOUSA

Purpose:This paper reports on a scientometric analysis bolstered by human-in-the-loop,domain experts,to examine the field of metal-organic frameworks(MOFs)*** analyses reveal the intellectual landscape of a *** study engaged MOF scientists in the design and review of our research *** materials are an essential component in next-generation renewable energy storage and biomedical *** research approach demonstrates how engaging experts,via human-in-the-loop processes,can help develop a comprehensive view of a field’s research trends,influential works,and specialized ***/methodology/approach:Ascientometric analysis was conducted,integrating natural language processing(NLP),topic modeling,and network analysis *** analytical approach was enhanced through a human-in-the-loop iterative process involving MOF research scientists at selected *** researcher feedback was incorporated into our *** data sample included 65,209 MOF research ***3 and software tool VOSviewer were used to perform the ***:The findings demonstrate the value of including domain experts in research workflows,refinement,and interpretation of *** each stage of the analysis,the MOF researchers contributed to interpreting the results and method refinements targeting our focus Research evolution of metal organic frameworks:A scientometric approach with human-in-the-loop on MOF *** study identified influential works and their *** findings also underscore four main MOF research directions and *** limitations:This study is limited by the sample(articles identified and referenced by the Cambridge Structural Database)that informed our *** implications:Our findings contribute to addressing the current gap in fully mapping out the comprehensive landscape of MOF ***,the results will help domain scientists target future research directions.

关键词： Scientometric Metal-Organic Frameworks(MOFs) Network analysis Topic modeling Human-in-the-loop

Trends of autoimmune liver disease inpatient hospitalization and mortality from 2011 to 2017:A United States nationwide analysis

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World Journal of Hepatology 2024年第7期16卷 1029-1038页

作者： Ali Wakil Yasameen Muzahim Mina Awadallah Vikash Kumar Natale Mazzaferro Patricia greenberg Nikolaos Pyrsopoulos Department of Gastroenterology and Hepatology The Brooklyn Hospital CenterBrooklynNY 11201United States Department of Gastroenterology and Hepatology University of Iowa Hospitals and ClinicsIowa CityIA 52242United States Department of Gastroenterology and Hepatology Rutgers the New Jersey Medical SchoolNewarkNJ 07103United States Department of Biostatistics and Epidemiology Rutgers School of Public HealthPiscatawayNJ 08854United States

BACKGROUND Autoimmune liver diseases(AiLD)encompass a variety of disorders that target either the liver cells(autoimmune hepatitis,AIH)or the bile ducts[primary biliary cholangitis(PBC),and primary sclerosing cholangitis(PSC)].These conditions can progress to chronic liver disease(CLD),which is characterized by fibrosis,cirrhosis,and hepatocellular *** studies have indicated a rise in hospitalizations and associated costs for CLD in the US,but information regarding inpatient admissions specifically for AiLD remains *** To examine the trends and mortality of inpatient hospitalization of AiLD from 2011 to *** This study is a retrospective analysis utilizing the National Inpatient Sample(NIS)*** subjects admitted between 2011 and 2017 with a diagnosis of AiLD(AIH,PBC,PSC)were identified using the International Classification of Diseases(ICD-9)and ICD-10 *** AiLD admission was defined if the first admission code was one of the AiLD *** AiLD admission was defined as having the AiLD diagnosis anywhere in the admission diagnosis(25 diagnoses).Subjects aged 21 years and older were *** national estimates of hospitalization were derived using sample weights provided by NIS.χ^(2)tests for categorical data were *** primary trend characteristics were in-hospital mortality,hospital charges,and length of *** From 2011 to 2017,hospitalization rates witnessed a significant decline,dropping from 83263 admissions to 74850 admissions(P65),mostly female(median 59%)(P<0.05),and primarily Caucasians(median 68%)(P<0.05).Medicare was the major insurance(median 56%),followed by private payer(median 27%)(P<0.05).The South was the top geographical distribution for these admissions(median 33%)(P<0.05),with most admissions taking place in big teaching institutions(median 63%)(P<0.05).Total charges for admissions rose from 66031 in 2011

关键词： Autoimmune hepatitis Autoimmune liver disease Epidemiology Cost-Effective care Admissions trend Mortality rate

Big Metadata,Smart Metadata,and Metadata Capital:Toward Greater Synergy Between Data Science and Metadata

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Journal of Data and Information Science 2017年第3期2卷 19-36页

作者： Jane greenberg College of Computing and Informatics Drexel University

Purpose： The purpose of the paper is to provide a framework for addressing the disconnect between metadata and data science. Data science cannot progress without metadata *** paper takes steps toward advancing the synergy between metadata and data science, and identifies pathways for developing a more cohesive metadata research agenda in data science. Design/methodology/approach： This paper identifies factors that challenge metadata research in the digital ecosystem, defines metadata and data science, and presents the concepts big metadata, smart metadata, and metadata capital as part of a metadata lingua franca connecting to data science. Findings： The ＂utilitarian nature＂ and ＂historical and traditional views＂ of metadata are identified as two intersecting factors that have inhibited metadata research. Big metadata, smart metadata, and metadata capital are presented as part ofa metadata linguafranca to help frame research in the data science research space. Research limitations： There are additional, intersecting factors to consider that likely inhibit metadata research, and other significant metadata concepts to explore. Practical implications： The immediate contribution of this work is that it may elicit response, critique, revision, or, more significantly, motivate research. The work presented can encourage more researchers to consider the significance of metadata as a research worthy topic within data science and the larger digital ecosystem. Originality/value： Although metadata research has not kept pace with other data science topics, there is little attention directed to this problem. This is surprising, given that metadata is essential for data science endeavors. This examination synthesizes original and prior scholarship to provide new grounding for metadata research in data science.

关键词： Metadata research Data science Big metadata Smart metadata Metadata capital

Salicylic Acid Signaling Controls the Maturation and Localization of the Arabidopsis Defense Protein ACCELERATED CELL DEATH6

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Molecular Plant 2014年第8期7卷 1365-1383页

作者： Zhongqin Zhang Jay Shrestha Chika Tateda Jean T. greenberg Department of Molecular Genetics and Cell Biology University of Chicago 929 East 57 Street GCIS W524 Chicago IL 60637 USA

ACCELERATED CELL DEATH6 （ACD6） is a multipass membrane protein with an ankyrin domain that acts in a positive feedback loop with the defense signal salicylic acid （SA）. This study implemented biochemical approaches to infer changes in ACD6 complexes and localization. In addition to forming endoplasmic reticulum （ER）- and plasma membrane （PM）-Iocalized complexes, ACD6 forms soluble complexes, where it is bound to cytosolic HSP70, ubiquitinated, and degraded via the proteasome. Thus, ACD6 constitutively undergoes ER-associated degradation. During SA signaling, the soluble ACD6 pool decreases, whereas the PM pool increases. Similarly, ACD6-1, an activated version of ACD6 that induces SA, is present at low levels in the soluble fraction and high levels in the PM. However, ACD6 variants with amino acid substitutions in the ankyrin domain form aberrant, inactive complexes, are induced by a SA agonist, but show no PM localization. SA signaling also increases the PM pools of FLAGELLIN SENSING2 （FLS2） and BRI1-ASSOClATED RECEPTOR KINASE 1 （BAK1）. FLS2 forms complexes ACD6; both FLS2 and BAK1 require ACD6 for maximal accumulation at the PM in response to SA signaling. A plausible scenario is that SA increases the efficiency of productive folding and/or complex formation in the ER, such that ACD6, together with FLS2 and BAK1, reaches the cell surface to more effectively promote immune responses.

关键词： ACD6 protein trafficking protein quality control salicylic acid.

Standardized Evaluation of Camera-based Driver State Monitoring Systems

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IEEE/CAA Journal of Automatica Sinica 2019年第3期6卷 716-732页

作者： Renran Tian Keyu Ruan Lingxi Li Jialiang Le Jeff greenberg Saeed Barbat IEEE the Transportation Active Safety Institute (TASI) and also with the Department of Computer Information and Graphics TechnologyPurdue School of Engineering and Technology Indiana University-Purdue University Indianapolis (IUPUI) the Transportation Active Safety Institute(TASI) and also with the Department of Electrical and Computer EngineeringPurdue School of Engineering and Technology Indiana University-Purdue University Indianapolis (IUPUI) the Ford Research and Innovation Center

Driver state sensing technologies, such as vehicular systems, start to be widely considered by automotive manufacturers. To reduce the cost and minimize the intrusiveness towards driving, the majority of these systems rely on the in-cabin camera(s) and other optical sensors. With their great capabilities in detecting and intervening of driver distraction and inattention,these technologies may become key components in future vehicle safety and control systems. However, to the best of our knowledge,currently, there is no common standard available to objectively compare the performance of these technologies. Thus, it is imperative to develop one standardized process for evaluation *** this paper, we propose one systematic and standardized evaluation process after successfully addressing three difficulties:1) defining and selecting the important influential individual and environmental factors, 2) countering the effects of individual differences and randomness in driver behaviors, and 3) building a reliable in-vehicle driver head motion tracking tool to collect ground-truth motion data. We have collected data on a large scale on a commercial driver state-sensing platform. For each subject, 30 to 40 minutes of head motion data was collected and included variables, such as lighting conditions, head/face features,and camera locations. The collected data was analyzed based on a proposed performance measure. The results show that the developed process can efficiently evaluate an individual camerabased driver state sensing product, which builds a common base for comparing the performance of different systems.

关键词： Data analysis data collection driver state sensing human factors performance evaluation

Bird community comparisons of four plantations and conservation concerns in South China

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Integrative Zoology 2014年第1期9卷 97-106页

作者： Fasheng ZOU Qiongfang YANG Yongbiao LIN Guoliang XU Russell greenberg Guangdong Entomological Institute GuangzhouChina South China Institute of Endangered Animals GuangzhouChina South China Botanical Garden Chinese Academy of SciencesGuangzhouChina Smithsonian Migratory Bird Centre National Zoological ParkWashingtonDCUSA

Plantations of non-native,fast-growing trees are increasing in the tropics and subtropics,perhaps with negative consequences for the native *** studied bird diversity in 4 types of plantations in South China to deter-mine which plantation types are especially detrimental,and compared our findings with studies in nearby natu-ral forests to assess the magnitude of the negative impact.A total of 57 species was *** mean capture rate of understory birds was 1.7 individuals *** richness and capture rate were lower in plantations than in nearby natural ***(Timaliidae),primarily forest-dependent species in South China,were particularly under-represented in *** richness,composition and bird density,particularly of un-derstory birds,differed between plantation *** of Schima,which is native to South China,had the highest species richness according to point count *** of Acacia(non-native)supported the highest understory species richness and produced the highest capture rate of understory birds,probably because of their complex structure and high arthropod *** bird diversity is to be considered,we strongly recommend that future re-afforestation projects in South China should,as far as possible,use mixed native tree species,and especially Schima,ahead of the other species.

关键词： babbler conservation bird community changing planting ways plantations tree species selection

Effects of neem-based insecticides on beet armyworm （Lepidoptera： Noctuidae）

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Insect Science 2005年第1期12卷 17-23页

作者： SHOILM.greenberg ALLANT.SHOWLER TONG-XIANLIU USDA-ARSAPMRU Texas A&M University Agricultural Experiment Station WeslacoTexasUSA

Three commercial neem [Azadirachta indica A. Juss (Meliaceae)]-basedinsecticides, Agroneem, Ecozin, and Neemix, and a non-commercial neem leaf powder, were evaluatedfor oviposition deterrence, antifeedant effect on larvae, and toxicity to eggs and larvae of thebeet armyworm, Spodoptera exigua (Huebner) (Lepidoptera: Noctuidae), on cotton leaves in thelaboratory. Oviposition deterrence in no-choice, and two- and five-choice assays, was observed forthe neem-based insecticide treatments when compared with a non-treated control. Neem-basedinsecticides also deterred feeding by beet armyworm larvae. Direct contact with neem-basedinsecticides decreased the survival of beet army-worm eggs. Survival of beet armyworm larvae fed for7 days on leaves treated with neem-based insecticides was reduced to 27, 33, 60, and 61% for neemleaf powder, Ecozin, Agroneem, and Neemix, respectively. Possibilities for adoption of neem-basedinsecticides in commercial cotton for beet armyworm control are discussed.

关键词： azadirachtin beet armyworm cotton feeding oviposition deterrence spodoptera exigua

Metadata as Data Intelligence

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Data Intelligence 2023年第1期5卷 1-5,F0004页

作者： Jane greenberg Mingfang Wu Wei Liu Fenghong Liu Metadata Research Center College of Computing and InformaticsDrexel University3675 Market St 10th floor PhiladelphiaPA 19104USA Australian Research Data Commons MelbourneVictoria 3145Australia Shanghai Library(Institute of Scientific and Technical Information of Shanghai) No.1555 Huaihai Middle Road Xuhui DistrictShanghai200031China Department of Library Informationand ArchiveSchool of Economic ManagementUniversity of Chinese Academy of Sciences33 BeisihuanxiluHaidian DistrictBeijing 100190China Data Intelligence National Science LibraryChinese Academy of Sciences33 BeisihuanxiluHaidian DistrictBeijing 100190China

*** Metadata,as a type of data,describes content,provides context,documents transactions,and situates *** in metadata has steadily grown over the last several decades,motivated initially by the increase in digital information,open access,early data sharing policies,and interoperability *** foundation has accelerated in more recent times,due to the increase in research data management policies and advances in *** to research data management,one of the larger factors has been the global adoption of the FAIR(findable,accessible,interoperable,and reusable)data principles[1,2],which are highly ***,researchers across nearly every domain are interested in leveraging metadata for machine learning and other Al applications.

关键词： initially Metadata motivated

Hepatic Kaposi sarcoma: A case report and review of the literature

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World Journal of Hepatology 2017年第4期9卷 171-179页

作者： Brett Van Leer-greenberg Abhisake Kole Saurabh Chawla Department of Medicine Emory University School of Medicine Division of Digestive Diseases Department of Medicine Emory University School of Medicine

Kaposi sarcoma(KS) is an aggressive cancer caused by human herpesvirus-8, primarily seen in immunocompromised patients. As opposed to the well-described cutaneous manifestations and pulmonary complications of KS, hepatic KS is rarely reported before death as most patients with hepatic KS do not manifest symptoms or evidence of liver injury. In patients with acquired immune deficiency syndrome, hepatic involvement of KS is present in 12%-24% of the population on incidental imaging and in approximately 35% of patients with cutaneous KS if an autopsy was completed after their death. Patients with clinically significant hepatic injury due to hepatic KS usually have an aggressive course of disease with hepatic failure often progressing to multi-organ failure and death. Here we report an unusual presentation of acute liver injury due to hepatic KS and briefly review the published literature on hepatic KS.

关键词： Herpesvirus 8 Acquired immune deficiency syndrome-related Kaposi sarcoma Acquired immune deficiency syndrome hepatopathy Human Kaposi sarcoma