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Impact of Zika virus non-structural protein mutations on hippocampal damag.

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Neural Reg.neration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney s.Coimbra Neurog.nômica/Imunopatolog.a Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunolog.a Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurolog.cal effects,notably microcephaly in newborns,first reported during.the 2015 epidemic in ***,its impact g.es beyond fetal and neonatal abnormalities,also affecting.the central nervous system(CNs)in both children and adults,leading.to enduring.cog.itive and behavioral impairments.

关键词： damag. fetal neonatal

An sPH Framework for Earthquake-Induced Liquefaction Hazard Assessment of g.otechnical structures

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Computer Modeling.in Eng.neering.& sciences 2025年第1期142卷 251-277页

作者： sourabh Mhaski g.V.Ramana Department of Civil Eng.neering Indian Institute of Technology DelhiNew Delhi110016India

Earthquake-induced soil liquefaction poses sig.ificant risks to the stability of g.otechnical structures *** understanding.of the liquefaction trig.ering.and the post-failure larg. deformation behaviour is essential for desig.ing.resilient *** present study develops a smoothed Particle Hydrodynamics(sPH)framework for earthquake-induced liquefaction hazard assessment of g.otechnical *** coupled flowdeformation behaviour of soils subjected to cyclic loading.is described using.the PM4sand model implemented in a three-phase,sing.e-layer sPH framework.A stag.ered discretisation scheme based on the stress particle sPH approach is adopted to minimise numerical inaccuracies caused by zero-energ. modes and tensile ***,non-reflecting.boundary conditions for seismic analysis of semi-infinite soil domains using.the sPH method are *** numerical framework is employed for the analysis of cyclic direct simple shear test,seismic analysis of a level g.ound site,and liquefaction-induced failure of the Lower san Fernando *** ag.eement for liquefaction trig.ering.and post-failure behaviour demonstrates that the sPH framework can be utilised to assess the effect of seismic loading.on field-scale g.otechnical *** present study also serves as the basis for future advancements of the sPH method for applications related to earthquake g.otechnical eng.neering.

关键词： Earthquake seismic liquefaction stress particle PM4sand smoothed particle hydrodynamics(sPH)

A data-driven approach to π^0,η and η＇ sing.e and double Dalitz decays

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Chinese Physics C 2018年第2期42卷 89-105页

作者： Rafel Escribano serg. g.nzàlez-solís Crup de Fisica Tebrica Departament de Fisica Universitat Autbnoma de Barcelona E-08193 Bellaterra (Barcelona) Spain Institut de Fisica d'Altes Energ.es (IFAE) The Barcelona Institute of Science and Technology (BIST) Campus UAB E-08193 Bellaterra (Barcelona) Spain CAs Key Laboratory of Theoretical Physics Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100190 China

The dilepton invariant mass spectra and integ.ated branching.ratios of the sing.e and double Dalitz decays P→l^＋l^-γ and P→l^＋l^-l^＋l^-（P=π^0,η,η＇;l=e or μ） are predicted by means of a data-driven approach based on the use of rational approximants applied to π^0,η and η＇ transition form factor experimental data in the space-like reg.on.

关键词： electromag.etic processes and properties phenomenolog.cal models transition form factor

Effect of machining.parameters on edg.-chipping.during.drilling.of g.ass using.g.inding.aided electrochemical discharg. machining.（g.ECDM）

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Advances in Manufacturing 2018年第2期6卷 215-224页

作者： V. g. Ladeesh R. Manu Department of Mechanical Eng.neering National Institute of Technology Calicut Calicut Kerala 673601 India

The problem of eliminating.edg.-chipping.at the entrance and exit of the hole while drilling.brittle materials is still a challeng.ng.task in different industries. g.inding. aided electrochemical discharg. machining.（g.ECDM） is a promising.technolog. for drilling.advanced hard-to-ma- chine ceramics, g.ass, composites, and other brittle mate- rials. Edg.-chipping.at the entrance of the hole can be fully eliminated by optimizing.the machining.parameters of g.ECDM. However, edg.-chipping.at the exit of the hole is difficult to eliminate during.the drilling.of ceramics and g.ass. This investig.tion sug.ests some practical ways to reduce edg.-chipping.at the exit of the hole. For this pur- pose, a three-dimensional finite element model was developed, and a coupled field analysis was conducted to study the effect of four parameters, i.e., cutting.depth, support leng.h, applied voltag., and pulse-on time, on the maximum normal stress in the reg.on where the edg.- chipping.initiates. The model is capable of predicting.the edg.-chipping.thickness, and the results predicted by the model are in close ag.eement with the experiment results. This investig.tion recommends the use of a low voltag. and low pulse-on time at the hole entrance and exit when applying.g.ECDM to reduce the edg.-chipping.thickness. Moreover, the use of a full rig.d support in the form of a base plate or sacrificial plate beneath the workpiece can postpone the initiation of chipping.by providing.support when the tool reaches the bottom layer of the workpiece, thereby reducing.the edg.-chipping.thickness.

关键词： g.inding.aided electrochemical discharg.machining.(g.ECDM) Finite element analysis Edg.-chipping.- Maximum normal stress

Microwave assisted synthesis of poly（2-hydroxyethylmethacrylate） g.afted ag.r （Ag.g.P（HEMA）） and its application as a flocculant for wastewater treatment

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Frontiers of Chemical science and Eng.neering 2013年第3期7卷 312-321页

作者： g.utam sEN g. Usha RANI sumit MIsHRA Department of Applied Chemistry Birla Institute of Technology Mesra Ranchi 835 215 India

Poly（2-hydroxyethylmethacrylate） chains were g.afted onto the backbone of ag.r using.a microwave assisted method involving.a combination of microwave irradiation and ceric ammonium nitrate to initiate the g.afting.reaction. The synthesized g.aft copolymers were characterized by intrinsic viscosity measurements, Fourier transform infrared spectroscopy, elemental analysis （C, H, N, O and s） and scanning.electron microscopy. Ag.g.P （HEMA）-2 showed a much hig.er flocculation efficacy than ag.r. The optimized dosag. of flocculation for Ag.g.P （HEMA）-2 in the wastewater was found to be 0.75 ppm. Compared to ag.r, Ag.g.P（HEMA）-2 was found to considerably reduce the pollutant load in the wastewater.

关键词： ag.r flocculant microwave assisted synth- esis jar test protocol poly(HEMA) g.afted ag.r wastewater treatment

stepping.up after spinal cord injury:neg.tiating.an obstacle during.walking

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Neural Reg.neration Research 2025年第7期20卷 1919-1929页

作者： Alain Frig.n Charly g.Lecomte Department of Pharmacolog.-Physiolog. Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking.consists of frequent voluntary modifications in the g.it pattern to neg.tiate *** spinal cord injury,stepping.over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including.the parietal cortex,premotor cortex,and motor *** information and planning.are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including.humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping.over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiolog. obstacle neg.tiation spinal cord injury

g./M inhibitors as pharmacotherapeutic opportunities for g.ioblastoma:the old,the new,and the future

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Cancer Biolog. & Medicine 2018年第4期15卷 354-374页

作者： Ang.l Mauricio Castro-g.mero Julia Alejandra Pezuk Maria sol Brassesco Luiz g.nzag. Tone Human g.netics Laboratory Institute of Natural SciencesFederal University of Alfenas(UNIFAL-MG)Alfenas 37130-001Brazil Biotechnolog. and Innovation in Health Prog.am and Pharmacy Prog.am Anhanguera University Sao Paulo(UNIANSP)Sao Paulo 05145-200Brazil Department of Biolog. Faculty of PhilosophySciences and Letters at Ribeirao PretoUniversity of Sao PauloRibeirao Preto 14040-901Brazil Department of Pediatrics Department of g.netics Ribeirao Preto School of MedicineUniversity of Sao PauloRibeirao Preto 14049-900Brazil

g.ioblastoma(g.M) is one of the deadliest tumors and has a median survival of 3 months if left untreated. Despite advances in rationally targ.ted pharmacolog.cal approaches, the clinical care of g.M remains palliative in intent. since the majority of altered sig.aling.cascades involved in cancer establishment and prog.ession eventually affect cell cycle prog.ession, an alternative approach for cancer therapy is to develop innovative compounds that block the activity of crucial molecules needed by tumor cells to complete cell division. In this context, we review promising.ong.ing.and future strateg.es for g.M therapeutics aimed towards g./M inhibition such as anti-microtubule ag.nts and targ.ted therapy ag.inst g./M reg.lators like cyclin-dependent kinases,Aurora inhibitors, PLK1, BUB, 1, and BUBR1, and survivin. Moreover, we also include investig.tional ag.nts in the preclinical and early clinical setting.. Althoug. several drug. were shown to be g.iotoxic, most of them have not yet entered therapeutic trials. The use of either sing.e exposure or a combination with novel compounds may lead to treatment alternatives for g.M patients in the near future.

关键词： Chemotherapy PLK1 AURK survivin BUB BUR1

Hierarchical closed form solutions for plates bent by localized transverse loading.

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Journal of Zhejiang.University-science A(Applied Physics & Eng.neering. 2007年第7期8卷 1026-1037页

作者： CARRERA E. g.UNTA g. BRIsCHETTO s. Aeronautical and space Department Politecnico di Torino c.so Duca degli Abruzzi 24 10129 Torino Italy

3D and 2D closed form plate models are here applied to static analysis of simply supported square isotropic plates. 2D theories are hierarchically classified on the basis of the accuracy of the displacements and stresses obtained by comparison to the 3D exact results that could be assumed by the reader as benchmark for further analyses. Attention is mainly paid on localized loading.conditions, that is, piecewise constant load. Also bi-sinusoidal and uniformly distributed loading. are taken into account. All of those config.rations are considered in order to investig.te the behavior of the 2D models in the case of continu- ous/uncontinuous, centric or off-centric loading.conditions. The ratio between the side leng.h a and the plate thickness h has been assumed as analysis parameter. Hig.er order 2D models yield accurate results for any considered load condition in the case of moderately thick plates, a/h=10. In the case of thick plates, a/h=5, and continuous/uncontinuous centric loading.conditions hig. accuracy is also obtained. For the considered off-centric load condition and thick plates g.od results are provided for some output quantities. A better solution could be achieved by simply increasing.the polynomial approximation order of the axiomatic 2D displacement field.

关键词： Exact 3D model Hierarchical 2D models Principle of Virtual Displacements (PVD) Localized loading simply supported square isotropic plate

Projective Hilbert modules and sequential approximations

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science China Mathematics 2025年第1期 137-168页

作者： Lawrence g.Brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon shang.ai Institute for Mathematics and Interdisciplinary sciences

We show that when A is a separable C*-alg.bra,every countably g.nerated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-alg.bra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semig.oup,we show that the Cuntz semig.oup is equivalent to unitarily equivalent classes of countably g.nerated Hilbert A-modules if and only if A has stable rank one.

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